KEGG   PATHWAY: mdo03015Help
Entry
mdo03015                    Pathway                                

Name
mRNA surveillance pathway - Monodelphis domestica (opossum)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
BRITE hierarchy
Pathway map
mdo03015  mRNA surveillance pathway
mdo03015

Ortholog table
Module
mdo_M00399  Cap binding complex [PATH:mdo03015]
mdo_M00430  Exon junction complex (EJC) [PATH:mdo03015]
Other DBs
BSID: 193369
GO: 0071028
Organism
Monodelphis domestica (opossum) [GN:mdo]
Gene
100019930  NCBP1; nuclear cap binding protein subunit 1 [KO:K12882]
100021231  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
100027785  nuclear cap-binding protein subunit 2 [KO:K12883]
100019877  UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast) [KO:K14328]
100020995  UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast) [KO:K14328]
100012987  RBM8A; RNA binding motif protein 8A [KO:K12876]
103104584  MAGOH; mago homolog, exon junction complex core component [KO:K12877]
100016341  CASC3; cancer susceptibility candidate 3 [KO:K14323]
100026301  EIF4A3; eukaryotic translation initiation factor 4A3 [KO:K13025] [EC:3.6.4.13]
100018743  SAP18; Sin3A associated protein 18 [KO:K14324]
100024467  PNN; pinin, desmosome associated protein [KO:K13114]
100030457  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
100013200  RNPS1; RNA binding protein with serine rich domain 1 [KO:K14325]
100025556  ALYREF; Aly/REF export factor [KO:K12881]
100010859  NXF1; nuclear RNA export factor 1 [KO:K14284]
100024916  NXT2; nuclear transport factor 2 like export factor 2 [KO:K14285]
100028638  NTF2-related export protein 2-like [KO:K14285]
100019223  NTF2-related export protein 2-like [KO:K14285]
100010857  SRRM1; serine and arginine repetitive matrix 1 [KO:K13171]
100025582  RNGTT; RNA guanylyltransferase and 5'-phosphatase [KO:K13917] [EC:3.6.1.- 2.7.7.50]
100018821  RNMT; RNA guanine-7 methyltransferase [KO:K00565] [EC:2.1.1.56]
100024631  PABPN1; poly(A) binding protein nuclear 1 [KO:K14396]
100026268  PABPN1L; poly(A) binding protein nuclear 1 like, cytoplasmic [KO:K14396]
100015269  NUDT21; nudix hydrolase 21 [KO:K14397]
100013834  CPSF6; cleavage and polyadenylation specific factor 6 [KO:K14398]
100027234  CPSF7; cleavage and polyadenylation specific factor 7 [KO:K14398]
100031962  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
100023813  PAPOLA; poly(A) polymerase alpha [KO:K14376] [EC:2.7.7.19]
100022871  CLP1; cleavage and polyadenylation factor I subunit 1 [KO:K14399] [EC:2.7.1.78]
100017655  polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
100026507  PCF11; PCF11 cleavage and polyadenylation factor subunit [KO:K14400]
100015835  CPSF1; cleavage and polyadenylation specific factor 1 [KO:K14401]
100014121  CPSF2; cleavage and polyadenylation specific factor 2 [KO:K14402]
100028117  CPSF3; cleavage and polyadenylation specific factor 3 [KO:K14403] [EC:3.1.27.-]
100011934  CPSF4; cleavage and polyadenylation specific factor 4 [KO:K14404]
100013342  FIP1L1; factor interacting with PAPOLA and CPSF1 [KO:K14405]
100018567  WDR33; WD repeat domain 33 [KO:K15542]
100030984  WDR82; WD repeat domain 82 [KO:K14962]
100031298  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
100019898  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
100010439  SSU72; SSU72 homolog, RNA polymerase II CTD phosphatase [KO:K15544] [EC:3.1.3.16]
100022256  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
100016102  CSTF2; cleavage stimulation factor subunit 2 [KO:K14407]
100031302  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
100010885  SYMPK; symplekin [KO:K06100]
100013572  MSI2; musashi RNA binding protein 2 [KO:K14411]
100020847  DAZAP1; DAZ associated protein 1 [KO:K14411]
100026140  MSI1; musashi RNA binding protein 1 [KO:K14411]
100029897  PABPC1L; poly(A) binding protein cytoplasmic 1 like [KO:K13126]
100025062  PABPC4; poly(A) binding protein cytoplasmic 4 [KO:K13126]
100023528  PABPC1; poly(A) binding protein cytoplasmic 1 [KO:K13126]
100020176  ETF1; eukaryotic translation termination factor 1 [KO:K03265]
100023786  GSPT1; G1 to S phase transition 1 [KO:K03267]
100012828  UPF1; UPF1, RNA helicase and ATPase [KO:K14326] [EC:3.6.4.-]
100013371  UPF2; UPF2 regulator of nonsense transcripts homolog (yeast) [KO:K14327]
100018609  SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase [KO:K08873] [EC:2.7.11.1]
100024097  SMG7; SMG7, nonsense mediated mRNA decay factor [KO:K14409]
100023077  SMG5; SMG5, nonsense mediated mRNA decay factor [KO:K11125]
100013042  SMG6; SMG6, nonsense mediated mRNA decay factor [KO:K11124] [EC:3.1.-.-]
100012652  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
100017519  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
100026516  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
100028805  PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
100023749  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
100014202  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
100018121  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
100023958  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
100011289  PPP2R3B; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
100011688  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
100016573  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
100017824  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
100010758  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
100022186  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
100016488  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
100025482  HBS1L; HBS1 like translational GTPase [KO:K14416]
100016211  PELO; pelota homolog (Drosophila) [KO:K06965]
Reference
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
KO pathway
ko03015   
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