Macrotis lagotis (bilby): 141521984 Help Entry 141521984         CDS       T11097                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism mlao  Macrotis lagotis (bilby) Pathway mlao04020   Calcium signaling pathway mlao04371   Apelin signaling pathway mlao04713   Circadian entrainment mlao04921   Oxytocin signaling pathway mlao04970   Salivary secretion mlao05010   Alzheimer disease mlao05012   Parkinson disease mlao05020   Prion disease mlao05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mlao00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     141521984 (RYR3)    04020 Calcium signaling pathway     141521984 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     141521984 (RYR3)   09154 Digestive system    04970 Salivary secretion     141521984 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     141521984 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     141521984 (RYR3)    05012 Parkinson disease     141521984 (RYR3)    05020 Prion disease     141521984 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     141521984 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mlao04040]     141521984 (RYR3) Ion channels [BR:mlao04040]  Voltage-gated cation channels   Ryanodine receptor    141521984 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  141521984 NCBI-ProteinID:  XP_074091116 LinkDB All DBs Position 4:complement(191072897..191906673) Genome browser AA seq 4904 aa AA seqDB search MTDLEMKNLIDFSSEPGLYKEEDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSEA KYVPPDLCICNFVLEQSLSVRALQEMLANTGENDSEGVAQGGGHRTLLYGHAILLRHSFS RMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSV SSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRFFHGHDECLTT LSTDQNDSQHRRIFYETGGAGSRARSLWRVEPLRISWSGSNIRWGQAFRLRHITTGHYLA LTEDQGLILQDRGKSDTKSTAFCFRASKEIKEKLDSSHKRDIEGMGIAEIKYGDSICFVQ HIASGLWLTYKAQDAKTSRLGPLKRKVIVHQEGHMDDGLTLQRCQHEESQAARIIRNTTS LFSQFISGNNRTSAPITLPIEEVLQTLQDLITYFKPPEEEMQHEDKQNKLRSLKNRQNLF KEEGMLALVLNCIDRLNVYNSVAHFTGFAREESGTAWKEILNLLYQLLAALIRGNRNNCA QFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLISEGHIKSIISLLDKHGRNHK VLDVLCSLCLCNGVAVRANQNLICDNLLPRRDLLLQTRLINDVTSIRPNIFLGVAEGSAQ YRKWYFELIIDQVDPFLTAEPTHLRVGWASSPGYAPYPGGGEGWGGNGVGDDLYSYGFDG LHLWSGRVPRAVASVNQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFF PVVSFSAGIKVRFLLGGRHGEFKFLPPSGYAPCYEALLPKEKMILEPVKEYKRDSEGIRD LLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRD DNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIVHVNLAAEEDLKKVKLPKN YMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRN PRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNVEPSDQELADQTMEKVSVDKIRFFRV EQSYAVKTGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSKGQRWHQGSG YFGRNWQAGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLS QIGRINLGMDASTFKYYTMCGLQEGFEPFAVNMNRDVAMWFSKHLPTFVNVPKDHAHIEV TRIDGTMDTPPCLKVTHKTFGTQNSSADMIYCRLSMPVECYSSFHHSTGLESDIFQKRKQ IQEIVTHMTTQCYYSVRIFAGQDPSYTWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERG RVHESVKRSNCYMIWGGDVIASSQRSSRSNVDLEIGCLIDLATGMISFSANGKELDTCYQ VEPNTKVFPAVFLQPTSTSLVQFELGKLKNAMPLSAAIFKSEEKNFVPQCPPRLDVQTIQ PILWSRMPNSFLKIEMERVSERHGWMVQGLEPLQMMALYIPEENRCVDILELCEQEDLMW FHYHTLKLYSAVCALGNNRVAYALCSHVDLSQLFYTIDNQYLPGLLRCGFYDLLISIHLA HAKEGKLMMKNEFIIPITNTTQKIRLYPDESKRHGLPGVGLSTCLKPGFNFSTPCFIVTG EERQKLSPEIPLEILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMG VFDNDDVRQILLLIDPTVFGEHTEEAAESMEKEVTQVEEKAVEAGEKASKNTQAPLRGLL QTRLPESVKLQMCELLSYFCDCELQHRVEAIIAFGDIYVSKLQANQKFRYNELMQALNMS AALTAKKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHDDLLIHCGIPLEEEE EEEEDTSWTGKLRALIYKIKGQPKLEKEQPMEEEEQCPTTLKELISQTMVRWAQEDQIQD PELVRIMFNLLRRQYDSIGELLQAMRKTYTISHASIEDTINLLAALGQIRSLLSVRMGKE EELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGEKSQIAFPKMVASCCR FLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPAMRGSTPLDVAASSVMDNNELALGLE EPDLEKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFAVFVNSESVEENAS VVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREISSEEDDGE EEIVHMGNSIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISI PLKLPTLNKDGSVNEPDMAANFCPDHKAPMVLFLDRVYGIEDQTFLLHLLEVGFLPDLRV SASLDTVSLSTTEAALALNRYLCSAVLPLLTRHAPLFAGTEHYTSLIDSTLQTIYRLSKG RSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPLLNEYCKMPLKLLTNHYEQCW KYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDTDLFRMALPCLSAIAGALPP DYLDTRITAILEKHTSVDAEGNFDPKPINTINFSLPEKLEYVVTKYAEHSHDKWACDKSQ NGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTRESEVI IQQRENEKLRNISQANQGNSYNPAPLDLSNVVLSREVQGMVEVVAENYHNIWAKKKKMEL ENKGGGSHPLLVPYDTLTAKEKFRDREKAQELFKFLQVNGIVVSRDLKDMELDASSMEKR FAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHC LYFLSSPLKPLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQT LDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTV ALLPILTSIYEHVAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECL ASLAAAMPVAFLEPSLNCYNSLSVFNTKTPRERSILGMPDSVEEMCPDIPQLDGLMKEIN NLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPSSAGPCCTLVTSEHLSIILGN ILKIINNNLGIDEASWMKRIAVYAQPIISKARSDLLKSHFIPTLEKLKKKAVKIVLEEEQ LKADSKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKNPDADSDELFRMV AEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKIRYSYRDTDEEVKDHLRNNLHLQEKS DDPAVKWQLNLYKDVLKNEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHKINNFFLSTFQRVWLENVYEKTQYDRLILMLTKPPKVE EEEEEEAEKQPDPLHQIILHFSRYALTEKSHLEDDPLYTAYSGMMAKSCQSGEEEEEEEK EKTFEEKEMEKQKTLYQQARLHDRGAAEMVLQMISASKGEMGPMVVETLKLGIAILNGGN PGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNHEFTCDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQRNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIKLLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTNSDAFKEYDPDGKGIISKKEFQKAMEGQKQYPQSEIE FLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSAERPEEEEDEEEFSCVVEAEEDDEENKSLESAS AFVTACVSVKKNVTSFLKMASLRNLKKQYRKVKKMTVKEMVKVFLSFFWMFFWGLFQLFF TILWGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDVIEAERAEVIEQNI TAELVHFVKGDKGEVDIMSDLFGLHPKKEGGTKHGPDPGLGDLSEIIGNDGPPTLESTVR KKRKAQAAEMKTESEREGKVESEKADMEDGEKEDKVKEEEQQEENLDEERTKKKRRHGPK DERPEAFMANFFKGLEIYQTKMLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPFED DAEDSNLWTPFNEEEEEEEGMVFFVLQESTGYMAPTLRALAIIHTIISFVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPSNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEQTEPEEASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQVREIIFSNINHIPQANESVCI CSLPLSLSPSPPSLPSSLKAQSLNHYLCELFVNKNLLIFKWMDL NT seq 14715 nt NT seq  +upstreamnt  +downstreamnt atgactgatttggagatgaaaaatcttatagactttagctctgaaccaggattatataaa gaggaagatgaagtggttctacagtgtgttgctaacatccacaaggaacaaagaaagttc tgtttggcagctgaaggacttgggaaccgcctgtgtttcttggagccaacttctgaagct aaatatgtgcctccagatctctgcatctgcaattttgtactggaacagtctctctctgta agagctctacaagaaatgcttgccaacacaggtgaaaatgacagtgaaggagtagcacag ggaggtggtcaccggacactattgtatggacatgcaattctccttcggcattcatttagt agaatgtatctgacatgcttgaccacatcaagatcccagacagataaacttgcctttgat gtgggactccgggaacatgccacaggggaagcatgctggtggaccatacaccctgcatcc aaacagagatctgaaggagagaaggtgcgaatcggtgatgacctcatccttgtcagcgtg tcttcggaaagatatcttcatctctccatatcgaatggcaacatacaagtggatgcctct tttatgcaaacactctggaatgtacatcctacatgctcaggaagtagcatcgaagaagga tacctacttggtgggcatgtggtacgttttttccatggccatgatgagtgtttgacaacc ctgtctacagaccagaatgattctcagcacaggaggatattctatgaaactggtggagct ggaagccgagccaggtcactgtggagagtggaaccccttcggataagctggagtggcagc aacatcaggtggggtcaggccttcagacttcggcacattaccactggtcattacctggct ctgacagaagatcaaggccttatcttgcaagatagggggaaatcagacaccaaatccaca gctttttgtttccgggcatctaaggaaatcaaggaaaaattggattcaagtcataagcgg gatattgaaggcatgggaattgcagaaataaagtatggagattccatatgctttgtccag catatagctagtggtctgtggctgacctacaaagcacaagatgccaagacatcacgcctt ggcccactgaaaagaaaggttatagtccatcaagagggtcacatggatgatggcttaaca cttcaaagatgtcaacatgaggagtcccaggctgctcggatcatccggaacacaacatct ttatttagccaatttataagtggaaacaatcgaacttctgcacccatcactctgccaata gaggaagtccttcagacattgcaagatctgataacctactttaaacctccagaggaagag atgcaacatgaagataagcaaaacaagctccggtcactcaaaaatagacagaatctgttt aaagaagagggaatgttggcccttgtgttaaattgcattgatcgtttaaatgtctacaac agtgtagcacattttactggatttgcaagggaagaaagtggtacagcttggaaagaaatt ctgaacctcctctaccaattgctagccgccctcattcgtggtaacagaaataactgtgct caattctccaataaccttgattggctgattagtaaattggacagactggaatcttcctca ggcattttggaagtattgcactgcatcttgattgaaagcccagaagccttaaatttgata tcagagggacacattaagtccatcatttctcttctggataagcatggccgcaatcataag gttcttgatgtcctttgctctctctgtctctgtaatggggtcgcagtaagagccaaccag aatcttatctgtgacaacctgctaccccgaagagacttgctactccagacccggctgatt aatgatgtgacaagcattcggccaaatattttcctgggagttgctgaaggctcagctcag tacaggaagtggtactttgagcttatcatagatcaggtggatcctttcctaacagccgaa cccacacacctccgagtaggctgggcttcttcaccaggttatgctccttaccctggtggt ggagaaggttggggaggcaatggtgttggtgatgacctatactcctatggctttgatggg cttcatctgtggtctggccgggttccaagagcagtggcctctgtcaaccagcatttgtta aagtctgatgatgtggtgagctgctgccttgaccttggtgtgcccagcatctctttccga atcaatgggcaacctgtacaaggaatgtttgagaacttcaatactgatggacttttcttc cctgtggtgagcttttcagcaggcatcaaagtgcgtttccttctgggtggacgtcacgga gagtttaagtttttgcctccatctggttatgccccctgctatgaagccttgcttccaaaa gagaagatgatattggaacctgtcaaagaatataagcgtgattctgaaggaataagggat ttgttgggcactacgcacttcctctctcaagcctccttcatcccatgccctatagacacc agccagatagttttgcctccccatctagaaaagatccgagacagactggctgaaaatatc catgagctatggggaatgaataaaatagaactaggatggacctttggcaagattcgggat gacaacaaaaggcaacacccctgtcttgtggaattctcaaagctacctgaaactgagaag aattataacctgcaaatgtcaacagaaactttaaaaacccttctagctctgggatgtcac attgttcatgttaatctggctgctgaggaagatctcaagaaagtaaaacttcccaaaaac tacatgatgtcaaatggctataagcctgcccctttggatctgtctgatgtgaaattattg cctcctcaagaaattttagttgacaaacttgcagagaatgcacacaatgtttgggcaaaa gacagaataaagcaaggatggacctatggcatccaacaggatctgaagaataaaagaaat cctcgcttggtaccatatgcattactcgatgaacgtacaaaaaagtcaaacagagacagt ctacgcgaagcagttcgaacatttattggatatgggtataatgttgagccttcagatcaa gaattagctgaccaaactatggaaaaagtcagtgtagacaaaatacgatttttccgggtg gaacagtcttatgcagtgaaaactggaaagtggtattttgaatttgaagtggtgacagga ggagatatgcgtgttggctgggccagaccaggttgtcggcctgacattgagctgggagca gatgatcaagcttttgtatttgaaggcagcaagggtcagcgctggcatcaggggagtgga tattttggacgcaattggcaagcaggggatgtagttggctgtatgatcaacttagatgat gcatcaatgattttcactctgaatggggaactgctgatcaccaataaaggttcagaactt gcctttgcagactatgagattgagaatggtttcgtccccatttgctcactgggtttatct cagattggtcgcataaaccttgggatggatgccagtaccttcaagtattacaccatgtgt ggcctccaggagggctttgagccttttgctgtaaacatgaatcgagatgttgctatgtgg tttagcaaacacctccctacatttgtcaatgtgccaaaggatcatgctcatatagaggtc acaaggattgatggtacaatggataccccaccatgccttaaggttacccataagacattt ggcacgcagaatagcagtgctgatatgatctattgtcgcctaagcatgcctgtggaatgc tattcctccttccaccatagtactggcttggaaagtgacatttttcagaaaaggaaacag atacaagaaatagttactcatatgacaacacagtgttattattctgtacgcatatttgct ggccaagacccttcctatacctgggttggctgggtgacaccagactaccacctatacagt gagaagtttgacttgaataaaaactgcacagtgactgtgactctgggagatgaaagaggc cgagttcatgaaagtgtgaagcgcagcaactgctacatgatttggggtggagatgtaatc gccagttcccagagatcaagtcgaagtaatgtggacctagaaattggctgcctcattgac ttggccacaggcatgatatccttctcagccaatgggaaagaactggatacctgctaccag gttgagcctaacaccaaggtatttccagctgttttcctgcaaccaacaagcacttctttg gttcagtttgaacttggcaagttaaagaatgcaatgcccctatcagcagcaatatttaaa agtgaagagaagaattttgttccccagtgtccccctcgactggatgtccagactatacag cctatactctggagtcgtatgcctaacagttttctgaagatagaaatggaaagggtgagc gaacggcatggctggatggtgcagggcctggagccattgcagatgatggccctctacatc cctgaggaaaacaggtgtgtggatatcttggaactctgtgaacaagaggatttgatgtgg ttccactatcacacactaaaactttatagtgcagtctgtgccttaggaaacaatcgggtg gcctatgccctttgtagccatgtagacctgtctcagctcttctacacaattgataaccag tatctccctggtcttctgcgctgtggcttctatgatctactcataagcatccacctggca cacgcaaaggagggaaaactgatgatgaaaaatgagttcatcatccctataaccaataca acccagaaaattagactatacccagatgaatccaagcgacatgggctgccaggggtgggc ttgagcacatgccttaaaccaggattcaatttctccaccccttgcttcattgtaaccggt gaagaacgccaaaaactaagccctgagattcctttggagattctcaagaccaaagcactg agtatgctgacagaggcagtgcattgcagtggggcacacatccgtgaccctgttggagga tctgtggaattccaatttgtaccagttttgaaactcattgggactttgctggtcatgggt gtatttgataatgatgatgttcggcaaatcctactcctcattgatcccactgtgtttggg gagcatacagaagaagcagcagaaagcatggaaaaggaggtgacacaggtcgaggagaag gcagtagaggctggagaaaaggccagcaaaaatacccaagcccctcttcgaggtttgctt cagactcgtttgccagaatctgtcaagctgcagatgtgtgagcttctcagctatttctgt gattgtgagctgcagcatcgagtggaagccattattgcatttggtgatatttatgtgtcc aagctacaggcaaaccagaaattccgctacaatgagcttatgcaggccctgaacatgtca gcagccctgactgccaaaaagaccagagagttccgatctcctccacaagaacagatcaat atgctgctaaattttcaactaggagagaattgtccctgtccagaggagatccgagaagaa ctttatgacttccatgatgatcttcttattcattgtggtatacctttggaagaagaggaa gaagaagaggaggacacatcatggactggcaaactaagggctctgatatataaaatcaaa ggacaaccaaagctagagaaggaacaacctatggaggaggaagaacagtgtccaacaacc ctaaaggaacttatctcacagaccatggtgcgctgggctcaagaagaccaaatccaggac ccagaacttgttaggataatgtttaatcttctccgtcggcagtatgatagcattggagag cttctgcaagccatgaggaagacttatacaattagccatgcttcaatagaggatactatc aacctgctagctgccctaggccagattcgctccctcctcagtgtaagaatggggaaggaa gaagagttacttatgattaatggactaggggatataatgaataacaaagttttttaccag catcccaacctcatgagagtcctgggcatgcatgagactgtaatggaggtgatggtgaat gttcttggaggagagaaatctcagattgcttttccaaagatggttgctagctgttgccga ttcctttgctatttttgccgaatcagcagacaaaatcaaaaagctatgtttgaacatcta agctacctacttgaaaatagcagtgttggtttagcctctccagcaatgaggggttctact cctcttgatgtggcagcttcatcagtcatggacaataatgaattggcactgggcttggaa gagccagaccttgagaaggtggtgacatacttagcaggctgtggtctgcagagctgccct atgctcttagccaagggatatcctgacattggctggaatcctattgaaggggagcgttac ttgtccttcctacgatttgctgtctttgtgaatagtgaaagtgtggaagaaaatgctagt gttgttgtcaaacttcttataagacgtccagagtgctttggaccagctctgaggggtgaa ggaggaaatggtctgttggcagccatgcaaggagctattaaaatttctgagaacccagcc cttgatcttccttctcagggatataagagagaaatcagttcagaagaggatgacggtgag gaggagattgtccacatgggcaattctatcatgtctttttattcagctctcatagaccta ctgggccgctgtgcacctgaaatgcaccttattcaaacaggaaaaggggaagccattcga atcaggtctatccttcgctccctggtccctactgaagatttggttgggattatcagtatt cctttgaaacttcccacacttaacaaagatggatcagtaaatgagccagatatggctgcc aacttttgccctgaccacaaagcacccatggtgctattcttggaccgtgtgtatggtatt gaagaccagactttcctccttcatcttctggaggtgggatttttgcctgatttaagagta tcagcctctctggatacagtttctctgagtaccacagaggcagcacttgccctaaataga tatctgtgttctgctgtgctccctctcctcacaagacatgcccctttgtttgctggaaca gaacattatacatctctaattgattccacacttcaaaccatctatagactctccaaagga cgttccctcaccaaagcacagagagacaccatagaagaatgtctgcttgctatctgcaat cacttacgaccttccatgttacaacaactcctacgtcgtcttgtttttgatgtaccactc ctcaatgaatactgtaaaatgccacttaagcttttgacaaatcattatgaacagtgctgg aagtattactgcctaccttcaggatgggggagctatggcttggcagtagaagaagagttg catttgacagagaagctcttctgggggattttcgactctctttctcataagaaatatgac acagatcttttccgaatggccttaccttgtctcagtgcgatagctggggccttgccacct gattatttagacaccagaatcacagccatattggaaaagcatacatcagtggatgcagaa ggaaactttgaccccaaacctattaataccatcaacttttctcttcctgaaaaactggaa tatgtagtcaccaagtatgctgagcattcacatgacaaatgggcctgtgacaagagtcag aatggatggaaatatggcatctctctggatgaaaatgtgaagacacatccattaataaga ccttttaaaacattaaccgaaaaggaaaaggaaatttatcgctggcctgccagagagtct ctgaaaaccatgctagctgtgggttggacagtagagagaaccagagaaagtgaagtgatt atacaacagagagaaaatgaaaagcttcgcaacatttcccaagccaaccaaggtaacagc tataatcctgctccacttgatctctcaaatgttgtactttctagggaagtccagggtatg gtggaggttgtggctgagaactaccacaatatctgggccaaaaagaaaaagatggaactg gaaaacaaaggtggaggcagtcacccactcttagtgccttatgacaccttgacagccaag gagaagttcagggacagagagaaagcccaggagctatttaaattcctccaagtgaatggt attgttgtatctagggatctgaaggatatggaattagatgcttcctcaatggaaaagaga tttgcctataaatttttgaagaagattctaaaatatgttgactctgctcaagaatttatt gctcatttggaagccattgtgagcagtgggaaaacagaaaagtctccccatgaccaagaa attaaattctttgccaaagttctccttcccttggttgaccagtacttcaccaatcactgc ctctacttcctttcatccccactaaaaccactcagtagcagtgggtatgcctctaataaa gagaaagaaatggtggccagcctattctgcaaacttgctgctcttgttagacataggatt tccctctttggaagtgattccactacaatggtgagctgcctacacatcctagctcagaca cttgacacaagaacagtaatgaaatcaggatccgaactggtaaaggctgggttacgtgca ttctttgaaaatgctgcagaagatttggagaagacttcagaaaatctaaagcttgggaag ttcacccattcccgaacacagattaaaggtgtctctcaaaatatcaattataccacagtg gctcttttgcctatattgacctccatctatgagcatgtggctcagcatcagtttggagtg gatttgcttttgagtgatgtgcagatttcatgctaccacattctgtgcagcctgtactcc cttgggacaggaaagaacatctatgtggaaaggcaacgtccagcacttggagaatgcctc gcttcgttggcagctgctatgccagtagcattcttggagccctccctcaattgctacaac tcgctctcagtcttcaacaccaaaacccccagggagaggtctattctagggatgcctgat tcagtagaagagatgtgccctgacattccccagctggatggactgatgaaggaaatcaac aatctggccgagtcaggagccagatatacagagatgccccatgtcatcgaagtcatctta cccatgctctgtaattacctttcttactggtgggaaagaggacctgaaaatctaccctcc agtgcaggcccctgctgcaccctggtgacctctgaacatctcagcatcattcttgggaat atcctgaaaatcatcaacaacaacctaggcattgatgaggcctcctggatgaagcgaatt gcagtatatgcccagcctatcataagtaaagccagatctgacctgcttaaaagtcacttc atcccaactctggaaaaactgaagaagaaagcagtgaagattgtattggaagaggaacag cttaaagcagacagcaaaggtgatacccaagaagctgaactcctcattttggatgagttt gctgtcctctgcagggacctctatgcattctatcctatgttaatccgttatgttgataat aacagatctaactggctaaaaaacccagatgctgattctgatgagctcttccgaatggtg gctgaggtttttatcctttggtgtaaatcacacaacttcaaacgggaagagcaaaatttt gtgattcagaatgaaattaataatctggcatttttaacgggagacagcaagagcaagatg tcaaaatctggaggacaagatcaagagcggaagaagacaaaacgaaggggtgatttgtac tctattcagacatctcttattgtagctgcattgaagaaaatgctgcccattggcttaaat atgtgtactccaggtgatcaggagctgatctctcttgcaaaaataagatatagttacagg gacacagatgaagaagtcaaagatcatctgaggaataacctgcatttgcaggaaaagtct gatgatccagctgtaaagtggcaacttaacctatacaaggatgttctaaagaatgaggaa ccctttaatccagaaaagacagtggagcgagtacaaaggatctcagcagctgttttccac ttagagcaggtggagcaaccacttagatccaagaaggctgtctggcacaaactcttatcc aagcaacgtaaaagggcagtagtagcctgctttaggatggctcccttgtataatctcccc agacacaaaattaataatttcttcctgagcaccttccaacgggtttggctggaaaatgtt tatgaaaaaactcagtatgacaggcttatactcatgttaacgaaacctccaaaggtagag gaggaggaagaagaagaagctgaaaagcagccagacccactccatcagatcattcttcat tttagtcgttatgctctcacagagaaaagtcatctggaagatgatcctctttatactgcc tattcaggcatgatggccaagagttgtcagagtggtgaagaagaggaggaagaagaaaag gaaaagacatttgaagaaaaagaaatggagaagcagaaaactctttatcagcaagctcgt ttgcatgaccgtggtgctgcagagatggtcctccagatgattagtgctagtaaaggtgag atgggacccatggttgtagagactctgaagcttggcattgccatcctgaatgggggcaac cctggagtgcagcagaaaatgctggattatctaaaggagaaaaaggatgctggattcttt caaagcctctctggccttatgcagtcttgcagtgtccttgatctgaatgcatttgagagg cagaacaaagctgaaggccttggaatggtcactgaggaaggaacactcatcgttcgggag cgtggtgaaaaggttctccagaatcatgagtttacctgtgatctcttcagattcctgcag ctgctttgtgaaggccataacagtgactttcagaacttccttcgtactcaaatgggcaat accaccactgtaaatattatcatcagcactgttgattacctcctacgtcttcaggaatca atcagtgacttctactggtactattcagggaaggacatcattgatgaatctggacagcga aacttctccaaagctttggctgtgaccaaacaaattttcaattccctaacagagtacatt cagggtccttgcattggaaaccagcagagcctggctcatagcagattgtgggatgcagtt gttggtttccttcacgtgtttgctaatatgcagatgaaactctctcaggattccagtcag atcaagttgctgaaagaactcttagatctcttacaggacatggtggtgatgctactatct ctcttggaagggaatgttgtaaatggaaccattggcaaacagatggttgacacccttgtg gagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttcctcaaactgaag gacttgaccaattcagatgccttcaaagaatatgacccagatgggaaaggaattatttct aagaaagaattccagaaagccatggaagggcagaaacagtatccccagtcagaaattgag ttcctcctctcctgtgcagaggctgatgagaatgacatgtttaattacattgattttgtg gacaggttccatgagccagccaaagacattgggtttaatgtggctgtgttactaaccaat ctttcagagcatatgcccaatgactcccgcctgcagtgtttgctggatccagctgaaagt gtcctgaattactttgaaccatatctggggcgtattgaaataatgggtggagccaagaaa attgaacgagtttactttgagataagtgagtctagccgaacccagtgggagaaaccccag gttaaagagtccaaacgacagtttatctttgatgttgtcaatgaaggtggggaacaggaa aagatggaattatttgtaaacttctgtgaagacacaatctttgaaatgcagttggcctct caaatctctgaatctgactcagctgaaagacccgaagaggaggaggatgaagaagaattt tcctgtgtagtagaagcagaggaggatgatgaagaaaacaaatcattggaatctgcttct gcatttgtcactgcctgtgtttcagtgaaaaaaaatgtgaccagttttctgaaaatggcc agtctgagaaacctcaagaaacagtataggaaggtgaagaaaatgactgtgaaagaaatg gttaaagtgtttttatctttcttctggatgtttttttgggggttgttccaattattcttc accattctttggggaatttttcagatcctctggaacactgtgtttgggggtggcttagta gaaggagcaaagaacatcagagttaccaagattcttggtgacatgcctgatcctacacag tttggcatccatgatgatgttatagaagcagaaagggcagaagtaattgagcagaacatc acagctgaactagtgcactttgtaaagggtgataagggagaggtagatatcatgtcagat ctctttgggctccacccaaagaaagagggtggcacaaagcatggtcctgaccctggcctt ggagatctttctgagatcattggaaatgatgggcctcccactttagagagcacagttcgg aagaaaaggaaagcacaggcagcagaaatgaaaactgaaagtgaaagagaaggaaaagtc gaatcagagaaggcagatatggaagatggagaaaaagaggacaaagtgaaggaggaggag caacaagaagaaaatctagatgaagagaggaccaagaagaagcgtcgtcatggcccaaag gatgagaggcctgaagcattcatggccaatttcttcaaaggtctagaaatctatcagacc aaaatgttgcattacctagccagaaatttctacaacctgagattccttgctctgtttgtg gcctttgccatcaacttcatcttgctcttctacaaggtaactgaggagccctttgaggat gatgcagaggactccaacctgtggactcccttcaatgaagaggaggaggaagaagaaggg atggtgttctttgtcctgcaggagagtactgggtacatggcaccaaccctgagggctctg gccatcatccacaccatcatctcctttgtatgtgttgtgggctattactgcttaaaggtc cctttggtggtgttcaaaagagaaaaggaaatagccaggaagttggagtttgatggtttg tatatcactgaacagccttcagaagatgacatcaaagggcagtgggatcgcctagtcatc aatacaccttcttttccgagcaactactgggacaagtttgtaaagagaaaggtgatcaac aaatatggtgacctctatggagcggagcgtattgctgaacttctgggtttggataaaaat gcacttgactttagcccagttgaacagacagaaccagaggaggcttcccttgtatcatgg ctgagctccatcgatatgaagtatcatatctggaagctgggagttgtttttaccgacaat tccttcttatacctggcctggtacacgactatgtctatccttggtcactacaacaacttc ttctttgctgctcacttactggacattgcaatgggtttcaagacactgaggacaatttta tcttctgtaactcacaatggcaaacagctggtactaactgtgggactcctggctgttgtt gtttatctctacactgtggtggctttcaacttcttccgaaagttctacaacaagagtgaa gatgaagatgagccagatatgaaatgtgatgacatgatgacgtgttacctattccatatg tatgttggagtaagagctgggggtggcattggagatgaaatcgaagaccctgctggtgat ccttatgaaatgtatcggattgtctttgatattacattcttcttttttgttattgttatc ctactggccatcattcaaggtttgatcattgatgcctttggagaactgagagaccagcaa gaacaagtgagagaagacatggagacaaaatgtttcatctgtgggattggcaatgactac tttgatactactccccatggttttgaaacacatacattacaagagcacaatctagccaac tatttgttctttctgatgtatctgattaataaagatgaaacagaacacacaggtcaggtg agagaaattatattttcaaatatcaatcacattcctcaggctaatgaaagtgtgtgcata tgttctctccctctttctctctctccctcaccaccttctctgcccagttcccttaaagca caatctttgaatcattatctttgtgaactcttcgtgaataaaaatctcttgatttttaag tggatggatctgtaa

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