KEGG   Manis javanica (Malayan pangolin): 108394341
Entry
108394341         CDS       T06054                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mjv  Manis javanica (Malayan pangolin)
Pathway
mjv01521  EGFR tyrosine kinase inhibitor resistance
mjv01522  Endocrine resistance
mjv04010  MAPK signaling pathway
mjv04012  ErbB signaling pathway
mjv04014  Ras signaling pathway
mjv04015  Rap1 signaling pathway
mjv04022  cGMP-PKG signaling pathway
mjv04024  cAMP signaling pathway
mjv04062  Chemokine signaling pathway
mjv04068  FoxO signaling pathway
mjv04071  Sphingolipid signaling pathway
mjv04072  Phospholipase D signaling pathway
mjv04140  Autophagy - animal
mjv04150  mTOR signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04210  Apoptosis
mjv04218  Cellular senescence
mjv04270  Vascular smooth muscle contraction
mjv04360  Axon guidance
mjv04370  VEGF signaling pathway
mjv04371  Apelin signaling pathway
mjv04510  Focal adhesion
mjv04540  Gap junction
mjv04550  Signaling pathways regulating pluripotency of stem cells
mjv04613  Neutrophil extracellular trap formation
mjv04625  C-type lectin receptor signaling pathway
mjv04630  JAK-STAT signaling pathway
mjv04650  Natural killer cell mediated cytotoxicity
mjv04660  T cell receptor signaling pathway
mjv04662  B cell receptor signaling pathway
mjv04664  Fc epsilon RI signaling pathway
mjv04666  Fc gamma R-mediated phagocytosis
mjv04720  Long-term potentiation
mjv04722  Neurotrophin signaling pathway
mjv04726  Serotonergic synapse
mjv04730  Long-term depression
mjv04810  Regulation of actin cytoskeleton
mjv04910  Insulin signaling pathway
mjv04912  GnRH signaling pathway
mjv04914  Progesterone-mediated oocyte maturation
mjv04915  Estrogen signaling pathway
mjv04916  Melanogenesis
mjv04917  Prolactin signaling pathway
mjv04919  Thyroid hormone signaling pathway
mjv04921  Oxytocin signaling pathway
mjv04926  Relaxin signaling pathway
mjv04928  Parathyroid hormone synthesis, secretion and action
mjv04929  GnRH secretion
mjv04935  Growth hormone synthesis, secretion and action
mjv05010  Alzheimer disease
mjv05022  Pathways of neurodegeneration - multiple diseases
mjv05034  Alcoholism
mjv05132  Salmonella infection
mjv05152  Tuberculosis
mjv05160  Hepatitis C
mjv05161  Hepatitis B
mjv05163  Human cytomegalovirus infection
mjv05164  Influenza A
mjv05165  Human papillomavirus infection
mjv05167  Kaposi sarcoma-associated herpesvirus infection
mjv05170  Human immunodeficiency virus 1 infection
mjv05200  Pathways in cancer
mjv05205  Proteoglycans in cancer
mjv05206  MicroRNAs in cancer
mjv05207  Chemical carcinogenesis - receptor activation
mjv05208  Chemical carcinogenesis - reactive oxygen species
mjv05210  Colorectal cancer
mjv05211  Renal cell carcinoma
mjv05212  Pancreatic cancer
mjv05213  Endometrial cancer
mjv05214  Glioma
mjv05215  Prostate cancer
mjv05218  Melanoma
mjv05219  Bladder cancer
mjv05220  Chronic myeloid leukemia
mjv05221  Acute myeloid leukemia
mjv05223  Non-small cell lung cancer
mjv05224  Breast cancer
mjv05225  Hepatocellular carcinoma
mjv05226  Gastric cancer
mjv05230  Central carbon metabolism in cancer
mjv05231  Choline metabolism in cancer
mjv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mjv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    108394341 (RAF1)
   04012 ErbB signaling pathway
    108394341 (RAF1)
   04014 Ras signaling pathway
    108394341 (RAF1)
   04015 Rap1 signaling pathway
    108394341 (RAF1)
   04370 VEGF signaling pathway
    108394341 (RAF1)
   04371 Apelin signaling pathway
    108394341 (RAF1)
   04630 JAK-STAT signaling pathway
    108394341 (RAF1)
   04068 FoxO signaling pathway
    108394341 (RAF1)
   04072 Phospholipase D signaling pathway
    108394341 (RAF1)
   04071 Sphingolipid signaling pathway
    108394341 (RAF1)
   04024 cAMP signaling pathway
    108394341 (RAF1)
   04022 cGMP-PKG signaling pathway
    108394341 (RAF1)
   04151 PI3K-Akt signaling pathway
    108394341 (RAF1)
   04150 mTOR signaling pathway
    108394341 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    108394341 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    108394341 (RAF1)
   04218 Cellular senescence
    108394341 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    108394341 (RAF1)
   04540 Gap junction
    108394341 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    108394341 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    108394341 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    108394341 (RAF1)
   04625 C-type lectin receptor signaling pathway
    108394341 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    108394341 (RAF1)
   04660 T cell receptor signaling pathway
    108394341 (RAF1)
   04662 B cell receptor signaling pathway
    108394341 (RAF1)
   04664 Fc epsilon RI signaling pathway
    108394341 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    108394341 (RAF1)
   04062 Chemokine signaling pathway
    108394341 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    108394341 (RAF1)
   04929 GnRH secretion
    108394341 (RAF1)
   04912 GnRH signaling pathway
    108394341 (RAF1)
   04915 Estrogen signaling pathway
    108394341 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    108394341 (RAF1)
   04917 Prolactin signaling pathway
    108394341 (RAF1)
   04921 Oxytocin signaling pathway
    108394341 (RAF1)
   04926 Relaxin signaling pathway
    108394341 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    108394341 (RAF1)
   04919 Thyroid hormone signaling pathway
    108394341 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    108394341 (RAF1)
   04916 Melanogenesis
    108394341 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    108394341 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    108394341 (RAF1)
   04720 Long-term potentiation
    108394341 (RAF1)
   04730 Long-term depression
    108394341 (RAF1)
   04722 Neurotrophin signaling pathway
    108394341 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    108394341 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    108394341 (RAF1)
   05206 MicroRNAs in cancer
    108394341 (RAF1)
   05205 Proteoglycans in cancer
    108394341 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    108394341 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    108394341 (RAF1)
   05230 Central carbon metabolism in cancer
    108394341 (RAF1)
   05231 Choline metabolism in cancer
    108394341 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    108394341 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    108394341 (RAF1)
   05212 Pancreatic cancer
    108394341 (RAF1)
   05225 Hepatocellular carcinoma
    108394341 (RAF1)
   05226 Gastric cancer
    108394341 (RAF1)
   05214 Glioma
    108394341 (RAF1)
   05221 Acute myeloid leukemia
    108394341 (RAF1)
   05220 Chronic myeloid leukemia
    108394341 (RAF1)
   05218 Melanoma
    108394341 (RAF1)
   05211 Renal cell carcinoma
    108394341 (RAF1)
   05219 Bladder cancer
    108394341 (RAF1)
   05215 Prostate cancer
    108394341 (RAF1)
   05213 Endometrial cancer
    108394341 (RAF1)
   05224 Breast cancer
    108394341 (RAF1)
   05223 Non-small cell lung cancer
    108394341 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    108394341 (RAF1)
   05161 Hepatitis B
    108394341 (RAF1)
   05160 Hepatitis C
    108394341 (RAF1)
   05164 Influenza A
    108394341 (RAF1)
   05163 Human cytomegalovirus infection
    108394341 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    108394341 (RAF1)
   05165 Human papillomavirus infection
    108394341 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    108394341 (RAF1)
   05152 Tuberculosis
    108394341 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    108394341 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    108394341 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    108394341 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    108394341 (RAF1)
   01522 Endocrine resistance
    108394341 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mjv01001]
    108394341 (RAF1)
Enzymes [BR:mjv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     108394341 (RAF1)
Protein kinases [BR:mjv01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   108394341 (RAF1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 108394341
NCBI-ProteinID: XP_017511325
LinkDB
Position
Unknown
AA seq 668 aa
MEHIQGAWRTISNGFGVRDTVFDGPSCVSPTIAQQFGFQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PIMCVDWSNIRQLLLFPNSTIGDTGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPMPAQRERAPGSGAQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSILWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPIF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggggcctggaggaccatcagcaacggctttggagtgagagacaca
gtgttcgatggccccagctgcgtctcccccacaatagctcagcagttcggcttccagcgc
cgggcatcagatgatggcaaacttacagactcttcaaagacaagcaacactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtgcgaaatggaatgagcttgcatgat
tgccttatgaaagcactcaaggtgcggggcctgcagccggaatgctgtgccgtgttcaga
ctgctccacgaacacaaaggtaaaaaagcacgtttagattggaatactgacgctgcctcg
ctgattggagaagaactccaagtagacttcctggatcatgttcccctcacaacacacaac
tttgctcggaagaccttcctgaagcttgccttctgtgacatctgtcagaagttcctgcta
aatggctttcgatgtcagacttgtggctacaaatttcacgagcactgtagcaccaaagta
cctatcatgtgtgtggactggagtaacatcagacagctcctattgtttccaaattccact
attggtgatactggggtcccagcactgccttctttgacaatgcgtcggatgcgagagtct
gtttcccggatgcctgttagttcccagcacagatactccacaccccatgccttcaccttc
aacacctccagtccctcctctgaaggttccctttcccagaggcagaggtcaacatccaca
cccaatgtccatatggtcagcacaaccctgcctgtggacagtaggatgatcgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacagtgaatcagcttcaccttcagccttgtccagcagccccaacaatctg
agcccaacgggctggtcacagcccaaaacccccatgccagcacagagagagcgggcgccg
ggatccggggcccaggagaaaaataaaattaggcctcgtgggcagagagactccagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggatcgggtcaggctccttt
ggaactgtttataagggcaagtggcatggagatgttgcagtaaagatcctaaaggttgtc
gaccccacaccagaacagttccaggcctttaggaacgaggtggctgtcctgcgcaaaaca
cggcatgtgaacatcctcctcttcatggggtacatgacaaaggacaacctggcgattgtg
acccagtggtgtgaaggcagcagtctctacaaacacctgcatgtccaggagacaaagttc
cagatgttccagttgattgacattgcccggcagacagctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatatttctccatgagggcctg
acggtgaaaattggagactttggtttggcaacagtgaagtcacgctggagtgggtctcag
caagttgaacaacccactggctccatcctatggatggccccagaggtgatccgaatgcag
gacaataacccgttcagcttccagtctgacgtctactcctatggcattgtcctgtatgag
ctcatgacaggggagcttccgtactcccacatcaacaaccgtgatcagatcatcttcatg
gtgggccgggggtatgcctccccagacctcagcaagctctacaagaactgccccaaagca
atgaagaggctcgtagctgactgtgtgaagaaagtcaaggaagagaggcctctttttccc
cagatcctgtcatccatcgagctgctccaacactctctaccgaaaatcaaccggagtgct
tctgagccatccctgcatcgggctgcccacaccgaggacatcaatgcctgcacgctgacc
acgtccccaaggctgcctatcttctga

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