KEGG   PATHWAY: map00998
Entry
map00998                    Pathway                                
Name
Biosynthesis of various antibiotics
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
map00998  Biosynthesis of various antibiotics
map00998

Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine [PATH:map00998]
M00787  Bacilysin biosynthesis, prephenate => bacilysin [PATH:map00998]
M00788  Terpentecin biosynthesis, GGAP => terpentecin [PATH:map00998]
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone [PATH:map00998]
M00848  Aurachin biosynthesis, anthranilate => aurachin A [PATH:map00998]
M00877  Kanosamine biosynthesis, glucose 6-phosphate => kanosamine [PATH:map00998]
M00889  Puromycin biosynthesis, ATP => puromycin [PATH:map00998]
M00890  Roseoflavin biosynthesis, FMN => roseoflavin [PATH:map00998]
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin [PATH:map00998]
M00904  Dapdiamides biosynthesis, L-2,3-diaminopropanoate => dapdiamide A/B/C [PATH:map00998]
Drug
D05653  Puromycin (USAN)
Reference
  Authors
Sandmann A, Dickschat J, Jenke-Kodama H, Kunze B, Dittmann E, Muller R
  Title
A Type II polyketide synthase from the gram-negative Bacterium Stigmatella aurantiaca is involved in Aurachin alkaloid biosynthesis.
  Journal
Angew Chem Int Ed Engl 46:2712-6 (2007)
DOI:10.1002/anie.200603513
Reference
  Authors
Vetter ND, Langill DM, Anjum S, Boisvert-Martel J, Jagdhane RC, Omene E, Zheng H, van Straaten KE, Asiamah I, Krol ES, Sanders DA, Palmer DR
  Title
A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis.
  Journal
J Am Chem Soc 135:5970-3 (2013)
DOI:10.1021/ja4010255
Reference
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006
Reference
PMID:8576156
  Authors
Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.
  Title
The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.
  Journal
J Biol Chem 271:1579-90 (1996)
DOI:10.1074/jbc.271.3.1579
Reference
  Authors
Hollenhorst MA, Clardy J, Walsh CT
  Title
The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics.
  Journal
Biochemistry 48:10467-72 (2009)
DOI:10.1021/bi9013165
Reference
  Authors
Schwarz J, Konjik V, Jankowitsch F, Sandhoff R, Mack M
  Title
Identification of the Key Enzyme of Roseoflavin Biosynthesis.
  Journal
Angew Chem Int Ed Engl 55:6103-6 (2016)
DOI:10.1002/anie.201600581
Reference
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
Reference
  Authors
Hamano Y, Kuzuyama T, Itoh N, Furihata K, Seto H, Dairi T
  Title
Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin.
  Journal
J Biol Chem 277:37098-104 (2002)
DOI:10.1074/jbc.M206382200
Reference
  Authors
Quaderer R, Omura S, Ikeda H, Cane DE
  Title
Pentalenolactone biosynthesis. Molecular cloning and assignment of biochemical function to PtlI, a cytochrome P450 of Streptomyces avermitilis.
  Journal
J Am Chem Soc 128:13036-7 (2006)
DOI:10.1021/ja0639214
Reference
PMID:7500951
  Authors
Hidaka T, Goda M, Kuzuyama T, Takei N, Hidaka M, Seto H
  Title
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis.
  Journal
Mol Gen Genet 249:274-80 (1995)
DOI:10.1007/BF00290527
Related
pathway
map00010  Glycolysis / Gluconeogenesis
map00020  Citrate cycle (TCA cycle)
map00030  Pentose phosphate pathway
map00220  Arginine biosynthesis
map00250  Alanine, aspartate and glutamate metabolism
map00260  Glycine, serine and threonine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00440  Phosphonate and phosphinate metabolism
map00900  Terpenoid backbone biosynthesis
KO pathway
ko00998   
LinkDB

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