Leopardus geoffroyi (Geoffroy's cat): 123583236 Help Entry 123583236         CDS       T10761                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism lgf  Leopardus geoffroyi (Geoffroy's cat) Pathway lgf04020   Calcium signaling pathway lgf04371   Apelin signaling pathway lgf04713   Circadian entrainment lgf04921   Oxytocin signaling pathway lgf04970   Salivary secretion lgf05010   Alzheimer disease lgf05012   Parkinson disease lgf05020   Prion disease lgf05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:lgf00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     123583236 (RYR3)    04020 Calcium signaling pathway     123583236 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     123583236 (RYR3)   09154 Digestive system    04970 Salivary secretion     123583236 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     123583236 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     123583236 (RYR3)    05012 Parkinson disease     123583236 (RYR3)    05020 Prion disease     123583236 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     123583236 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lgf04040]     123583236 (RYR3) Ion channels [BR:lgf04040]  Voltage-gated cation channels   Ryanodine receptor    123583236 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  123583236 NCBI-ProteinID:  XP_045306081 LinkDB All DBs Position B3:68907320..69436425 Genome browser AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCEESQAARIIRNTTALFSQ FVSGNNRTAAPITLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKTRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAGEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYLRLSMPVECHSSFSHSPCLDSDAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSATIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTSEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHSGETENRAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKPAKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDGEYEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHYTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR ISATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQREN EKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTK GDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHVRNNLHLQEKSD DPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKCPKVEEE EEEETDKHPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA GVQQKMLDYLKEKKDAGFFQSLSSLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESI SDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSNQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDF LLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDSAERPEEEEEDEDSSYTLEIEGEEEDDKSFESASA FAMACASVKKNVANFLKKATLKNFRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFQLFFT ILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVTEPGIT PELVHFVKGEKGDADIMSDLFGFRSKKEGGLKHGPEVGLGDLSEIIGKDEPPTLESTVQK KRRAQAAEMKASHEAEGKVEPEKTDMEDGEKEGTAKEEEQTDALWAEVTKKKKRRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEE TEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAIIHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGVVFTDNS FLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaagggggagaaggaggcgaggacgagatccagttcctgaggactgaggatgaa gtggttctccagtgcatcgcaaacattcacaaggagcagaggaagttctgcctcgcagcc gagggcctgggaaaccgcctgtgcttcctggaacccacttcagaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagctctgcag gaaatgcttgccaatacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgcggcactccttcagcggaatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatcc gagggagagaaagttcgaattggtgatgacctcatcctcgtcagcgtgtcctctgaaaga taccttcatctctccgtatcaaatgggaacatacaagtggatgcctcttttatgcaaaca ctctggaatgtacatcccacgtgctcaggaagtagcatcgaagaaggatacctacttggt gggcatgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaatgactcccagcacaggaggatattctatgaagctgggggagctgggactcgagcc agatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatcagatgg ggccaggctttccgcctccggcatctcaccacaggccactacctggccttgacagaggac caaggccttatactgcaggaccgggcaaagtcagacaccaagtccacagccttctctttc cgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgggatatagaaggc atgggagttccggaaatcaaatacggagattccgtctgctttgtccagcatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccatcaggaaggccacatggatgacgggctaacactgcagagatgc cagtgcgaggaatcccaggctgctcggatcatccggaacacgacagccttattcagccag tttgtaagtggaaacaatcgtacggcggcccccatcaccctgccgatagaagaggtcctg cagaccttacaggacctgatcgcctacttccagcccccggaggaggagatgcaacacgaa gacaaacagaacaagctccgctcacttaagaacagacagaatcttttcaaggaagaagga atgttggcccttgtgttaaactgcatcgatcgcttaaacatctacaacagcgtggcgcac tttgcaggaattgcaagggaggagagtggcatggcttggaaagagatcctgcgcctgctc tacaaactgctggctgctctcattcgtggaaacagaaacaactgtgctcaattctctaat aaccttgattggctaatcagcaaattggatagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgactgaaagcccagaagccttaaatctgatagcagagggccac atcaagtctatcatctccctgttggataagcatgggcggaatcacaaggttctggatgtg ctgtgctccctctgtctctgcaatggggtcgccgtgagagccaaccagaatctgatttgt gacaacttgctgccccggagaaacctgctcctgcagacacggctgattaatgacgtgaca agcattcggccaaacatcttcctgggagttgctgagggctcagcacagtacaagaagtgg tacttcgagctgatcatagaccaagtggaccccttcctaacagctgagcccacacaccta cgggtgggctgggcctcttcctcaggctatgctccgtaccctggaggtggagaaggatgg ggaggcaacggtgttggagacgacctgtattcctatggctttgatggccttcacctttgg tcaggccgcatacccagagccgtggcctccatcaaccagcacctcctgagatcagacgac gtggtaagctgttgcctcgaccttggggtgcccagcatctctttccgcatcaacgggcag cctgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctacgaagccttactgccaaaagaaaagatgaga ttggagcctgtcaaagaatataaacgcgatgctgaaggagttagagatctgttgggtacc acccagttcctctctcaagcctctttcatcccatgccccatagacaccagtcaggtggtt ttgccacctcacctagagaagatccgagacaggctggctgaaaacatccacgaactttgg ggaatgaataaaatagagcttggctggacttttggcaagacacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaactgagaagaattataaccta caaatgtcaacggaaaccttaaaaacccttctggccctggggtgccacattgctcacgtt aatccagctgctggggaggatctcaagaaggtcaagttgcccaaaaactatatgatgtcc aatggctacaagccagcccctttggatttgtctgatgtgaagctattacctcctcaagaa attttggtggataagcttgcagaaaatgcacataatgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttgaagaacaaaagaaatccccggctggtg ccatacgcattactggatgagcgtacgaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgagccgtcagaccaagaactagctgac ccagctgtggagaaagtcagcatagataaaattcgatttttccgggtagagcggtcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgaccggaggagacatgcgc gttggctgggccaggccgggctgtcggcccgacgttgagctgggagccgatgatcaagcc tttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagtgggtattttggacgt acgtggcagccaggagatgtggttggatgtatgattaaccttgatgatgcttcaatgatc ttcacactgaatggggagctgctgattaccaacaaaggctctgaacttgccttcgctgat tatgagattgagaatggctttgtgcccatctgctctctgggactgtctcagatcggccgc atgaatcttgggatggatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagacgtggcgatgtggttcagcaagcgc ctcccgacatttgtcaacgtgccaaaggatcatccgcacatagaggttgtgaggatagat ggcactatggacagccctccatgcctcaaggtgacccacaagacattcggcacacagaat agcaatgccaacatgatctacctacgcctgagcatgcccgtcgaatgccactcctccttc agccacagcccctgcttggacagtgacgcattccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgctactatgcaatccgcatcttcgctggacaggacccc tcctgcgtctgggtcggatgggtgactccggactatcacttgtacagcgagaagtttgac ctgagtaaaaactgcacggtgactgttactctaggggatgaaagaggccgggtccacgaa agcgtgaaacgcagcaactgctacatggtctggggcggggatattgtggccacttcgcaa agatcaagccggagcaatgtggacctggagatcggctgcctcgtggatctggcgatgggc atgttgtctttctcagccaatgggagagagctcggtacctgctatcaggtggagcccaat accaaagtgtttccagcagtcttcctgcagcccacgagcacttcattgtttcagtttgaa cttgggaagctgaagaatgcgatgcccttgtcggcgaccatatttaagagtgaagagaag aacccagttccgcagtgtccacctcggctggacgtccaaaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacagagcgggtgagcgagcgccatggc tgggtggtgcagtgcctggagcccctgcagatgatggcactccacatccctgaggagaac aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccattaccac acactgcgactctacagtgcagtgtgcgccctgggaaacagccgcgtggcctacgcccta tgcggccacgtggatctctcccagctgttctacgccattgacaacaagtacctccctggc ctccttcggtctggtttctatgacctgctcatcagcatccatctggccaacgctaaggag aggaagctaatgatgaagaatgagtacatcatccccatcaccagcaccaccagaaaaatc cgcctgtatccagatgagtccaagagacatgggctgcctggggtgggcctgagaacgtgc ctcaagccagggttcaggttctccaccccttgctttgtcgtgacgagtgaggagcaccag aagcagagccctgagatccccttggagattctcaagacgaaggcactgagcatgctgacg gaggcagtgcagcacagcggggctcacatccgggaccctgtcggtgggtctgtagagttc cagtttgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgtttgatgac gatgacgtcaggcagatcctcctcctgatcgatccctctgtgtttggggagcacagtggg gagacggagaacagagcagagaaggaggaagtgacccaggtggaggagaaggcagtggag gccggagaaaaggccggcaaggaggctccagtcaaaggcttgttgcagacccgactgcca gagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaggccattgtggcatttggcgacatttatgtctctaagctccaggcaaat cagaagttccgctacaacgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaaaaccagggagttccgctcacccccccaggagcagatcaacatgcttcttaacttt caactgggagagaattgcccctgcccagaagagatccgagaggagctatatgacttccat gaggaccttctcattcactgtggtgttcccctggaggaggaagaagaggaggaggaagac acatcctgggctgggaaactccgtgccttggtgtataaaatcaaaggccctcccaagcct gcaaaggaacagccaacagaggaggaagagagatgccctacgaccttgaaggagctcatc tcacagaccatgatccgctgggctcaggaggaccagatccaggatgcggagttggtccgg atgatgttcaacctcctccggaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacatacaccatcagtcaggcctccgtgagcgacaccatcaacctgttggccgcc ctgggtcagatccgctgcctcctcagtgtcaggatgggcaaggaagaggagctgctcatg atcaatgggctgggagacattatgaacaacaaggtgttctaccagcatcccaacctcatg cgagtccttggcatgcacgagacagtgatggaggtgatggtgaacgtgttggggacagag aagtctcagattgcctttccaaaaatggttgctagctgttgccgcttcctctgttacttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagttacctgttggag aacagcagcgttggcctagcctccccttcgatgaggggatctacccctctggatgtggca gcttcctccgtgatggacaacaacgagttagccctgggcttagaggaacctgaccttgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa gggtaccctgacgtcggctggaaccccatcgaaggggaacgctacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagcgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagccttgcgaggtgaaggaggaaacggtcta ttggcagccatgcagggtgccattaagatctctgagaacccagctctcgacctcccctct cagggatataagagagaagtcatggaggacggtgaatatgaagaagagatcgtgcacatg ggcaatgcaattatgtctttctattcagcccttatagatctcctgggccgctgtgctcct gaaatgcatcttatccagacaggaaagggggaagccatccggatcaggtcaatcctgcgc tccctggtccccactgaggacctggttgggatcatcagcatccccttgaagctgccttcc ctgaacaaagatgggtcggtcagtgagccagatatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggatcgtgtttatggcattaaggatcaaacttttctg ctccatttgctagaggttggatttttacctgacttaagagcctctgcctctctagataca gtttccctaagcaccacagaggccgcgctcgcactaaataggtatctctgttctgctgtg cttccgctcctcacaagatgcgcccctctctttgccggagcagaacactacacctctttg atcgattctacactacagacaatatataggctttccaagggacgttccctcaccaaagct cagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgaggccttcaatg ttacagcaactcttgcgacgtcttgtctttgacgtgccgcagctcaacgaatactgcaaa atgcctcttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctgcct tcaggatgggggagctacgggctagctgtggaggaggaattgcacctgacagagaagctc ttctgggggattttcgactccctctcccataagaagtatgacccagaccttttccgaatg gcccttccttgtctcagtgctatagctggggcgctaccaccagattacttagataccaga atctcagccacgttggagaaacagatctcagtggatgcagatggcaactttgaccccaaa cccatcaacaccatgaatttttccttgcctgaaaaatgggagtacatcgtcaccaagtac gcggagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatatgga atttccctggatgaaaatgtgaagacccatccactgataaggcctttcaagacattaaca gaaaaggagaaggaaatttaccgctggcctgctagagagtccctgaaaaccatgctggct gtgggctggtctgtggagaggaccaaagagggagaggccctggtgcaacagcgggaaaat gagaagcttcggagcgtgtcccaggccagccagggcaacagctacagtcctgctcccctg gacctctccaatgttgtgctctccagggagctccagggaatggtggaggtcgtggccgag aactatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggcggc agtcaccctctgttggtaccatatgacaccttgacagccaaggagaagttcagggaccga gaaaaggcacaggacctgtttaaattcctccaggtgaacggcatcgtggtttctagaggt atgaaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttg aagaagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccgctggttgaccagtacttcacaaatcaccgcctctacttcctgtcatcc cctctaaaacccctcagcagcagtggctatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaactcgctgctcttgttcgacacaggatttccctctttggaagtgat tctactacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggaccgtc atgaagtcaggctcagagctggtgaaggctgggttacgagctttctttgaaaatgcggcg gaagacttagagaagacttcggaaaatctgaagctcgggaagtttacgcattccagaaca cagattaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctg acgtccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggtgat gtgcagatttcatgctaccacatactctgcagcctctactcccttgggaccggaaagaac atctacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgcc ataccagtggcattcttggagcccactcttaaccgctacaatccactctcagtcttcaac accaaaacccccagagagaggtctattctggggatgccagacacagtggaagagatgtgt cctgacatccctcagctggaaggcctgatgaaggaaatcagcgacctggccgagtcaggg gcccggtacacggagatgccccacgtcatcgaggtgatcttgcccatgctgtgcaactac ctgtcctactggtgggagcgggggccagagcacctgccccccagcacggggccttggtgc accaaggtcacctctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaac aacaacctgggaatcgacgaggcatcctggatgaagcgcatcgcagtgtatgcccagcca atcatcagcaaagccaggccggacctgctgaaaagccacttcatcccaactctggagaag ctgaagaaaaaggctgtgaagactgtgcaggaggaggagcagctgaaggccgacaccaaa ggagacactcaggaggcggagctcctcatcctggatgagtttgcagtcctctgcagagac ctctacgccttctaccccatgctcatccgctacgtggacaacaacagatcgaactggctc aaaagtcccgatgctgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgcaaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaatt aataatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagta aagtctggaggacaggaccaggaacggaagaagaccaagaggaggggagacttgtactcc atccagacctctctcatcgtggctgcgctcaagaaaatgctgcccattggtttgaatatg tgcacgccaggcgatcaggagctaatctcccttgcaaagtcacgatacagctatagggac accgatgaagaggtgaaagaacatgtgcggaataacttgcacctgcaggaaaagtcggat gacccagcagtaaagtggcagctgaacctctacaaagatgttttgaagagtgaagaacct tccaatccagaaaagaccgtagagcgcgtacagagaatttccgcagctgtcttccatctg gagcaggtcgaacagcctttgaggtccaagaaggcagtctggcacaaactgttatcaaag cagcggaaacgggcagtggtggcctgtttcaggatggcccctctgtacaacttgcccagg caccgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggag tattcctttgaagagaaactagtacaggacttggctaaatgccccaaggtggaagaggag gaggaggaggagacagacaagcacccagacccacttcatcagatcattctccattttagc cgcaatgctctcacggagaggagcaaattggaagacgaccccttgtacacctcctattcc agcatgatggccaagagttgtcagagtggggaggacgaagaagaagaggaagacaaggaa aagacatttgaagagaaggaaatggaaaagcagaaaaccctctaccaacaagctcgactg catgagcgtggggctgcagagatggtcctccagatgataagtgccagtaaaggtgagatg agccccatggtggttgagactctgaagctggggatcgccattctgaatgggggcaacgct ggtgtacaacagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaa agcctttccagccttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag aataaagctgaaggcctggggatggttactgaggaaggaacactcattgtccgtgagcgt ggtgaaaaagtactccagaatgacgagtttacacgagatctctttagattcctgcagtta ctttgtgaaggacataacagtgacttccagaacttcctgcggactcagatgggcaacacc accactgtaaatgtcatcatcagtaccgtggactatctcctgcgtctgcaggaatcaatc agtgatttctactggtattattcagggaaggacatcattgatgaatctggacagcacaac ttttccaaagctctggcagtcacgaagcagattttcaattctcttacagaatacatccag ggcccttgcattgggaaccaacagagcctggctcacagcaggctgtgggatgcagtggtc ggcttcctgcacgtatttgctaacatgcagatgaaactctctcaggattccaatcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc ctggaagggaatgtggtaaatggaactattggcaagcagatggttgacacgctggtagag tcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagac ctaaccagctcagacaccttcaaagaatatgacccagatggtaaagggattatctccaaa aaagaattccagaaggccatggaagggcaaaaacagtacacacagtcagagattgacttt ctcctttcatgcgcagaagctgatgagaatgatatgtttaattacattgattttgtagac cggtttcatgagccggccaaggacatagggtttaatgtggcagtgttattgacaaatctc tccgaacacatgccaaatgattctcgccttaagtgcctattggacccagcggaaagtgta ctaaattacttcgaaccctacctaggacgtattgagatcatgggtggggccaagaaaatt gagcgcgtttattttgagatcagtgaatccagtcgaacccagtgggagaagccccaagtg aaggaatctaagcggcagttcatctttgatgtggtcaatgaaggtggagagcaagaaaag atggaactgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcgtctcag atctctgaatctgactcagccgaaaggccagaagaggaggaggaagatgaagattcttct tacacattagaaattgagggggaagaggaggatgacaagtcttttgagtctgcctctgca tttgccatggcctgtgcctcagtgaagaaaaacgttgccaacttcctgaagaaggcaacc ctgaagaacttcaggaagcagtacaggaaggtgaagaagatgaccgtgaaggagctggtg aaggtgttcttctctttcttctggatgttatttgtggggctattccagttgttcttcacc atattgggaggaatctttcagatcctctggaacacagtgtttggagggggcctagtggaa ggggcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccaacccagttt ggtatccatgacgatgccatggaggctgagcgggcagaggtgactgagccaggtattaca ccagaactagtccacttcgtcaagggtgagaaaggagatgcagatatcatgtcagatctc tttggattccgctcaaagaaagaaggtggcttaaagcatgggcctgaagtgggtttgggt gatctctctgagattattggcaaggatgaaccccctacactagagagtactgtacagaag aaaaggagagcacaggcagcagaaatgaaagcatcacatgaagcagaaggaaaagtggag cctgagaagacagacatggaagatggggagaaggagggtacggccaaagaggaagagcaa actgacgccctgtgggcagaagtgacaaagaagaagaagcggcgacggggccagaaagtt gagaagcctgaagccttcatggctaatttcttcaaagggctggaaatctatcagaccaag ttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgtttgtagcc ttcgctatcaacttcatcctgctcttttacaaggtcactgaagagcctttagaagaagag acagaggacgttgcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatg gtgttctttgtcctacaggagagcactgggtatatggcaccagcactgcgggccttggcc attatccacaccatcatctctttggtctgtgtggtgggctattactgcctgaaggtccct ttggtggtgttcaaaagagaaaaagaaattgccaggaagctggagttcgatggcctgtat atcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtaatcaac acaccatcttttcctaataactactgggacaagtttgtaaagagaaaggtgattaacaag tatggtgatctctacggagcagaacgcattgctgaactcctaggtttggacaaaaatgcc cttgatttcagcccagtagaagaaagcaaagcagaggcggcctctctggtgtcatggctg agttccatcgacatgaagtaccatatctggaagctgggagttgtttttaccgataactcc tttctctaccttgcctggtatacaaccatgtcgatcctgggccactacaacaacttcttc tttgctgcccatctgctagacattgcaatgggcttcaagacgcttaggactattctgtca tctgtaactcacaacggcaaacagctggttctgactgtgggtctcctggccgtggtggtt tacctctacaccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagat gacgatgagcctgatatgaagtgtgacgacatgatgacgtgttacctattccacatgtat gtgggagtaagagcaggaggcggcattggcgacgaaattgaagaccctgctggtgatcct tacgaaatgtaccgcattgtcttcgacatcacgttcttcttctttgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caggtgcgagaagatatggagactaaatgtttcatctgcgggattggcaatgactacttt gacacgacccctcatggttttgaaacacacaccttacaggagcacaacttagccaactat ttgttcttcctgatgtatctgattaacaaagatgaaacagaacacacgggtcaggaatct tatgtctggaagatgtaccaagaaaggtgttgggatttcttcccagctggtgactgcttt aggaaacaatatgaagatcagcttggataa

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