Ictalurus punctatus (channel catfish): 108270491 Help Entry 108270491         CDS       T04658                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism ipu  Ictalurus punctatus (channel catfish) Pathway ipu04020   Calcium signaling pathway ipu04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ipu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108270491    04020 Calcium signaling pathway     108270491  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ipu04040]     108270491 Ion channels [BR:ipu04040]  Voltage-gated cation channels   Ryanodine receptor    108270491 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  108270491 NCBI-ProteinID:  XP_053538586 Ensembl:  ENSIPUG00000018608 UniProt:  A0A9F7RKM1 LinkDB All DBs Position 9:9093537..9325815 Genome browser AA seq 4876 aa AA seqDB search MAEGGEAEDEIQFLRTDDEVVLQCVASIQKENRKFCLSAEGLGNRLCYLELTSEAKYVPP DLCICNFVLEQSLSVRALQEMLAKTGENNEAAHGGGHRTLLYGHAILLRHSFSRMYLTCL KTSRSLTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLH LSISNGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVMRLFHGHDEVLTIPGSDQSE EQQRIVNYETGKVGAKARSLWRLEPLRISWCGSHIRWGQPFRLRHLTTGHYLALTEDKGL VLQDRENSDTVSTAFCFRASKEKLESSPKKDVEGMGVPEIKYGDSLCFIMHMTTGLWLSY QAPDVKSTRLGPLKRRACLHAEGHMDDGFTLQRCQNEESRAARIIRNTTRLFSHFIRDLD SLAGKNRTAVVLPIYEVLQTLNDLITYFQLPDAELEHEEKQIKLRSLKNRQNLFKQEGML ILVSNCIDRLSVYNSAAHFGECVGEEAGTAWKDILNLLYELLAALIRGNRNNCTQFSQNL DWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVLC SLCVCNGVAVRANQNLICDQLLPKRDLLLQTRLVNDVQSMRPNIFLGVREGSAQYKKWYF ELMIDQVEHFITSEPSHLRVGWASSKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSG RIPRRVASVNQHVLASDDVVSCCLDLGAPSISFRINGQPVQGMFESFNTDGLFFPVVSFS AGVKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMRVEPVKEYKRDVDGVRDLLGTTQ FLSQASFIPTPVDTSQIVMPPHLEKVRDRLAENIHELWAINKIELGWSYGKIRDDNKRQH PCLVDFSKLPETERNYNLQMSTETLKTLLALGCHVVQVSVNAEEELKKVKLPKNYMMSNG YKPMPLELSEVKLSPAQELLVDKLAENAHNVWAKDRVKQGWTYGIQQDLKSKRNPRLVPY ALLDERTKKSNRDSLRETVRTLIGYGYNIEPPDQEGGQVMERLSIDKIRFFRLERTYAVK TGKWYFEFEVVTGGDMRVGWARPGVRPDVELGTDDQAYVFDGYKGHRLHQGSRLFGRCWH AGDVVGCMINMEDKSMIFTLNGEILITNKGSELCFADFETEDGFIPVCSLGLSQVGRMNL GKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPKDHSHIAVTRIDGTI DSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSTYKSVPATEVNGVHEEEPLKLKYRY PVKSMKHIDEGRRIDYSSITTYYHSVRVFAGQDPSCVWVGWVTPDYHYYSNYFNLSKTRT VTVTLGDERGRVHESVRRSNCYMVWGGDAISSGHSSSRSNVDLEIGCHIDLATGLVAFTV NGRELPASYQVESNTKLFPAVFVRPTSPNLFQFELTKIKNAMPLSSAIFKSEHKNPIPQC PPRLDIQTIKSVLWSRMPNTFLKVDTARVSERHGWQVQCLDPLQMLAVHIPEENWCVDIM ELSEQEDLQTFHYHTLKLYRALCALGNTRVAHALCSHLDQSQLLYIIDNQYLSGMLRQGF YDVLISIHLETAKAAQLMMNNEFIIPITAETRSIRLFPDSSKQHQPPGVGLSTSLKPRLS FAPPCFITPKRDQYLYSPEIPLDVLREKAISMLTEAVQGGGDHIRDPVGGSVEYQFVPIL RMISTLLTMGVLNSQDVHKILLLIEPHVFGEQKSDEMGKATEKEGMTGAEEKAVEAGEEE AKDTKQPIKGLLEKKLPESVKLQMCKLLQYFCDCELRHRIEAIVSFSDSFVSKLQYNQKF RYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGDDCPCPVDIQEELYDFHSEL RLHCGIPMEEEEEDQDTSIKGRLMALVNKIKGQPHKAEMKPTEKEQAIPSNLKELISQTM VSWAQESHIQDPELVRAMFSLLRRQYDSIGELLRAMRKSYTISAASVHDTIHLLASLGQI RSLLSVRMGKEEEQLMIHGLSDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGGKSQE IAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAASS VMDNNSLALALEEPDLEKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAV FVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEALKISETPALDLSSTTQ GLISDASTEDEEEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILRS LVPTEDLVGIISIPLRMPVVNKDGSVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLL HLLEVGFLPDLRAAASLDTEALRTTETALTMNRYIGSAMLPLLTRCAPHFAGTEHHATLI DSTLHTIYQLSKGSSLTKAQRDAIEECLLAVCKYLRPSMLQQLLRRLVFDVPLLSEYCKM PLKLLTNHYDQNWKYYCLPSGWGSYGMASEEELLLTKKIFWGIFDSLSQKKYEQELFKMA MPCLSAIAGALPPDYVDSSLSTTLEKPVFLDVQGNFDPRPISTTNISLPEKLEYITHKYA EHSHDKWSTEKVVLGWKYGDSIDEKAKTHPMLRSYKSLTEKEKEVYRFPVKESLKSMLAM GWNIDRTKEGEAMFQQRENEKMRKISQASQANGSGFHPSPVDMSNVLLSRELQAMVEVLA ENYHNIWAKKKKSDLAVKGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLQINGYSITRG LKDMEQDSSSMEKRFAYKFLKKLLKYVDCAQEYIAHLEAMASSGKNDRSPHEQEIKFFAK VLLPLIDQYFKNHSLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSD STTMVSCLHILAHTLDTRTVMKSGSELVKAALRTFFENAADDLEKTLENLKLGKFTHSRS QMKGVSQNINYTTVALLPILTALFEHITEHQFGVDLLLDDVQVSCYRILSSLYSLGTGKN IYVERQLPALGECLATLAGAMPVAFLEPHLNTHNPFSVFNTKAARERAILGMPDTVEQMC PEVPHLDCLMKDINDMSESGARYTEMPHVIEVVLPMLCNYLSYWWERGTENQAKGTETAC STTVTSEHLSVILGNILKILNSNLGIDEASWMKRIAVYAQPIISKARADLLKAHFLPTLE KLKKKTVKVVAEEELLKADNKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDSDSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKMSKVGG QDQERKHKKRRGEIYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYGLKDTDEE VKEHLRRNLHLQEKSEDPAVRWQLHLYKDVIVKNEGPPDPERTIDRLQTISAAVFHLEQV EQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLTGYQRIWIETETYSF EEKLVQDLARTQRKLEEEEEELDEIQHDPLHQLILHFSHNALTEKSSLEDDLLYIAYTDM MAKSCAEDENEDEEGKEKTFEEKEMEKQKILYQQARLHDRGAAEMVLQMISASRGRLGPM VTFTLKLGISILNGGNILVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKA EGLGMVTEEGSINVRERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTTTV NIIISTVDYLLRLQESISDFYWYYSGKDIMDEAGQRNFSKALAVAKQIFNSLTEYIQGPC IGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIKLLKELMDLQKDMIVMMLSLLEG NVVNGTIGKQMVDTLVESSNNVEMILKFFDMFLKLKDLTTSDNFKEHDSDAKGVISKREF QKSMENQKQYSQSEIEFLLSCVEADENDMFNYVEFVKRFHEPAKDIGFNVAVLLTNLSEH MPHDSRLATFLSLAESVLNYFEPFLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASLISEPDAVERGEEDEIELQKVSKD LEMEEEENTLESSSAFTMACVSMKKNLCSLGRLLTLKSLRKRYKKLRKMSLREMISGFFF FFWIIFTGLLHFLYNLVWCFFHILWSSLFGGGLVEGAKNMKVTDILGNMPDPTQFGIHGD VLESEKLEVSEASLVAEINQMAQGDKTEIDLMSELLSIQPKKEGGKHGTEPGLGDVSEVV GVDSPSLVSAVQQKKAQEAASKSVENESNAESEKADTEDGEKNDQDKAKELLIEPPSQEE KKLPKRRCGQKKEQPEAIMASFFAGLDIYQTKILNYLARNFYNLRFLALFVAFAINFILL FYKVTGEESEEVDSWTGRHEEEDEGGIEYFILQENTGYMAPTLRFLAVLHTIISFLCVVG YYYLKVPLVVFKREKEIARKLEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFV KRKVINKYGDLYGAERIAELLGLDKSALDFNPTEETIAKEASLVSWLSSIDTKYHIWKMG VVITDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV GLLAVVVYLYTVVAFNFFRKFYNKSENEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEI EDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFIC GIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLVNKDETEHTGQESYVWKMYQERCWDF FPAGDCFRKQYEDQLG NT seq 14631 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggcggagaagcggaagacgagatccagttcttacgaacggatgatgaggtg gtgttgcaatgtgtggccagcattcagaaggagaatcgcaagttctgtctgtctgctgag ggacttggcaatcggctatgttacttggaactcacctcagaggccaagtatgtccctcca gatctgtgcatatgtaactttgtgctggagcagtcactgtctgtacgggcactgcaagag atgctggccaaaactggggaaaataatgaagcagcccatggaggtggacacagaacacta ctgtatggacatgctatcctcctgcgacactcgttcagtagaatgtatctgacatgttta aagacatccaggtctctgacagataagttgtcttttgatgtcggacttcaggaggactcg acaggtgaagcttgttggtggactatccatcctgcttccaagcagagatcagagggggag aaagttcgtattggtgatgaccttattcttgtcagtgtatcatctgagcgctatttacac ctgtccatctccaatggcaacattcaggtggatgcatctttcatgcagactctgtggaat gtccatcccacctgttcaggcagcagtgtggaggaaggatatctccttggtggtcatgtg atgcgtttgttccatgggcatgatgaggttttgacgatcccgggctcagatcagagtgag gaacagcagagaatagtcaactatgagacaggcaaagtaggggccaaggccagatctctt tggagattggaacctctacggatcagttggtgtggcagtcatatccgctgggggcaacca tttcgcctgcgccacctcaccactggtcattatctggccctgactgaagacaaaggcctt gtgctgcaagatcgggagaactcagacacagtctccaccgccttctgcttccgagcctcc aaggagaaactggagtcaagtccaaagaaagatgttgagggcatgggggtgcctgagatt aagtatggggactcgctttgtttcatcatgcacatgaccactggcctgtggctctcatac caggcaccggatgtaaaatcaactcgattggggcctctcaagagacgggcatgtctccat gcagaaggacacatggatgatggcttcactcttcagcgctgtcagaatgaagaatcacgt gctgcacgcatcatccgcaacaccaccagactcttcagccatttcattagagatctggac agtctggctgggaagaatcgcacagctgttgttcttcccatctatgaggttctccagacc ttaaacgacctcattacatattttcaactccctgatgccgaactggagcatgaggagaag cagatcaagctacgctcgctcaagaaccgccagaacctcttcaaacaggaggggatgctg atattggtgtctaactgcattgatcgtttgagtgtctacaacagtgcagcacactttgga gaatgcgtgggagaggaagctggcacagcttggaaagatattctcaacctgctctatgag ctcctggctgctttgatccgaggaaatagaaataactgcacacagttctcccaaaatctg gactggctggtcagcaagctggagagactggagtcatcctcagggatcctggaagtcctt cactgcatcttaattgaaagcccagaggcgcttaatatcattcagagaggacatatcaaa tctatcatctcgctgctatacaaacatggccgcaaccacaaaatcctagatgttctgtgc tcactctgtgtttgtaatggagtagctgtaagagccaatcagaacctgatctgcgatcaa ctgctcccaaaacgagacctgttactccagacacggctggtgaatgatgtccaaagcatg agacctaacatctttctgggagtgagggaaggttctgctcagtacaagaagtggtacttt gaactgatgatagaccaggtggagcactttataaccagcgaaccttctcacctgcgggtc gggtgggcttcctccaaaggctatgccccctacccagggggtggagagggctggggggga aacggagttggagatgacctctattcttatgggtttgatggacttcacttgtggtcaggt cgaatcccacggagagtagcttcagtaaaccagcatgtacttgcctcagatgatgtggtg agctgctgtttagatcttggagctccaagcatctcctttagaatcaatggtcagcctgtt caaggcatgtttgagagcttcaacacagatggtctcttcttccctgttgtcagcttctcc gctggtgtcaaggtgcgtttccttttaggtggccgccacggtgaatttaagttcctgcct ccgtcaggctacgctccctgctatgaggcactgcttcccaaagaaaagatgcgagtagaa ccagttaaggagtacaaaagggatgtggatggagtgagagacttgctgggcaccacacaa tttctgtcccaggcttcttttatacccactccagtggacacctctcaaattgtcatgcct cctcacctggagaaagtacgtgataggctggctgagaacatccatgaactgtgggccatt aacaagattgaactgggctggtcttatggcaagataagagatgataataaaaggcagcac ccctgcctggtggatttctcaaagctgcctgaaacagagaggaattacaacctgcagatg tcaacagagacattaaagactcttttggctctgggctgccatgtggttcaggtcagtgtc aacgctgaagaggagctaaaaaaagtgaaactcccaaagaattacatgatgtctaatggc tacaagcccatgccactggagctttcagaagtgaagctgagccctgcgcaagagctcctt gtggacaagttggccgagaacgcacacaacgtttgggccaaagatcgggtcaaacaaggc tggacctatggcatacagcaggatctgaaaagtaagcgcaatccccgtcttgtgccatat gcattgcttgatgaacgcaccaagaagtcaaaccgagacagcctgcgtgaaaccgtccgt acactaattggatatggctataacatcgagcctcccgatcaggaggggggtcaagtgatg gagagactaagtatcgataagattcgctttttccgtttagagaggacgtatgcagtgaaa acagggaagtggtattttgaatttgaagtggtgactggaggagatatgagggttggctgg gctcgaccaggtgtgcggcctgatgtggaactgggaaccgatgatcaggcctacgtcttt gatggttataaaggtcatcgtcttcaccagggcagccgtttgtttggtcgttgttggcat gctggggatgtggtgggctgcatgattaacatggaggacaaatccatgatcttcacgctt aatggagaaatactcattacaaacaagggctcagaactttgctttgctgactttgagact gaggatggctttattccagtctgtagtctgggcctttcccaagttggacgtatgaaccta ggcaaggatgccagtaccttcaaatattacaccatgtgtggcctgcaagagggatttgaa ccttttgctgtcaacatgaaccgagaggtcaccatgtggtttagcaagcggctccctact tttttcaacgttcccaaagatcatagtcatattgcggtcacgaggattgatgggactatt gacagccccccatgtctaaaagtgactcacaagacatttgggacacagaacagcaatgct gacatggtgttctgtcgtctgagtatgcctgtcgagttccactccacctacaagagcgtc cctgccactgaagtgaatggagtgcatgaagaagagccactcaaactcaaatacaggtat cctgtcaaatctatgaaacacatagatgaggggaggagaattgactatagtagcataaca acttactaccattcagtacgagtgtttgctggtcaggatccctcatgtgtgtgggttggc tgggtcacaccggactaccattactatagcaactactttaatctcagcaagacccgaact gtgacagttacgttaggggacgagcgaggtcgagtccatgaaagtgttagaaggagtaac tgttacatggtgtggggaggtgatgccattagctccggccactcctccagcagaagtaat gtggatttggagattggttgccacattgatttggctactggcttggtggcctttactgtc aatggcagagagcttcctgcctcatatcaggtggagtcaaatacaaagcttttccctgct gtgtttgtacgtcccaccagtccaaatctgttccagtttgaattgacaaagatcaagaat gctatgcccctttcatcagcaatttttaagagtgaacacaaaaacccaatccctcaatgt cctcctcgtctggatatccagaccattaaatcagttctatggagccggatgcccaacacc tttctgaaggtggacacagctcgagtgagtgagagacatggctggcaggtgcaatgtctg gatcctctgcagatgttggcagtacacattccagaggaaaactggtgtgtggacatcatg gaactctctgagcaggaagacctgcagacattccattatcacaccctaaaactttaccgt gctctctgtgcccttggtaacacccgtgtagctcatgctctctgcagccaccttgaccag tcacagctcctttacattattgacaaccaatacctgtctggcatgctgcgccaaggcttc tatgatgtcctcatcagtattcatctagagactgccaaagctgcgcagcttatgatgaac aatgagttcatcatcccaatcacagcagagacccgcagcatccgactctttccagattcc tccaagcaacaccagccacctggtgtaggactcagtacatctttaaaacccaggcttagc tttgctccaccatgcttcatcactccaaagcgtgaccagtatctctacagcccagaaatt cctctagatgttctgagggagaaggcaattagcatgctaacagaggctgttcagggtggc ggagaccacattcgagatcctgtagggggcagcgtggagtatcagtttgtgccaattctc agaatgattagcacgttgctaaccatgggtgtgctaaacagccaggatgttcataaaatc ttgcttctcatcgaaccacatgtctttggggagcagaaatcagatgaaatgggaaaagct acagagaaagagggcatgacaggagcagaagagaaggcagtggaggctggagaggaggaa gctaaagataccaagcagccaataaagggattgctggagaagaaattgccagagtcagtc aaactgcagatgtgcaaacttcttcagtacttctgtgactgtgaattgaggcaccgtatt gaggccattgtgtcattctctgatagctttgtgtcaaagctgcagtacaaccagaagttc cgttacaatgagttaatgcttgctctcaacatgtctgctgctgttactgctaagaagact aaagagttccgctcacctccacaggagcagatcaatatgctgttaaatttcagtatgggt gatgactgtccatgtcctgtggacattcaggaggaactctatgacttccacagcgaactt cgtctacactgtggtattccaatggaggaagaggaagaggatcaggacacatctattaaa ggccgtctgatggctctagttaacaagatcaaggggcagcctcacaaagcagaaatgaag ccaacagagaaagagcaagccataccttccaacctgaaggagttgatctctcagaccatg gtaagctgggctcaggagagccacatccaagacccagagctggtgcgtgccatgttcagc ctactacggcgacaatatgacagcattggcgagctgttgcgtgctatgcgcaaaagctac accatcagtgctgcatctgtgcatgacaccatccacctgctagcctcactgggtcagatc cgctcactgctcagcgtccgtatgggcaaagaggaagagcagctcatgattcatggcctc agtgacataatgaacaataaggtgttctaccagcacccgaatctgatgagagtactgggc atgcacgagactgtcatggaggttatggtgaatgtactggggggaggcaagtctcaggaa attgcttttcccaaaatggtggccagttgctgccgcttcctgtgctatttctgtcgaatc agccgacagaaccagaaggccatgtttgatcacttgagttacctgctagagaacagcagt gtgggtttggcttctccatcaatgagaggttccactcctctagatgtagctgcttcctct gtaatggacaacaacagcctggcacttgctcttgaggagcctgatctcgaaaaggtcgta acatatctggctggctgtggactgcagagttgtcccatgctccttgccaaaggctatcca gatataggctggaacccaattgagggagagcgctacctctcctttctccgctttgctgtt tttgtcaatggtgagagcgtagaagagaactccagtgttgtagtgaagctgctgattcgt cggcccgagtgctttggccctgctctgcgtggagaaggcggtaatggcctgctagctgcc atgaaggaagcccttaaaatatcagaaacaccagcacttgacctgtccagcaccacccag ggcctaatttctgatgcgtctacagaagatgaggaggaggaagaggtggttcacatgggc aatgctatcatgtcgttctactcagccctcattgatctgctgggacgctgtgcacctgaa atgcatctaataaataaaggcaaaggagaggctctgaggatccgtgccatcttgcgctcc ttggtgcccactgaagaccttgttggcataatcagcatcccactcaggatgcctgttgtc aataaagatggtagtgtgacagagcctgacatgtcagcctgtttctgtccggaccacaag gcacccatggttctgtttcttgaccgagtctatggcatagaagaccaaagcttcctcctg catcttctggaagttggcttcctgcctgacctaagagcggctgcctctctggacacagaa gcactaaggaccactgaaacagcactgaccatgaaccgttatatcggctctgcgatgctg cccttgctaactcgctgtgcccctcattttgctggtacagaacaccacgccacactcatt gattccacacttcacactatctaccagctgagcaagggctcatcactcactaaggcccag agagatgctatcgaggagtgccttctggccgtgtgcaagtacttgaggccatctatgctt caacagctgctgcgtcgattagtgtttgacgtgcctttgctttctgaatactgtaagatg cctcttaagctgttgactaaccattatgaccagaactggaagtattactgtctgccttct ggttggggcagctatggcatggcctctgaggaggaattactcctcaccaagaagatattt tggggcatctttgattcactctctcaaaaaaagtatgagcaggagctgtttaagatggcc atgccatgtctgagtgctatagctggagctttgcctccggattatgttgactcttctctc agcacaacgctggagaagccggtctttttggatgtgcagggcaactttgaccccagaccc atcagcacaacaaacatctccctcccagagaagctggaatacataactcacaaatacgcg gaacattctcatgataaatggtccactgagaaggttgttttaggctggaagtatggggat agcatcgatgagaaagcaaaaacacaccccatgctgagatcctacaaatcactcacagag aaggaaaaggaggtttaccgtttcccagtgaaggagtctttgaagagtatgctagccatg ggctggaacattgacaggaccaaagagggagaggccatgtttcagcaaagagagaacgag aagatgcgcaaaatttcccaagcatctcaggcaaatggtagcggttttcacccaagtcca gtagacatgagcaatgtactgctgtctcgagaactgcaggctatggtagaggttttggct gaaaactaccacaacatttgggctaaaaagaagaagagtgacctagcggtgaaaggtgga acacatcccttgttggtgccatatgatacacttacggccaaagaaaaagccagagaccgt gagaaagcccaggacctgttccgcttcctgcagataaatggctattccattaccaggggt ttgaaagacatggaacaggactcatcctcaatggagaaaaggtttgcctataaattcctg aaaaaactgctgaaatatgtggactgtgcacaggaatacattgctcacctggaggctatg gctagcagtggaaagaatgataggtcacctcatgagcaagaaatcaagttctttgccaag gtgcttctaccactaattgatcagtacttcaagaaccactcgctctacttcctctcctcc cccagtaagaacctcagcagcagtggctatgcttcaaacaaagagaaagagatggttacc agtcttttctgtaagctggcagctcttgttagacacaggatctctctctttggaagtgac tctaccacgatggttagctgtcttcatatcctggcccacacacttgacactagaacggtg atgaagtctggttcagagttggtgaaggctgccttgaggacattctttgagaatgcagca gatgacttggagaaaacactggagaacttgaagttagggaagtttacacactcacgcagc cagatgaagggtgtatcacagaacatcaactacaccacagttgccctgttgcccatcctc actgccctgtttgagcacatcactgaacatcagttcggagtggaccttctgttggatgat gtccaagtgtcatgctatcggatcctgagcagcctctactcattgggaactgggaagaac atctatgttgaaagacagcttccagctctaggtgagtgtttggccacccttgcaggagcg atgcccgtggcatttttggagcctcacctcaacacacataacccattctctgtcttcaac accaaagcagcacgggaacgggccatattaggcatgcctgatactgtagaacagatgtgt ccagaagtgccacatctggactgcctgatgaaagacatcaatgacatgtctgagtcagga gcacgctacactgaaatgccccatgtcattgaggtagtgctgcctatgctgtgtaactac ttatcctactggtgggagagaggcacagagaaccaggccaagggcacagaaactgcatgt agcaccactgtcacctctgagcaccttagcgtcatcctgggtaacattctcaagatcctg aatagcaatctgggcattgatgaggcctcttggatgaagaggattgcagtgtatgctcag cctatcatcagcaaggcaagggcagatcttttaaaggcacacttcctgccaacactagag aaattaaagaagaagacagtgaaggtggtggcagaggaggagcttctcaaagctgacaac aaaggtgatacccaggaggcagagctactgatcctggatgagtttgcagtgctgtgcagg gatctatatgcattctatcccatgctcattcgctatgtggacaacaacaggtcacgatgg ctgaaagagcctgattctgactccaatgagcttttcaggatggtagcagaaattttcatc ctttggtgcaagtcacacaattttaagagagaagaacagaactttgttgtgcagaatgag atcaataatctctccttccttactggggacagcaagacaaagatgtcaaaggtaggagga caagatcaggagagaaagcacaagaagagacgtggcgagatttactccatccagacctca ttgattgtggcagctctgaaaaaaatgctacctattggcctgaacatgtgtacgcctgga gaccaggaacttatctcattggctaaaactcgctatggcctgaaagatacagatgaagag gtgaaggagcatttgcggcgaaatctacacctgcaagagaagtcagaggaccctgctgtg aggtggcagcttcatctgtataaagacgtgattgtgaagaatgagggtccacccgatcca gagcgcacaattgatcgccttcagaccatctcagctgctgtgtttcaccttgagcaggtg gagcagccactaaggtccaagaagtgtgtgtggcaaaaactactgtccaaacagcgtaag cgtgcggtagtggcctgtttccgtatggcaccgttatacaacctgcccaggcatcgctct attaacctgttcctcactggctaccaaagaatatggatagagacagagacgtactcattt gaggagaagctagtgcaggatttggcaaggacacagcggaaattagaggaggaggaagag gaattagatgaaatacaacacgaccctcttcatcagctcattctgcactttagtcataat gctctgacagaaaaaagttccctagaggatgatttgctatatatagcatacacagacatg atggcaaagagttgtgctgaagatgaaaatgaggatgaagaaggaaaagaaaaaaccttt gaggaaaaggagatggaaaagcagaaaatattgtatcagcaggccaggttacatgaccgt ggggctgctgagatggttttgcagatgatcagtgccagcagaggtcgactgggtcccatg gttacgttcacccttaagcttggtatctctattctaaatgggggcaatattttagttcag cagaaaatgctggattatctaaaggagaagcgagatgctggcttcttcaagagtctgtca ggactcatgcagtcatgcagtgtattggacctgaatgcatttgagagacaaaacaaagct gaaggattgggtatggtgactgaggagggatcaatcaacgtgagggagcggggttccaag gttcttcagaatgacgagttcactaaagatctgtttaggtttctgcaactcctctgtgag ggtcacaacaatgacttccagaactttttgaggactcagactggaaatacaactacagtt aatataataataagcacagtggactatcttcttagactccaggagtccatcagcgatttt tactggtattactcagggaaagatataatggatgaggctggtcagcgtaatttctctaaa gcattagctgtggccaagcagatttttaactccctcactgaatatatacagggtccatgt ataggaaaccaacaaagcttagcccacagcaggttatgggatgcagttgttggctttttg catgtttttgctaacatgcagatgaagctctcacaggactccagccagattaagttgctg aaagaactgatggatctacagaaggacatgatagtcatgatgctgtcccttctagaaggt aatgttgtaaatggcaccatcggtaaacagatggtggacaccttggtggagtcctccaac aatgtggaaatgatcctcaaattttttgatatgttcctcaagctaaaggacctcaccaca tctgacaatttcaaagagcatgactctgatgccaaaggagtcatctccaagagagagttc cagaaatcaatggaaaatcagaagcagtactctcagtctgaaatcgagttcttgctttct tgtgttgaggcagatgaaaatgacatgttcaactatgtggaatttgtaaaacgcttccat gaacctgccaaggacattggtttcaatgtcgcagtactgcttacaaatctgtcagaacac atgccccatgactcccgtctggctaccttcctgagcctggccgagagtgtccttaattac tttgagccattcctgggacgtattgagatcatgggtggtgccaagagaatcgaaagggtc tattttgaaatcagcgagtccagtagaacccagtgggagaaaccacaagttaaggaatct aagagacagtttatctttgatgtagtcaatgagggtggagaatctgagaagatggagttg tttgtaaatttctgtgaggacaccatttttgagatgcagctggcctcactaatatcagag cctgatgctgtggaaaggggagaagaagatgagattgaattacagaaggtatccaaggac ctggagatggaagaggaggagaatacactggaatcttcctcagctttcaccatggcatgt gtatcaatgaagaagaacctctgtagccttggcagactgctcaccctaaagagcctgagg aaacgatacaagaagctcaggaagatgagcctgagggagatgatttctgggttcttcttc tttttctggattatcttcactggcctcctccacttcctctacaacctggtgtggtgcttc ttccatatcctgtggtcaagtctgtttggtggtggcttggtcgaaggtgccaagaatatg aaggtgacagacatccttggcaacatgccggaccccacacagtttggcatccatggtgat gtgctggagtctgaaaaactagaggttagtgaggcttctttggttgctgagataaaccag atggcacaaggagacaaaacagaaatagacctcatgtcggagctgctaagtatacagccc aagaaggagggaggaaagcatggaaccgagcctggtctgggtgatgtgtctgaagtggtt ggagttgattccccatctttagtttctgctgtgcagcagaaaaaggctcaggaagctgca agtaagtcagtcgagaatgaatcaaatgcagaatcagagaaagcagatacagaggatggg gagaagaatgaccaagacaaggctaaagagttactcatagaacctccatcacaggaagag aagaagctacccaagaggaggtgtgggcagaagaaagaacaaccagaagccattatggcc agcttttttgctggcctggacatctatcaaaccaagattctaaattacctggctcgaaac ttctacaacctgcgattcctggctctgtttgtggcatttgccatcaacttcatcctgctt ttctataaggttactggtgaggagtctgaggaggtggactcatggacagggagacatgaa gaggaggatgaaggtggcattgagtattttatcctgcaggagaacactggttacatggca cctacactccgctttctagctgttctacacactatcatctccttcctctgtgtggtgggg tattactatctgaaggtgcctttggtagtttttaagcgagagaaggaaattgccaggaaa cttgaatttgatggtctttatatcactgaacaaccttctgatgatgacattaaagggcaa tgggacagacttgttattaacacaccatcttttcctaataactactgggataagtttgtc aagcggaaggtaataaataaatatggggacttgtatggagcagagcggattgctgagttg ctcggtctggacaaaagtgctctggacttcaaccctactgaagaaactattgctaaagag gcttcactggtgtcctggttaagctccattgacacaaagtatcatatctggaaaatgggt gtggtgattacagacaattctttcctgtacctggtgtggtacaccacgatgtccatccta ggccactataacaatttcttctttgctgctcacctgctagacattgccatgggtttcaag actttgaggaccatcctgtcttcggttacccacaacggcaaacagctggtgctgactgtg ggtctgctggctgtagttgtgtatctatacactgtggtggcctttaacttcttccgcaaa ttctacaacaagagtgagaacgaggacgagccagatatgaagtgcgatgatatgatgact tgctatctgttccacatgtatgtgggtgtgcgtgctggtgggggaataggagatgagatt gaagatccagcgggtgatccctacgagctttaccgcatcctctttgatatcacctttttc ttctttgtcattgttatccttctggccattatccaaggtttgatcattgatgcctttgga gaactgcgagaccagcaggagcaagtcaaagaggacatggagactaaatgcttcatctgt ggcattgggaatgactactttgacacaactccacatggctttgagacacacacattacaa gagcacaacttggcaaactacctgtttttcttaatgtaccttgtcaacaaggatgaaacc gagcatactggccaggagtcgtatgtgtggaagatgtatcaggagcgatgctgggatttc tttccagctggagactgtttcaggaaacagtatgaggaccagctgggctaa

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