KEGG   PATHWAY: ko00350
Entry
ko00350                     Pathway                                
Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
ko00350  Tyrosine metabolism
ko00350

Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350]
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350]
M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350]
M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350]
Other DBs
GO: 0006570
Orthology
K00001  E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]
K00055  E1.1.1.90; aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00121  frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00135  gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K00146  feaB, tynC; phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K00151  hpaE, hpcC; 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K00157  AOX; aldehyde oxidase [EC:1.2.3.1]
K00270  pdh; phenylalanine dehydrogenase [EC:1.4.1.20]
K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
K00276  AOC3, AOC2, tynA; primary-amine oxidase [EC:1.4.3.21]
K00422  E1.10.3.1; polyphenol oxidase [EC:1.10.3.1]
K00431  TPO; thyroid peroxidase [EC:1.11.1.8]
K00450  E1.13.11.4; gentisate 1,2-dioxygenase [EC:1.13.11.4]
K00451  HGD, hmgA; homogentisate 1,2-dioxygenase [EC:1.13.11.5]
K00455  hpaD, hpcB; 3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15]
K00457  HPD, hppD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00483  hpaB; 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K00484  hpaC; flavin reductase (NADH) [EC:1.5.1.36]
K00501  TH; tyrosine 3-monooxygenase [EC:1.14.16.2]
K00503  DBH; dopamine beta-monooxygenase [EC:1.14.17.1]
K00505  TYR; tyrosinase [EC:1.14.18.1]
K00506  TYRP1; tyrosinase-related protein 1 [EC:1.14.18.-]
K00545  COMT; catechol O-methyltransferase [EC:2.1.1.6]
K00553  PNMT; phenylethanolamine N-methyltransferase [EC:2.1.1.28]
K00811  ASP5; aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspB; aspartate aminotransferase [EC:2.6.1.1]
K00813  aspC; aspartate aminotransferase [EC:2.6.1.1]
K00815  TAT; tyrosine aminotransferase [EC:2.6.1.5]
K00817  hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K01555  FAH, fahA; fumarylacetoacetase [EC:3.7.1.2]
K01557  FAHD1; acylpyruvate hydrolase [EC:3.7.1.5]
K01592  TYDC; tyrosine decarboxylase [EC:4.1.1.25]
K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K01618  E4.1.1.107; 3,4-dihydroxyphenylacetaldehyde synthase [EC:4.1.1.107]
K01668  E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2]
K01800  maiA, GSTZ1; maleylacetoacetate isomerase [EC:5.2.1.2]
K01801  nagL; maleylpyruvate isomerase [EC:5.2.1.4]
K01826  hpaF, hpcD; 5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]
K01827  DCT; dopachrome tautomerase [EC:5.3.3.12]
K02509  hpaH; 2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-]
K02510  hpaI, hpcH; 4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]
K03334  IL4I1; L-amino-acid oxidase [EC:1.4.3.2]
K04072  adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K05821  ARO9; aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
K05921  hpaG; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:4.1.1.68 5.3.3.-]
K07253  MIF; phenylpyruvate tautomerase [EC:5.3.2.1]
K10219  ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K10774  E4.3.1.23; tyrosine ammonia-lyase [EC:4.3.1.23]
K11358  yhdR; aspartate aminotransferase [EC:2.6.1.1]
K13371  aauA; aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  aauB; aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K13574  hcxB; hydroxycarboxylate dehydrogenase B [EC:1.1.1.237 1.1.1.-]
K13951  ADH1_7; alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13952  ADH6; alcohol dehydrogenase 6 [EC:1.1.1.1]
K13953  adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  yiaY; alcohol dehydrogenase [EC:1.1.1.1]
K13980  ADH4; alcohol dehydrogenase 4 [EC:1.1.1.1]
K14454  GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
K16163  K16163; maleylpyruvate isomerase [EC:5.2.1.4]
K16164  K16164; acylpyruvate hydrolase [EC:3.7.1.5]
K16165  nagK; fumarylpyruvate hydrolase [EC:3.7.1.20]
K16171  faaH; fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K16901  K16901; anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K16902  E1.5.1.45; FAD reductase [NAD(P)H] [EC:1.5.1.45]
K18606  HPPR; hydroxyphenylpyruvate reductase [EC:1.1.1.237]
K18857  ADH1; alcohol dehydrogenase class-P [EC:1.1.1.1]
K18933  mfnA, adc; tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
K20758  hbzF; maleylpyruvate hydrolase [EC:3.7.1.23]
K21425  RAS; rosmarinate synthase [EC:2.3.1.140]
K22203  DCE; dopachrome tautomerase [EC:5.3.3.12]
K22327  TYRDC-2; 4-hydroxyphenylacetaldehyde synthase [EC:4.1.1.108]
K22329  TDC-1; tyrosine decarboxylase [EC:4.1.1.25]
K22330  tyrDC; tyrosine decarboxylase [EC:4.1.1.25]
K23109  fldH; aromatic 2-oxoacid reductase
K23470  C1-hpah; 4-hydroxyphenylacetate 3-hydroxylase, reductase component
K23492  C2-hpah; 4-hydroxyphenylacetate 3-monooxygenase
K24287  lmbB2; L-tyrosine peroxygenase
K25271  tynA; tyramine oxidase subunit A
K25272  tynB; tyramine oxidase subunit B
K28347  atrA, greA, invA1_2_5; atromentin synthase
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
C23042  Atromentin
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00360  Phenylalanine metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00620  Pyruvate metabolism
ko00621  Dioxin degradation
ko00650  Butanoate metabolism
ko00940  Phenylpropanoid biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis

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