Lates calcarifer (barramundi perch): 108892522 Help Entry 108892522         CDS       T04895                                  Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism lcf  Lates calcarifer (barramundi perch) Pathway lcf04020   Calcium signaling pathway lcf04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:lcf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108892522    04020 Calcium signaling pathway     108892522  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lcf04040]     108892522 Ion channels [BR:lcf04040]  Voltage-gated cation channels   Ryanodine receptor    108892522 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  108892522 NCBI-ProteinID:  XP_050933913 UniProt:  A0AAJ8DWC5 LinkDB All DBs Position LG19:9880075..9980999 Genome browser AA seq 4882 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQCVACIQKENRKFCLAAEGLGNRLCYLEPTSEAKYVPP DLCICTFVLEQSLSVRALQEMLAKSGQNSEGAAQSGGHKTLLYGHAILLRHSFSSMYLAC LKTSRSQTDKLSFDVGLQEDSTGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYL HLSISNGNIQVDASFMQTLWNVHPICSGSNIEEGYLLGGHVMRLFHGHDEVVTIPGSDQS EEQQRIVNYETGKAGAKARSLWRLEPLRISWSGSHIRWGQPFRLRHLTTGHYLALTEDKG LVLQDREKSDTVATAFCFRASKEKLEQSPKRDIEGMGVAEIKYGDSLCFITHVATGLWLS YQAPDVKSARLGPLKRRACLHSEGHMDDGLTLQRCQHEESRAARIIRNTTLLFKRFIRDL DCLGVKNRALVALPVEEVLQTLNDLITYFQLPDAELEHEERQIKLRSLKNRQNLFKQEGM LTLVSNCIDRLNVYNSAAHFGECAGSEAGVAWKDILNLLYELLAALIRGNRNNCTQFSNN LDWLVSKLERLESSSGILEVLHCILIESPEALNIIQRGHIKSIISLLYKHGRNHKILDVL CSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKWY YELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWS GRIPRAVASMNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVSF SAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEQVKEYKRDVDGVRDLLGTT QIMSQASFIPTPVETSQVVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRDDNKRQ HPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRVVQVNPNAEDSLKKIKLPKNYMMSN GYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLVP YVLLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQESGQVAERLSIDKIRFFRVERTYAV KTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRLFGRCW HAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLAQVGRMN LGKDASTFKYYTMCGLQEGFEPYAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVTRIDGT VDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSSFKSSPVVDMNGVHEEDTLKVKHR YPLRSVRHSDESRRVDYSSITVYYHSVRVFAGQDPAGVWVGWVTPDYHYYSNNFNLSKNR TVTVTLGDERGRVHESVKRSNCYMVWGGDVTNAAHTSSRSNVDLEIGCLIDLATGLVTFT VNGKEISTSYQVEPNTKLFPAVFVRPTSPNLFQFELAKIKNAMPLSSAIFKSEHKNPVPQ CPPRLDVQTINAVLWSRMPNTFLKVETARVNERHGWVVQCVEPLQMLAVHIPEENRCVDI MELSEQEDMRKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREG FYNVLISIHLETAKEARLMMKDEFIIPVTAETRSIRLFPDASKKHLPPGVGLSTSLKPRL NFAPPCFISTKREQHLYSPQIPLDALKEKAILMLTEAVQGGGHHIRDPVGGGVEYQFVPI LKLISTLLTMGVLGSEDVHKILLLIDPNVFRETREEGTTGATDKEGLTGAEEKAVEAGEE EAAKEAKQPMKGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDNFVSKLQYNQ KFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLTFSMGEDCPCPTDIQEELYDFHN QLQLHCGIPMEEDEDEQDTSIKGRLLMLVNKIKGQSHKAEEPTEKEQAAPSNLKELISQT MVSWAQECHIQDPELVRKMFSLLRRQYDSIGELLRAMRKTYTISAASVQDTINLLASLGQ IRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKSQ EIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAS SVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFA VFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDLPGSV QGVSSDVSADGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILR SLVPTEDLVGIISIPLKMPIINKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGIEDQSFL LHLLEVGFLPDLRAATSLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLFGGTEHYASL IDSTLHTIYRLSKGRSLTKAQRDAIEECLLAVCKHLRPSMLQQLLRRLVFDVPLLTDYCK MPLRLLTNHYEQNWKYYCLPSGWGSYGTASEDELLLTKKIFWGVFDSLSQRKYDPELFKM AMPCLSAIAGALPPDYVDASISTTVEKPVSVDAQGNFDPKPINTANIALPEKLEHFANKY AEHSHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKALTEKEKEIYRWPIRESLKSMLA MGWSIDRTKDGESMSQQRESEKMRKISQASQANGFNPSPIDTSNVVLSRELQGMVEVVAE NYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLQINGYSITRG LKDLEQDSSSMEKRFAYKFLKKLLKYVDSAQEFIAHLEAMAASGKTDRSPHEQEIKFFAK VLLPLIDQYFKNHSLYFLSSPSKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSD STTMVSCLHILAHTLDTRTVMKSGSEMVRVGLRTFFENAAEDLEKTFENLKLGKFTHSRS QMKGVSQNINYTTVALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGKN IYVERQLPALGQCLATLAGAMPVAFLEPLLNTYNPCSVFNTKSARERAILGIPDSVEEMC PGMPRLDGLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPASGGSVC CTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKSHFLPTLE KLKKKTVKVVAEEELLKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDADSNELFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDSKTKMAKSGG QDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLLKDTDDE VKDHIRQNLHLREKSEDPAVRWQLNLYKDIVMRSEGPPDPDRVVDRIQRISAAVFNLEQV EQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHKNNNYFLNAYRHIWLEIMHENT DYDSLLSMLTKTQLKVEEEEEEEIRKQPDPLHQLILHFSHNALTECSSLEEDPLYIAYAD MMAKSCAEGEEEEDEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISASKGRLG AMVTFTLKLGISILNGGNTLVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLNAFERQN KAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQTGNTT TVNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSKALAVAKQVFNSLTEYIQG PCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMIVMMLSLL EGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPESKGIISKK DFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAVLLTNLS EHMPHDARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVK ESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERPEEDEDDNQSVV ENQEEAEEESIMLESSSAFTIACISLRKSLCHFRQMLTLKSMRRQYRKFRKMSVKEMVRG FFSFFWMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPDPTQFGI HGDVLETEKMEASEASALAEMGQMAQGDAAEADLMAELLNIQPKKEGKHGAEPGLGDVSE VVVGDAPSIASAVRQKKAQMAAKKRAANGDYKSDSEKGDSEDGEKKDHDKAKDEAPPEHS AEEKKAPKKRLGQKKEPPEAFMASFFAGLEIYQTKMLNYLARNFYNLRFLALFVAFAINF ILLFYKVTGDYSDDEDPWNGRGRAGEEEDEGALEYFVLQESTGYMAPTLCCLAILHTIIS FLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTPSFPNN YWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSWLSSIDTKY HVWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGK QLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGG GIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDME TKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQ ERLWDFFPAGDCFRKQYEDQLG NT seq 14649 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggtggagaaggagaggatgaaatccagttcctcagaactgatgatgaagtg gtgctccagtgtgtggcctgcatccagaaggagaatcgcaagttctgcctggctgccgag gggctgggcaaccggctgtgttacctggagcccacgtccgaggccaagtatgttcctcca gacctgtgcatctgtacctttgtgctggaacagtctctgtcggtgcgggccctgcaggag atgctggctaagagtggacagaacagtgagggggcagcgcagagcggcggacacaagacc cttctgtacggacacgccatcctcctgcggcattcctttagctctatgtacctggcctgt ttgaagacatcaaggtcacagactgataagctgtcctttgatgtcggcctgcaggaggac tcaacaggtgaggcctgctggtggacgatccaccctgcctccaaacagagatcagaagga gagaaggtgcgcatcggtgatgacctcatcctcgtcagtgtgtcctcagagcgatacctt cacttatccatctccaatggcaacattcaggtggatgcttctttcatgcaaaccctgtgg aatgtccatcccatctgctctggtagcaacatagaggaaggctacctgctgggtggtcat gtgatgcggctgttccatggacatgacgaggtagtgaccatcccaggatcagaccagagc gaagagcagcagaggatagtcaactatgagacgggtaaagccggtgccaaggccagatcc ttgtggaggctggagccactcagaatcagctggagcgggagccacatccgctggggccag cctttccgactgcggcacctgaccacgggtcactacctggccctcaccgaggacaagggg ttggtgttgcaggaccgggagaagtccgacacggtcgccacagccttctgcttcagagcc tctaaggagaagctggagcagagccccaagcgggacatcgagggcatgggggtggcggag attaaatacggggactcgctctgcttcatcacacacgtggccacgggactctggctctcc tatcaggcacctgatgtcaaatctgcccgtctgggtcccctcaagagacgagcatgccta cactctgaaggtcacatggatgatgggttaaccctgcagcgctgtcaacacgaagagtcc cgtgccgcacgcattatccgcaacaccaccctactctttaaacgattcatcagagacctg gactgtctgggtgttaagaatagggcactggtcgccctgcctgtcgaggaggtgctccaa actctcaatgacctcatcacctattttcagctccctgacgctgagctggagcacgaagag aggcagatcaagctgcgctcgctcaagaaccggcagaaccttttcaaacaggaaggcatg ctgactctggtgtccaactgtattgaccgtctgaacgtgtacaacagcgccgcccacttt ggggagtgcgccgggtctgaggccggagtagcctggaaagatattctgaacttgctgtac gagctgctggcggcgttgatccgagggaacaggaacaactgcacccagttctccaacaac ttggactggctggtgagcaagctggagaggctggagtcttcctcaggcatcctggaagtt ctgcactgcattctaattgagagcccggaggccctcaacatcatccagagaggacacatc aaatccatcatatcgctcctctacaagcacggacgcaaccacaagattctggatgtgctc tgctcgctgtgtgtgtgtaatggcgtagctgtgcgaaccaatcagaaccttatctgtgat cacttgctgcccaaaagagatctgctgctgcaaacccagctggtcaatgatgtccagagt atgagaccgaacatcttcctgggggtgagcgagggctcagctcagtataagaagtggtac tacgagctgatgattgaccaggtggaccactttgtcaccagcgagccctcccacctgaga gtgggctgggccaacactaaaggatatgcgccctaccctggaggaggagagggctggggg ggcaatggagttggagatgacctctactcttacggttttgatggactccacctctggtca ggtcgtatcccgcgggcggttgcgtccatgaaccagcacatcctgacctcagaggatgtg gtgagctgttgtctggacctgggagcgcccagcatctcttttaggatcaacggacagccc gtccaaggcatgtttgaaaatttcaacacagacggcctcttcttccccgtcgtcagcttc tctgcaggggtcaaggtgcgtttcctgttgggcggtcgacatggtgacttcaagttcttg cctccatcgagttacgccccgtgttatgaggctctgctgccgaaagagaagatgaaggtg gagcaggtgaaagagtacaagagggatgtggatggagtcagagatctgctgggcaccacc cagatcatgtcacaggcctccttcatccccacacccgtggaaaccagccaggttgtgatg ccgccccatttggagaaggtccgtgacaaactggctgagaacattcatgaactgtggggc atgaataagatcgagctgggctggtcatatggcaagataagggatgataataaacggcag catccatgcctggtggatttctccaagctgccagaaacggaaaagaactacaatctgcag atgtcaacagaaactctgaagaccctgctggcattgggttgccgtgtagttcaggtgaat ccaaatgctgaggactccctcaagaagataaaactcccgaagaactacatgatgtccaat ggatataagccatcccctttggacctatctgacataaaactgactccaggtcaggagctg ctggtggacaaactggcagagaacgctcacaatgtgtgggccaaggatcgcatcaaacag ggatggacctatggcattcagcaggatctgaagagtaagcgtaaccctcgcctggttccc tatgttctgctggatgagcgaaccaagaagtcaaacagggacagcctgcgggaggctatc cgcactctgatcggctatggatacaacatcgagccctcggaccaggaaagtggacaagtg gctgagcggctcagcatcgacaagatccgcttcttcagagtagagaggacgtatgcagtg aagactgggaaatggtactttgaatttgaggctgtgacaggaggagacatgagagtgggc tgggccagacctgggtgtaagccagatgtggaacttggcacagacgagcttgcttttgtc tttgatggatataggggtcattgtttgaacatgggcagccgtttattcgggcgctgctgg catgctggggacgtggtgggctgtatgatcaacatggaggacaagtccatgatcttcacc cttaatggagagatcctcatcacaaccaagggctctgaactctgcttcacagactttgaa acagaggatgggttcattcctgtgtgtagtctcgggctggctcaggtgggtcgtatgaat ctggggaaagacgctagcaccttcaagtactacaccatgtgcggccttcaggaagggttt gaaccctacgctgtcaacatgaacagagaggtcaccatgtggttcagcaaacgtctgcct acttttgtcaatgtgccgaaggaccacaaccacattgcagtaaccaggattgacggcacc gtcgacagccccccgtgtcttaaagtgacccacaagacatttggcacccagaacagtaat gctgacatggtgttttgtcgtctcagcatgcctgtagagttccattcctccttcaagtcc agtccagttgtagacatgaacggagtgcacgaggaggacacacttaaagtcaaacacagg tatccattgagatctgtgaggcacagtgatgaaagcagacgagtggactacagcagcatc actgtgtactatcattcagtgagggtattcgctggtcaggaccctgctggtgtgtgggtt ggatgggttacccccgactaccattactatagcaacaatttcaacctcagcaaaaacaga acggtgaccgtgacccttggtgacgagagaggacgggtccatgagagtgtgaagaggagt aactgctacatggtgtggggtggtgacgtgaccaatgctgctcacacctccagtcgcagc aatgtggacttggagattggctgtctgatagacctggccaccggcctggtgacattcact gtcaacggcaaagagatatccacatcctaccaggtggaaccaaacactaagctcttccct gctgtgtttgtgcgaccaacaagcccaaacctcttccagtttgagctggctaaaataaag aatgccatgcctctgtcatcagccatctttaaaagcgaacacaagaacccagtgccacag tgtccaccccgtctggatgtccagaccattaatgcagtgctgtggagccgcatgcccaac acctttctgaaggtggaaacagccagggtcaacgaaagacacggctgggtggtccagtgt gtggagcccctgcagatgttggctgtacacatacccgaggagaacagatgtgtcgacatc atggagctgtcagagcaggaggacatgaggaagttccactaccacaccctgaagctctac tgcgccctctgcgctttgggcaacacccgtgtggcccacgccctctgcagccacctcgac caatcccagctcctatacaccatcgacaatcagtacctgtcgggcatgttacgtgagggc ttctacaatgtcctcatcagcatccacctggagaccgccaaggaggcacgactcatgatg aaagacgagttcatcatccccgtcacggccgagacacgctccattcgactctttcctgac gcttccaaaaagcacctgccgccgggggtggggctaagcacctcgctcaaaccacgtctc aactttgctccgccctgtttcatcagcaccaaacgggaacagcatctgtatagtccccaa atcccactggacgcactgaaggagaaagcaattttgatgctgactgaggctgttcaaggt ggagggcaccacatccgagaccctgtgggaggaggcgttgagtaccagtttgtgccaatc ctgaagctcattagcaccttgctgactatgggcgtattagggagtgaggatgttcataaa atcctgctgctcatcgacccgaatgtgttcagagagacacgtgaggagggaaccacaggg gccacagacaaagagggacttacaggggcagaggagaaggcagtggaagctggggaggag gaggcggccaaagaggctaaacagccgatgaaaggactgctggaaaagaggctgcctgag cccgtcaaacgacagatgtgcgagctgcttcactatttctgcgactgcgagctgaagcac cgcatcgaggccatcgtgtcattctctgacaacttcgtctcgaagctacagtacaaccag aagttccgctacaatgagctgatgcttgccctcaacatgtccgccgcagtgacagcaaag aagaccaaagagttcagatcacctcctcaagaacagatcaacatgctgctgacctttagt atgggcgaggactgtccatgtccaacggacatccaggaggaactctacgatttccacaac cagctgcagctccactgtggaatccctatggaggaagacgaagatgagcaagatacgtct attaaaggtcgcctgctaatgctggtgaacaagatcaaaggccagtctcacaaagcagag gagcccacagagaaggagcaagccgcgccatctaatctgaaggagctgatctctcagacg atggtcagctgggcccaggaatgtcacatccaggacccagagctcgtccggaagatgttc agcctgctgaggagacagtatgacagcatcggggagctgcttcgggccatgagaaagact tataccatcagcgccgcctcggtgcaggacaccatcaacctcttggcctcactgggtcag atcagatctctgctgtctgtccgcatggggaaagaggaggagaagctcatgattgatgga cttggcgatattatgaacaacaaggtgttctaccagcacccaaacctaatgagaatactg ggcatgcatgagactgtgatggaggtcatggtcaatgtgcttggaggagacaaatcccag gaaattgccttccccaagatggtggccagctgctgtcgcttcctgtgctacttctgccgg atcagccgtcagaaccagaaagccatgtttgaccaccttagttacctgctggagaacagc agcgtgggtctagcttcaccagctatgaggggctccactcctttagatgtggctgcttca tcagtgatggataacaatggcctggctctggccctggaagaacctgatctggacaaggtg gtgacctacctggcaggatgtggtcttcagagctgtccaatgcttctggctaaaggttat ccagacattggctggaaccccattgaaggagaacgttacctttcctttttgcggttcgct gtcttcgtcaatggtgagagtgtggaggagaattcgagcgtcgtagtcaagctgctcatc cgtcgtccggagtgtttcggccctgccctgaggggagagggagggaacggcctgctggct gccatgaaggaagccatcaaaatctcagagacacccgctttggacctgccgggctctgtc cagggagtcagctctgatgtgtctgctgatggggatgacgaggaggaggtggtccacatg ggcaatgccattatgtccttttactctgccctcattgaccttttaggacgttgcgcccca gagatgcacctcatcaacaaggggaaaggtgaagccctgcgtattcgcgccatcttgcga tctctggtgcccactgaggaccttgtgggaattatcagcataccactcaaaatgcccatc atcaacaaagatggttcagtgacagagccggacatgtcagccagtttttgtccagaccac aaggcccccatggttctgtttctggacagggtgtacggtattgaggaccagagctttctg cttcacctgctcgaagtgggctttctgccagaccttagggccgctacctctctggatacg gagggtctgtgcaccacagagacagccctggccatgaaccgctacatcggctcggccatg ctgccgctcctcacccgctgcgcccctctcttcggcggcaccgagcactatgccagcctc atcgactccactcttcacaccatctaccgcctctccaagggccgctcgctcaccaaggcc cagagagacgccatagaggagtgcctgctggctgtctgcaaacaccttcgtccttctatg ctgcagcagctcctgcgccgcctcgtctttgatgtgcccttgctgactgattactgcaag atgcctctgaggctgctcaccaaccactatgagcagaattggaagtactactgcctcccg tcgggctggggcagctacggcacggcgtctgaggatgaactgctgctcaccaagaaaatc ttctggggagtgtttgactcactgtcccagaggaaatatgacccagagctattcaagatg gccatgccttgcctcagtgccatagctggagctttgccgccagactatgtggacgcctcc attagtaccacagtggagaagcctgtttctgtagatgctcagggcaactttgaccccaaa cccatcaatactgctaacattgcccttccagagaagcttgagcactttgccaacaaatat gccgagcattcccatgagaaatggtctgcagagaaggtgctgctgggatggaaatatgga gactgtgtggatgaaaaggccaagactcaccctcagctcaggacctacaaagccctaaca gagaaggagaaggaaatttacagatggccaattagagaatccctgaagagtatgctggca atgggctggagcatcgacaggaccaaggatggagagagcatgtctcaacagagggagagt gagaaaatgaggaagatctctcaggcttcacaggcaaatgggttcaatcccagcccgata gacacaagcaatgtggttctatccagggaactgcaggggatggtggaggtagtcgctgaa aattaccataacatctgggccaagaagaagaagagtgaccttggaagcagaggcggagga acacaccctctgttggtgccctacgacacgctgacagccaaggagaaggcccgtgatcga gagaaggcccaggacctttttcgcttcctgcaaatcaatggctacagcatcacaagaggt ttgaaggacttggagcaggattcttcttccatggaaaagaggttcgcttataagttcctc aagaagctgctcaagtatgttgactcagctcaggagttcatcgcccatctagaggccatg gctgccagtggaaaaacagaccggtcccctcatgaacaagaaatcaagttttttgccaaa gttcttctccctctcatcgaccagtacttcaagaaccactctctctacttcctctcctcc cccagtaagaacctgagcagcagtggctacgcctccaacaaggagaaggagatggtcacc agcctgttttgtaaactggcagctcttgtcagacataggatttcactctttgggagcgac tccaccaccatggtgagctgtctgcatatcctggcacacactctggacaccaggacggtg atgaagtcgggctcggagatggtgcgggtggggctgcggacgttcttcgagaacgccgca gaggacctagagaagaccttcgagaacctgaagctggggaagttcactcattcgcgctca cagatgaagggggtgtcgcagaacatcaactacaccaccgtggccctgctccccatcctg accgctctgttcgagcacatcacccagcaccactttggggtcgacctgctgctggatgat gtccaagtgtcctgctatcgaatcctgaccagcctctatgcactgggcactggaaaaaac atctatgtagaaagacagctgccagctctcggtcagtgtctggccaccctggccggggcc atgcccgtagccttcctggagccgctgctcaacacgtacaacccctgctcggtttttaat accaagagtgcccgagaacgagccatcctaggcataccagactcagttgaggagatgtgt cctgggatgccacggctggacggcctgatgaaggacatcaatgacatggctgagtctgga gcgcggtacacagagatgcctcatgtcatcgaggtggtgcttcccatgctgtgtaactac ctgtcctactggtgggagagggggcccgagaaccagccagccagcgggggcagcgtctgc tgcaccactgtcacctcggagcacctcagcctcattctgggcaacatcctcaagatcctc aacaacaacctgggcatcgacgaggcctcgtggatgaagaggattgcagtgtacgtgcaa cccatcattagcaaggctcgcgcagacctgctgaagagccacttcctgcctacactggag aagctaaagaagaaaacggtgaaggtggtggcagaggaggagctgctgaaggcagacagc aagggagacacccaggaggccgagttgctcatcctggatgagtttgccgtgctctgcagg gacttgtacgccttttaccccatgcttatccgctacgtggacaacaacaggtccaggtgg ctgaaagaacctgatgctgactccaatgagctcttcaggatggtcgctgagatttttatc ctctggtgcaagtcacacaattttaaaagagaggagcagaactttgtggtccagaatgag attaacaacctttccttcttgactggagatagtaaaaccaagatggctaagtctggagga caagaccaggagaggaaacacaagaaaaggcgtggcgagttctactctatccagacctcg ctgatcgtggctgctttgaagaagatgctgccaatcggcctcaacatgtgcaccccaggg gatcaggagctcatatctctagccaagactcgctacctcctgaaagacacagatgatgag gtcaaagatcacattcgacagaatctgcatcttcgagaaaagtcagaggacccagcagtg aggtggcagctcaacctgtacaaggacatagtgatgaggagcgaagggcctccagaccct gacagagtggtggaccgtatccagaggatctctgctgctgttttcaacctggagcaggtg gagcagccactgagatccaaaaaatgtgtttggcagaagttgctgtccaagcagaggaag agagcggttgtcgcctgttttcgcatggctccactttataacctaccaaggcacaaaaat aataattacttcctgaatgcctaccgacatatttggctggagataatgcatgagaacaca gactatgacagtctgctctccatgctgacgaaaacgcagctcaaagtggaggaggaggaa gaggaggagatcagaaaacaaccagacccgcttcaccagctcattctgcacttcagccac aacgctctgaccgagtgcagttctttggaagaggatcccctgtacattgcatatgcagat atgatggccaagagttgtgccgaaggtgaagaagaggaagacgaggagggaaaagagaag acgtttgaggaaaaggaaatggagaagcaaaagatgctgtatcagcaagccagacttcat gacagaggagctgcggagatggtgctccagatgatcagtgccagcaaaggtcgactgggc gctatggtgactttcaccctcaaactgggtatctccatactgaatggaggaaacacactg gtgcagcagaaaatgctggactatctgaaagaaaaaagagatgttggctttttcaaaagt ctatctggactaatgatgtcctgcagtgtcctggacttgaatgcttttgaaaggcagaac aaagctgaaggtctggggatggttactgaagaaggatcaatcaacgtgagtgagcggggt tccaaggtattgcagaacgatgagttcactaaggatctctttaggtttctgcagcttctc tgtgagggccacaacaatgattttcagaacttcctgaggactcagacagggaacacaact acagtcaacatcattattagtactgtagactacctgctaagactccaggaatctatcagc gatttctactggtactactctggtaaggatgtcattgatgaggccggtcaaaggaacttc tccaaagccctagcagtggccaagcaggtcttcaactctttaactgagtatatacagggt ccgtgcatcgggaaccagcagagtctggctcacagcaggctgtgggatgctgtggtgggc ttcctgcatgtttttgccaacatgcagatgaagttatcccaggactccagccagattgaa ttattgaaggagctgctggacctacagaaggacatgattgttatgatgctctctcttctc gaaggcaatgttgtcaatggtaccatcggcaaacaaatggtggacactttagtggaatct tctagcaacgtggagatgatcctaaaattctttgacatgttcctcaagttgaaggactta accacttcagacagcttcaaggagtatgaccctgagagcaaagggatcatctcaaagaag gatttccagaagtccatggagaaccagaaacagtactcccagtctgagatcgagtttctt ctctcttgcgccgaggctgatgagaatgacatgttcaactacgagcagtttgtggagaga ttccacgaacctgccaaggacattggctttaacgtagctgtgttgctaaccaatctctct gagcatatgcctcatgatgctcgcctctcaacgttcctcgacctggctgagagcgttctc agctactttgagccctatttgggtcgcattgagatcatgggtggagccaagcgcatcgag agagtctacttcgagatcagtgagtcgagtcgtacccagtgggaaaagccccaggtcaag gagtcgaagcggcagttcatcttcgatgtcgtcaatgaaggtggagagagcgagaagatg gaactgtttgtcaacttctgtgaggacaccatctttgagatgcaactggcttcccaaatt tcagagccagacccggtggagcggccggaggaagatgaagacgacaaccagagtgtggtg gagaaccaggaggaagcagaggaggaaagtataatgttggagtcttcctccgccttcaca attgcctgtatctctttgagaaaaagcctctgccacttccgccaaatgctaactctcaag agcatgaggcgacagtacaggaagttcaggaagatgagtgtgaaggagatggtgcgaggc ttcttctctttcttctggatgatcatcacgggactcttccacttcgtctacagcctaatt tggggtttcttccatatcttgtggactactatgtttggtggcggccttgttgaaggggct aagaacatgaaggtgacggacattttgggaaacatgccggaccccactcagtttggcatc cacggagatgtgttggagacggagaagatggaggcgagcgaagcgtcagctttggcagag atgggtcagatggcgcagggggacgcagcagaggcagacctgatggctgagttgctgaac atccaacctaagaaggagggaaagcacggggctgagccagggttgggggatgtgtctgag gtggtggtgggggacgctccatccattgccagtgctgtcaggcagaagaaggcacagatg gctgcaaagaagagagctgcaaatggagactacaaatctgattcagagaaaggagattca gaggacggcgagaagaaggaccacgacaaggccaaagacgaagcccctccggagcactca gcagaggagaagaaagccccgaagaagaggctcggccagaagaaggaaccaccagaggcc ttcatggccagcttctttgctggcttggaaatctaccagactaagatgctgaactacctt gcgagaaacttctacaacctccgctttctggcactttttgtcgcctttgccatcaacttc attctgctcttctacaaagtaactggtgattactcagatgatgaagacccctggaatggt cgaggtagagctggggaggaggaagatgaaggggcgcttgagtacttcgtcctgcaggag agcacaggctacatggcaccaacactttgctgtctggcaatactacacactatcatatct ttcctgtgtgtagtgggatactactacctgaaggtgcctctggtggtgttcaaacgcgag aaggagatagcgaggaagctggagtttgccggcctctacatcaccgagcagccgtctgat gatgacatcaaaggacagtgggacagactggtcatcaatactccttcattcccgaacaac tactgggataaatttgtcaaacgcaaagtgatcaaaaagtacggagacctgtatggagcg gagaggatagcagagctgctgggcttggataagagtgccctggatttcaaccctacagag gaaactgttgccaaggaggcgtcattggtgtcatggttgagctcaatcgatacaaagtac cacgtctggaaaatgggagtggtgtttacagacaattctttcctgtatctggtatggtac accaccatgtccattctgggccactacaacaacttcttcttcgctgcccacctgctggac atcgccatgggctttaagacccttcgcaccatcctctcctctgtcacacacaatggcaaa cagttggtgttgacggtaggcctgctggcagtcgtggtctatctctacactgtggtggcc ttcaacttcttcaggaagttctacaacaagagcgaggatgacgatgagccggacatgaag tgtgatgacatgatgacgtgctacctattccacatgtacgtcggggtgagagcaggaggg ggcatcggggatgagatcgaggacccagctggtgacccttatgagctctaccgtattctt tttgacatcaccttcttcttctttgtcatcgtaatcctcctggccatcatccagggtttg atcattgatgcctttggagaactgagagaccagcaggaacaggtcaaagaagacatggag accaaatgtttcatttgcgggatcggtaatgattacttcgacacaacacctcatggcttc gagactcacaccttacaagagcacaatttggccaactacctgtttttcctgatgtacctt atcaacaaggatgagacagagcacactggccaggagtcatatgtgtggaagatgtaccag gagcgactgtgggatttcttcccagctggagattgctttcgcaaacagtacgaagatcag cttggatag

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