KEGG   PATHWAY: mcc04115
Entry
mcc04115                    Pathway                                
Name
p53 signaling pathway - Macaca mulatta (rhesus monkey)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
mcc04115  p53 signaling pathway
mcc04115

Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100427400  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
713668  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
714443  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
713358  CHEK1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
702571  GORAB; RAB6-interacting golgin isoform X1 [KO:K19748]
709988  cyclin-dependent kinase inhibitor 2A [KO:K06621]
718284  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
699563  MDM4; protein Mdm4 isoform X1 [KO:K10127]
716170  TP53; cellular tumor antigen p53 [KO:K04451]
714389  PPP1R13L; relA-associated inhibitor [KO:K27356]
719199  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
574320  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
710379  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
695215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
715650  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
701822  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
700589  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
700382  CCNE2; G1/S-specific cyclin-E2 isoform X2 [KO:K06626]
711002  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
715055  SFN; 14-3-3 protein sigma [KO:K06644]
696097  RPRM; protein reprimo [KO:K10128]
699504  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
702184  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
699269  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
697835  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
701054  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
711257  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
714207  GTSE1; G2 and S phase-expressed protein 1 isoform X1 [KO:K10129]
705436  ZNF385A; zinc finger protein 385A isoform X1 [KO:K26543]
574332  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
700580  PIDD1; p53-induced death domain-containing protein 1 isoform X1 [KO:K10130]
716826  TNFRSF10A; tumor necrosis factor receptor superfamily member 10A [KO:K04722]
716650  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722]
702781  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
100426724  BID; BH3-interacting domain death agonist isoform X2 [KO:K04726]
718948  BAX; apoptosis regulator BAX [KO:K02159]
702789  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
717955  BBC3; bcl-2-binding component 3 [KO:K10132]
100425793  TP53AIP1; LOW QUALITY PROTEIN: p53-regulated apoptosis-inducing protein 1 [KO:K13773]
706688  SIVA1; apoptosis regulatory protein Siva [KO:K22744]
713035  BCL2L1; bcl-2-like protein 1 [KO:K04570]
707407  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
704206  TP53I3; quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
713226  EI24; etoposide-induced protein 2.4 homolog [KO:K10134]
709615  SHISA5; protein shisa-5 isoform X1 [KO:K10135]
703890  PERP; p53 apoptosis effector related to PMP-22 [KO:K10136]
710132  ZMAT3; zinc finger matrin-type protein 3 [KO:K10137]
716629  SIAH1; E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
694921  E3 ubiquitin-protein ligase SIAH1 [KO:K04506] [EC:2.3.2.27]
705449  cytochrome c-like [KO:K08738]
716056  cytochrome c-like [KO:K08738]
711309  cytochrome c-like [KO:K08738]
698225  cytochrome c-like [KO:K08738]
701246  cytochrome c-like [KO:K08738]
699951  cytochrome c-like [KO:K08738]
702488  cytochrome c-like [KO:K08738]
100425223  CYCS; cytochrome c [KO:K08738]
106995399  cytochrome c-like [KO:K08738]
712148  cytochrome c-like [KO:K08738]
694164  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
694544  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
711037  AIFM2; apoptosis-inducing factor 2 isoform X1 [KO:K22745]
696868  IGFBP3; insulin-like growth factor-binding protein 3 precursor [KO:K10138]
698444  IGF1; insulin-like growth factor I precursor [KO:K05459]
713883  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
694367  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
715606  CD82; CD82 antigen [KO:K06509]
705413  THBS1; thrombospondin-1 [KO:K16857]
700713  SERPINB5; serpin B5 [KO:K10139]
713813  DDB2; DNA damage-binding protein 2 [KO:K10140]
114672263  LOW QUALITY PROTEIN: DNA damage-binding protein 2-like [KO:K10140]
703138  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
707062  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
699329  SESN3; sestrin-3 [KO:K10141]
700232  SESN1; sestrin-1 isoform X1 [KO:K10141]
716904  SESN2; sestrin-2 [KO:K20394]
705121  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
694965  TSC2; tuberin isoform X7 [KO:K07207]
100427279  STEAP3; metalloreductase STEAP3 [KO:K10142] [EC:1.16.1.-]
708802  COP1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
701580  RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [KO:K10144] [EC:2.3.2.27]
697738  CCNG1; cyclin-G1 [KO:K10145]
699793  CCNG2; cyclin-G2 isoform X2 [KO:K10146]
713045  PPM1D; protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
695164  TP73; tumor protein p73 isoform X1 [KO:K10148]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
mcc04110  Cell cycle
mcc04210  Apoptosis
mcc04218  Cellular senescence
KO pathway
ko04115   
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