KEGG   PATHWAY: ko00350
Entry
ko00350                     Pathway                                
Name
Tyrosine metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
ko00350  Tyrosine metabolism
ko00350

Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350]
M00043  Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350]
M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350]
M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350]
Other DBs
GO: 0006570
Orthology
K14454  aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K00811  aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspartate aminotransferase [EC:2.6.1.1]
K00813  aspartate aminotransferase [EC:2.6.1.1]
K11358  aspartate aminotransferase [EC:2.6.1.1]
K15849  bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
K00815  tyrosine aminotransferase [EC:2.6.1.5]
K00817  histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00832  aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K05821  aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
K00270  phenylalanine dehydrogenase [EC:1.4.1.20]
K03334  L-amino-acid oxidase [EC:1.4.3.2]
K00457  4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00451  homogentisate 1,2-dioxygenase [EC:1.13.11.5]
K01800  maleylacetoacetate isomerase [EC:5.2.1.2]
K01555  fumarylacetoacetase [EC:3.7.1.2]
K16171  fumarylacetoacetate (FAA) hydrolase [EC:3.7.1.2]
K00422  polyphenol oxidase [EC:1.10.3.1]
K00505  tyrosinase [EC:1.14.18.1]
K00501  tyrosine 3-monooxygenase [EC:1.14.16.2]
K24287  L-tyrosine peroxygenase [EC:1.11.2.6]
K01827  dopachrome tautomerase [EC:5.3.3.12]
K22203  dopachrome tautomerase [EC:5.3.3.12]
K00506  tyrosinase-related protein 1 [EC:1.14.18.-]
K22329  tyrosine decarboxylase [EC:4.1.1.25]
K01592  tyrosine decarboxylase [EC:4.1.1.25]
K22330  tyrosine decarboxylase [EC:4.1.1.25]
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K00503  dopamine beta-monooxygenase [EC:1.14.17.1]
K00553  phenylethanolamine N-methyltransferase [EC:2.1.1.28]
K00545  catechol O-methyltransferase [EC:2.1.1.6]
K00274  monoamine oxidase [EC:1.4.3.4]
K00276  primary-amine oxidase [EC:1.4.3.21]
K13371  aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K25271  tyramine oxidase subunit A [EC:1.4.3.-]
K25272  tyramine oxidase subunit B [EC:1.4.3.-]
K01618  3,4-dihydroxyphenylacetaldehyde synthase [EC:4.1.1.107]
K00129  aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00146  phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K13951  alcohol dehydrogenase 1/7 [EC:1.1.1.1]
K13980  alcohol dehydrogenase 4 [EC:1.1.1.1]
K00121  S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1]
K13952  alcohol dehydrogenase 6 [EC:1.1.1.1]
K04072  acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]
K13953  alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
K13954  alcohol dehydrogenase [EC:1.1.1.1]
K18857  alcohol dehydrogenase class-P [EC:1.1.1.1]
K00001  alcohol dehydrogenase [EC:1.1.1.1]
K22327  4-hydroxyphenylacetaldehyde synthase [EC:4.1.1.108]
K00483  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K23492  4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.9]
K16901  anthranilate 3-monooxygenase (FAD) / 4-hydroxyphenylacetate 3-monooxygenase [EC:1.14.14.8 1.14.14.9]
K00484  flavin reductase (NADH) [EC:1.5.1.36]
K23470  4-hydroxyphenylacetate 3-hydroxylase, reductase component [EC:1.5.1.36]
K16902  FAD reductase [NAD(P)H] [EC:1.5.1.45]
K00455  3,4-dihydroxyphenylacetate 2,3-dioxygenase [EC:1.13.11.15]
K00151  5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60]
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K01826  5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10]
K05921  5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:4.1.1.68 5.3.3.-]
K02509  2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-]
K02510  4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52]
K00135  succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20]
K01668  tyrosine phenol-lyase [EC:4.1.99.2]
K10774  tyrosine ammonia-lyase [EC:4.3.1.23]
K00431  thyroid peroxidase [EC:1.11.1.8]
K00055  aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00157  aldehyde oxidase [EC:1.2.3.1]
K00450  gentisate 1,2-dioxygenase [EC:1.13.11.4]
K01801  maleylpyruvate isomerase [EC:5.2.1.4]
K16163  maleylpyruvate isomerase [EC:5.2.1.4]
K01557  acylpyruvate hydrolase [EC:3.7.1.5]
K16164  acylpyruvate hydrolase [EC:3.7.1.5]
K16165  fumarylpyruvate hydrolase [EC:3.7.1.20]
K20758  maleylpyruvate hydrolase [EC:3.7.1.23]
K07253  phenylpyruvate tautomerase [EC:5.3.2.1]
K23109  aromatic 2-oxoacid reductase [EC:1.1.1.110]
K18606  hydroxyphenylpyruvate reductase [EC:1.1.1.237]
K13574  hydroxycarboxylate dehydrogenase B [EC:1.1.1.237 1.1.1.-]
K21425  rosmarinate synthase [EC:2.3.1.140]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
ko00020  Citrate cycle (TCA cycle)
ko00360  Phenylalanine metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00620  Pyruvate metabolism
ko00621  Dioxin degradation
ko00650  Butanoate metabolism
ko00940  Phenylpropanoid biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
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