KEGG   PATHWAY: mgp03430
Entry
mgp03430                    Pathway                                

Name
Mismatch repair - Meleagris gallopavo (turkey)
Description
DNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preventing mutations from becoming permanent in dividing cells. MMR also suppresses homologous recombination and was recently shown to play a role in DNA damage signaling. Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
The Escherichia coli MMR pathway has been extensively studied and is well characterized. In E. coli, the mismatch-activated MutS-MutL-ATP complex licenses MutH to incise the nearest unmethylated GATC sequence. UvrD and an exonuclease generate a gap. This gap is filled by pol III and DNA ligase. The GATC sites are then methylated by Dam. Several human MMR proteins have been identified based on their homology to E. coli MMR proteins. These include human homologs of MutS and MutL. Although E. coli MutS and MutL proteins are homodimers, human MutS and MutL homologs are heterodimers. The role of hemimethylated dGATC sites as a signal for strand discrimination is not conserved from E. coli to human. Human MMR is presumed to be nick-directed in vivo, and is thought to discriminate daughter and template strands using a strand-specific nick.
Class
Genetic Information Processing; Replication and repair
Pathway map
mgp03430  Mismatch repair
mgp03430

Other DBs
GO: 0006298
Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100550883  SSBP1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
100543172  PMS2; mismatch repair endonuclease PMS2 [KO:K10858]
100547634  MLH1; DNA mismatch repair protein Mlh1 [KO:K08734]
100541959  MSH6; DNA mismatch repair protein Msh6 [KO:K08737]
100542264  MSH2; DNA mismatch repair protein Msh2 [KO:K08735]
104915285  MSH3; DNA mismatch repair protein Msh3 [KO:K08736]
100543308  MLH3; DNA mismatch repair protein Mlh3 isoform X2 [KO:K08739]
100550696  RFC1; LOW QUALITY PROTEIN: replication factor C subunit 1 [KO:K10754]
100551330  RFC2; replication factor C subunit 2 [KO:K10755]
100545948  RFC4; replication factor C subunit 4 [KO:K10755]
100545359  RFC3; replication factor C subunit 3 [KO:K10756]
100551274  RFC5; replication factor C subunit 5 [KO:K10756]
100551390  PCNA; proliferating cell nuclear antigen [KO:K04802]
104909663  EXO1; exonuclease 1 [KO:K10746] [EC:3.1.-.-]
100538396  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
100542097  RPA2; replication protein A 32 kDa subunit [KO:K10739]
104915636  RPA3; replication protein A 14 kDa subunit [KO:K10740]
100543187  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
104909450  DNA polymerase delta subunit 3 [KO:K03504]
100551403  DNA polymerase delta subunit 3-like [KO:K03504]
100550112  LIG1; LOW QUALITY PROTEIN: DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
  Authors
Jiricny J.
  Title
The multifaceted mismatch-repair system.
  Journal
Nat Rev Mol Cell Biol 7:335-46 (2006)
DOI:10.1038/nrm1907
Reference
  Authors
Li GM.
  Title
Mechanisms and functions of DNA mismatch repair.
  Journal
Cell Res 18:85-98 (2008)
DOI:10.1038/cr.2007.115
Reference
  Authors
Marti TM, Kunz C, Fleck O.
  Title
DNA mismatch repair and mutation avoidance pathways.
  Journal
J Cell Physiol 191:28-41 (2002)
DOI:10.1002/jcp.10077
Reference
  Authors
Ikejima M, Shimada T.
  Title
[Molecular mechanism of mismatch repair] Japanese
  Journal
Tanpakushitsu Kakusan Koso 46:1124-9 (2001)
KO pathway
ko03430   
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