KEGG   PATHWAY: lruf04662
Entry
lruf04662                   Pathway                                
Name
B cell receptor signaling pathway - Lynx rufus (bobcat)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
Pathway map
lruf04662  B cell receptor signaling pathway
lruf04662

Other DBs
GO: 0050853
Organism
Lynx rufus (bobcat) [GN:lruf]
Gene
124501030  [KO:K07860]
124501085  [KO:K05697] [EC:3.1.3.48]
124501639  [KO:K06504]
124502506  [KO:K06268]
124502703  [KO:K07827]
124502945  [KO:K17332]
124503577  [KO:K12362]
124504040  [KO:K03099]
124504103  [KO:K06268]
124504954  [KO:K04735]
124504967  [KO:K15909] [EC:3.1.3.86]
124506908  [KO:K04348] [EC:3.1.3.16]
124507021  [KO:K07371]
124507023  [KO:K12230]
124507057  [KO:K04467] [EC:2.7.11.10]
124507653  [KO:K05854] [EC:2.7.10.2]
124508471  [KO:K04368] [EC:2.7.12.2]
124508912  [KO:K04734]
124509577  [KO:K07370] [EC:2.7.10.2]
124509903  [KO:K12560]
124510071  [KO:K04012]
124510270  [KO:K04456] [EC:2.7.11.1]
124511073  [KO:K06506]
124511119  [KO:K04456] [EC:2.7.11.1]
124511146  [KO:K02581]
124511236  [KO:K06467]
124511421  [KO:K17333]
124511524  [KO:K05859] [EC:3.1.4.11]
124512209  [KO:K03099]
124512474  [KO:K04456] [EC:2.7.11.1]
124512631  [KO:K04379]
124513422  [KO:K04364]
124513533  [KO:K06507]
124514527  [KO:K02649]
124514827  [KO:K00922] [EC:2.7.1.153]
124514943  [KO:K03084] [EC:3.1.3.86]
124515660  [KO:K07368]
124516245  [KO:K07828]
124516273  [KO:K04448]
124516558  [KO:K05730]
124516980  [KO:K04446]
124517115  [KO:K07369] [EC:3.4.22.-]
124517730  [KO:K19662] [EC:2.7.11.13]
124517731  [KO:K04371] [EC:2.7.11.24]
124517840  [KO:K02649]
124517940  [KO:K06465]
124519099  [KO:K07367]
124519305  [KO:K04392]
124519861  [KO:K04371] [EC:2.7.11.24]
124519949  [KO:K04348] [EC:3.1.3.16]
124519955  [KO:K12229]
124520125  [KO:K26239]
124520800  [KO:K02580]
124520848  [KO:K08890] [EC:2.7.10.2]
124521006  [KO:K04348] [EC:3.1.3.16]
124521298  [KO:K07209] [EC:2.7.11.10]
124522388  [KO:K05730]
124522479  [KO:K07861]
124523730  [KO:K02649]
124523760  [KO:K04366] [EC:2.7.11.1]
124524673  [KO:K05730]
124524782  [KO:K04369] [EC:2.7.12.2]
124525847  [KO:K07210]
124525968  [KO:K00922] [EC:2.7.1.153]
124526728  [KO:K03083] [EC:2.7.11.26]
124527077  [KO:K00922] [EC:2.7.1.153]
124527556  [KO:K19831]
124527565  [KO:K02833]
124527735  [KO:K06512]
124527736  [KO:K06512]
124527767  [KO:K05855] [EC:2.7.10.2]
124527768  [KO:K06512]
124527769  [KO:K06512]
124527780  [KO:K06512]
124527881  [KO:K06508]
124528719  [KO:K05872]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12461567
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
PMID:10358768
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
PMID:15886119
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
PMID:15752555
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
PMID:12033741
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
PMID:15364057
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
PMID:15771577
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
PMID:15886112
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
PMID:15457440
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
PMID:15322145
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
PMID:15626471
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
PMID:12119152
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
PMID:11163197
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
PMID:18086859
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
Related
pathway
lruf04010  MAPK signaling pathway
lruf04020  Calcium signaling pathway
lruf04064  NF-kappa B signaling pathway
lruf04120  Ubiquitin mediated proteolysis
lruf04151  PI3K-Akt signaling pathway
lruf04610  Complement and coagulation cascades
lruf04810  Regulation of actin cytoskeleton
KO pathway
ko04662   

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