KEGG T01001: 959

Homo sapiens (human): 959

Entry

959               CDS       T01001

Symbol

CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L

Name

(RefSeq) CD40 ligand

K03161

tumor necrosis factor ligand superfamily member 5

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04064

NF-kappa B signaling pathway

hsa04514

Cell adhesion molecules

hsa04660

T cell receptor signaling pathway

hsa04672

Intestinal immune network for IgA production

hsa05144

Malaria

hsa05145

Toxoplasmosis

hsa05310

Asthma

hsa05320

Autoimmune thyroid disease

hsa05322

Systemic lupus erythematosus

hsa05330

Allograft rejection

hsa05340

Primary immunodeficiency

hsa05416

Viral myocarditis

hsa05417

Lipid and atherosclerosis

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06223  TNF signaling (cancer)
nt06516  TNF signaling

Element

N00505

CD40-NFKB signaling pathway

Disease

H00086

Immunodeficiency with hyper-IgM

H00093

Combined immunodeficiency

Drug target

Frexalimab:

Letolizumab:

Ruplizumab:

Toralizumab:

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    959 (CD40LG)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    959 (CD40LG)
   04514 Cell adhesion molecules
    959 (CD40LG)
09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    959 (CD40LG)
   04672 Intestinal immune network for IgA production
    959 (CD40LG)
09160 Human Diseases
  09174 Infectious disease: parasitic
   05144 Malaria
    959 (CD40LG)
   05145 Toxoplasmosis
    959 (CD40LG)
  09163 Immune disease
   05310 Asthma
    959 (CD40LG)
   05322 Systemic lupus erythematosus
    959 (CD40LG)
   05320 Autoimmune thyroid disease
    959 (CD40LG)
   05330 Allograft rejection
    959 (CD40LG)
   05340 Primary immunodeficiency
    959 (CD40LG)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    959 (CD40LG)
   05416 Viral myocarditis
    959 (CD40LG)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    959 (CD40LG)
   04090 CD molecules [BR:hsa04090]
    959 (CD40LG)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Tumor necrosis fators
   959 (CD40LG)
CD molecules [BR:hsa04090]
Proteins
  959 (CD40LG)

SSDB

Motif

Pfam:

TNF

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

X:136648158..136660390

AA seq 261 aa
MIETYNQTSPRSAATGLPISMKIFMYLLTVFLITQMIGSALFAVYLHRRLDKIEDERNLH
EDFVFMKTIQRCNTGERSLSLLNCEEIKSQFEGFVKDIMLNKEETKKENSFEMQKGDQNP
QIAAHVISEASSKTTSVLQWAEKGYYTMSNNLVTLENGKQLTVKRQGLYYIYAQVTFCSN
REASSQAPFIASLCLKSPGRFERILLRAANTHSSAKPCGQQSIHLGGVFELQPGASVFVN
VTDPSQVSHGTGFTSFGLLKL

NT seq 786 nt +upstreamnt +downstreamnt
atgatcgaaacatacaaccaaacttctccccgatctgcggccactggactgcccatcagc
atgaaaatttttatgtatttacttactgtttttcttatcacccagatgattgggtcagca
ctttttgctgtgtatcttcatagaaggttggacaagatagaagatgaaaggaatcttcat
gaagattttgtattcatgaaaacgatacagagatgcaacacaggagaaagatccttatcc
ttactgaactgtgaggagattaaaagccagtttgaaggctttgtgaaggatataatgtta
aacaaagaggagacgaagaaagaaaacagctttgaaatgcaaaaaggtgatcagaatcct
caaattgcggcacatgtcataagtgaggccagcagtaaaacaacatctgtgttacagtgg
gctgaaaaaggatactacaccatgagcaacaacttggtaaccctggaaaatgggaaacag
ctgaccgttaaaagacaaggactctattatatctatgcccaagtcaccttctgttccaat
cgggaagcttcgagtcaagctccatttatagccagcctctgcctaaagtcccccggtaga
ttcgagagaatcttactcagagctgcaaatacccacagttccgccaaaccttgcgggcaa
caatccattcacttgggaggagtatttgaattgcaaccaggtgcttcggtgtttgtcaat
gtgactgatccaagccaagtgagccatggcactggcttcacgtcctttggcttactcaaa
ctctga

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