Ictalurus furcatus (blue catfish): 128625006 Help Entry 128625006         CDS       T09387                                  Symbol obscnb Name (RefSeq) obscurin isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism ifu  Ictalurus furcatus (blue catfish) Pathway ifu04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:ifu00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     128625006 (obscnb)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ifu01001]     128625006 (obscnb)   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ifu04131]     128625006 (obscnb) Enzymes [BR:ifu01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      128625006 (obscnb) Protein kinases [BR:ifu01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    128625006 (obscnb) Membrane trafficking [BR:ifu04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     128625006 (obscnb) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Izumo-Ig Ig_4 Ig_6 Ig_5 V-set_CD47 C2-set_2 C1-set SOS1_NGEF_PH fn3 RhoGEF FN3_DSCAM-DSCAML_C PH IQ IQ_SEC7_PH RHG20_PH Pur_ac_phosph_N DUF1722 Motif Other DBs NCBI-GeneID:  128625006 NCBI-ProteinID:  XP_053509006 LinkDB All DBs Position 1:complement(2366910..2423506) Genome browser AA seq 6034 aa AA seqDB search MDQNLFGGAPRFLTRPKAFSLSVGRDATLSCTVVGTPVPAVTWEKDKLRISTGGRFKTIE DGDVYRLTIYDLTLEDSGQYMCRAKNNVGEAYAAVTLKVGLPATLVDRAPVFTAKPVSTR VGLGGDVTFFCRVAAHPAPKFDWEKDGRYLGETNRIKITSDSESSSVRIQGVRNMDSGTY TCRAQNSIGRAQAGAALVVDAQDTRLLNADKSTSLLSHLQKRKEEMCKDISLFRTTESHS LTSSSNIIEGLSKSDLASDQERRVVALAGKLPKGVFTRTCMVTEGKHAKLSCFVTGHPKP QIIWRKDGVNISEGRRHTMYEDQAENFILKVLYCKQSDNGLYTCNASNLAGQTYSAVLVI VKEPTVAFKKKLQDVEVKEKETAMLLCEVPIPSTQASWFMEETRLEQNAKYRMEQEGTLR RLTIHNVTTNDDAVYICEMKEGSRTVAELTVLGNITKKLPRRTVVPVSDTVIFCVELEQP VEDAYWTRNGEKLKEDSRVIIARTLQQYTLTIRDCTAEDSGEVAFVAGDCKTSTRFSVTA PRKYPPDPPVKPIVLNKTDSSITLSWSRADSERPVPVNGYVVERRKVGAQTWVRVTGMEL VSTSQYTISNFTEESSYQFRISAVNNFGQSAYLEVPGTYYLEPTASVTSGLQSCTAVSGE EATFSVELSAACSGSWTLNGRLIRSGADYLITRSKTVHTLVIREVTTALDGAQVKFVGGG SESVCSLSVKAAPARFTKKYSEVEIFTFSAHSSAQLYTEVSDASVQVSWMKNGMELRMGK KYEASSVGCKRTLTIHNVTHEDAGMYECVCDGDKMSIQLAIKEEAAKFVNKPKTQPLEVS PLMGDVALSCEVASPTTTVVWKKEHKEIAEDNRVTLVSQGTERKLVIKGAKQSDEGHYSC ETVEDKVTFRVKIQETRAMFINKDTYQKEVKVSASQKATLSCEVCDSKTEVKWYKDGKQL ISSKTVHVETKGKIRQLVLDSVEKKDAGEYTCEVGNEKLDFKIHVTATPIETQALATFVN KDTYQKEVKVSASQKATLSCEVSDSKTEVKWYKDGKHLMSSKTVHVETKGKIRQLVLDSV EKKDAGEYTCEVGNEKLDFKIHVTAALKETQAQATFVNKDTYQKEVKVSASQKATLSCEV SDSKTEVKWYKDGKQLMSSKTVHVETKGKIRQLVLDSVEKTDAGEYTCEVGNEKLLFKIQ VAETQAVFINKDTYQKEVKVSASQKATLSCEVSDSKTEVKWYKDSKQLMPSKTIHVETKD KIRQLVLDSVEKKDAGEYTCEVGNEKLLFKIQVTEPQAVFSNKDTYQKEVKVSASQKATL SCEVCNSKTEVKWYKDGKQLMSSKTVHVGTKGKIRQLVLDSVEKKDAGEYTCEVGNEKLL FKIQVTETHATFTNKDTYQKEVKVSASQKATLSCEVSDSKTEVKWYKDGKQLVSSKTVHV ETKGKIRQLVLDSVEKKDAGEYTCEVGNEKLAFKIQVAEPQATFINKDTYQKEVKVSASQ KATLSCEVCDSKTEVKWYNDGKQLISSKTVHVETKGKIRQLVLDSVEKKDAGEYTCEVGN EKLAFKIQVTEPQATFINKDTYQKEVKVSASQKATLSCEVFDSKTEVKWYKDGKQLISSK TVHVETKGKIRQLVLDSVEKKDAGEYTCEVGNEKLLFKIQVAESQATFINKDTYQKEVKV SASQKATLSCEVSDSKTEVKWYKDGKQLMSSKTVHVETKDKIRQLVLDSVEKEDAGEYTC EVGSEKLAFKIQVADISAKFQKKPSTKETIAVQETENIILTTVVTTEHANVSWFRDGVQL KEGNKYEMKREGSSHVLIVKSSEAKDTGTYTCQTADDKMEFQVQIKESPLKFVVGLEPVS VVLGSTMTLSCQLNRAAGDVLWRHNGKEMKLGGRYVIRADGPQRLLTVSSVAHEDEGEYS CECRDDKTTAKVTTKAPRLVKFVSKLNNVVANEGKDAIFKCCVTPADVSVRWLYNNVPVV SGPKFMIAHGGTSHSLTITAVTLEDVGEISVDAEGKVCKATLQVQKLPVMFVKKLENKTV QEQDTVELEVELSRPSTEVKWMKNGIVLQPEGNLTIQADGVKQTLIFKSVTCADRGFYSC ETLDDKTQAKLTVEMKKIQVVKGLKEMKVHEQETATMEVELSQPDVEAFWTKDGQKLRAS PKILITALGNKHSLTMSQLKMEDSGMISFQAEGVHTSAKLIITEPPAKILRPLEDVTTPE KEKATFECDVSRVNADVTWFKNDEELKPGKRYMMHSQGRKRSLLIQKCTYEDQGVYVCKT TDDNTSAKLTVHARDIKIIKQLHDLEVTEKESAAFVCEVSHDEVEGQWFKDDVRLKAGDN IKMRQEGRTYILLFKSVKPEDAAEIKFMAEKASSVAKLTVKELPVRFVKKLRDKIAMYKH RGHLECQVSRASATVTWYKNKDKIRASQKHVISSEDVYRKLTITDVDSGDEATYTCDAVD EKTSCKLLVEEQAISIVKELSAVEVTEPFAAHFEVEVSVETVKPVKWALNGESLSESSDI ELEKEGTMHRLTFKKTKASMSGTVQFTAGKSKSTARLIVKERPIEVVEPLRNVTGQEKAS AKLSCRLSAVPKEVSWFKGQTALEESSKYIMKQNGAEVQLLIQVLSPDDAGEYRCQTGTC ETKATLTVEVRDVRITKRLTDVEVDEGGDAVFTCEVNYADEEAEWFLNDKPLFSNEVNVI QHVNKTHTITLKNLAPQDGGMITFKIREQKQTVCLNVKEKKAVFLKLLDDVIGEEKGIVT LKCEASKHTVSPVWRKDGAVLSADSKHELLHDGRILGLTIRDIAQADAGEYSCDLGTDVT KSKVTIREISIGITKRLKSVEAKAGETCVFECILSRESSDTCSWSLKGQHVTSGGRFQIS SKGRKHTLSIQGVTGSDSGEVIFTLKDLNSRATLSVEGEVPTFSKELQGVSVAPGEDATF LCELSLAGLDVVWWKNGKTIQKSLKYEIIQENKVVKLIVHSVTAKDSGEYGCEVTGGPTS KAHLEIKEPVNKFIRELKDLTAHEKGAVSFECETAQPASKVTWLKGVKEIKAGRKYQMTQ KERILILTVKDLEEADGDTYSCNIDTAKSTAKLTVQVLPAIFTQELKDQKAMEKGSVTWC CELSKPGIPVQWRKGEVDLCSCTKYEFRQDGHLVQLIIHDLDPEDSGVYTCDSGDQKTTA HLEVKALPILFKTPLKKLEAEAGETAVFRCELTKPGAPVVWRKDQKILQSSNKHQLRQDG AVVELVIYKLQEADSGEYSCDSGYEMTSAQLTVKEPDITIDTELKSCIVNEGDDVSFECF VSHDGAQNVKWELQGVPLQSNEMNVIQAEGKRHLLTLRSVTEKDSGTVSFHVGSHTSFAC LTVKAVPVLKFTKDLMNQEATEGDKVTLSCETSTPDALVTWKKDRKVISEGDKYSIQKNG TIQTLVICKLTVGDAGEYVCEVGEKQSKATLSVKEHVRITRKLKDVTVTTGEDAAFDCEV SKTGVTNAEWWLGFNHLQNNDLNQISSRGREHSLVLKMVTPDDSGDVAFVVGCERTVASL VVKEKPKETPAFFRKELANVDAVEGDTVTLRCELSKPGVSVEWRKGGVVLQPNKKFQLKQ EACVQELHIHDLKPEDSGYYTCDAGNQLTTASVSVQEAEVLIVSGIKSTDVFAGEQAVFS CQLSRRAKGRVQWWLDGTRLENSPFSVIGVGEDNIHTLTLKNLAPNDSGTVLFKTGSLTS SARLLVKDPTVEVVSAMEDINIAENQPAEFICQFSRPVRAIWKRNGQPVQPDGQRLIVEQ DWTVARLYISRVTAQDVGVYSCEAEGTCIEAHLRVQAKPIEIIQGLDNVETIEGGEALFE CSLSLPESKDCRWLVDGQPVKESAKVEIVCFENGRRHLLLLKDLRAGDNSTVTFQAGTAS SSALLSVKGLELEVVKPLEDKTVVVGEQAEFTCVLSEPVPEKDVNWYANGSELRPDDIWA MKNNGCACTLILKKAQVRSPLEITFAAQDAISVAKLMTIAVPDPPEDPELVTKGPTSVTL SWFTPLNDGGSPILGYRVEMRRVDSALWQPCHTEPVCNTEFTVENLVSGSGYRFRVAAIN RAGIGDSVQLPQTVTLDAPVTIAKKLNVSELRKGKIARLECELSSESKQVIWQKDHQEIE IGAKYQMVTEGKSQILLIKDFQPADQGVYTCVASEEVETSINLDLEEDRTVIPQPEEGGQ PGLPPEAASEGDLHVLWDALAKKRRMSREPTLDSISELPEEDGKDKTQDLEGKGVGKAQI KEKEKPIEIKPELQLYTSSEDESVSGSLVSYLKKSSKSSVTVMSESETVASQKFYEHFQM TEKTVQQTTAAPPLEIAKDDDRDELQEAAIKIQAAFKGFKARKDMRPAFKEVFKDQNKEP NMTIHLECIADGKPDKVRWLKDGKPLVDGKHHHIDIYNDGTCSLIVPAATTNDTGVYTCE VTNKFGVASHSGKVVVGSVRESSGRRPLTLGYSADSEPESSGSEMDESLRQASRRLQKLL RTRLPPNVEEEPFVSADEGDLPPPDPHSYREDDSYIYIRFDTRSEAQVASQRFQEMFTHQ GVPVDTTIIEIGTKIELRIKKMGSTQDGSQTPTKEKPVFMSGPLAAPVFLTQLQNQEVPD GYPVNFDCVIIGKPSPSIRWFKDGKVLHEDDHYMINEDQEGCHQLIITTVRPSDMGVYRC VAENDSGIASSKAELRVEMSCSSDYDTAADATETSSYISAKDYVSSSEHRDTEAFESVVE DEQLPQVVDELHDLFLSPGAPNAKMSVRIKGFPTPKVYWFKDGVALSATDRVLLSAERDV FSLEIVEVKREDSGEYSVYVSNAAGAAYSSARMVVLSPGDRIPETLKIRDSKEPLVPPRF LEKFCNRTVKQGASITLSVKVEGSPTPCVNWLKEEALKDLLWIKADTPGYKIASSGSQHS LILMDVGKEHSGSYTCIASNRAGQSVNTARLDVDQGVTALPTLQQSGVTPEICGITVSPP EEEGKGEPKLPYLAGVDTADFLQKLTSHITEMVSAKITQASLRVPGGDSDDETKTPSPYH GRSRPASLITDSSSESDEGEARGEMFDIYVATADYNPTGLSKESIALKEGQYVEVLDSAH PLKWLVRTKPTKTTPSRQGWVSPAYLDKKLKISADTSEVPETTGEEVTEGEYKRKLCQLI QELITSEKEFIKEVGFVTSHHLKHVDEESTPPEIRSRKETIFCNISDISAFHSSSFLPGL QECDTDDDIAMHFIKNTEGFENYLPYFVGQAKAKATISEKDVQQYFKKYTDSELANVDPA EGPVLSVNNYLQRPLDRIQKYKDLLKELIKNKARNGQNCCLLEEAYAMVSSLPTRSENTH HVSLIANYPANLEALGEPIRQGPFIVWEGAPGIRTSSRGHHRHVFLFKNYVVICKQKRDT DMDVQTYTFKNMMKLTNIDVNETVEGDERAFEIWHEREDSVRKYTLQARTVILKNSWLRD LRNLQQRYSMPAWSPPDFEAVLTDCTAELGQTVKLACKVTGSPKPIVAWFKDGRAVEVDP HHIIIEDPDGSCTLILDNMTADDSGQYMCFATSGAGNASTLGKITVQVPPRFVHKLRNAA FVAGEDAQFTCTIISAPSPKIRWFKEGRLLADQEKYQTYSEPRSGVVVFVIKNPGEKDLG RYECELSNRLGSVRCAAELVLPTLAMAGGEQAIRIEVTEQETKVPKKTIIIEETITTVVK NTRMKRHASPRPSSMGVYRSEASTSEPPRQKRTMSKKAVPTLYVTEPEGTAARNPKWVEV EEIIEYKVNKSPKLPRRRGASPGRRQPPDNPNVNNSNNKLVEEMQVSGASVDSQTFSWDG ESETASLDSPEVEVVDFDQPCVLMEICDTDTDDDDQAAVCEDFSDDILDDGNKVFTLEDL EDYVPKEGETFGCGDSHVPAERPVEISVLQTEINEPTVGRPVLLNLGRPLLPTPKVRPGF FSRFKEHFSNVFSDPSSAGEKFIPIRVSGVSYSQSASAPGSSTSHGKVEVTQRYCSEVQR GTAGGQQSFKAQISAPVGQPVTVPIPKMNQSGKP NT seq 18105 nt NT seq  +upstreamnt  +downstreamnt atggaccagaatctttttggaggagctcctcggttcctgacccggcccaaagcgttctcc ctcagtgtgggtcgggatgctactctcagttgcaccgttgtggggacccctgttcctgct gtcacctgggaaaaagacaaactgcgcatttccactggagggcgcttcaaaactatagag gatggggatgtgtatcggctcaccatctatgacctgacgctggaggacagcgggcagtac atgtgccgcgcaaagaataatgtcggagaagcttacgcagctgtgacactgaaggtgggt cttccagcaacattggtcgatcgagcacccgtgttcacggcgaagcccgtctccaccaga gtgggtttgggcggtgatgttaccttcttctgtcgtgtggcagctcaccccgctcccaaa tttgactgggagaaggacggtcgttatctaggtgagaccaatcgcatcaagatcacgtcg gacagcgagtccagctccgtgcggattcagggcgtcaggaatatggacagcggcacttat acctgccgggctcagaactccatcggtcgagcgcaagctggcgccgctctggtggtggac gcacaggatactcgacttctcaacgccgacaaaagcacctccctcctgtctcacctgcag aagcgcaaagaggagatgtgtaaggatatttcccttttccgaacgaccgagagccactcc ctgacctcctcgtctaatatcatagaagggcttagcaagtcggaccttgcctccgatcag gagcggcgggtcgttgctttggctggcaaactgcccaaaggcgtcttcacccgaacctgc atggtgaccgagggcaagcacgccaagctcagctgctttgtcacgggccaccccaaaccc cagatcatctggaggaaggatggtgtgaacatcagcgagggtcgtaggcacaccatgtat gaggaccaagcagagaacttcattctcaaagtactgtactgcaagcagagtgataatggc ctctatacctgcaacgcctccaacttagctggacaaacctacagcgctgttctggtgatt gtgaaagagccaacagtggcatttaagaagaagctgcaggacgtggaggtgaaggagaag gagacggccatgttgttgtgtgaggtgcccataccgagcactcaggcgtcctggttcatg gaggagactcgcctggagcagaatgcgaagtaccgcatggagcaggagggcacgctgcgt cgcctcaccatccacaacgtcacgaccaacgacgacgccgtttacatctgcgaaatgaag gaagggagtcgcactgtagctgagctcactgttctgggaaacatcaccaagaagttaccc aggaggacggtcgtgccggtgagcgatacagtgatcttctgcgtggagctcgagcagccg gttgaagatgcttattggacccggaatggagagaagctgaaggaggactccagggtcatt attgctcgcacgcttcaacagtacacgctcaccatccgggactgcactgcagaagactcg ggcgaggtggcgttcgttgccggcgactgcaagacctccacgcgattctcagtaactgca ccgaggaagtatcctccagatcccccggtcaaacccattgtgttgaacaagacggacagc tccatcactctaagctggtctcgggcagacagcgagcggcccgtaccagtcaacggctac gtggtggagaggaggaaggtcggagctcagacgtgggttcgagtcacgggaatggagctc gtgtcgaccagccaatacaccatcagcaacttcaccgaggagagcagctaccagttccgc atttcagccgttaacaattttggtcagagcgcctatctggaggttcctggaacgtattat ctcgagccgaccgcctcggtgacgtcaggtctgcaaagctgcaccgccgtgtctggcgag gaggccaccttcagcgtggagctctccgcggcgtgctctggaagttggacgctgaacggc cgactgatccgcagcggcgcagactatctcatcactcgctcgaagaccgttcacacgctg gtgatcagggaggtgaccacggcactggatggagctcaggtcaaattcgtgggtggaggt tctgaaagcgtctgctctctcagtgtaaaagctgctccggcacgttttaccaagaaatat tctgaagtggagatcttcacgttcagcgctcactcctctgcccagctgtacacggaggtc tcagacgccagtgtccaggtctcctggatgaagaacggtatggaattgaggatgggcaaa aagtatgaggcgtccagtgtgggatgtaaacgcacgctgactattcataacgtgactcat gaggatgcagggatgtatgagtgtgtgtgtgacggtgataagatgtccatccagctcgct attaaagaggaagcagcgaagtttgtgaacaagcccaagactcaacccctggaggtttct ccattgatgggtgatgtggcattgagttgtgaggtggcgtcgcctacaactactgttgtg tggaagaaggagcataaagaaattgcggaggacaacagagtgaccttggtgtcccagggg acagagagaaagctggttatcaaaggagccaagcagagcgatgaaggacactattcatgt gagacggtagaggacaaggtcacattcagggtcaaaatacaagaaactcgagccatgttt atcaacaaggacacctatcagaaggaggtgaaagtttctgcctctcagaaagccacgctg agctgtgaagtgtgcgactctaagaccgaggtgaaatggtataaagacggcaaacagctg atctccagtaagaccgtccacgtggagacgaagggcaaaatccgtcaactggtgttggac agtgtggagaagaaggatgcaggagagtacacctgtgaagttgggaatgagaagctggat tttaagattcatgtcacagccaccccaatagaaactcaagctctagcgaccttcgtgaac aaggacacctatcagaaggaggtgaaagtttctgcctctcagaaagcaacactgagctgt gaagtgtccgactccaaaaccgaggtgaaatggtataaagacggcaaacatctgatgtcc agtaagaccgtccacgtggagacgaagggcaaaatccgtcaactggtgttggacagtgtg gagaagaaggatgcaggagagtacacctgtgaagttggaaatgagaagctggattttaag attcatgtgactgctgccctaaaagaaactcaggctcaagcgacctttgtgaacaaggac acctatcagaaggaggtgaaagtttctgcctctcagaaagccacactgagctgtgaagtg tccgactccaaaaccgaggtgaaatggtataaagacggcaaacagctgatgtccagtaag accgtccacgtggagacaaagggcaaaatccgtcaactggtgttggacagtgtggagaag actgatgcaggagagtacacctgtgaagttggaaatgagaagctgctctttaagattcag gtggcagaaactcaagcagttttcatcaacaaggacacctatcagaaggaggtgaaagtt tctgcctctcagaaagccacgctgagctgtgaagtgtccgactccaagacagaggtgaaa tggtataaagacagcaaacagctgatgcccagtaagaccatccacgtggagacgaaggac aaaatccgtcaactggtgttggacagtgtggagaagaaggatgcaggagagtacacctgt gaagttgggaatgagaagctgctctttaagattcaggtgacagaaccccaagcagttttc agcaacaaggacacctatcagaaggaggtgaaagtttctgcctctcagaaagccacgctg agctgtgaagtgtgcaactccaaaactgaggtgaaatggtataaagacggcaaacagctg atgtccagtaagaccgtccacgtggggacgaagggcaaaatccgtcaactggtattggac agtgtggagaagaaggatgcaggagagtacacctgtgaagttggaaatgagaagctgctc tttaagattcaggtgacagaaactcatgccactttcaccaacaaggacacctatcagaag gaggtgaaagtttctgcctctcagaaagccacgctgagctgtgaagtgtccgattctaaa accgaggtgaaatggtataaagacggcaaacagctggtctccagtaagaccgtccacgtg gagacgaagggcaaaatccgtcaactggtgttggacagtgtggagaagaaggatgcagga gagtacacctgtgaagttggaaatgagaagctggcttttaagattcaggtggcagaacct caagccactttcatcaacaaggacacctatcagaaggaggtgaaagtttctgcctctcag aaagccacgctgagctgtgaagtgtgtgactccaagaccgaggtaaaatggtataacgac ggcaaacagctgatctccagtaagaccgtccacgtggagacgaagggcaaaatccgtcaa ctggtgttggacagtgtggagaagaaggatgcaggagagtacacctgtgaagttggaaat gagaagctggcctttaagattcaggtgacagaacctcaagccactttcatcaacaaggac acctatcagaaggaagtgaaagtttctgcctctcagaaagccacgctgagctgtgaagtg ttcgactctaagaccgaggtgaaatggtataaagacggcaaacagctgatctccagtaag accgtccacgtggagacgaagggcaaaatccgtcaactggtgttggacagtgtggagaag aaggatgcaggagagtacacctgtgaagttgggaatgagaagctgctctttaagattcag gtggcagaatctcaagccactttcatcaacaaggacacctatcagaaggaggtgaaagtt tccgcctctcagaaagccacgctgagctgtgaagtgtccgattctaagaccgaggtgaaa tggtataaagacggcaaacagctgatgtccagtaagaccgtccacgtggagacgaaggac aaaatccgtcaactggtgttggacagtgtggagaaggaggatgcaggagagtacacctgt gaagttggaagtgagaagctggcttttaagattcaggtggcagacatctctgctaaattc caaaagaaacccagtacgaaggaaactatagctgtgcaagaaaccgagaacattatccta acgactgtggtaacaacagaacatgctaatgttagttggttcagggacggtgtacagctg aaggagggtaataagtacgaaatgaagagagaaggttcgtctcatgtcctcatcgttaag tcctctgaagcaaaggataccggcacttatacgtgtcagacagctgacgacaagatggaa ttccaagttcagatcaaagagtctccactgaaatttgtggttggcttggagccagtatct gttgtccttggcagcaccatgactttgtcctgccagctaaacagagctgctggagatgtc ctctggagacacaacggcaaagaaatgaagcttggaggcagatacgtcatccgtgctgac ggtcctcaacgtttactcacagtgtcttctgtagcccatgaagatgaaggagagtacagt tgcgaatgcagagatgacaagactactgctaaggtcaccactaaagctccacgtctggtg aagttcgtgtccaagttgaacaatgtcgtggcaaacgaaggcaaggatgcgatctttaaa tgttgcgtcactcctgcggacgtaagcgtgagatggctgtataataacgtgcctgtcgtc tctgggcccaaattcatgatcgctcacggcggcaccagccattcgctcacgatcacggcg gtcacgttagaggacgtgggagaaatcagtgtggatgctgaagggaaagtgtgtaaagcg actctgcaagtgcaaaagctccctgttatgttcgttaagaagcttgagaacaaaacggtc caagaacaggacaccgtggagcttgaggtggaactgagtaggccgtccactgaggtaaag tggatgaagaacggcattgtgctgcagcctgaagggaatctgacgattcaagctgacgga gttaaacagactctgatctttaagagtgtaacctgcgctgaccgaggcttctactcttgt gagactctggatgacaagactcaggccaaactgactgtagaaatgaagaagatccaggtt gttaagggcttgaaagagatgaaagtccacgaacaggagacggcgacaatggaggttgaa cttagccagcctgatgtggaagccttctggaccaaagatgggcaaaaactgagagcgagt cccaaaatcctcattacagctctgggtaataaacattccttgaccatgtcccagctgaag atggaagacagtgggatgatctctttccaggcagaaggtgtccacacgtcggcaaaactc atcatcactgaacctcctgcaaagatcctcagaccattagaagatgtgactactccggaa aaggagaaagccacctttgagtgtgacgtgtcccgagtgaatgctgacgtgacgtggttt aagaatgatgaggaactgaaaccaggaaagagatacatgatgcattcccaaggtcggaag cgtagcctcctcatccagaagtgtacttatgaagaccaaggcgtgtacgtgtgcaaaacg acggatgacaacacatcagccaagctaaccgttcatgcccgtgacattaagattattaag cagctgcacgatttggaagtgacggagaaagagagtgcggcgtttgtctgtgaggtgtcg catgacgaagtggaaggtcagtggtttaaagatgacgtcagactcaaagccggggacaac atcaagatgagacaggaagggagaacatatattctactcttcaaatctgtgaagcctgaa gatgctgctgaaatcaagttcatggctgagaaggcttcatcagtcgctaagctcacagtc aaagaattgcctgtgagattcgtgaagaaactccgagacaaaattgccatgtacaagcac cggggacatttggagtgccaggtgtctcgagccagtgccacggtcacatggtataagaac aaggacaagatccgagccagtcagaagcacgtgatctccagcgaggacgtgtatcgcaag ctgaccatcactgacgtggactctggggatgaagccacgtacacgtgcgacgctgtcgat gaaaagacatcatgcaagctactcgtggaggagcaggccatcagcatcgtcaaggagctc agcgcagtggaagtgacggaaccgttcgcggctcacttcgaggttgaggtcagcgtggaa acggtcaagccggtcaagtgggccctgaacggagaaagtctgagcgagagcagcgatatt gagctcgagaaggaaggcacaatgcatcgccttacgtttaagaagaccaaggcttccatg tcaggaacagtgcagttcacagctgggaaaagcaaatccacggctcggctcatcgtgaaa gagcgccccatcgaggtggtcgagcccctcagaaacgtgaccggccaagaaaaggcttca gccaagctgtcatgcaggctatcggctgttcctaaagaagtgtcttggtttaagggtcaa actgctctggaggaatccagcaagtatattatgaaacaaaatggtgctgaagtgcagctg ctcatccaggtgctgagtccagatgatgctggagagtatcgctgtcagactgggacctgt gagaccaaagcaacactcactgttgaagtgcgtgacgttcggatcaccaagcgcttgacg gatgtggaggtcgatgaaggcggggatgctgtgtttacctgcgaggtgaattatgctgac gaggaagccgagtggttcctcaacgacaagccgctgttcagtaatgaggttaacgtcatc cagcacgtgaataagacgcataccatcactctcaagaacctggcacctcaagatggtggg atgatcaccttcaagattagggaacagaagcagacagtctgcctgaatgtaaaagaaaag aaagccgtcttccttaagttgttagacgacgtgatcggagaagaaaagggcattgtaacg ctgaaatgtgaagcctcaaaacacacagtgtcccctgtttggcggaaagatggtgccgtc ctttctgcggacagcaagcatgagcttttgcatgacggcagaatcctgggtctgacaatc cgggacatcgcgcaggcggacgccggagagtacagctgtgatcttggtacagatgttacg aaatcaaaggtcaccattagagaaatcagcatcggcatcacaaaacgcttgaagtcagtg gaggctaaagcgggtgagacctgcgtgttcgagtgcattctctctcgagaaagctcggac acgtgctcatggagcctgaaaggccaacacgtgacgagcggagggcgtttccagattagc agcaaagggcgcaagcacacgcttagcatccaaggagtgactgggtcagactcgggggag gtcattttcactctcaaggatttgaactcgagagcgacgttgtctgtggaaggtgaagtt cctaccttctctaaagagctccagggtgttagcgttgctcctggagaagatgctacattc ctctgtgagctctctctggccggcttggatgttgtttggtggaagaacggaaagacgatc cagaaaagcctaaagtatgagattattcaggaaaataaggtggtgaagctgattgttcac agtgttactgccaaggattctggagaatacggctgcgaggtgaccggtggaccgacatcg aaagctcatctggaaatcaaagagcctgtgaacaagttcatccgtgagctcaaagatctc accgcgcatgaaaaaggtgccgtcagtttcgaatgtgaaaccgcacaaccggcttccaaa gtcacctggctgaaaggcgtgaaggagatcaaggcagggagaaagtatcagatgacgcag aaggaaagaatcctcattctcacggtgaaagatttggaggaggctgacggtgatacgtac tcgtgcaatatagacactgccaagagcaccgccaagctgactgttcaagttcttccagcc attttcactcaggagttgaaggaccagaaggctatggagaagggaagtgtcacctggtgc tgcgagctgtctaaaccaggtataccggttcagtggcgcaagggggaagtagacctttgt tcttgcaccaagtatgaattccggcaagacggccacctcgtccagttgatcatccacgac cttgaccctgaagactctggagtctacacctgcgatagtggagatcagaaaacgacagca cacctagaagtaaaggcactacccattctgtttaaaacccctctgaaaaagctggaagcc gaagccggggaaacggccgtattccggtgtgaacttaccaaaccgggagcacctgtagta tggagaaaagatcaaaagattctacagtcgagcaacaaacaccagttaaggcaggatgga gctgtagtcgagctagtcatctacaagctacaggaagcagactcgggagagtattcctgt gattcagggtatgaaatgacatctgcccaactcacggtaaaggaacccgacattactatc gacaccgagctgaagagctgcatcgttaacgaaggagacgatgtgtcctttgagtgcttc gtatctcacgacggcgcccagaacgtgaagtgggaacttcagggcgttcctctccagagc aacgagatgaacgtaatccaagcggaaggcaagaggcacttgctcactctaaggagcgtg accgagaaagactcgggcaccgtgtccttccatgtggggagccatacttcgttcgcttgt ctcacggttaaagctgtccctgtgctgaagtttacaaaagacttgatgaaccaggaagcc acagaaggagataaagttacgttatcctgtgaaacgtcaacccccgacgcccttgtgacc tggaagaaggaccgaaaagtcatttctgaaggagacaagtattccattcagaagaacggt acaatccagactctggtgatctgcaagctaacggttggcgatgctggagaatacgtgtgt gaagtcggagagaaacaaagcaaagccactttgagtgtcaaagaacatgtacgaattaca aggaaacttaaggacgtaaccgtgacgaccggcgaggatgctgcattcgattgcgaggtg tccaagacaggagtaactaatgccgaatggtggctaggcttcaatcacctgcaaaacaat gacttgaatcagataagcagccgagggagggaacacagcctagtgttaaaaatggtcacg cctgatgattcgggtgacgtggcctttgtggttggctgtgagaggactgttgcttccttg gtggtgaaggagaaacccaaagaaaccccggccttcttccgcaaggagttggcgaacgta gacgctgtagaaggtgacacggttacactccgctgtgaactttctaagcccggcgtcagc gtggagtggcgtaaaggtggagtagtcctgcaacccaataagaagtttcagctgaagcaa gaggcatgcgtacaagagcttcacatacacgacctgaaaccggaggacagtggctattac acttgtgacgcaggaaatcagttaacgacggcttcggtttcagtgcaagaggctgaggtg ctcatagtgtctggtataaaaagcactgatgtctttgcgggagagcaggcagtgttctcc tgccagctgtctcgccgtgccaaagggagagtccagtggtggctggatggcacccgtttg gagaacagtcccttcagtgttattggggtgggtgaagacaatattcacaccctcacccta aagaatctggcaccaaatgactcgggcaccgtcctgttcaaaacgggaagcttgacgtcc tcggctaggctgttagttaaagatcctactgtggaggtagtcagtgccatggaggatatc aacatagcagagaaccagcctgcagagttcatctgccagttctcacgcccagtcagggcc atatggaagcgaaacgggcaacccgtgcagcctgacggccagaggcttatagtggagcaa gactggactgtagcgcggttgtacattagccgggtaaccgcacaggatgtgggtgtatac tcctgtgaggcagaagggacctgtattgaggcacacctgagggtgcaagcgaaacccatt gagatcattcaaggtctggataacgtggagacaattgaaggtggtgaggcacttttcgag tgctccctatctctccccgagtctaaagattgccggtggttggttgatggacaacctgtg aaggagtctgcaaaagtggaaatcgtttgcttcgagaatggtcgacgccatcttttgctg ctgaaggacttgagagctggtgacaactcgacagtaacctttcaggctggcactgcctcc agctctgcccttctctcagtcaaagggttggagctggaagtggtgaaacccttggaggac aagactgttgttgttggtgagcaagcagagttcacttgcgtcctgagtgagcccgtacca gagaaagacgtgaactggtatgctaatggttctgaactacggccagatgacatttgggcg atgaagaataacggatgtgcgtgcaccctcattctgaaaaaagcccaagtccggtcacca ctggagatcacgtttgctgctcaggatgccatttcagtggccaagctaatgactattgcc gtacctgacccccctgaggatcccgagctggtcactaagggaccaacttcagtgactctg tcctggttcacacctctcaatgatggtggaagcccaatcctgggataccgtgtggaaatg cggcgagtggatagtgctctctggcagccctgccatacagaaccagtgtgcaatactgag tttacggtggaaaatcttgtctctggctctggatacaggttccgtgtggcagctattaac cgtgcagggattggagactctgtccagcttccacaaactgttacattggatgcaccggtg accattgccaagaagttaaacgtgtctgagctcagaaagggtaagattgcccgtctggag tgcgagctttcatctgagagtaagcaggtcatctggcaaaaagaccatcaggagattgag atcggtgccaaataccagatggtaacagagggcaaatcccaaattttgctcattaaggat ttccagcctgctgaccagggggtctatacttgtgtggcctcagaagaggtggaaacctcg ataaacctcgaccttgaagaagatcgcactgtgataccccagcccgaggaaggtggccag cctggcttgccccctgaggctgcctccgagggagatctgcatgttttatgggatgctctg gccaagaagaggaggatgagcagggaacccacactggactccatatctgagctgccagaa gaagatggtaaagacaagacacaagatctggagggtaaaggcgtggggaaagcgcagatc aaagagaaagagaagcccatcgaaatcaaaccagagctgcaactgtataccagttctgaa gacgagtccgttagtggaagtctggtgtcttaccttaaaaaaagcagcaaatcctctgtc acggtgatgagcgaaagtgaaaccgttgcatcccagaagttttacgaacattttcaaatg accgagaaaacagtgcagcagaccacagcagcaccgccgcttgagattgcgaaggatgac gacagggatgagctgcaggaggcagccatcaaaatccaagctgccttcaaaggcttcaaa gccagaaaggacatgcgacctgcctttaaagaggtctttaaggaccagaacaaagaacca aatatgacaattcatctcgagtgtattgcagacggcaagccagacaaagttcgctggctg aaggacggcaaaccgttggtagatggcaaacaccaccacatcgacatatacaacgatgga acttgttctctgattgtgccagctgctacgactaacgacactggggtgtacacttgtgag gtcacgaataagtttggggttgcgtcccacagtggaaaagtcgtcgttggctctgtgcga gagtcatcaggacgtcgtccgctaactctcggatatagtgcagacagtgagcctgagagc tccggcagcgagatggacgagtctttacgacaggcgagcaggaggctccagaagctgctt cgtacacgtcttccaccgaacgtcgaggaggaaccgttcgtaagtgccgacgagggtgac ctaccgcctccggatcctcattcgtaccgcgaagacgacagctacatctacatccgcttt gacacacgcagtgaagctcaggttgcatcccagcgattccaggagatgtttacacaccaa ggtgtgcctgtagacaccactattatcgaaatcggaaccaagatagaacttcgcatcaag aagatgggatccacccaagatggttcccaaaccccgactaaagaaaagccggttttcatg tcgggaccactcgcagccccagtcttcctgacacagctccaaaaccaggaagtcccagac ggatacccggtcaactttgactgtgtgatcatcggcaaaccctcccccagcatacggtgg ttcaaagacgggaaagtgctacacgaagatgaccattatatgatcaacgaagaccaggag ggctgccatcaattgatcattacaactgtacggccatccgacatgggcgtgtacagatgt gtggctgaaaatgacagtggcattgcatccagcaaggcggagcttagggtggaaatgtct tgcagctctgactacgacaccgcagccgacgccacagaaacgtcttcgtatattagtgct aaagattacgtctccagttctgagcacagagacactgaggcgttcgaatcggtggtggag gacgaacagcttcctcaagtggtggatgagttgcatgacctctttctcagtcccggagcg cccaatgccaagatgagcgtcagaatcaaaggattccccacaccaaaagtttactggttc aaggacggcgtggcactgtcggccacggacagggttttgctgtcggccgagagagacgtg ttcagtctggagatcgtggaggtgaagcgtgaagatagcggcgagtattccgtctacgtc agcaacgcagccggagctgcctactcctccgcacgcatggtcgtgctcagtccaggcgat cgcatacctgagactctgaagattagagactccaaagaacctctggtaccgccacgtttt ctggagaagttctgcaaccggacggtgaagcaaggagcgagcatcacgctgtctgtcaaa gtagaaggctccccgactccctgtgtgaactggctgaaggaagaagcgctgaaggatttg ttgtggattaaagcagacacgcccggatacaagatcgccagctctggctcccagcacagc ctcatcctgatggatgtcgggaaggagcacagcggcagctacacctgcatcgccagcaac cgcgccggccagtcggtcaacaccgcccgcctggacgtggaccaaggtgtgaccgctctc ccaactctacagcagagcggcgttacgccagagatttgtgggattacagtcagccctcca gaggaagaaggcaaaggagagccgaaactgccttacctggctggcgtcgataccgcagat ttcttacagaagctcacgtcgcacatcaccgagatggtctctgccaagatcacgcaagcc tcattacgcgtgcctggaggcgacagcgacgacgagaccaagactccatctccctaccac ggccgctcgcgtcccgcttccctgatcaccgactcgtcctccgaatccgacgagggtgaa gcccgaggagagatgtttgacatctacgtcgcgacggcggattataaccccacgggactg agtaaagagagcatcgctctaaaggaggggcagtacgtggaggtcctggactcggctcat ccgctcaaatggctcgtgcgcactaaacccaccaaaaccacaccctcgcgtcagggctgg gtctctccagcgtacctcgacaagaagttgaagatttctgcagatacatcggaagttccc gagaccacaggagaggaggtcactgagggagagtacaaaaggaagctctgccaactcatc caggagctcattaccagtgagaaggagtttataaaggaggtgggcttcgttacgtcgcac catctgaagcacgtcgacgaggagagcacaccgcctgaaatccgcagtcgcaaggagacc atcttctgcaacattagcgacatcagtgcgttccacagcagctcttttctccctgggcta caagagtgtgacacggatgacgatatagccatgcacttcataaaaaacacagaaggattt gagaactatctgccgtactttgtcggtcaggctaaggccaaggctaccatcagtgagaaa gatgttcagcagtatttcaagaaatacacggattcagagctggcgaatgtggatcctgca gaaggtccggtactgagtgtgaataattatcttcagagacctctggacagaatccagaaa tacaaggacctcttaaaggagttgattaaaaacaaggcgaggaatggacagaactgctgt cttctagaagaggcctacgccatggtttcttctcttcccacacgctctgaaaacacgcat cacgtctccctgattgcgaactaccctgctaacctggaagcgttaggagagcccatcaga cagggtcctttcatagtgtgggagggcgctccaggaatcagaacgtcttcgagaggacat caccgtcacgtcttcctcttcaaaaactacgtcgtcatctgcaaacagaaacgagacacg gacatggacgtccaaacgtacacgttcaagaatatgatgaagctcaccaacattgacgtg aacgagactgtggaaggagacgagagggcgttcgagatctggcacgagcgtgaggactcg gtgaggaagtacacgctgcaagcacgcacagtcattctgaagaactcctggctccgtgat ctgcgcaacctccaacaacgctacagcatgccagcgtggagtccacctgattttgaggca gtgttgactgactgcacagcagaactgggacagacggttaaactggcttgcaaggtcacg ggatctccgaaacccatagtggcctggtttaaagacggccgggccgtggaggtcgaccct caccacatcatcatcgaggaccccgacggttcctgcaccctcatcctggataacatgact gcagatgactctggccagtacatgtgcttcgccaccagcggtgctggaaacgccagcacc ctgggcaagattacagtccaggtaccgccacgctttgtccacaagttgaggaacgccgcg ttcgtcgcaggagaggacgctcagttcacttgcacaatcataagtgctccaagtccaaaa ataaggtggtttaaagagggcagactgctagcggaccaggagaagtatcagacttacagc gaaccacgtagcggcgtggtggttttcgtgattaagaaccccggagagaaagacctgggg cgttatgaatgcgagctttctaaccggctgggcagcgtgaggtgtgcggcagagctggtc cttcctacgttagcgatggccggaggagagcaggccatcaggattgaagttacagagcaa gagactaaagtaccaaagaaaaccataatcatagaggagaccatcacgactgtcgtgaag aacactcgaatgaagcgccacgcgtctccccgcccgtcctccatgggagtttaccgctcc gaagcctccacttctgaaccgccgcgacagaagaggacaatgtctaaaaaagccgtcccc actctgtacgtcacggaacccgaggggactgcagccaggaacccgaaatgggtcgaagtg gaagagattatcgagtataaagtgaacaagtcgccaaagctgccgaggagacgaggtgct tcccccggcaggagacagccacctgataaccctaacgtgaacaactcgaacaacaagtta gtggaggaaatgcaagtgtccggggctagcgtggactcgcaaactttctcttgggacggc gagtccgaaacagcgagtttggattctccagaagtggaagttgtggatttcgatcagccg tgtgtcttgatggaaatctgtgacacggacactgatgatgatgatcaggcagccgtatgc gaggacttcagcgatgacatcttagacgacgggaataaagtgttcaccctggaagacctg gaggattacgttcccaaagagggcgagacatttggttgtggagattctcacgtacctgcg gagaggccggttgaaatttcggttctacaaacggaaattaacgaacccaccgtcggtcga cccgtcctgctaaacctgggccgtccgcttttgccaaccccgaaagtacgtcctgggttc ttcagtcgctttaaagagcacttctcgaacgtcttttccgacccctcatcagctggggag aagtttataccgatccgtgtcagcggggtgtcctacagccagtctgcgtccgctcccgga tcgtcgacgagtcacggaaaggtggaagtaactcaaaggtactgctccgaggttcagcga gggacggctggcggccagcagagcttcaaagctcaaatctctgcaccagttggacaaccg gttacagttccgatccccaagatgaaccagtctggaaagccgtaa

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