Lutra lutra (Eurasian river otter): 125104347 Help Entry 125104347         CDS       T08100                                  Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism llv  Lutra lutra (Eurasian river otter) Pathway llv04020   Calcium signaling pathway llv04371   Apelin signaling pathway llv04713   Circadian entrainment llv04921   Oxytocin signaling pathway llv04970   Salivary secretion llv05010   Alzheimer disease llv05012   Parkinson disease llv05020   Prion disease llv05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:llv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125104347    04020 Calcium signaling pathway     125104347  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     125104347   09154 Digestive system    04970 Salivary secretion     125104347   09159 Environmental adaptation    04713 Circadian entrainment     125104347  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     125104347    05012 Parkinson disease     125104347    05020 Prion disease     125104347    05022 Pathways of neurodegeneration - multiple diseases     125104347  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:llv04040]     125104347 Ion channels [BR:llv04040]  Voltage-gated cation channels   Ryanodine receptor    125104347 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  125104347 NCBI-ProteinID:  XP_047592943 LinkDB All DBs Position 7:complement(53509710..54027116) Genome browser AA seq 4869 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCITNIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLRENATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSVSNGNVQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRLFHGHDECLTIPSTD QNDAQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHITTGHYLALTED QGLLLQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRAAAPVTLPIQEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGIRDLLGT TQSLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLYQIGR MNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWAVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYH TLRLYSAVCALGNSRVACALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSATRKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTGEEHQ KQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHGVETEDGAEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKSRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEEEEEED TSWAGKLRALVYKIKGPPKSEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFSLLQRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDSEDEEIVHMG NAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSL NKDGSISEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTV SLSTTEAALALNRYLCSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRSLTKAQ RDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPS GWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRI SATLEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQNGWKYGI SLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALVQQRENE KLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGS HPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGVKDMELDASSMEKRFAYKFLK KILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHHLYFLSSP LKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVM KSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILT SIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAAI PVAFLEPMLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISDLAESGA RYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNILKIINN NLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKADTKG DTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPNADSDQLFRMVAEVFILW CKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSI QTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQEKSDD PAVKWQLNLYKDVLKSEEPFNAEKTIERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQ RKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEE DEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEEEDKEK TFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNAG VQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERG EKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESIS DFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVG FLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVES STNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSEIDFL LSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAGSVL NYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKM ELFVNFCEDTIFEMQLASQISESDSAERPDEEEEEDEDSSYVLEIEGEEEDDNSFESASA FAMACASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGLFRLFFT ILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDALDAERAEVTEPGVP TELIHFVKGEKGDADIMSDLFGFHPKKEGGLKHGPEGGLGDLSEIIGKDEPPTLESTVQK KRKAQAAEMKAAHEAEGKVEPEKTDLEDGEKEDTAKEEEQAEALWADVTKKKKRRRGQKV EKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPVEEE TEDVANLWNSFTDEEEEEAMVFFVLQESTGYMAPALRALAIIHTIISLVCVVGYYCLKVP LVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINK YGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSVDMKYHVWKLGVVFTDNS FLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVV YLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDP YEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYF DTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCF RKQYEDQLG NT seq 14610 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggaggagaaggaggcgaggacgagatccagttcctgcggactgaagacgag gtggttctccagtgcatcacgaacattcacaaggagcaaaggaagttctgcctggcagcc gagggcctcgggaaccgcctgtgcttcttggagcccacttccgaagccaagtatgttcct ccagatctctgcgtctgcaattttgtgctggaacagtccctctctgtgagagccctgcag gaaatgcttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccac aggaccctgctatatggccacgcgattctcctgaggcactccttcagtggcatgtatcta acatgtttgaccacatcaagatcccagacagataaacttgcctttgatgtaggtctacgg gaaaatgccacaggagaagcctgttggtggaccatacatccggcttccaaacagagatcc gaaggagagaaagttcgaattggtgatgacctcattcttgtcagcgtgtcctctgaaaga taccttcatctctccgtgtcaaacgggaacgtacaagtggacgcctcttttatgcagaca ctctggaatgtacatcctacatgctcaggaagtagcgttgaagaaggatacctacttggt gggcacgtagtacgtctcttccatggtcatgatgagtgtttgacgataccatctacagac cagaacgatgcccagcacaggaggatattctatgaagctgggggagctgggacacgagcc cgatctctgtggagagtggaaccccttcggataagttggagtggcagtaacatccgatgg ggccaggctttccggctccggcatatcaccacaggccactacctggccctgacagaggac caaggccttctactgcaggaccgggcgaagtcagacaccaagtccacggccttctctttc cgggcttccaaggaaatcaaggagaaattggattctagtcacaagcgagatatagaaggc atgggcgttccagaaatcaagtatggagattccgtctgctttgtgcagcatatagccagt ggtctgtgggtgacctacaaagcacaagatgccaagacctcccgccttggacctctgaaa agaaaggtcatactccaccaagaaggccacatggatgacgggttaacactgcagagatgc cagcgtgaggagtcgcaggctgctcgaatcatccggaacacaacagccttattcagccag tttgtaagcgggaacaaccgcgcagcggcccctgtcaccctgccgatccaggaggtcctg cagaccttgcaggacttgattgcctactttcagccccccgaggaggagatgcagcacgag gacaaacagaacaaactccgctcgctcaagaacagacagaatctcttcaaggaggaggga atgttggcccttgtgttaaactgcattgaccgcttaaatatctacaacagtgtcgcacac tttgcggggatcgcaagggaggagagtggcatggcttggaaggaaatcctgaacctcctc tacaaactgcttgctgctctcattcgtggaaacagaaacaactgtgctcaattctctaat aacctcgattggctaatcagcaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagccgagggccac atcaagtccatcatctccctgttggataagcatgggcggaatcacaaggttctggacgtg ctgtgttccctctgtctctgcaatggggttgctgtcagagccaaccagaatctgatttgt gacaacttgctgccccggaggaacttgctcctgcagacacggctaattaatgatgtgacc agcattcggcccaacatcttcctgggagttgccgagggctcggctcagtacaagaagtgg tacttcgagctgatcatcgaccaggtggaccccttcctaacagctgagcccacacacctg cgggtgggctgggcctcctcctccggctatgctccataccctggcgggggagaaggatgg ggaggcaatggtgtcggtgatgacctctactcctatggctttgatggacttcacctttgg tcaggccgcatacccagagccgtagcctccatcaaccagcacctcctgagatcagacgac gtggtgagctgttgcctcgaccttggagtgcccagcatctccttccgcatcaacgggcag cccgtgcaggggatgtttgagaacttcaacacagatgggctcttcttccctgtggtgagc ttctcagcaggtgtcaaagtgcgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaagaaaagatgaga ttggagcctgtgaaagaatataaacgtgacgcggaaggcattagagatctgctgggtacc acccagtccctctcccaagcctccttcatcccatgtcccattgacaccagtcaggttgtt ttgccccctcacctagaaaagatccgagatagactggctgaaaacatccacgagctttgg ggaatgaataaaatagagcttggctggacttttggcaagatacgggatgacaataaaaga caacacccctgtcttgtggagttttcaaagctgcctgaaaccgagaagaattataaccta cagatgtcaactgaaaccttaaagaccctcctggccctggggtgccatattgctcatgtg aatccagctgctgaggaagatctcaagaaggtcaaattgcccaaaaactatatgatgtcc aatggctataagccagcccctttggatctgtctgacgtgaagctattacctcctcaagaa gttttagtggataagcttgcagaaaatgcacataacgtttgggccaaagacagaataaaa caaggatggacctatggcatccaacaggatttaaagaataaaagaaatccccggctggtg ccatacgctttactggatgaacgtaccaagaagtccaatagggacagccttcgtgaagct gttcgcacatttgttggttatggctataacattgaaccttcagaccaagaactggctgac ccagctgtggagaaagtcagcatcgacaagattcgatttttccgggtggagcggtcttat gcagtgagatctggaaaatggtattttgagtttgaggtggtaactggaggagacatgcgc gttggctgggccaggccaggttgtcggcctgacattgagctgggggccgatgaccaagcc tttgtgtttgaaggcagcaggggccagcggtggcatcaaggtagtgggtattttggacgt acgtggcagccaggagacgtggttggatgtatgattaacctggatgatgcttcgatgatc ttcacactgaatggcgagctgctgatcaccaacaaaggctctgaactcgccttcgctgat tacgaaattgagaatggatttgtgcccatctgctccctgggactgtatcagattggccgc atgaatctcgggatggatgccagcaccttcaagttttataccatgtgtggcctccaagag ggctttgagccttttgctgtcaacatgaaccgggacgttgcgatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccaaaggatcatccccatatagaggtcgtgaggatcgat ggcaccatggacagtcctccatgcctcaaggtgacccacaagacgtttggcacacagaat agtaatgccagcatgatctactgccgcctgagcatgcccgtcgagtgccactcctccttc agccacagcccctgcctggacagtgaagcattccagaaaaggaaacagatgcaagaaata ctctctcatacgacaacgcagtgctactatgcaatccgcatctttgctggacaggacccc tcctgcgtctgggtcggatgggtgacaccagactatcacttatacagtgaaaagttcgac ctgaataaaaactgcacagtgactgtcactctaggggatgaaagaggacgggtccatgaa agtgtgaaacgcagcaactgctacatggtctggggtggggatattgtggccacttcccaa agatcaagtcgaagcaacgtggacctggagatcggctgcctcgtggatctggcaatgggc atgttgtctttttccgccaatgggagagaactcggcacctgctaccaggtggagcccaat accaaagtgtttccagcggttttcctacagcccacgagcacttccttgtttcagtttgaa cttgggaagctgaagaacgcaatgcccctgtcggcggccatctttaagagcgaagagaag aacccagttccacagtgtccacctcggctggatgtccagaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgcgtgagtgagcgccacggc tgggcggtgcagtgcctggagcccctgcagatgatggccctccacatccccgaggagaac aggtgtgtggacattctggagctgtgtgagcaggaggacctgatgcagttccattaccac acgctccgactctacagcgctgtgtgcgccctgggaaacagccgggtggcctgcgccctg tgcggccacgtggacctctcccagctcttctatgccatcgataacaagtacctccctggc ctccttcgctcggggttctacgacctcctcatcagcatccacctggccaacgctaaggag aggaagctaatgatgaagaacgagtacatcattcccatcaccagcgccaccaggaaaatc cgcctgtacccggatgagtccaagaggcacgggctgccgggggtgggcctgagaacgtgc cttaagcccgggttcaggttctccaccccttgctttgttgtgaccggcgaggagcaccag aagcagagccctgagatccccttagagattctcaagacgaaggcgctgagcatgctgacg gaggcggtgcagcatagcggggctcacatccgcgaccctgtgggcgggtctgtggagttc cagttcgtgcctgtgctgaaactcatcgggaccctgctggtcatgggggtgttcgatgac gatgatgtccggcagatcctcctcctgatcgatccctctgtgttcggggagcacggtgtg gagacggaggacggagcagagaaggaggaagtgactcaggtggaggagaaggcagtggag gctggggaaaaggctggcaaggaggctcccgtcaaaggcttgctgcagacccgactgcct gaatccgtcaagctgcagatgtgtgagctcctcagctatctctgtgactgtgagctgcag catcgagtggaggccattgtggcatttggcgacatttatgtctccaaactacaggcaaat cagaagtcccgctacaatgagctcatgcaggccttgaacatgtctgcagccctgactgcc cggaagaccagggagttccgctcccccccgcaggagcagatcaacatgcttcttaacttc caactgggagaaaattgcccctgcccagaggagatccgggaggagctatatgacttccat gaggaccttctcattcactgtggcgttccactggaggaggaagaagaggaagaggaggac acctcctgggctggaaaactccgtgccttggtgtataaaatcaaaggccctcccaagtct gagaaggaacagccaacagaagaggaagagagatgccctaccaccttgaaggagctcatc tcacagaccatgatccgctgggcccaggaggaccagatccaggatgcggagttggtccga atgatgttcagcctccttcagagacagtacgacagcatcggggagctgctgcaggccctt cggaagacctacaccatcagccaggcctctgtgagcgacaccatcaacctgctggctgcg ctgggccagatccgctgcctgctcagtgtccggatgggcaaggaggaggagctgctcatg atcaacgggctgggagacattatgaacaacaaggtgttttaccagcatcccaacctcatg cgagtccttggcatgcacgagacggtgatggaggtgatggtgaatgtgctgggtgcagag aagtctcagattgcttttcccaagatggttgctagctgttgccgcttcctctgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctgagttacctgctggag aatagcagtgttggcctagcctccccttccatgaggggatctaccccactggacgtggca gcttcctctgtgatggacaacaatgagttagctctgggcttagaggaaccggacctcgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctagccaaa ggataccctgatgtcggctggaaccccattgaaggggaacgttacctgtccttcctgagg tttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagtgtcgtggtcaagctg ctcatcagacgcccggagtgcttcggcccagccctgcgaggtgaaggaggaaacggtcta ttggcagccatgcagggcgccattaagatctctgagaacccagccctcgacctcccctct cagggatacaagagagaagtcatggaggacagtgaagatgaagagattgtgcacatgggc aacgccattatgtctttttattcagctcttatagatctcctgggccgctgtgcgcctgaa atgcaccttatccagacaggaaagggagaagccatccggatcaggtcaatcctacgctcc ctggtccccactgaggacctggtcggcatcatcagcatccccttgaagctgccatcccta aacaaagatgggtccatcagtgagccagatatggcagctaacttctgccctgaccacaag gcacccatggtgcttttcttggatcgtgtttatggcatcaaggatcaaacatttctgctc cacttgctagaggttggatttttacctgacttaagagcctctgcctctctagatacagtt tccctgagcaccacagaggctgcgcttgccctaaataggtacttatgttccgccgtgctc ccactcctcacaagatgcgccccgctctttgccggaacggagcactacacatctctcatc gattctacactgcagaccatataccggctttccaagggacgttccctcaccaaagctcag agggacaccatagaagaatgtttgctcgccatttgcaatcacttgaggccttccatgtta cagcagctcctgcgacgtctggtttttgatgtgccacagctcaacgaatactgcaaaatg ccccttaagcttctgacaaatcactatgaacagtgctggaagtattactgtctgccttca ggatgggggagctacgggctagctgtggaagaagaattgcacctgacggagaagctcttc tgggggatttttgactccctttcccataagaagtatgacccagaccttttccgaatggcc cttccttgtctcagtgctatagcgggggccctgccaccagattatttagacaccagaatc tcagccacattggagaagcagatctcagtggatgcggatggcaactttgaccccaaaccc atcaacaccatgaatttctccttgcctgaaaaatgggaatacatcgtcaccaagtatgca gagcattcacatgataaatgggcctgtgacaagagtcagaatggatggaaatacggaatt tccctggacgaaaatgtgaagacccatccactgatcaggcctttcaagacattaacggaa aaggagaaggaaatttaccgctggcccgcccgggagtccctgaaaaccatgctggctgtg ggctggtctgtggagaggaccaaagagggagaggccctggttcaacagcgggaaaatgag aaacttcggagcgtgtcccaggccagccagggcaacagctacagccctgctcccctggac ctctccaacgtggtgctctccagggagctccagggaatggtggaggtcgtggctgaaaac tatcacaacatctgggccaagaagaagaagctggaactggagagcaaaggtggtggcagt caccctctgttggtaccatatgataccctgacagccaaggagaagttcagggaccgagag aaggcacaggacctgtttaaattcctccaagtgaacggcatcgtggtttctagaggtgtg aaggatatggagctggatgcctcctccatggaaaagaggtttgcctataaatttttgaag aagatcctgaaatatgttgattccgcccaagagtttattgcccatttggaagccattgtc agcagtggaaaaacagaaaagtctccccacgaccaggagatcaaattctttgccaaagtt ctcctcccactggttgaccagtacttcaccaatcaccacctctacttcttgtcatcccct ctgaagccccttagcagcagcggctatgcctctcataaggagaaagaaatggtggctagc ctcttctgcaaactcgctgctcttgttcgacacaggatttccctctttgggagtgattct actacaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatg aagtcaggctcagagctggtcaaggccggattacgagcattctttgaaaatgctgcagaa gacttagagaagacttcggaaaacctgaagctggggaagtttacccattccagaacgcag attaaaggcgtgtctcagaatattaactataccacggtggctctgctccccatcctgacg tccatctttgagcatgttgctcagcatcagttcggggtggatttactcttaggcgatgtg cagatttcatgctaccacatactgtgcagcctctactcccttgggactggaaagaatatc tacgttgaaaggcaacgtcctgcccttggagaatgtctggcctcactggcagctgccatc ccagtggcattcctggagcccatgcttaatcgctacaatccactctccgtcttcaacacc aaaacccccagggagaggtctattctgggcatgccggacacagtggaagagatgtgtcct gacatcccgcagctggaaggcctgatgaaggagatcagcgacctggctgagtcaggggcc cggtacacagagatgccccatgtcatcgaggtgatcttgcccatgctctgcaactaccta tcctactggtgggagcgggggcctgagcacctgccccccagcacagggccctggtgcacc aaggtcacatctgaacacctcagtgtcatcctgggaaacattctgaaaatcatcaacaac aacctgggcatcgatgaggcatcctggatgaaacgtatcgcagtgtatgcccagccgatc atcagcaaagcccggccagacctgctgaaaagccacttcattccaactctggagaagctg aagaaaaaggcggtaaagactgtgcaggaggaggagcagctgaaagccgacaccaaggga gacactcaggaggcggagctcctcatcctggacgagtttgcggtcctctgcagagacctc tatgccttctaccccatgctgatccgctatgtggacaacaacagatctaactggcttaaa agtcccaatgctgactctgaccagctcttccgcatggtggcagaggtcttcatcctgtgg tgtaaatctcacaacttcaagagggaagagcagaattttgtgattcagaatgaaattaat aatttggcatttttaactggagacagcaaaagcaagatgtcgaaagccatgcaagtaaag tctggaggacaggaccaggaacggaagaagacaaagcggaggggagacttgtattccatc cagacctctctcattgtggccgcactcaagaaaatgctgcccattggtttgaatatgtgc acaccaggcgatcaggagctcatctccctggccaaatctcgatacagctatagggacaca gatgaagaggtgaaggaacatctgcggaataacttgcacctgcaggagaagtctgatgac ccagcagtaaagtggcaactgaacctctacaaagatgttctaaagagtgaagaacctttc aatgcagaaaagaccatagagcgtgtacagagaatttcagcagcggtgttccacctggag caggtggaacagcctttgaggtccaagaaggcggtctggcacaaactgttgtcaaagcag cggaaacgggcagtggtggcctgtttcaggatggcccctctctacaacctgcccaggcac cgctccattaacctcttcctccatggctatcagagattttggatagaaacagaggagtat tcctttgaagagaaactagtacaggatttggctaaatcccccaaggtggaagaggaggag gacgaggagacggaaaagcaaccagacccacttcatcagatcattctccattttagccgc aatgctctcacggagaggagcaaactggaagatgaccccttgtacacgtcctattccagc atgatggccaagagttgtcagagtggggaggacgaagaagaggaggaagacaaggagaaa acattcgaagagaaagagatggaaaagcagaaaaccctctaccagcaagcacggctgcat gagcggggagctgcagagatggtccttcagatgataagtgccagcaaaggtgagatgagc cccatggtggttgagactctgaagctgggcatcgccattctgaatgggggcaacgctggc gtgcagcagaaaatgctagattacctaaaggagaaaaaggatgctggattctttcaaagc ctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgaaaggcagaat aaagcggaaggcctggggatggttactgaggaaggaacactcattgttcgtgagcgtggt gaaaaagtactccagaatgacgagtttacacgcgatctctttcggttcctgcagttactt tgtgaaggacataacagtgactttcagaacttcctgcggactcagatgggcaataccacc accgtaaacatcatcatcagtaccgtggactacctcctgcgtctgcaggagtcaatcagt gatttctactggtattattcagggaaggacatcattgacgaatctggacagcacaatttt tccaaagctctggcagtcacgaagcagattttcaattctcttacggaatatatccagggc ccttgcattgggaaccagcagagcctggctcacagcaggctgtgggatgcggtggtcggc ttcctccatgtgtttgctaacatgcagatgaaactctctcaggattccagtcagatcgag ctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctg gaagggaatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatca tctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagaccta accagctcagacaccttcaaagaatatgaccccgatggtaaagggattatctctaaaaaa gagttccaaaaggccatggaagggcagaaacagtacacacagtcagagattgactttctc ctttcgtgcgcagaagctgatgagaatgatatgtttaattacattgattttgtagaccgg ttccatgagccggccaaggacatagggtttaatgtggcagtgttactgaccaatctctcc gaacatatgccaaatgattctcgccttaagtgtctgttggacccagcaggaagtgtacta aattactttgaaccatacctgggacgaattgagatcatgggcggggccaagaaaattgag cgtgtttatttcgagatcagtgaatccagtcgaactcagtgggagaagccccaagtgaag gaatcgaagaggcagttcatctttgatgtggtcaatgaagggggagagcaagaaaagatg gaactgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcctctcagatc tccgaatctgactcagctgagaggcccgatgaggaggaggaagaagatgaagattcatct tatgtgttagaaattgagggtgaagaggaggatgacaattctttcgagtcagcctctgcg tttgccatggcctgtgcctcagtgaagagaaacgttgccaactttctgaagaaggcaacc ctgaagaacctccggaagcagtacaggaaggtgaaaaagatgaccgtgaaggagctggta aaggtgttcttctctttcttctggatgttgtttgtggggctcttccggttgttcttcacc atattgggaggaatcttccagatcctctggaacacagtgtttggaggggggctcgtggaa ggggcaaagaatatcagagtgaccaagatcctgggtgacatgcctgaccccacccagttt ggtatccatgacgatgctttggatgctgagcgggcagaggtgactgagccaggggttcca acggaactaattcacttcgtgaagggtgagaagggagatgcagatattatgtcagatctc tttggattccacccgaagaaagaaggcggcttaaagcatgggcctgaagggggtttgggt gacctctctgagattattggcaaggatgaaccccctacactagagagtactgtccagaag aaaaggaaagcacaggcagctgagatgaaagcagcacatgaagcagaagggaaagtggag cctgagaagacagacctggaagacggggagaaagaggatacggccaaagaggaagagcag gccgaggccctgtgggcagatgtgacaaagaagaagaagcgacggcgcggccagaaagtc gagaagcccgaagccttcatggctaatttcttcaaagggctagaaatctatcagaccaag ttactgcattacctggccaggaatttctacaacctgaggttcctcgctctgttcgtagcc ttcgcgatcaacttcatcctactcttttataaggtcaccgaggaacctgtagaagaagag acggaagacgttgcaaacctgtggaattcctttaccgatgaggaagaggaagaagcaatg gtgttctttgtcctgcaggagagcactgggtacatggcacccgcattgcgggccttggcc attatccacaccatcatctctttggtctgcgtggtgggctattactgcttgaaggtccct ctggtggtattcaaaagggaaaaagaaatcgccaggaagctggagtttgatggcctatat atcactgaacagccatctgaagatgacatcaaggggcagtgggaccgcctggtaatcaac acaccatcttttcctaataactactgggacaagtttgttaagagaaaggtgatcaacaag tacggcgacctctatggagcagaacgcattgcggaactcctgggtttggacaaaaatgcc ctggatttcagcccagtcgaagagagcaaagcagaggcggcctctctggtgtcatggctg agttccgttgacatgaagtaccatgtctggaagctgggagttgtttttaccgacaactcc tttctctacctggcctggtataccaccatgtcagtcctgggccactacaacaacttcttc tttgctgctcatctgctggacatcgcgatgggcttcaagacgctgaggactattctgtca tctgtaactcacaacggcaagcagctggttctgactgtcggtctcctggccgtggtggtt tacctctacaccgtggtggccttcaacttcttccgcaagttctacaacaaaagtgaagac gacgatgagcccgatatgaagtgtgatgacatgatgacgtgttacctgttccacatgtat gtgggagtgagagctggagggggcattggtgacgaaattgaagaccctgctggtgaccct tatgagatgtaccgcattgtctttgacattaccttcttcttcttcgtcattgtcatcttg ctggccatcattcaaggtcttattattgatgcttttggagagctaagagaccagcaggaa caagtgcgagaagatatggagactaaatgtttcatctgtgggattggcaatgactatttt gacacgactcctcatggctttgagacacataccttgcaggagcacaacttagccaactat ttgttcttcctgatgtacctgattaataaagatgagaccgaacacacgggtcaggaatct tacgtctggaagatgtaccaagaaaggtgttgggatttcttcccggctggtgactgcttt cggaaacaatatgaagatcagcttggataa

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