 | | PATHWAY: ko00350 | |
Entry |
|
Name |
Tyrosine metabolism |
Class |
Metabolism; Amino acid metabolism
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Pathway map |

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Module |
M00042 | Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline [PATH:ko00350] |
M00043 | Thyroid hormone biosynthesis, tyrosine => triiodothyronine/thyroxine [PATH:ko00350] |
M00044 | Tyrosine degradation, tyrosine => homogentisate [PATH:ko00350] |
M00533 | Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:ko00350] |
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Other DBs |
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Orthology |
K00121 | frmA, ADH5, adhC; S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase [EC:1.1.1.284 1.1.1.1] |
K00151 | hpaE, hpcC; 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase [EC:1.2.1.60] |
K00506 | TYRP1; tyrosinase-related protein 1 [EC:1.14.18.-] |
K00811 | ASP5; aspartate aminotransferase, chloroplastic [EC:2.6.1.1] |
K01826 | hpaF, hpcD; 5-carboxymethyl-2-hydroxymuconate isomerase [EC:5.3.3.10] |
K02509 | hpaH; 2-oxo-hept-3-ene-1,7-dioate hydratase [EC:4.2.1.-] |
K02510 | hpaI, hpcH; 4-hydroxy-2-oxoheptanedioate aldolase [EC:4.1.2.52] |
K05921 | hpaG; 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase / 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase [EC:4.1.1.68 5.3.3.-] |
K10219 | ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312] |
K13953 | adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] |
K14454 | GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1] |
K14455 | GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1] |
K23109 | fldH; aromatic 2-oxoacid reductase |
K23470 | C1-hpah; 4-hydroxyphenylacetate 3-hydroxylase, reductase component |
K23492 | C2-hpah; 4-hydroxyphenylacetate 3-monooxygenase |
K24287 | lmbB2; L-tyrosine peroxygenase |
K25271 | tynA; tyramine oxidase subunit A |
K25272 | tynB; tyramine oxidase subunit B |
K28347 | atrA, greA, invA1_2_5; atromentin synthase |
|
Compound |
C00355 | 3,4-Dihydroxy-L-phenylalanine |
C01161 | 3,4-Dihydroxyphenylacetate |
C01179 | 3-(4-Hydroxyphenyl)pyruvate |
C03765 | 4-Hydroxyphenylacetaldehyde |
C03964 | (R)-3-(4-Hydroxyphenyl)lactate |
C04043 | 3,4-Dihydroxyphenylacetaldehyde |
C04045 | 3-(3,4-Dihydroxyphenyl)pyruvate |
C04052 | 5-Carboxy-2-oxohept-3-enedioate |
C04185 | 5,6-Dihydroxyindole-2-carboxylate |
C04186 | 5-Carboxymethyl-2-hydroxymuconate |
C04368 | 3-Amino-3-(4-hydroxyphenyl)propanoate |
C04642 | 2-Hydroxy-5-carboxymethylmuconate semialdehyde |
C04796 | 4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde |
C04797 | 5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde |
C05338 | 4-Hydroxyphenylacetyl-CoA |
C05350 | 2-Hydroxy-3-(4-hydroxyphenyl)propenoate |
C05576 | 3,4-Dihydroxyphenylethyleneglycol |
C05577 | 3,4-Dihydroxymandelaldehyde |
C05581 | 3-Methoxy-4-hydroxyphenylacetaldehyde |
C05583 | 3-Methoxy-4-hydroxyphenylglycolaldehyde |
C05584 | 3-Methoxy-4-hydroxymandelate |
C05594 | 3-Methoxy-4-hydroxyphenylethyleneglycol |
C05595 | 4-Hydroxyphenylacetylglutamic acid |
C05596 | p-Hydroxyphenylacetylglycine |
C05600 | 2-Hydroxyhepta-2,4-dienedioate |
C05604 | 2-Carboxy-2,3-dihydro-5,6-dihydroxyindole |
C06201 | 2,4-Dihydroxyhept-2-enedioate |
C10447 | 3,4-Dihydroxyphenylpropanoate |
C17938 | 5,6-Indolequinone-2-carboxylic acid |
C22038 | (R)-3-(3,4-Dihydroxyphenyl)lactate |
|
Reference |
|
Authors |
Prieto MA, Diaz E, Garcia JL. |
Title |
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster. |
Journal |
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Reference |
|
Authors |
Sparnins VL, Dagley S. |
Title |
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases. |
Journal |
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Reference |
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Authors |
Ito S, Wakamatsu K |
Title |
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone. |
Journal |
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Reference |
|
Authors |
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC |
Title |
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase. |
Journal |
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Related pathway |
ko00400 | Phenylalanine, tyrosine and tryptophan biosynthesis |
ko00940 | Phenylpropanoid biosynthesis |
ko00950 | Isoquinoline alkaloid biosynthesis |
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