Homo sapiens (human): 920 Help Entry 920               CDS       T01001                                  Symbol CD4, CD4mut, IMD79, Leu-3, OKT4D, T4 Name (RefSeq) CD4 molecule   KO K06454   T-cell surface glycoprotein CD4 Organism hsa  Homo sapiens (human) Pathway hsa03250   Viral life cycle - HIV-1 hsa03260   Virion - Human immunodeficiency virus hsa04060   Cytokine-cytokine receptor interaction hsa04514   Cell adhesion molecules hsa04612   Antigen processing and presentation hsa04640   Hematopoietic cell lineage hsa04658   Th1 and Th2 cell differentiation hsa04659   Th17 cell differentiation hsa04660   T cell receptor signaling pathway hsa05135   Yersinia infection hsa05166   Human T-cell leukemia virus 1 infection hsa05170   Human immunodeficiency virus 1 infection hsa05235   PD-L1 expression and PD-1 checkpoint pathway in cancer hsa05340   Primary immunodeficiency Network nt06183  Yersinia nt06537  TCR/BCR signaling   Element N01106   TCR-PLCG-ITPR signaling pathway Disease H02526   Disorders of adaptive immunity Drug target Antithymocyte immunoglobulin (rabbit):  D09190<JP/US> Cedelizumab:  D03420 Ibalizumab:  D09575<US> Lifileucel:  D12833<US> Priliximab:  D05610 Zanolimumab:  D06356 Brite KEGG Orthology (KO) [BR:hsa00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03250 Viral life cycle - HIV-1     920 (CD4)    03260 Virion - Human immunodeficiency virus     920 (CD4)  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04060 Cytokine-cytokine receptor interaction     920 (CD4)    04514 Cell adhesion molecules     920 (CD4)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     920 (CD4)    04612 Antigen processing and presentation     920 (CD4)    04660 T cell receptor signaling pathway     920 (CD4)    04658 Th1 and Th2 cell differentiation     920 (CD4)    04659 Th17 cell differentiation     920 (CD4)  09160 Human Diseases   09161 Cancer: overview    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     920 (CD4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     920 (CD4)    05170 Human immunodeficiency virus 1 infection     920 (CD4)   09171 Infectious disease: bacterial    05135 Yersinia infection     920 (CD4)   09163 Immune disease    05340 Primary immunodeficiency     920 (CD4)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     920 (CD4) CD molecules [BR:hsa04090]  Proteins   920 (CD4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  CD4-extracel C2-set ig Tcell_CD4_C V-set I-set Ig_3 Ig_2 Receptor_2B4 Motif Other DBs NCBI-GeneID:  920 NCBI-ProteinID:  NP_000607 OMIM:  186940 HGNC:  1678 Ensembl:  ENSG00000010610 UniProt:  P01730 B4DT49 A0A4Y5UGE4 Structure PDB LinkDB All DBs Position 12:6789528..6820799 Genome browser AA seq 458 aa AA seqDB search MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIK ILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQL LVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSG TWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWW QAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLA LEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWV LNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCV RCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI NT seq 1377 nt NT seq  +upstreamnt  +downstreamnt atgaaccggggagtcccttttaggcacttgcttctggtgctgcaactggcgctcctccca gcagccactcagggaaagaaagtggtgctgggcaaaaaaggggatacagtggaactgacc tgtacagcttcccagaagaagagcatacaattccactggaaaaactccaaccagataaag attctgggaaatcagggctccttcttaactaaaggtccatccaagctgaatgatcgcgct gactcaagaagaagcctttgggaccaaggaaactttcccctgatcatcaagaatcttaag atagaagactcagatacttacatctgtgaagtggaggaccagaaggaggaggtgcaattg ctagtgttcggattgactgccaactctgacacccacctgcttcaggggcagagcctgacc ctgaccttggagagcccccctggtagtagcccctcagtgcaatgtaggagtccaaggggt aaaaacatacagggggggaagaccctctccgtgtctcagctggagctccaggatagtggc acctggacatgcactgtcttgcagaaccagaagaaggtggagttcaaaatagacatcgtg gtgctagctttccagaaggcctccagcatagtctataagaaagagggggaacaggtggag ttctccttcccactcgcctttacagttgaaaagctgacgggcagtggcgagctgtggtgg caggcggagagggcttcctcctccaagtcttggatcacctttgacctgaagaacaaggaa gtgtctgtaaaacgggttacccaggaccctaagctccagatgggcaagaagctcccgctc cacctcaccctgccccaggccttgcctcagtatgctggctctggaaacctcaccctggcc cttgaagcgaaaacaggaaagttgcatcaggaagtgaacctggtggtgatgagagccact cagctccagaaaaatttgacctgtgaggtgtggggacccacctcccctaagctgatgctg agtttgaaactggagaacaaggaggcaaaggtctcgaagcgggagaaggcggtgtgggtg ctgaaccctgaggcggggatgtggcagtgtctgctgagtgactcgggacaggtcctgctg gaatccaacatcaaggttctgcccacatggtccaccccggtgcagccaatggccctgatt gtgctggggggcgtcgccggcctcctgcttttcattgggctaggcatcttcttctgtgtc aggtgccggcaccgaaggcgccaagcagagcggatgtctcagatcaagagactcctcagt gagaagaagacctgccagtgtcctcaccggtttcagaagacatgtagccccatttga

Homo sapiens (human): 925 Help Entry 925               CDS       T01001                                  Symbol CD8A, CD8, CD8alpha, IMD116, Leu2, p32 Name (RefSeq) CD8 subunit alpha   KO K06458   T-cell surface glycoprotein CD8 alpha chain Organism hsa  Homo sapiens (human) Pathway hsa04514   Cell adhesion molecules hsa04612   Antigen processing and presentation hsa04640   Hematopoietic cell lineage hsa04660   T cell receptor signaling pathway hsa05135   Yersinia infection hsa05340   Primary immunodeficiency Disease H00093   Combined immunodeficiency Drug target Antithymocyte immunoglobulin (rabbit):  D09190<JP/US> Lifileucel:  D12833<US> Tucidinostat:  D10993<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04514 Cell adhesion molecules     925 (CD8A)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     925 (CD8A)    04612 Antigen processing and presentation     925 (CD8A)    04660 T cell receptor signaling pathway     925 (CD8A)  09160 Human Diseases   09171 Infectious disease: bacterial    05135 Yersinia infection     925 (CD8A)   09163 Immune disease    05340 Primary immunodeficiency     925 (CD8A)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     925 (CD8A) CD molecules [BR:hsa04090]  Proteins   925 (CD8A) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  V-set Ig_3 I-set ig Ig_2 Motif Other DBs NCBI-GeneID:  925 NCBI-ProteinID:  NP_001139345 OMIM:  186910 HGNC:  1706 Ensembl:  ENSG00000153563 UniProt:  P01732 Q6ZVS2 Q8TAW8 Structure PDB LinkDB All DBs Position 2:complement(86784605..86808396) Genome browser AA seq 235 aa AA seqDB search MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSWLFQP RGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSDFRRENEGYYFCSALSN SIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEACRPAAGGAVHTRGLDFA CDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVVKSGDKPSLSARYV NT seq 708 nt NT seq  +upstreamnt  +downstreamnt atggccttaccagtgaccgccttgctcctgccgctggccttgctgctccacgccgccagg ccgagccagttccgggtgtcgccgctggatcggacctggaacctgggcgagacagtggag ctgaagtgccaggtgctgctgtccaacccgacgtcgggctgctcgtggctcttccagccg cgcggcgccgccgccagtcccaccttcctcctatacctctcccaaaacaagcccaaggcg gccgaggggctggacacccagcggttctcgggcaagaggttgggggacaccttcgtcctc accctgagcgacttccgccgagagaacgagggctactatttctgctcggccctgagcaac tccatcatgtacttcagccacttcgtgccggtcttcctgccagcgaagcccaccacgacg ccagcgccgcgaccaccaacaccggcgcccaccatcgcgtcgcagcccctgtccctgcgc ccagaggcgtgccggccagcggcggggggcgcagtgcacacgagggggctggacttcgcc tgtgatatctacatctgggcgcccttggccgggacttgtggggtccttctcctgtcactg gttatcaccctttactgcaaccacaggaaccgaagacgtgtttgcaaatgtccccggcct gtggtcaaatcgggagacaagcccagcctttcggcgagatacgtctaa

Homo sapiens (human): 926 Help Entry 926               CDS       T01001                                  Symbol CD8B, CD8B1, CD8beta, LEU2, LY3, LYT3, Ly-3, P37 Name (RefSeq) CD8 subunit beta   KO K06459   T-cell surface glycoprotein CD8 beta chain Organism hsa  Homo sapiens (human) Pathway hsa04514   Cell adhesion molecules hsa04612   Antigen processing and presentation hsa04640   Hematopoietic cell lineage hsa04660   T cell receptor signaling pathway hsa05135   Yersinia infection hsa05340   Primary immunodeficiency Drug target Antithymocyte immunoglobulin (rabbit):  D09190<JP/US> Lifileucel:  D12833<US> Tucidinostat:  D10993<JP> Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04514 Cell adhesion molecules     926 (CD8B)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     926 (CD8B)    04612 Antigen processing and presentation     926 (CD8B)    04660 T cell receptor signaling pathway     926 (CD8B)  09160 Human Diseases   09171 Infectious disease: bacterial    05135 Yersinia infection     926 (CD8B)   09163 Immune disease    05340 Primary immunodeficiency     926 (CD8B)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     926 (CD8B) CD molecules [BR:hsa04090]  Proteins   926 (CD8B) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  V-set Ig_3 I-set ig Ig_2 Motif Other DBs NCBI-GeneID:  926 NCBI-ProteinID:  NP_004922 OMIM:  186730 HGNC:  1707 Ensembl:  ENSG00000172116 UniProt:  P10966 LinkDB All DBs Position 2:complement(86815369..86861886) Genome browser AA seq 210 aa AA seqDB search MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQA PSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVG SPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGV LVLLVSLGVAIHLCCRRRRARLRFMKQFYK NT seq 633 nt NT seq  +upstreamnt  +downstreamnt atgcggccgcggctgtggctcctcttggccgcgcagctgacagttctccatggcaactca gtcctccagcagacccctgcatacataaaggtgcaaaccaacaagatggtgatgctgtcc tgcgaggctaaaatctccctcagtaacatgcgcatctactggctgagacagcgccaggca ccgagcagtgacagtcaccacgagttcctggccctctgggattccgcaaaagggactatc cacggtgaagaggtggaacaggagaagatagctgtgtttcgggatgcaagccggttcatt ctcaatctcacaagcgtgaagccggaagacagtggcatctacttctgcatgatcgtcggg agccccgagctgaccttcgggaagggaactcagctgagtgtggttgatttccttcccacc actgcccagcccaccaagaagtccaccctcaagaagagagtgtgccggttacccaggcca gagacccagaagggcccactttgtagccccatcacccttggcctgctggtggctggcgtc ctggttctgctggtttccctgggagtggccatccacctgtgctgccggcggaggagagcc cggcttcgtttcatgaaacaattttacaaatga

Homo sapiens (human): 927 Help Entry 927               CDS       T01001                                  Symbol CD8B2, CD8BP Name (RefSeq) CD8B family member 2   KO K06459   T-cell surface glycoprotein CD8 beta chain Organism hsa  Homo sapiens (human) Pathway hsa04514   Cell adhesion molecules hsa04612   Antigen processing and presentation hsa04640   Hematopoietic cell lineage hsa04660   T cell receptor signaling pathway hsa05135   Yersinia infection hsa05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09133 Signaling molecules and interaction    04514 Cell adhesion molecules     927 (CD8B2)  09150 Organismal Systems   09151 Immune system    04640 Hematopoietic cell lineage     927 (CD8B2)    04612 Antigen processing and presentation     927 (CD8B2)    04660 T cell receptor signaling pathway     927 (CD8B2)  09160 Human Diseases   09171 Infectious disease: bacterial    05135 Yersinia infection     927 (CD8B2)   09163 Immune disease    05340 Primary immunodeficiency     927 (CD8B2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:hsa04090]     927 (CD8B2) CD molecules [BR:hsa04090]  Proteins   927 (CD8B2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  V-set Ig_3 I-set ig Ig_2 Motif Other DBs NCBI-GeneID:  927 NCBI-ProteinID:  NP_001336656 HGNC:  1708 Ensembl:  ENSG00000254126 LinkDB All DBs Position 2:106487364..106544297 Genome browser AA seq 210 aa AA seqDB search MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMCIYWLRQRQA PSSDSHHEFLTLWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVG SPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPVTLGLLVAGV LVLLVSLGVAMHLCCRRRRARLRFMKQFYK NT seq 633 nt NT seq  +upstreamnt  +downstreamnt atgcggccgcggctgtggctcctcctggccgcgcagctgacagttctccatggcaactca gtcctccagcagacccctgcatacataaaggtgcaaaccaacaagatggtgatgctgtcc tgcgaggctaaaatctccctcagtaacatgtgcatctactggctgagacagcgccaggcc ccgagcagtgatagtcaccacgagttcctgaccctctgggattccgcaaaagggactatc cacggtgaagaggtggaacaggagaagatagctgtgtttcgggatgcaagccggttcatt ctcaatctcacaagcgtgaagccggaggacagtggcatctacttctgcatgatcgtcggg agccccgagctgaccttcgggaagggaactcagctgagtgtggttgatttccttcccacc actgcccagcccaccaagaagtccaccctcaagaagagagtgtgccggttacccaggcca gagacccagaagggcccactttgtagccccgtcacccttggcctgctggtggctggcgtc ctggttctgctggtttccctgggagtggccatgcacctgtgctgccggcggaggagagcc cggcttcgtttcatgaaacaattttacaaatga

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