Homo sapiens (human): 92 Help Entry 92                CDS       T01001                                  Symbol ACVR2A, ACTRII, ACVR2 Name (RefSeq) activin A receptor type 2A   KO K04670   activin receptor type-2A [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells hsa05418   Fluid shear stress and atherosclerosis Network nt06507  TGFB signaling   Element N01426   BMP9/10 signaling pathway N01453   BMP signaling pathway N01456   Activin signaling pathway N01459   Nodal signaling pathway N01462   BMP9/10 signaling pathway, BMP9/10 coreceptor Drug target Bimagrumab:  D10620 Elritercept:  D12891 Sotatercept:  D09670<US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     92 (ACVR2A)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     92 (ACVR2A)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     92 (ACVR2A)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     92 (ACVR2A)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     92 (ACVR2A) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      92 (ACVR2A) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    92 (ACVR2A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Pkinase_fungal Activin_recp Motif Other DBs NCBI-GeneID:  92 NCBI-ProteinID:  NP_001265508 OMIM:  102581 HGNC:  173 Ensembl:  ENSG00000121989 UniProt:  P27037 Structure PDB LinkDB All DBs Position 2:147844517..147930822 Genome browser AA seq 513 aa AA seqDB search MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL NT seq 1542 nt NT seq  +upstreamnt  +downstreamnt atgggagctgctgcaaagttggcgtttgccgtctttcttatctcctgttcttcaggtgct atacttggtagatcagaaactcaggagtgtcttttctttaatgctaattgggaaaaagac agaaccaatcaaactggtgttgaaccgtgttatggtgacaaagataaacggcggcattgt tttgctacctggaagaatatttctggttccattgaaatagtgaaacaaggttgttggctg gatgatatcaactgctatgacaggactgattgtgtagaaaaaaaagacagccctgaagta tatttttgttgctgtgagggcaatatgtgtaatgaaaagttttcttattttccggagatg gaagtcacacagcccacttcaaatccagttacacctaagccaccctattacaacatcctg ctctattccttggtgccacttatgttaattgcggggattgtcatttgtgcattttgggtg tacaggcatcacaagatggcctaccctcctgtacttgttccaactcaagacccaggacca cccccaccttctccattactaggtttgaaaccactgcagttattagaagtgaaagcaagg ggaagatttggttgtgtctggaaagcccagttgcttaacgaatatgtggctgtcaaaata tttccaatacaggacaaacagtcatggcaaaatgaatacgaagtctacagtttgcctgga atgaagcatgagaacatattacagttcattggtgcagaaaaacgaggcaccagtgttgat gtggatctttggctgatcacagcatttcatgaaaagggttcactatcagactttcttaag gctaatgtggtctcttggaatgaactgtgtcatattgcagaaaccatggctagaggattg gcatatttacatgaggatatacctggcctaaaagatggccacaaacctgccatatctcac agggacatcaaaagtaaaaatgtgctgttgaaaaacaacctgacagcttgcattgctgac tttgggttggccttaaaatttgaggctggcaagtctgcaggcgatacccatggacaggtt ggtacccggaggtacatggctccagaggtattagagggtgctataaacttccaaagggat gcatttttgaggatagatatgtatgccatgggattagtcctatgggaactggcttctcgc tgtactgctgcagatggacctgtagatgaatacatgttgccatttgaggaggaaattggc cagcatccatctcttgaagacatgcaggaagttgttgtgcataaaaaaaagaggcctgtt ttaagagattattggcagaaacatgctggaatggcaatgctctgtgaaaccattgaagaa tgttgggatcacgacgcagaagccaggttatcagctggatgtgtaggtgaaagaattacc cagatgcagagactaacaaatattattaccacagaggacattgtaacagtggtcacaatg gtgacaaatgttgactttcctcccaaagaatctagtctatga

Homo sapiens (human): 93 Help Entry 93                CDS       T01001                                  Symbol ACVR2B, ACTRIIB, ActR-IIB, HTX4 Name (RefSeq) activin A receptor type 2B   KO K13596   activin receptor type-2B [EC:2.7.11.30] Organism hsa  Homo sapiens (human) Pathway hsa04060   Cytokine-cytokine receptor interaction hsa04350   TGF-beta signaling pathway hsa04550   Signaling pathways regulating pluripotency of stem cells hsa05418   Fluid shear stress and atherosclerosis Network nt06507  TGFB signaling   Element N01453   BMP signaling pathway N01456   Activin signaling pathway N01457   Myostatin signaling pathway N01458   BMP-HAMP signaling pathway N01459   Nodal signaling pathway N01461   BMP-HAMP signaling pathway, auxiliary factor Disease H00632   Heterotaxy Drug target Bimagrumab:  D10620 Luspatercept:  D11701<JP/US> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04350 TGF-beta signaling pathway     93 (ACVR2B)   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     93 (ACVR2B)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     93 (ACVR2B)  09160 Human Diseases   09166 Cardiovascular disease    05418 Fluid shear stress and atherosclerosis     93 (ACVR2B)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hsa01001]     93 (ACVR2B) Enzymes [BR:hsa01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.30  receptor protein serine/threonine kinase      93 (ACVR2B) Protein kinases [BR:hsa01001]  Receptor serine/threonine kinases (RSTK): TKL group   TGFBR2 family [OT]    93 (ACVR2B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Activin_recp Pkinase_fungal Motif Other DBs NCBI-GeneID:  93 NCBI-ProteinID:  NP_001097 OMIM:  602730 HGNC:  174 Ensembl:  ENSG00000114739 UniProt:  Q13705 Structure PDB LinkDB All DBs Position 3:38453890..38493142 Genome browser AA seq 512 aa AA seqDB search MTAPWVALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQSGLERCEGEQDKRLHCY ASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFCCCEGNFCNERFTHLPEAG GPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEDPGPPP PSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMK HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSY LHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVG TRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQ HPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSL IRRSVNGTTSDCLVSLVTSVTNVDLPPKESSI NT seq 1539 nt NT seq  +upstreamnt  +downstreamnt atgacggcgccctgggtggccctcgccctcctctggggatcgctgtgcgccggctctggg cgtggggaggctgagacacgggagtgcatctactacaacgccaactgggagctggagcgc accaaccagagcggcctggagcgctgcgaaggcgagcaggacaagcggctgcactgctac gcctcctggcgcaacagctctggcaccatcgagctcgtgaagaagggctgctggctagat gacttcaactgctacgataggcaggagtgtgtggccactgaggagaacccccaggtgtac ttctgctgctgtgaaggcaacttctgcaacgaacgcttcactcatttgccagaggctggg ggcccggaagtcacgtacgagccacccccgacagcccccaccctgctcacggtgctggcc tactcactgctgcccatcgggggcctttccctcatcgtcctgctggccttttggatgtac cggcatcgcaagcccccctacggtcatgtggacatccatgaggaccctgggcctccacca ccatcccctctggtgggcctgaagccactgcagctgctggagatcaaggctcgggggcgc tttggctgtgtctggaaggcccagctcatgaatgactttgtagctgtcaagatcttccca ctccaggacaagcagtcgtggcagagtgaacgggagatcttcagcacacctggcatgaag cacgagaacctgctacagttcattgctgccgagaagcgaggctccaacctcgaagtagag ctgtggctcatcacggccttccatgacaagggctccctcacggattacctcaaggggaac atcatcacatggaacgaactgtgtcatgtagcagagacgatgtcacgaggcctctcatac ctgcatgaggatgtgccctggtgccgtggcgagggccacaagccgtctattgcccacagg gactttaaaagtaagaatgtattgctgaagagcgacctcacagccgtgctggctgacttt ggcttggctgttcgatttgagccagggaaacctccaggggacacccacggacaggtaggc acgagacggtacatggctcctgaggtgctcgagggagccatcaacttccagagagatgcc ttcctgcgcattgacatgtatgccatggggttggtgctgtgggagcttgtgtctcgctgc aaggctgcagacggacccgtggatgagtacatgctgccctttgaggaagagattggccag cacccttcgttggaggagctgcaggaggtggtggtgcacaagaagatgaggcccaccatt aaagatcactggttgaaacacccgggcctggcccagctttgtgtgaccatcgaggagtgc tgggaccatgatgcagaggctcgcttgtccgcgggctgtgtggaggagcgggtgtccctg attcggaggtcggtcaacggcactacctcggactgtctcgtttccctggtgacctctgtc accaatgtggacctgccccctaaagagtcaagcatctaa

DBGET integrated database retrieval system