Macrotis lagotis (bilby): 141499428
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Entry
141499428 CDS
T11097
Symbol
PDE8B
Name
(RefSeq) high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1
KO
K18437
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC:
3.1.4.53
]
Organism
mlao Macrotis lagotis (bilby)
Pathway
mlao00230
Purine metabolism
mlao01100
Metabolic pathways
mlao04927
Cortisol synthesis and secretion
mlao04934
Cushing syndrome
mlao05032
Morphine addiction
Brite
KEGG Orthology (KO) [BR:
mlao00001
]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
141499428 (PDE8B)
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
141499428 (PDE8B)
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
141499428 (PDE8B)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
141499428 (PDE8B)
Enzymes [BR:
mlao01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
141499428 (PDE8B)
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Motif
Pfam:
PDEase_I
PDE8A_N
PAS_9
PAS
PAS_3
PAS_4
PAS_8
MBR1
DUF4194
Motif
Other DBs
NCBI-GeneID:
141499428
NCBI-ProteinID:
XP_074058246
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Position
X:247419069..247731996
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AA seq
813 aa
AA seq
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MHEPGAREGPRYSRREQVSTAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGY
RCNIARTPESALECFLDKHHEIIVIDHRQDQHFDAEAVCRSIRATNPSEHTVILAVVSHI
SGEREETSVLPLLHAGFNRRYMENNSITACYNELIQIEHGEVRSQFKLRACNSIFTALDH
CHEAIEITSDDHVIQYVNPAFERMMGYHKGELIGKELTELPKSDQNRADLLDTINTCIKK
GKEWQGVYYARRKSGDSVQQHVKITPVIGQGGPSLFRKAKQRIYCFQPESSRKIRHFVSL
KKLCCTADSNKQIHKIHRDSGDKSQTESHSFRYKNRRKESIDVKSITSRSSDAPSLQNRR
YPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDE
DPHTSDLVGGLMTDGLRRLSGNEYVFSKNMHHSHSHLSLPITINDVPPCIAQLLDNEESW
DFNIFELEAVTHKRPLVYLGLKVFARFGVCEFLNCSEATLRAWLQVIEANYHSSNSYHNS
THAADVLHATAFFLGKERVKGSLDHLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVL
YNDTAVLESHHTALAFQLTVKDNKCNIFKNIDRTHYRTLRQAIIDMVLATEMTKHFEHVN
KFVNSINKPMAAEETNSHGEGSDCECNPTGKNFPENQILIKRMMIKCADVANPCRPLEMC
IEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFA
HLPALMQHLADNYKHWKMLDELKCKSLRLPSDS
NT seq
2442 nt
NT seq
+upstream
nt +downstream
nt
atgcatgagccgggcgctcgcgagggaccgaggtacagccgcagggagcaggtttcaact
gcagaagtaagaatcgggccgatgagactgacgcaagatcctattcaggttttgctgatt
tttgcgaaggaagacagtcaaagtgatggattctggtgggcctgtgatagagctggctac
agatgtaatattgcacgaactccggaatctgcccttgagtgctttttagataagcaccat
gaaatcatagtaattgaccatagacaagaccaacactttgatgcagaagccgtgtgcaga
tcaattcgagctacgaatccttcagaacacacggttatacttgcagttgtttcacatata
tcgggtgaacgtgaagaaacatcagtccttcctcttctccatgcaggcttcaataggaga
tatatggagaataacagtatcactgcttgttacaatgaactgattcaaatagaacatggt
gaagttcgatcacagttcaagttacgggcatgcaactcaatttttacggcacttgaccat
tgtcatgaagccatagaaataaccagtgatgatcatgtcattcagtatgtcaaccctgcc
tttgaaaggatgatgggctatcacaaaggagagctcataggtaaagaactcactgaattg
cccaaaagcgaccaaaaccgtgcagatctcctggacaccatcaacacgtgtatcaagaag
ggaaaggaatggcaaggggtttactatgccagaagaaaatctggagacagtgttcaacag
catgtgaagatcacaccagtgattggccaaggagggcccagtctatttagaaaagcaaag
caaagaatctattgtttccaacctgaatcatctaggaaaattagacattttgtgtctctc
aagaaactgtgttgtactgctgacagcaataaacagatacacaagattcaccgtgattca
ggagataagtctcagacagagtctcactcatttagatacaagaacagaaggaaagaatct
attgatgttaaatcaataacatctcgaagtagtgatgcaccaagtctgcagaatcgtcgt
tatccatccatggcaaggatccactccatgaccattgaagctccgattacaaaggtcatt
aatataatcaatgctgcccaggagaacagcccagtaactgtagcagaagccttggacaga
gttttggaaattttacgaactacagaactctactctcctcagctgggcactaaagacgaa
gacccccacactagtgatctagttggaggactgatgactgatggcttgagaaggttgtca
gggaatgagtacgtgttttctaaaaacatgcaccacagccacagtcatctttcactgcca
atcacaatcaatgatgttccaccctgtattgcacaattactcgataatgaagagagctgg
gatttcaacatctttgaattagaagctgtcacacataaaagaccgttggtttacctgggg
ttaaaagtctttgcccgctttggggtctgtgagtttttgaactgttcagaagccactctt
cgggcctggctacaggtgattgaagccaactaccactcatcaaactcctaccacaactcc
actcatgctgcagatgtcctacatgctacagcatttttccttggaaaagaaagagtaaag
ggaagtctggatcacctagacgaagtggctgcattgatagcagccactgtccatgacgtg
gatcaccccggacggaccaactctttcctgtgcaatgctggcagtgagctagctgtgctt
tacaatgacacagctgtcctggagagtcaccacactgccctggctttccagctcacagtc
aaggacaacaaatgcaatattttcaagaacattgacaggacccactatcgaacattgcgc
caggcaatcattgacatggttttggcaacagagatgacaaagcactttgaacacgtgaac
aagtttgtgaatagcatcaacaaacccatggccgctgaggaaaccaactcccatggggaa
ggcagtgactgtgaatgtaaccccactgggaagaacttccctgaaaaccaaatcctgatc
aagcgcatgatgatcaagtgtgcagacgtggccaacccgtgccgccctctggagatgtgc
atcgaatgggctggaaggatctcagaagagtattttgcacagacagatgaagagaagaga
caagggctaccagtggtgatgccagtatttgatcgaaatacttgtagcatcccaaagtcc
cagatctccttcattgactatttcataacagatatgtttgatgcttgggatgcatttgca
catctcccagctctgatgcaacatttggctgataactacaaacactggaaaatgctggat
gagttaaaatgcaagagcctgaggcttccatctgacagctaa
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