KEGG   PATHWAY: mgp03420
mgp03420                    Pathway                                

Nucleotide excision repair - Meleagris gallopavo (turkey)
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Genetic Information Processing; Replication and repair
Pathway map
mgp03420  Nucleotide excision repair

Other DBs
GO: 0006289
Meleagris gallopavo (turkey) [GN:mgp]
100543550  RBX1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:]
100549149  CUL4A; cullin-4A [KO:K10609]
100542698  CUL4B; cullin-4B [KO:K10609]
100538577  DDB1; DNA damage-binding protein 1 [KO:K10610]
100548596  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
100541674  XPC; LOW QUALITY PROTEIN: DNA repair protein complementing XP-C cells [KO:K10838]
104915230  RAD23B; UV excision repair protein RAD23 homolog B [KO:K10839]
100546510  CETN2; centrin-2 [KO:K10840]
104914907  ERCC8; DNA excision repair protein ERCC-8 isoform X1 [KO:K10570]
100549522  ERCC6; LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6 [KO:K10841]
100540873  cyclin-dependent kinase 7 isoform X1 [KO:K02202] [EC:]
100544339  MNAT1; CDK-activating kinase assembly factor MAT1 isoform X1 [KO:K10842]
100549908  CCNH; LOW QUALITY PROTEIN: cyclin-H [KO:K06634]
100543981  ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:]
100545256  GTF2H5; general transcription factor IIH subunit 5 [KO:K10845]
100550131  GTF2H1; general transcription factor IIH subunit 1 [KO:K03141]
100546474  general transcription factor IIH subunit 2 isoform X1 [KO:K03142]
100539471  GTF2H3; general transcription factor IIH subunit 3 [KO:K03143]
100543855  XPA; DNA repair protein complementing XP-A cells [KO:K10847]
100538396  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
100542097  RPA2; replication protein A 32 kDa subunit [KO:K10739]
104915636  RPA3; replication protein A 14 kDa subunit [KO:K10740]
100542086  ERCC4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
100543187  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
104909450  DNA polymerase delta subunit 3 [KO:K03504]
100551403  DNA polymerase delta subunit 3-like [KO:K03504]
100546821  POLE; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:]
100539609  POLE2; DNA polymerase epsilon subunit 2 [KO:K02325] [EC:]
100549999  POLE3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:]
104914653  POLE4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:]
100551390  PCNA; proliferating cell nuclear antigen [KO:K04802]
100550696  RFC1; LOW QUALITY PROTEIN: replication factor C subunit 1 [KO:K10754]
100551330  RFC2; replication factor C subunit 2 [KO:K10755]
100545948  RFC4; replication factor C subunit 4 [KO:K10755]
100545359  RFC3; replication factor C subunit 3 [KO:K10756]
100551274  RFC5; replication factor C subunit 5 [KO:K10756]
100550112  LIG1; LOW QUALITY PROTEIN: DNA ligase 1 [KO:K10747] [EC:]
Sugasawa K.
[Molecular mechanism of mammalian nucleotide excision repair] Japanese
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Nakatsu Y.
[Transcription-coupled repair and Cockayne syndrome] Japanese
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Nakagawa N, Masui R, Kuramitsu S.
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8] Japanese
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
Neuroscience 145:1388-96 (2007)
Saldivar JS, Wu X, Follen M, Gershenson D.
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
Gynecol Oncol 107:S56-71 (2007)
Sugasawa K.
[DNA repair pathways involving Cul4A ubiquitin ligases] Japanese
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Ito S, Ando D, Tanaka K.
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders] Japanese
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
mgp03020  RNA polymerase
mgp04120  Ubiquitin mediated proteolysis
KO pathway

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