KEGG   PATHWAY: mea00230
Entry
mea00230                    Pathway                                
Name
Purine metabolism - Methylorubrum extorquens AM1
Class
Metabolism; Nucleotide metabolism
Pathway map
mea00230  Purine metabolism
mea00230

Module
mea_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:mea00230]
mea_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mea00230]
mea_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mea00230]
mea_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mea00230]
Other DBs
GO: 0006163 0042278
Organism
Methylorubrum extorquens AM1 [GN:mea]
Gene
Mex_1p0010  purL; phosphoribosylformylglycinamide synthetase [KO:K23269]
Mex_1p0318  [KO:K01519] [EC:3.6.1.66]
Mex_1p0412  purC; phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase) [KO:K01923] [EC:6.3.2.6]
Mex_1p0423  yexA; Phosphoribosylformylglycinamidine synthetase PurS [KO:K23264]
Mex_1p0424  purQ; phosphoribosylformylglycinamidine synthase I [KO:K23265]
Mex_1p0425  apt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
Mex_1p0431  [KO:K01768] [EC:4.6.1.1]
Mex_1p0535  amn; AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
Mex_1p0602  [KO:K13483]
Mex_1p0603  [KO:K11178] [EC:1.17.1.4]
Mex_1p0604  [KO:K11177] [EC:1.17.1.4]
Mex_1p0773  purB; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
Mex_1p0776  purA; adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
Mex_1p0795  [KO:K22602] [EC:3.5.1.126]
Mex_1p0872  nrd; ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent, large subunit [KO:K00525] [EC:1.17.4.1]
Mex_1p0975  ureAB; urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) [KO:K14048] [EC:3.5.1.5]
Mex_1p0976  ureC; Urease subunit alpha (Urea amidohydrolase subunit alpha) [KO:K01428] [EC:3.5.1.5]
Mex_1p1073  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
Mex_1p1074  [KO:K01429] [EC:3.5.1.5]
Mex_1p1075  ureA; urease gamma subunit [KO:K01430] [EC:3.5.1.5]
Mex_1p1365  [KO:K11751] [EC:3.1.3.5 3.6.1.45]
Mex_1p1653  guaD; guanine deaminase [KO:K01487] [EC:3.5.4.3]
Mex_1p1666  allA; ureidoglycolate hydrolase [KO:K01483] [EC:4.3.2.3]
Mex_1p1667  [KO:K14977] [EC:3.5.3.26]
Mex_1p1670  [KO:K16842] [EC:3.5.2.5]
Mex_1p1671  [KO:K07127] [EC:3.5.2.17]
Mex_1p1808  deoB; phosphopentomutase [KO:K01839] [EC:5.4.2.7]
Mex_1p1936  purE; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit [KO:K01588] [EC:5.4.99.18]
Mex_1p1937  purK; phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit [KO:K01589] [EC:6.3.4.18]
Mex_1p1978  gmk; Guanylate kinase (GMP kinase) [KO:K00942] [EC:2.7.4.8]
Mex_1p2044  purN; phosphoribosylglycinamide formyltransferase 1 [KO:K11175] [EC:2.1.2.2]
Mex_1p2045  purM; phosphoribosylaminoimidazole synthetase (AIR synthetase) [KO:K01933] [EC:6.3.3.1]
Mex_1p2050  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Mex_1p2171  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
Mex_1p2228  cysN; ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase) [KO:K00956] [EC:2.7.7.4]
Mex_1p2229  cysD; Sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit) [KO:K00957] [EC:2.7.7.4]
Mex_1p2363  [KO:K09769] [EC:3.1.4.16]
Mex_1p2535  purH; bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal) [KO:K00602] [EC:2.1.2.3 3.5.4.10]
Mex_1p2596  [KO:K01129] [EC:3.1.5.1]
Mex_1p3014  [KO:K13483]
Mex_1p3015  [KO:K11178] [EC:1.17.1.4]
Mex_1p3016  [KO:K11177] [EC:1.17.1.4]
Mex_1p3063  hpt; Hypoxanthine phosphoribosyl transferase [KO:K00760] [EC:2.4.2.8]
Mex_1p3089  [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
Mex_1p3093  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
Mex_1p3135  guaA; GMP synthetase (glutamine aminotransferase) [KO:K01951] [EC:6.3.5.2]
Mex_1p3145  guaB; IMP dehydrogeanse [KO:K00088] [EC:1.1.1.205]
Mex_1p3170  xapA; xanthosine phosphorylase (purine nucleoside phosphorylase) [KO:K03783] [EC:2.4.2.1]
Mex_1p3224  ureC; urease alpha subunit [KO:K01428] [EC:3.5.1.5]
Mex_1p3227  ureAB; urease gamma (N-terminal) and beta (C-terminal) subunits (urea amidohydrolase gamma/beta subunits) [KO:K14048] [EC:3.5.1.5]
Mex_1p3294  cyaA; Adenylate/guanylate cyclase [KO:K01768] [EC:4.6.1.1]
Mex_1p3348  guaD; Guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH) (GDEase) [KO:K01487] [EC:3.5.4.3]
Mex_1p3400  [KO:K01768] [EC:4.6.1.1]
Mex_1p3408  relA; GTP pyrophosphokinase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
Mex_1p3621  dgt; Deoxyguanosinetriphosphate triphosphohydrolase-like protein [KO:K01129] [EC:3.1.5.1]
Mex_1p3660  ade; Adenine deaminase (Adenase) (Adenine aminase) [KO:K01486] [EC:3.5.4.2]
Mex_1p3662  [KO:K01524] [EC:3.6.1.11 3.6.1.40]
Mex_1p3666  [KO:K01951] [EC:6.3.5.2]
Mex_1p3922  [KO:K13483]
Mex_1p3923  [KO:K11178] [EC:1.17.1.4]
Mex_1p3924  [KO:K11177] [EC:1.17.1.4]
Mex_1p4244  purD; phosphoribosylglycinamide synthetase (GAR synthetase) [KO:K01945] [EC:6.3.4.13]
Mex_1p4249  prs; phosphoribosylpyrophosphate synthetase [KO:K00948] [EC:2.7.6.1]
Mex_1p4291  mazG; nucleoside triphosphate pyrophosphohydrolase MazG [KO:K04765] [EC:3.6.1.9]
Mex_1p4314  purF; amidophosphoribosyltransferase (PRPP amidotransferase) [KO:K00764] [EC:2.4.2.14]
Mex_1p4513  [KO:K15778] [EC:5.4.2.8 5.4.2.2]
Mex_1p4626  surE; 5'-nucleotidase surE (Nucleoside 5'-monophosphate phosphohydrolase) [KO:K03787] [EC:3.1.3.5 3.1.3.6]
Mex_1p4703  [KO:K06952] [EC:3.1.3.89]
Mex_1p5234  [KO:K01768] [EC:4.6.1.1]
Mex_1p5308  [KO:K22602] [EC:3.5.1.126]
Mex_2p0021  nrd; ribonucleoside-diphosphate reductase [KO:K00525] [EC:1.17.4.1]
Mex_2p0990  [KO:K00939] [EC:2.7.4.3]
Mex_2p0999  [KO:K01939] [EC:6.3.4.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mea00030  Pentose phosphate pathway
mea00220  Arginine biosynthesis
mea00250  Alanine, aspartate and glutamate metabolism
mea00260  Glycine, serine and threonine metabolism
mea00340  Histidine metabolism
mea00630  Glyoxylate and dicarboxylate metabolism
mea00730  Thiamine metabolism
mea00740  Riboflavin metabolism
mea00790  Folate biosynthesis
KO pathway
ko00230   

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