Meleagris gallopavo (turkey): 100189600 Help Entry 100189600         CDS       T01523                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism mgp  Meleagris gallopavo (turkey) Pathway mgp04020   Calcium signaling pathway mgp04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:mgp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100189600 (RYR3)    04020 Calcium signaling pathway     100189600 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mgp04040]     100189600 (RYR3) Ion channels [BR:mgp04040]  Voltage-gated cation channels   Ryanodine receptor    100189600 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_6 EF-hand_1 TBK1_ULD EF-hand_8 Motif Other DBs NCBI-GeneID:  100189600 NCBI-ProteinID:  NP_001290140 Ensembl:  ENSMGAG00000012087 UniProt:  B4XW98 LinkDB All DBs Position 5:complement(31169591..31228020) Genome browser AA seq 4868 aa AA seqDB search MAEGGEGGEDEIQFLRTDDEVVLQCVSSIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVP PDLCICNFVLEQSLSVRALQEMLTNTGDNASEGAAQGGHRTLLYGHAILLRHSFSEMYLT CLTSSRSQTDKLAFDVGLRENAAGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSMSNGSIQVDASFMQTLWNVHPTCSGSNITEGYLLGGHVVRFFHGHDECLTIPSTDQ NDSQQKKVLYETGGAGVRARSLWRVEPLRISWSGSNIRWGQPFRLRHITTGMYLALNDDE GLVMLDREKSDTTSSAFCFRASKELKEKQDSTLKRDIDGMGVPEIKYGDSVCFVQHVASA LWLTYKAPDAKSARLGLLKRKVILHQEGHMDDGLTLQRCQHEESQAARIIRNTTSLFSQF ISGNNRTLSPIALPVEEMAQTLQDLIKYFQPPGEDLEHEDKQNKLRSLKNRQNLFKDEGM LALVLNCIDRLNDYNSAAHFAEIAREENSTAWKEILNLLYELLAALIRGNRNNCTQFSSN LDWLISKLDRLESSSGILEVLHCILIESPEALNVIAEEHIKSIISLLDKHGRNYKVLDVL CSLCVCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWY FELIIDQVDPFLTAEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLYSFGFDGLHLWS GRVPRAVASVNQHLLSSDDVVSCCLDLGVPSISFRINGQPVQGMFENFCTEGFFFPVVSL SAGVKARFLLGGRHGEFKFLPPAGYAPCYEALLPKEKMKLEPVKEYKRDSDGVRDLLGTT QFLSQASFIPCPIDTSQIALPFHLEKIRDKLAENIHELWGMNKIELGWTYGKIRDDNKRH HPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHANPAAEEDLKKVKLPKNYIMSN GYKPAPLDLSEVKLLPSQEFLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVP YALLDERTKKSNRDSLREAVRTFAGYGYNIEPPDQEIADQTLEKVSIDKIRFFRVEQSYA VKSGKWYFEFEAVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSGFFGRS WQPGDVVGCMINLDDKSIIFTLNGELLITSKGSELAFADFGIESGFVPICSLGLAQIGRM NLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKNHPHIEIWRIDG TIESPPRLKVTHKTLGTQNSNSDMIYCRLSMPIEFRSSFNFGVGVENASSDALQKRKHSQ EFPASSTTYFYSLRIFAGQDPSSVWVGWVTPDYHFYSENFDINKNCTVTVTLGDERGRVH ESVKRSNCYMVWGGDITANSQRSGRSNVDLEIGCFVDLATGMLSFTANGKELGTCYQVEP NTKLLPAAFVQPTSTNLIQFELGKLKNTMPLSAAIFKSEERNPVPQCPPRLDVQTITPVL WSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMKFHY HTLKLYSSVCALGNTRVAYALCSHVDISQLFYTIDNQYLPGLLRSGFYDLLISIHLDHAK QAKLMMNNEFIIPVTEETRTIKLYPDETKKHGLPGVGLSTCLKPSFNFSTPCFIVTSEEH QTSSPEIPLDTLKSKAISMLTEAVQCSGSHIRDPVGGHIAFQFVPVLKLIATLLIMGVFD DDDVKQVLILIDPNVFGDNKEETEERTEKEEVTQVEEKAVEAGEKAVKETKTPTKGLLQT RLPESGKLQMCHLLNYFCDCELQHRVEAIVSFADHYVSKLQYNQKYRYNELMQALDMSAA LTAKKTKEFRSPPQEQINMLLNFQLGEDCPCPEEIRDELYDFHDDLLIHCGIPLEEEEEE EEDSSLTGKLRSLIYKIKGPPKPEKIEPREEEDKSPTTLKELISQTMVRWSQEDQIQDPE LVRIMYTLLRRQYDSIGELLQALRKAYTISAGSVKDTINLLAALGQIRSLLSVRMGKEEE LLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMDVMVNVLGGDKSQIVFPKMVASCCRFL CYFCRISRQNQKAMFEHLSYLLENSSVGLAFPSMRGSTPLDVAAASVMDNNELALALEEP DLDKVVTYLAGWGLQRCPVLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENASVV VKLLIRRPECFGPELRGEGGNGLLAAMQEAIRISENPSRDLPSQGYKREGDEEEEEEEIV HMGNAIMSFYSALIDLLGRCAPEMHLIQSGKGEAIRIRSILRSLVPTEDLVGIISIPLKL STVNKDGTVNEPDMSANFCPDHKAPMVLFLDRVYGIKDQSFLLHLLEVGFLPDLRASASL DTVSLSTTEAALALNRYICSAVFPLLKRCAPLFSGTEHHASLVDSMLHTIYRLSKGRSLT KAQRDTIEECLLAICHHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCWKYYC LPSGMGSYGIAAEDELHLTEKLFWGIFDSLSHKKYDPELFRMALPCLSAIAGALPPDYLD TRIRSTLEKQTSVDPEGNFDPKPINTANLVLPEKLEYIVSKYAEHSHDKWAFDKTNNGWK YGVSLDENTKTHPLIRPFKTLTEKEKEIYRWPVRESLKTMLAMGWSLERTKEGGEGMLHQ RENEKLRSISQSSQGNGYSPAPLDLTNVVLSRELQGMVEVMAENYHNIWAKKKKMELESK GGGSHPLLVPYDTLTAKEKSRDREKAQELFKFLQVNGIIISRGLNDMDLDASSMEKRFAF KFLKKILKYVDSAQEFIAHLEAIVTSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHCLYF LSSPTKTLSSSGYASNKEKEMVASLFCKLAALVRHRISIFGSDSTTMVSCLHILAQSLDT RTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALL PVLTSIFEHISQYHFGVDLLLGDVQVSCYRILCSLYSLGTGKNIYVERQRPALGECLASF AAAIPVAFLEPSLNHYNPLSVFNTKSARERAILGMPDTVEEMCPEIPQLDGLIKEINNLA ESGARYTEMPHVIEVILPMLCNYLSYWWERGSESVPESAGPCCTMITSEHLSIILGNILK IINTNLGIDEASWMKRIAVYAQPIISKARPDLLKTHFIPTLEKLKKKAIKIVMEEEQLRA DSKSDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRANWLKKPDADSDELFRMVAEV FILWCKSHNFKREEQNFVIQNEINNLAFLTGDTKSKMSKAMQVKSGGQDQERKKSKRRGD LYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYSHKDTDEEVKEHIRNNLHLQE KSDDPAVKWQLNLYKDILKSDEPPDPEKNVERVQRISAALYHLDQVEQPLRSKKAVWHKL LSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQNYWIETEEYSFEEKLVQDLATSPKK EEEEEEDTEKEQPDPLHQIILYFSRNALTERSKLEDDPLYIAYAAMMAKSCQEEEEEEEE DKEKTFEEKEMEKQRTLYQQARLHDRGAAEMVLQMISASKGHTGPMVVETLKLGIAILNG GNTIVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGEKVLQHDEFTRDLFRFLQLLCEGHNNDFQNYLRTQMGNTTTVNIIISTVDYLLRLQ ESISDFYWYYSGKEFIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSAQIELLKELLDLLKDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSSNVELILKFFDMFLKLKDLTNSDAFKEHDPDGKGIISKKDFQKSMEAQKQYIQSE IEFLLSCTEADENDMFNYIDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQSLLEPA ESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRMQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISETDSAERPEEEEEEPCYIVDIGDDEEEEKSLESPS AFAMACAAVKKNVANFFKMVTVKNLRKQYRKVRKMTVKEMVKVFFSFFWILFVGVFQLFF TIVWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVTEAEKTEGAEHGI RDELVQFVKGEKGEADIISDIFGIPTKKEGGSKHGHDAGLGDIAEILGSDIQSSLENNVR KKKGLQTPETAKDAEAERKVEAEKADMEDGEKQDKAKEEHSEQQEEGKTKKKKRRHGQKI EKPVAVMANFFKALEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLDEV EEDSNLWNSFEEEEEEEGMVFFVLEESTGYMAPTLRALAVIHTIISFVCVIGYYCLKVPL VVFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKY GDLYGAERIAELLGLDKNALDFSPVEESEPEAASLVSWLSSIDTKYHIWKLGVVFTDNSF LYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPY EIYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD TTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESFVWKMYQERCWDFFPAGDCFR KQYEDQLG NT seq 14607 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggtgaaggaggagaagatgaaatacagttcctacgaactgatgacgaa gtagtacttcagtgtgtttccagtattcacaaagaacaaaggaagttttgcttggcagct gagggacttggaaatcgcttgtgctttttggaaccaacgtcagaagctaaatatgttcct ccagacctttgcatctgtaactttgtccttgaacagtctctgtctgtaagagcccttcaa gagatgctgaccaacacaggggataatgccagtgaaggggcagctcaaggtggtcacaga actttgctgtatggccatgctatactacttcgacattcattcagtgaaatgtatttaact tgcttaacatcatcaagatcccagactgataaacttgcatttgatgtgggactacgagaa aatgcagcaggtgaggcatgctggtggacgatacaccctgcttctaaacaaagatcagaa ggagaaaaagttcgaataggtgatgatcttatcctggttagtgtgtcctctgaaagatac ctgcatctctccatgtcaaatggaagtattcaggtggacgcctccttcatgcagacactt tggaatgtacatcctacatgctcaggaagcaatattacagaaggatatcttcttggtggg catgtagtacgttttttccatggtcatgatgagtgtttgacaattccttctacagatcag aatgattcacagcagaagaaagtactttatgaaactggaggagcaggtgttcgagcgaga tctttgtggagagtagaaccccttcgaataagttggagcggaagtaacatcagatgggga cagcctttccgtcttcgacatataacaacaggaatgtacttggctttgaatgatgatgaa ggtcttgtaatgttggacagagaaaagtcagacacaacatcttctgctttttgtttcaga gcatcaaaggaactaaaagaaaagcaggattctactcttaaacgtgacattgatggaatg ggagtcccagaaataaaatacggtgattcagtctgttttgttcaacatgtagccagtgcc ttatggctgacttataaagcaccagatgctaaatcagcacgcttagggctcctgaaaaga aaggttatattacaccaggaaggtcatatggatgatggtctaaccttacaaagatgtcaa catgaagaatcacaggctgctcgaatcattcgcaatactacaagcttattcagccagttt ataagtgggaacaacagaacactatcacccattgccctgcctgttgaggagatggctcag actctgcaagacctgatcaagtacttccagcctcctggagaagacctggaacatgaggat aagcaaaacaagcttcggtccctcaaaaacagacaaaacctattcaaagatgagggaatg ctggcactagttttgaattgcatcgatcgtttaaatgactacaacagtgcagctcatttt gcagaaattgcaagagaagaaaatagtacagcatggaaagaaattttaaatctcctttat gaactgcttgctgctctcattcgtggcaacagaaacaattgtactcagttctccagtaac cttgattggctaataagcaaattggacagactggaatcttcctcaggtattttggaagtg ttgcactgtatcttgattgaaagtccagaagctttaaatgtgatagctgaggagcatata aaatctattatttcactgttggacaagcatgggcgcaattacaaggttcttgatgtgctt tgctctctttgtgtgtgtaatggagttgcagttcgtgccaatcaaaacttgatctgtgac aatctactgccaagaagagacttacttttgcaaacacgtttgattaatgatgtgacaagc ataaggccaaacatatttttgggtgttgctgagggctctgcacaatacaagaagtggtac tttgaattaataattgatcaggttgatccattcttgacggcagaacccacccatttacgg gttgggtgggcttctacttcaggttatgccccttatcctggaggtggagaaggatggggt ggcaatggcgttggagatgacctatattcctttggttttgatggccttcatctgtggtct ggtcgtgtacccagagctgtggcatctgtcaatcaacatttgctgtcatctgatgatgta gttagctgctgcttggatttaggtgtgcccagcatttcattccgcattaatggtcagcct gtacaaggaatgtttgagaacttctgtactgaagggtttttcttccctgttgtaagctta tcagcaggtgtaaaagctcgtttcttactgggtggacgtcatggagagtttaaatttctg cctcctgctggctatgctccctgttatgaagccttgcttccaaaagaaaagatgaaattg gaaccagtgaaagaatataagagagattctgatggagtgagagatttgctgggtacgaca caattcctctcccaagcttcatttataccttgtcctatagacaccagtcagattgctctt ccttttcatcttgaaaagatcagggataaactagcagaaaatatccatgaactgtgggga atgaataaaatagagctgggctggacatatggcaagatacgggatgataataaaaggcat catccttgtcttgtggaattctcaaagttacctgagacagagaagaattataatctacaa atgtcaacagaaaccctcaaaacgcttttggcccttggatgtcacattgttcatgctaat ccagcagctgaggaagatcttaaaaaagtcaagcttcctaaaaattatatcatgtcaaat ggttataaacctgcccctcttgatctttctgaagtgaaattgttaccttctcaagaattt ctagttgacaaactagcagaaaatgcacataatgtctgggcaaaagacagaataaagcaa ggatggacctatggcattcagcaggatcttaagaacaaacgtaatcctcggctagtgcca tatgcattactagatgaacgtactaaaaaatcaaacagagatagcctccgtgaagctgtt aggacatttgcaggctatggttataatattgagccacctgaccaagaaatagctgaccaa acattggaaaaagtcagcattgacaagatacgttttttcagagtagaacagtcttatgca gtgaagtctggaaagtggtattttgaatttgaagctgtaacaggtggagatatgcgtgtt ggctgggccaggccaggctgtcgacctgacattgaactgggagctgatgaccaagcattt gtttttgaaggaagcaaaggccagcgttggcatcaaggcagtgggttttttggacgaagt tggcaaccgggagatgtggttggatgcatgataaacttggatgacaaatcaattatcttt actctgaatggagagttgcttataaccagtaaaggttcagaacttgcatttgctgacttt ggaatagaaagtggttttgttccaatttgctcactgggtctagctcagattggacgtatg aaccttggaatggatgccagtacattcaagtattataccatgtgtggtcttcaagaaggt tttgaaccttttgcagtgaacatgaaccgagatgtcgctatgtggtttagtaaacgctta ccaacatttgttaatgtgccaaaaaatcatcctcacatagagatatggagaattgatgga accattgagagtccacctcggttaaaagttactcacaaaacacttggtacacaaaacagc aattctgatatgatatattgtcgtttgagtatgcccattgagttccgttcatcattcaac tttggcgtgggtgtggaaaatgcctcatctgatgctcttcaaaaacgaaaacacagccaa gaatttcctgcttcttctaccacatatttttattccttacggatatttgctggccaagac ccatcttctgtctgggttggttgggtaacaccagactatcatttttacagtgagaatttt gacataaataaaaactgtacagtgacagttactttaggagatgagagaggcagggttcat gaaagtgtgaagcgcagtaattgctatatggtttggggaggagatataactgctaattct cagagatcaggtcgcagtaatgttgatttagaaattggatgctttgttgacctggctact ggaatgttgtcattcactgccaatggaaaagagcttggcacttgttatcaggttgaacca aacacaaaacttcttcctgcagcttttgtacagcctacaagcactaacttaattcagttt gaacttggtaaattaaagaataccatgccgttatcagcagcaatttttaaaagtgaggaa agaaatcctgttcctcagtgtccccctcgccttgatgtgcaaacaattacacctgtttta tggagtaggatgcctaacagctttctaaaagtagaaacagagcgcgtgagtgaacgtcat ggctgggttgtgcagtgtttggaaccactgcagatgatggcacttcatatcccagaggag aacagatgtgtggatattttggaactatgtgaacaagaagatttgatgaagtttcactat cacactttaaaactttatagctcagtttgtgctctaggtaacactagagttgcttatgca ctttgtagccatgtagatatatctcagttattttacacaatagataatcagtatttacct ggactcctacgttctggattctatgacttgctcattagtattcatttggaccatgccaag caagccaagctcatgatgaacaatgaatttattattccagttacagaggaaactcgaact attaaattatatcctgatgaaacaaagaagcatggtttacccggagtagggcttagcact tgtctcaaaccaagctttaatttttctactccttgctttattgtgacctcggaagaacat cagacatccagcccagaaattccccttgacacacttaaatccaaagcgataagtatgctg acagaggcggtacagtgcagtggttctcatatacgagatcctgttggaggacatattgca ttccagtttgttcctgttcttaaactcatagcaacattgcttataatgggagtttttgat gatgatgatgtgaagcaggtgttaatcctcattgatcccaatgtctttggagataacaag gaagaaacagaagagaggacagagaaggaagaagttacacaagttgaagaaaaagctgta gaagctggagaaaaggcagtaaaagaaacaaaaacacctacaaagggcttattgcagaca agattaccagaatctggtaagcttcagatgtgccacttactcaattatttctgtgactgc gagctgcaacatagagtggaagcgattgtatcatttgcagaccactatgtatcaaaactg caatataatcagaagtacaggtataatgaactcatgcaagccttggacatgtctgctgct ttgactgccaagaagactaaggaatttcgatctcctccacaagaacagattaatatgctg ctgaattttcaactgggagaggattgtccctgtccagaagagattcgggatgaactatat gacttccatgatgatcttctaattcactgtggtattccactagaagaggaggaagaggaa gaggaagattcctccttgactggcaagcttcgttcattaatatacaaaatcaaaggtcca ccaaaaccagaaaaaatagagcccagagaagaagaagataaatcgcctactacactgaag gaactcatatcccaaactatggtgcgctggtcccaggaagatcagattcaagatccagaa ttggttcggattatgtacactctgctgcgtaggcaatatgatagcattggtgagctactt caagctctgaggaaagcatacactattagtgctggctctgtgaaggataccattaatctg cttgctgcactgggccagattcgctcacttctcagtgtaagaatgggaaaagaagaggaa ctgctaatgattaatggattaggagatatcatgaacaacaaggttttttatcagcatcct aacttaatgagagtcttgggcatgcatgagacagttatggatgtgatggtgaatgtgctt ggaggagataaatctcagatcgtttttcctaagatggtggcaagctgttgtcgatttctg tgctacttctgtcgaattagtcgtcaaaaccaaaaagccatgtttgagcatctcagttac ttactggaaaacagcagcgttgggttggcatttccttcaatgagaggttcgacaccactt gatgttgcagcagcctctgtaatggacaacaatgagcttgcactagcactggaagaacca gatcttgataaagttgttacttacctggcaggttggggcctgcagagatgtccagtgttg ctagctaaaggatatccagacattgggtggaatccaatagagggtgaacgttacctgtca ttcctaagatttgcagtttttgttaacagtgaaagtgttgaagaaaatgcaagtgttgtt gtaaagcttcttattcgacgaccagagtgctttggaccagagcttagaggagaaggagga aatggattgctggcagctatgcaagaagctatacggatctcagagaatccttctcgtgac cttccctcacaaggatataagagagaaggtgatgaagaggaggaggaggaggagatcgta cacatgggcaatgcaatcatgtcattttactctgctctcatagatttacttggacgctgt gcaccagaaatgcaccttattcaaagtggaaaaggtgaagctattcgaatcagatcaatc cttcgatctctagtgccaactgaagatttggttgggattataagtataccactaaagctg tcaacagttaacaaagatggcactgtaaatgagccagacatgtctgcaaatttctgtcct gatcataaggcaccaatggtactctttttggaccgtgtgtatggcattaaggaccaaagc ttcctccttcacctacttgaagttggatttttaccagatttaagagcttctgcctctctg gatacagtttctctaagtaccacagaagcagctcttgcactaaacagatatatttgctca gctgtgtttccgttactcaaaagatgtgctcccctcttttctggaacagaacatcatgcc tctcttgttgactccatgcttcacacaatatataggttatccaaaggacgttcccttaca aaagcacaacgagacactattgaagaatgcctgcttgctatctgccaccacttacgtccc tctatgctccaacagctattgagaaggctagtttttgatgtgcccttactcaatgaatac tgtaaaatgccactcaagcttctgacaaatcactatgaacagtgttggaaatattattgt ctaccttcaggaatgggaagctatggaattgcagcagaagatgaattacatttaactgaa aaacttttttggggaatatttgattccttgtctcataagaagtatgatccagagctcttt agaatggccttgccctgcctaagtgctatagctggggctttgcctcctgattatttagat acacgaattagatcaacattggaaaagcagacctcagtggatccagaaggaaattttgat cccaaacccatcaacacagcaaaccttgtacttcctgaaaagctggagtatattgtcagc aaatatgctgagcattctcatgataaatgggcttttgataagactaataatgggtggaaa tacggtgtttcactggatgaaaatacaaagactcatccattaataagacctttcaaaact ttaactgagaaggaaaaagaaatttatcgttggcctgtgagagaatccctgaaaaccatg ttggccatggggtggagcctcgaaaggaccaaggaagggggcgaaggaatgttacatcag cgtgaaaatgaaaagctccgcagcatatctcagtctagccagggaaatggatatagccca gcaccacttgatctcactaacgtggtactttctagggaacttcagggaatggttgaggta atggcagaaaactaccataatatatgggccaaaaagaagaaaatggagttggaaagcaaa ggtggaggcagtcatcctttattggtaccttacgacacattgacagccaaggagaaatca cgggaccgtgaaaaggcacaagagctgtttaaattccttcaagtgaatggcataatcata tctcggggtctgaatgacatggatttggatgcttcatccatggaaaagaggtttgccttt aagtttctgaagaaaattttaaaatatgttgactctgctcaagagttcattgcacatttg gaagccattgttactagtggaaaaactgaaaaatccccgcatgaccaagaaataaaattc tttgccaaagttcttttaccattagttgatcaatactttacaaatcactgcttgtacttc ctgtcttctccaacaaaaacactcagtagcagtggatatgcatcaaataaggaaaaggaa atggtagcaagcctgttctgcaaactagctgctcttgttagacataggatctcaattttt ggtagtgattctacaacaatggtgagctgcctgcacatcttagctcagtctctggatact cgaactgttatgaaatcaggatctgagctagttaaagctggactacgtgctttttttgaa aatgcagctgaagatctggaaaaaacttcagaaaatcttaaacttggaaaatttacacat tcacgaacacaaatcaaaggtgtttcacagaacatcaattatactacagtagcattgcta cctgtcttgacgtcaatttttgagcatatttcacagtatcattttggagttgatttactt ctgggtgatgtacaagtttcatgttacagaattctttgtagcctctattctcttgggact gggaagaacatctacgttgaaaggcaacgtcctgcacttggtgaatgcttagcatctttt gcagcagccattccagtagcattccttgaaccttctctcaaccactacaacccattgtct gtcttcaacacaaaaagtgcaagagaaagagcaattttaggtatgcctgatacagtagag gaaatgtgtccagaaatccctcagctggatggactaataaaggaaattaataatttagca gagtctggagcaaggtatactgaaatgcctcacgtaattgaggttatcttacccatgctg tgcaattatttgtcctactggtgggaacgagggtctgagagtgttcctgaaagtgctggc ccttgctgtacgatgataacatctgagcatctgagcatcattctgggaaatattctgaaa atcattaacaccaatctgggaatagatgaagcatcttggatgaaaagaattgcagtttat gctcaacctatcatcagcaaagccagacctgatctgctgaaaactcactttattccaaca ctggagaaattgaagaagaaagctataaagattgtgatggaagaggagcaactgagagca gacagtaaaagtgacactcaagaagctgagctacttattctcgatgagtttgctgttctt tgtagagacctctatgccttctatccaatgctgatacgttacgtagacaacaacagagcc aactggctaaagaaaccagatgcagattctgatgaactgtttcgaatggtagctgaagtt tttatcctgtggtgcaagtcacataatttcaaaagagaagaacaaaattttgtcatacag aatgaaatcaacaatttggcatttttaacaggagataccaaaagcaagatgtctaaagcc atgcaagtaaagtctggaggtcaagatcaagagagaaagaaatcaaaacgcaggggggat ttgtactccatacaaacatccttgattgtagctgcacttaaaaagatgcttcctattggc ttgaatatgtgtactccaggagatcaagagctcatctcattggctaagactagatatagc cataaggacactgatgaagaagtcaaagagcatatccgtaacaatttacatttgcaggaa aagtctgatgatccagctgtgaaatggcagttaaatctatataaagacattctgaagagt gatgagcctcctgaccctgagaaaaatgtggaacgtgtgcagaggatatcagctgctctg tatcatctggaccaggttgaacaaccactgagatcaaagaaagctgtttggcacaaactt ctgtcaaaacaacgcaaaagagctgttgttgcttgttttagaatggcgccgttatacaac ttacccaggcaccgttctattaacctcttcctccatggctatcagaactattggatagaa acagaggaatattcatttgaggagaaactagttcaggatttggctacgtctccaaaaaaa gaggaagaagaagaggaagatacagagaaagaacaacctgacccacttcatcagattatc ctctattttagtcgcaatgctctcacagagaggagcaaactagaagatgatcccttatat attgcctatgctgccatgatggcaaagagctgtcaggaagaagaagaagaggaggaggaa gacaaagagaagacatttgaggagaaagaaatggaaaagcagagaactctttatcagcaa gctcgcttacatgatcgtggagctgctgagatggtccttcagatgatcagtgcaagcaaa ggtcatacaggacccatggttgttgaaacactaaaacttggtattgctattctaaatggt gggaatacaatagttcaacagaaaatgctagactacttgaaggagaaaaaggatgctgga ttctttcaaagtctttctggtttgatgcagtcctgcagtgttcttgacttgaatgcgttt gagagacaaaataaagcagaaggcctgggaatggttactgaagaaggaactctcatcgta cgtgagcgtggtgaaaaagtgttgcagcatgatgaatttactcgagatctatttagattt ttacaactgctctgtgaagggcataacaatgattttcaaaattatctacgcactcagatg ggcaacaccacaacagtgaatattatcattagtacagttgactacctcttgcgtcttcag gaatcaatcagtgacttctattggtactattcaggaaaagagtttattgatgaatcagga caacgtaacttctctaaagctctggctgtcaccaaacaaatattcaattcccttaccgaa tatatacagggaccttgcatcggtaaccaacagagtctggctcatagtaggctgtgggat gcagttgttggatttcttcatgtatttgccaatatgcagatgaaactttcacaggactct gctcagattgaactgcttaaggaactgctagatctgctaaaggatatggttgtgatgttg ttgtcattacttgaaggtaacgttgtaaatggaacaattggaaaacaaatggtcgataca cttgtagaatcatctagcaacgtagaattaatcttgaagttttttgacatgtttctcaaa ttaaaagatttaactaactcggatgctttcaaggagcatgacccagatggtaagggcatc atttcaaagaaggatttccagaagtcaatggaggctcaaaaacaatatatacaatcagag attgaattcctgttgtcatgtacggaagctgatgaaaatgatatgttcaactacattgat tttgtagaaagattccatgaaccagccaaagatattggctttaatgtagcagttttgcta acaaacctttcagagcatatgcctaatgactcacgccttcagagcttacttgaacctgca gaaagtgttcttaattactttgaaccataccttggccgtattgaaataatgggtggagcc aagaaaatagaaagagtttactttgaaatcagtgaatccagtagaatgcagtgggaaaag ccacaggtgaaggaatccaaaaggcaattcatatttgatgttgtaaacgaaggtggagag caagaaaaaatggagctcttcgtgaacttctgtgaagacacgatctttgaaatgcagtta gcatcccaaatctctgagactgattcagctgagagacctgaggaagaggaagaagagcct tgctacattgtggatatcggagatgatgaggaagaagaaaagtccctggaatctccttca gcttttgcaatggcctgtgctgcagtcaagaagaacgtcgccaacttttttaaaatggtt actgtgaagaacctaaggaaacagtacaggaaagtcagaaagatgacagtaaaagagatg gtgaaagtgtttttctcttttttctggattctatttgtaggggtgttccaactgtttttt actatagtatggggaattttccagattctttggagcaccgtatttgggggtggactggtt gaaggagccaaaaatattaaagttactaaaatactaggggacatgcctgacccaacgcag tttggaatccatgatgatgtcacagaagcagaaaaaactgaaggtgctgagcatggcatt agagatgaacttgtgcagtttgtaaagggtgaaaagggagaagctgacataatttcagat atttttggcattcctactaagaaagaaggtggctcaaaacatggtcatgacgctggactt ggagatattgcagaaatacttggctctgatatccagtcttctctggaaaacaatgttcgt aagaaaaaaggattacagacacctgaaactgcaaaagacgctgaagcagaaagaaaagta gaagctgagaaggctgacatggaagatggtgagaaacaggataaagcaaaggaagaacac tctgagcagcaggaagagggaaaaacaaagaaaaagaagcgaaggcatggacaaaaaatt gagaaacctgtggctgttatggctaatttcttcaaagctttggaaatatatcaaacaaaa atgcttcactacctggcaaggaacttttataacttacggtttcttgctctatttgttgca tttgccatcaactttattctgctattttacaaggtgacagaagagccacttgatgaagtg gaggaagactctaatctctggaactcttttgaagaagaggaagaggaggaaggaatggta ttttttgttttggaagaaagtacaggttacatggcacctactctcagagcactggcagtt attcatactatcatctcctttgtctgtgtgattggatactattgcttaaaggtccctttg gttgtattcaagagagaaaaggaggtagctaggaagctggaatttgatggattatacata actgaacaaccatctgaagatgatattaaaggacagtgggatcgcctggttataaacaca ccgtcctttcctaacaattactgggataaatttgtaaaacgaaaggttattaacaagtat ggagacttgtacggagcagagcgtatagcagaacttttgggtttggacaaaaatgccctt gattttagtccagtggaagagagcgaaccagaagcggcatctcttgtatcatggttaagt tccattgatacaaagtaccacatttggaagcttggtgttgttttcactgataattcattt ttgtatttggcttggtacacaactatgtctatccttggacactacaacaacttctttttt gctgctcatctgctggacatcgctatgggtttcaagacattgcgaaccattttgtcctct gtaactcacaatggcaaacagcttgtgcttactgtaggactcctggctgtagtagtgtat ctttacactgttgtggcattcaacttcttccgcaaattctacaataaaagtgaagatgaa gatgaaccagatatgaaatgtgatgacatgatgacgtgttacctattccacatgtatgtg ggtgtaagagctggtggtggcattggggatgaaattgaggatcctgctggagacccttat gaaatttatcgaattgtcttcgacatcacatttttcttctttgtcattgtcatcctactg gccattattcaaggtctgattattgacgcttttggtgaattaagagaccagcaagaacaa gtgagagaagatatggagaccaaatgctttatttgtggaattggcaacgactattttgac acaactccacatggctttgaaacacatactctgcaggaacacaacttggcaaactacctg ttcttcttaatgtacctcataaacaaggatgagactgagcatactggccaggagtcattt gtgtggaagatgtaccaagaaagatgctgggatttcttcccagcaggagactgcttccgg aaacagtatgaggatcaactcggctga

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