Klebsiella pneumoniae subsp. pneumoniae KPNIH32: KPNIH32_00455
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Entry
KPNIH32_00455 CDS
T03468
Symbol
metL
Name
(GenBank) aspartate kinase
KO
K12525
bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:
2.7.2.4
1.1.1.3
]
Organism
kpg
Klebsiella pneumoniae subsp. pneumoniae KPNIH32
Pathway
kpg00260
Glycine, serine and threonine metabolism
kpg00261
Monobactam biosynthesis
kpg00270
Cysteine and methionine metabolism
kpg00300
Lysine biosynthesis
kpg01100
Metabolic pathways
kpg01110
Biosynthesis of secondary metabolites
kpg01120
Microbial metabolism in diverse environments
kpg01230
Biosynthesis of amino acids
Module
kpg_M00016
Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kpg_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
kpg_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
kpg00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
KPNIH32_00455 (metL)
00270 Cysteine and methionine metabolism
KPNIH32_00455 (metL)
00300 Lysine biosynthesis
KPNIH32_00455 (metL)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
KPNIH32_00455 (metL)
Enzymes [BR:
kpg01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
KPNIH32_00455 (metL)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
KPNIH32_00455 (metL)
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Gene cluster
GFIT
Motif
Pfam:
AA_kinase
Homoserine_dh
NAD_binding_3
Motif
Other DBs
NCBI-ProteinID:
AIW74249
UniProt:
A0A1Y0Q702
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All DBs
Position
92193..94625
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AA seq
810 aa
AA seq
DB search
MSVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISW
LKLSQSDRLAAHQVQQSLRRYHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEA
VYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLM
AQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIER
VLASGTGARIVTSHDDVCLVEFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLL
QFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE
QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASEQLADQYLDFASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYN
ATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT
EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE
QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq
2433 nt
NT seq
+upstream
nt +downstream
nt
atgagtgtgattgcgcaggcaggggcgaagggtcgtcagctgcacaaatttggtgggagt
agtttagcggatgcgaaatgttacctgcgcgtcgcggggatcatgaaggagtattcgcag
gcgggggatatgatggtcgtctccgccgctggcagcaccaccaaccagctgatcagctgg
cttaagcttagccagagcgatcgccttgctgcgcatcaggttcagcagtcgcttcgccgc
tatcacaccgagctgattggcggtctgctggagcctgcggcggcggatacgttgatagcc
gcctttatccacgaccttgagcgtctggctggtctgctggacggcggggtttccgaagcg
gtctatgcggaagtggtcggccatggggaagtgtggtccgcgcgcctgatggcggcggtt
ctcaaccagctgggtatggaagccgcctggctggacgcgcgcgcgttcctgcgcgcggaa
cgcgccgcgcagccgcaggtggatgagggattatcttacccactgctgcagcagctgatg
gcgcagcatcctaacaaacgtctggtggtgaccggctttatctcccgcaaccaggccggc
gaaaccgtcctgctgggccgtaacgggtctgactactctgccacccagatcggcgcgctg
gcgggcgcctcccgggtcactatctggagtgacgttgccggggtgtacagcgcggatccg
cgcaaggtgaaagacgcctgcctgctgccgctgctgcgtctggacgaagccagcgagctg
gcgcgcctggccgcgccggtgctccatgcccgcacgctacagccggtttccgccagtgat
atcgatctgcagttacgctgcagctacacgccggaacagggttccacgcgcattgagcgc
gtgctggcctccggtaccggcgcacggattgtcaccagccatgacgacgtctgcctggtg
gagttccaggtgccggccggtcacgatttcaaactggcgcataaagagctggacgctctg
ctcaaacgcgcccagctgcgcccgttagccgttggcgtccatgccgaccgtaagctgctg
cagttctgctatacctccgaggtggccgacagcgcgctgaaattgctcgatgaagccggt
ctgccgggcgagctgcgtctgcgtcagaagctggcgctggtggcgatggtgggcgcggga
gtcacccgtaacccgctgcactgccaccgtttctggcagcagctcaaagggcagccggtg
gagttcacctggcagtctgaagaggggatcagcctggtggcggtgctacgcgccgggccg
acggaaagcctgatccaggggctgcatcagtccttgtttcgcgccgaaaagcgtattggc
ctgatgctgttcggcaaagggaacattggttcccgctggctggagcttttcgcccgtgaa
caaactacgctctcggcgcgtaccggtttcgagtttattctcgccggcgtagtcgacagt
aaacgcagcctgctgaattacgacgggctggatgccagccgggcgctggctttcttcaac
gatgaagcggtggagcaggatgaagagtcgctgttcctgtggatgcgcgcgcacccgtat
gatgatttagtggtgctggacgtcaccgccagcgaacagctggccgaccagtatcttgat
tttgccagccatggcttccacgtcattagcgccaacaagctggcgggcgccagcagcagt
gataaatatcgtcagatccacgacgcgtttgagaagacggggcgccactggctatataac
gccaccgtgggcgccggcttgccggtgaaccatacggtgcgcgacctgatcgacagcggc
gatactattctcggcctgagcggtatcttctcgggaacgctctcctggctgttcctgcag
ttcgatggcaccgtgccgttcaccgacctggtggatcaggcgtggcagcaggggctgacc
gagccggatccgcgcgtcgatctgtccggtaaggatgtgatgcgtaagctggtgatcctc
gcgcgggaagcgggctatgacatcgaaccggatcaggtgcgtgtggaatcactggtgccg
gcgcactgtgaagaggggtcggtcgatcacttctttgagaatggcgaagagttgaacgag
cagatgctgcagcgtctggaagcggcccgcgagatgggactggtgctccgctacgtggcg
cgctttgatgccaacggcaaagcacgcgtcggtgtggaagcggtacgcgaagagcacccg
ctggcggcgctgctgccgtgcgataacgtgtttgccatcgaaagccgctggtatcgcgat
aacccgctggtgatccgcgggccaggcgccgggcgcgatgtgaccgccggggcgatccag
tcggatattaaccgcctggcgcagctgctgtaa
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