Mandrillus leucophaeus (drill): 105546032 Help Entry 105546032         CDS       T08763                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism mleu  Mandrillus leucophaeus (drill) Pathway mleu04020   Calcium signaling pathway mleu04371   Apelin signaling pathway mleu04713   Circadian entrainment mleu04921   Oxytocin signaling pathway mleu04970   Salivary secretion mleu05010   Alzheimer disease mleu05012   Parkinson disease mleu05020   Prion disease mleu05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mleu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105546032 (RYR3)    04020 Calcium signaling pathway     105546032 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105546032 (RYR3)   09154 Digestive system    04970 Salivary secretion     105546032 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     105546032 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105546032 (RYR3)    05012 Parkinson disease     105546032 (RYR3)    05020 Prion disease     105546032 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     105546032 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mleu04040]     105546032 (RYR3) Ion channels [BR:mleu04040]  Voltage-gated cation channels   Ryanodine receptor    105546032 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  105546032 NCBI-ProteinID:  XP_011844521 Ensembl:  ENSMLEG00000043245 LinkDB All DBs Position Unknown AA seq 4854 aa AA seqDB search MFGSLFSPQEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIPPDLCVCNF VLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYLTCLTTSRS QTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERYLHLSVSN GNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTDQNDSQHRR IFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTEDQGLILQDR AKADTKSTAFSFRASKELKDKLDSSHKREIEGMGVPEIKYGDSVCFVQHIASGLWVTYKA QDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQFVSGNNRT AAPITLPIEEVLQTLQDLIAYFQPPEEGMRHEDKQNKLRSLKNRQNLFKEEGMLALVLNC IDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSNNLDWLISK LDRLESSSGEIFHCVLINSPESIHIGHLNSLISLCHDRNKKVLDILCSLCLCNGVAVRAN QNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTA EPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGRIPRAVASINQHL LRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRH GEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGTTQFLSQASFIPCPID TSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKRQHPCLVEFSKLPETE KNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMSNGYKPAPLDLSDVKL LPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLVPYALLDERTKKSNRD SLREAVRTFVGYGYNIEPSDQELADSAVEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVT GGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLD DASMIFTLNGELLITNKGSELAFADYEIENGFVPICCLGLSQIGRMNLGTDASTFKFYTM CGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVMRIDGTMDSPPCLKVTHKT FGTQHSNADMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIF AGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHESVKRSNCYMVWGGDI VASSQRSNRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPNTKVFPAVFLQPTSTS LFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLWSRMPNSFLKVESERV SERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMRFHYHTLRLYSAVCALGNSR VAYALCSHVDLSQLFYAIDNKYLPGLLRAGFYDLLISIHLANAKERKLMMKNEYIIPITS TTRNIRLFPDESKRHGLPGVGLRTCLKPGFRFSTPCFVATGEEHQKQSPEIPLESLRTKA LSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVF GEHSADTEEGTEKEEVTQVEEKAVEAGEKAGKEAPVKGLLQTRLPESVKLQMCELLSYLC DCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTARKTKEFRSPPQEQIN MLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEEDTSWTGKLRALVYKIK GPPKPEKEQPTEEEERCPTTLKELISQTMICWAQEDQIQDAELVRMMFNLLRRQYDSIGE LLQALRKTYTISHASVSDTINLLAALGQIRSLLSVRMGKEEELLMINGLGEIMNNKVFYQ HPNLMRVLGMHETVMEVMVNVLSTEKSQIAFPKMVASCCRFLCYFCRISRQNQKAMFEHL SYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLEKVVTYLAGCGLQSCP MLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKLLIRRPECFGPALRGE GGNGLLAAMQGAIKISENPALDLPSQGYKREVTEADEEEEEIVHMGNAIMSFYSALIDLL GRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPSLNKDGSVSEPDMAAN FCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDTVSLSTTEAALALNRY ICSAVLPLLTRCAPLFAGTDHCTSLIDSTLQTIYRLSKGRSLTKAQRDTIEECLLAICNH LRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELH LTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTRITATLEKQISVDADG NFDPKPINTVNFSLPEKLEYIVTKYAEHSHDKWACDKSQSGWKYGISLDENVKTHPLIRP FKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQRENEKLRSVSQANQGNSY SPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGGSHPLLVPYDTLTAKE KFKDREKAQDLFKFLQVNGVIVSRGMKDMELDASSMEKRFAYKFLKKILKYVDSAQEFIA HLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKE KEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTVMKSGSELVKAGLRAF FENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPILTSIFEHVAQHQFGMD LLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECVASLAAAIPVAFLEPTLNRYNP LSVFNTKTPRERSILGIPDTVEDMCPDIPQLEGLMKEINDLAESGARYTEMPHVIEVILP MLCNYLSYWWERGPENLPPSTGQCCTKVTSEHLSLILGNILKIINNNLGIDEASWMKRIA VYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLRADGKGDTQEAELLILDEFA VLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVAEVFILWCKSHNFKREEQNFV IQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYSIQTSLIVAALKKMLP IGLNMCTPGDQELISLAKSRYGHRDTDEEVREHLRNNLHLQEKSDDPAVKWQLNLYKDVL KSEEPFNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPL YNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEEEEEESEKQPDPLHQI ILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLY QQARLHERGAAEMVLQMISASKGDMSPMVVETLKLGIAILNGGNAGVQQKMLDYLKEKKD AGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLF RFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQESISDFYWYYSGKDIIDE SGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQ DSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVESSTNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGIISKREFQKAMEGQKQYTQSEIDFLLSCAEADENDMFNY IDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMG GAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEM QLASQISESDSADRPEEEEEDEDSSYVLEIAGEEEEDGSFEPASAFAMACASVKRNVADF LKRATLKNFRKQYRNVKKMTAKELVKVLCSFFWMLFLGLFQMLFTILGGIFQILWSTVFG GGLVEGAKNIRVTKILGDMPDPTQFGIHDDTMEAERAEVMEPGITTELVHFIKGEKGDTD IMSDLFGLHPKKEGSLKHGPEVGLGDLSEIIGKDEPPTLESTVQKKRKAQAAEMKAANEA EGKVESEKADMEDGEKEDKAKEEEQAEYLWTEVTKKKKRRCGQKAEKPEAFTANFFKGLD IYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEETEDVANLWNSFNDEE EEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPLVVFKREKEIARKLE FDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKYGDLYGAERIAELLG LDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGH YNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFDTTPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14565 nt NT seq  +upstreamnt  +downstreamnt atgtttgggtctctcttctcgccgcaggaggatgaagtggtactccagtgcatcgccacc attcacaaggagcagaggaagttttgcctggcagccgagggacttgggaatcgcctgtgc ttcttggaacccacttcagaagccaagtacattcctccagatctctgcgtctgcaatttt gtgctggaacagtccctatctgtcagagccctgcaggaaatgcttgccaacacaggtgaa aatggcggcgaaggggcagcacaaggaggtggccacaggaccctgttatatggccatgca attctcctgaggcactctttcagcggaatgtatctaacatgcttgactacatcaagatcc cagacagacaaacttgcctttgatgtaggtctacgggaacatgccacaggagaagcctgt tggtggactatacatcctgcttccaaacagaggtccgaaggagagaaagttagaattggc gatgacctcatcctcgtcagcgtgtcctctgaaagataccttcatctctcagtatcaaat ggtaacatacaagtggatgcctcctttatgcagacactctggaatgtacatcctacgtgc tcaggaagtagcatcgaagaaggatacctacttggtgggcatgtagtgcgtcttttccat ggtcatgatgagtgtctgacgataccatctacagaccagaatgattcccagcacaggagg atattctacgaagctgggggagctgggactcgagccaggtccctgtggagagtggaacca cttcggataagttggagtggcagtaacatcagatggggccaggcttttcgactccggcat ctcaccacaggccactacctggccttgacagaagaccaaggccttatactacaagaccgg gcaaaggcagacaccaagtccacagctttctctttccgggcatcaaaggaactcaaggac aaattagattccagtcacaagcgagagatagaaggcatgggagttccggaaatcaagtat ggagattctgtctgctttgtacagcatatagccagtggtctgtgggtgacctacaaagca caagatgccaaaacttcccgcctgggacctctgaaaagaaaggtcatactccatcaggaa ggccacatggatgatggattaacactgcagagatgccagcgtgaggagtcccaggctgct cggatcatccggaacactacagccttattcagccagtttgtcagcggaaacaatcgcaca gctgcccccatcaccctgcctatagaagaagtcctgcagaccctacaggacttgatcgcc tacttccagcccccggaggaggggatgcgacatgaagacaagcagaacaagctccgctca ctcaaaaacagacaaaatcttttcaaggaagagggaatgttggctcttgtcttaaattgc attgaccgcttaaatatctacaatagcgtagcacactttgcagggattgcaagagaagag agtggcatggcctggaaagaaattctgaacctcctctacaaattgctggctgctctcatt cgtggaaacagaaacaattgcgctcaattctccaataaccttgattggctcatcagtaaa ttggacagactagaatcttcctcaggtgagatattccattgtgttttgattaacagtcct gaaagcatccatataggccacctaaatagccttatttcgctttgccatgataggaacaaa aaggttctggatatcctgtgctccctctgtctctgcaatggggttgcagtgagagccaac cagaatctgatctgtgacaacctgctgccccggagaaacctgctcttgcagacacgactg attaacgatgtaaccagtatccggccaaacatcttcctgggagtcgcggagggctcagcc cagtacaagaagtggtacttcgagctgattatcgaccaggtggaccccttcctaacagca gagcccacacatctgcgggtgggctgggcctcttcctcaggctatgctccatacccaggc ggtggagaaggatggggaggcaatggtgttggcgatgacctgtactcctatggctttgat ggacttcacctttggtcaggccggatacccagagctgtggcttccatcaaccagcacctc ctgagatcagatgatgtggtaagctgctgcctggacctcggggtgcccagcatttcattc cgcatcaatggacaacctgtgcaggggatgtttgagaacttcaacacagacgggctcttc ttccctgtgatgagcttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcat ggagagtttaagttcctgccaccctctggctatgccccttgctatgaagccttacttcca aaagagaagatgagattggaacctgtcaaagaatataaacgtgatgctgatggcgttaga gatctcttgggtaccacccagttcctatcccaagcctctttcatcccatgccccatagac accagtcaggttgttttgccacctcacctcgaaaagatccgagacagactagctgaaaac atccacgagctttggggaatgaataaaatagagcttggctggactttcggcaagatacga gatgacaataaaagacagcacccttgccttgtggagttttcaaagctccccgaaactgag aagaattataacctgcaaatgtcaactgaaaccttgaaaaccctcctggccctggggtgc catattgctcatgttaacccagctgctgaggaggatctcaagaaggtcaaactgcccaaa aactatatgatgtccaatggctataagccagcccctttggatttgtctgatgtgaagctg ttacctcctcaagaaattttagtggataaacttgcagaaaatgcacacaatgtttgggca aaagacagaataaaacaaggatggacctatggcatccaacaggatttgaagaacaaaaga aatccccgtctggtgccatatgcattactggacgagcgtaccaagaagtcaaacagggac agcctgcgggaagctgtgcgcacttttgttggttacggatataacattgagccatcagac caagaactagctgactcggctgtggagaaagtcagcatagacaagatccgatttttccgg gtagagcgatcttatgcagtgagatctggaaagtggtattttgagtttgaggtggtgact ggaggagacatgcgagttggctgggccaggccaggctgtcggcctgatgtggaactgggg gccgatgaccaagcctttgtgtttgaaggcagcaggggccagcgttggcatcaaggaagt gggtattttgggcgtacgtggcagccaggagatgtggtcggatgtatgattaacctggat gatgcttcaatgatcttcacgctgaatggggagctgctgatcaccaacaaaggctctgaa cttgccttcgctgactacgagattgagaatggctttgtgcccatctgctgtctggggctg tctcagattggccgcatgaatctcgggacagatgccagtaccttcaagttttataccatg tgcggtctgcaagagggctttgagccttttgctgtcaacatgaacagagatgttgctatg tggttcagcaagcgcctcccgacgtttgtcaacgtgccaaaggaccatccacacatagag gtcatgaggattgatggcaccatggacagccctccgtgtctcaaggtgacccataagaca tttggcacacagcatagcaatgccgacatgatctactgccgcttgagcatgcctgtcgag tgccactcttccttcagccacagcccctgtctggacagtgaagctttccagaaaaggaaa cagatgcaagaaatactctctcatacaacaacacagtgctactatgccatccgcatcttt gctggacaagatccatcctgcgtctgggtcggatgggtgactccagactatcacttgtac agtgaaaagtttgacctgaataaaaactgcacagtgactgtcaccctaggggatgaaaga ggccgggtacacgaaagtgtgaaacgcagcaactgctacatggtctggggcggggacata gtggccagttcccagagatcgaatcggagcaacgtggacctggagattggctgtcttgtg gatctggcaatgggcatgttgtccttctcagccaacggaaaagaactgggcacctgctac caggtggagcccaacaccaaagtgttcccagcagtcttcctgcagcctacaagtacttcc ttgtttcagttcgaacttggaaagctgaagaacgcaatgcccctgtcagcagccatattc aagagtgaagagaagaacccagtcccacagtgtccacctcggctggacgtccaaaccatc cagcccgtgctctggagccgcatgcccaacagcttcctgaaggtggagagcgagcgtgtg agcgagcgccacggctgggtggtgcagtgcctggagcccctgcagatgatggcgctccac atccccgaggagaacaggtgtgtggatatcctggagctctgtgagcaggaggacctgatg cggttccattaccacacgctgaggctctacagcgcagtgtgcgccctgggaaacagccgt gtggcctacgccttgtgcagccacgtggacctctcccagctcttctatgccattgacaac aagtacctccccggtctccttcgagctggcttctatgacctgctcatcagcatccacctg gccaatgccaaggagaggaagctgatgatgaagaacgagtatatcatccccattaccagc accaccaggaatatccgcctcttcccggacgagtccaagaggcatggactgcctggggtg ggcctgagaacatgtctcaagcccgggttcaggttctccaccccttgctttgtcgcaact ggtgaggagcaccaaaaacagagccctgagattcccttggagagtctcaggacgaaggct ctgagtatgctgacagaggcggtgcagtgcagcggggcccacatccgagaccccgtaggg gggtctgtggagttccagtttgtgcctgtgctgaaactcattggaaccctgctggtcatg ggcgtgtttgatgatgacgatgttcggcagatcctcctcctgattgatccctctgtgttt ggggagcatagcgcagacacagaggagggaacagaaaaggaggaagtgacccaggtggag gagaaggctgtggaggctggggagaaggccggcaaggaggctcctgtcaaaggcttgttg cagactcgattacccgagtccgtcaagctgcagatgtgtgagctcctcagctatctctgc gactgtgagctgcagcaccgagtggaggccattgtggcatttggtgacatttatgtctcc aagctgcaggcaaatcagaagttccgctacaatgagctcatgcaggccctgaacatgtct gcggccctgactgcccggaagaccaaggagttccgctcacccccacaggagcagatcaac atgcttcttaactttcaactgggagagaactgcccctgcccagaggagattcgggaggag ctgtatgatttccatgaggaccttctccttcactgtggggttcctttggaagaagaggaa gaggaggaggaggacacctcctggacgggaaaactccgtgccttggtttacaaaatcaaa ggcccacccaagccagagaaggaacagccaacggaggaggaggagagatgccccaccaca ttgaaggagctcatctcacagacaatgatctgctgggcccaggaggaccagatccaggat gcagagctggtccgaatgatgttcaacctcctccggaggcagtatgacagcatcggggag ctgctgcaggcgctgcggaagacctacaccatcagccatgcctctgtaagcgacaccatc aacctgctggctgccctgggccagatccgctccctcctcagtgtcaggatgggcaaggaa gaggagttgctcatgatcaacgggctgggagaaataatgaacaacaaggtgttttaccag catcccaacctcatgagagtcctgggcatgcacgagacggtgatggaggtgatggtgaac gtgttgagtacagagaaatctcagattgcatttccaaagatggttgctagctgctgccgt ttcctttgctatttctgtcgaattagccggcaaaatcagaaggccatgtttgagcatctg agttatcttctggagaatagcagcgttggcctagcctccccgtcgatgaggggatccacc ccgctggatgtggcagcgtcctctgtgatggacaacaacgagttagcgctgggcttggag gaaccagacctggagaaggtggtgacctacttggcaggctgtggcctacagagctgcccc atgcttctggccaaaggataccctgacgtcggctggaaccccatcgaaggggaacgctac ctgtccttcctgaggtttgccgtcttcgtgaacagtgagagtgtggaagaaaatgccagc gttgtggtcaagctgctcatcagacgcccagagtgctttggcccggccctgcggggtgag gggggaaacggactgttggcggccatgcagggagccattaagatctctgagaaccccgcg cttgacctcccctctcaaggatacaaaagagaagtcacggaggccgatgaagaggaagaa gaaatcgtgcatatgggcaatgcaattatgtcattttattcggcccttatagatctactg ggccgctgtgctcctgaaatgcacctcatccagacgggaaagggggaggccatccgcatc aggtccatactgcgctctctggtccccacagaagacctggttgggatcatcagcatcccc ttgaaactgccctcccttaacaaagatgggtcggtcagtgagccggatatggcggccaac ttctgccctgaccacaaggcacccatggtgctgttcttggaccgcgtctatggcattaag gatcaaacttttctgctccacttgctggaggttggatttttacctgacctgagagcttct gcctctctagatacagtttccctgagcaccacagaggctgcgcttgcactaaataggtat atatgttctgctgtgctcccgctcctcacaagatgtgctcctctctttgccggaacagac cactgcacctctctgattgattccacactgcagacgatatacaggctttccaagggacgt tccctcaccaaagcacaaagggacactatagaagaatgtctgcttgccatttgcaatcac ttgaggccttccatgttacagcagctcctgcgacgcctcgtttttgatgtgccccaactc aatgaatactgcaaaatgcctctcaagcttctgacgaatcactatgaacagtgctggaaa tattactgcctgccttcaggatgggggagctatgggctagctgtggaagaagagctgcac ctaacggagaagcttttctgggggatttttgactctctctcccataagaaatatgaccca gatcttttccgaatggccctgccttgtctcagtgctatagctggggccttgccaccggat tatttagataccagaatcacagccacattggagaaacagatctcagtggatgcagatggc aactttgatcccaaacctatcaacactgtgaatttttccttgcctgaaaaattggaatac atcgtcaccaagtatgctgagcattcacatgataaatgggcctgcgacaagagtcagagc ggatggaaatatgggatttccctggatgaaaatgtgaagactcacccactgataaggcct ttcaagacattaacggagaaggagaaggaaatttatcgctggcctgcccgagagtccctg aaaaccatgctagctgtgggctggactgtggagaggaccaaagagggagaagcgttggtt caacagcgggaaaatgagaagcttcgaagcgtgtcccaggccaaccagggcaacagctac agccctgctcccctcgacctctcaaacgttgtactctccagagagctccagggaatggtg gaggtcgtggctgagaactatcacaatatctgggccaagaagaagaagctggagctggag agcaaaggtggtggcagtcaccctcttctggtaccatatgacaccttgactgccaaagaa aagttcaaggaccgggagaaggcacaggacctgtttaagttcctccaagtgaatggcgtc atagtttccaggggtatgaaggatatggagctggatgcctcctccatggaaaagaggttt gcctataagttcttgaagaagatcctgaaatatgttgattcggcacaagaatttattgcc catttagaagccattgtcagcagtgggaaaactgaaaagtctcctcatgaccaggagatc aaattctttgccaaagttctcctcccgctggttgaccagtacttcaccaatcatcgcctc tacttcttgtcatcccctctgaagccccttagcagcagcggatacgcctctcataaggag aaagaaatggtggccagcctgttctgcaaacttgctgcccttgttagacacagaatttcc ctctttggtagtgattctactacaatggtgagctgtcttcacatcttagctcagacactt gacacaaggactgtcatgaagtcaggctcagagctggtgaaggctgggttacgagcattc tttgaaaatgctgcagaagacttggagaagacttcagaaaacctgaaacttgggaagttc acccactcccgaacgcagattaaaggcgtttctcagaatattaactatactacagtggcc ctgctccccatcctgacgtccatctttgagcacgtcgctcagcatcagtttggaatggat ctactcttgggtgatgtgcagatttcctgctaccacatactgtgcagcctctactccctt gggacaggaaagaacatttatgttgaaaggcaacgccctgcccttggagaatgtgtggcc tcgctggcagctgccataccagtggcattcctggagcccaccctcaatcgctacaatcct ctctcggtcttcaacaccaaaacccctagggagaggtctattctggggataccagacacg gtggaagacatgtgtcctgacatcccccagctggaaggcctgatgaaggaaatcaacgac ctggccgagtcaggggcgcggtacacagagatgccgcatgtcatcgaggtgatcttaccc atgctctgcaactacctgtcctactggtgggagcgggggcctgagaacctgccccccagc acagggcagtgctgcaccaaagtcacctctgaacacctcagtctcatcctgggcaacatt ctgaaaatcatcaacaacaacctgggcatcgatgaggcctcctggatgaagcgcatcgca gtgtatgcacagcccatcatcagcaaagccaggcccgacctgctgagaagccacttcatc ccaactctggagaagctgaagaaaaaggctgtcaagaccgtgcaggaggaggagcagttg agagccgatggcaaaggggacacccaggaggcggagctcctcatcctggacgaattcgcg gtcctctgccgagatctctatgccttctaccccatgctgatccgctacgtggacaacaac agatctaactggctgaaaagccctgatgctgattctgaccagctcttccgcatggtggca gaagtcttcatcctgtggtgtaaatctcacaacttcaagagggaagagcaaaattttgtg attcagaatgaaattaataatttggcatttttaactggagacagcaaaagcaagatgtca aaagccatgcaagtaaagtctggaggacaagaccaggagcggaagaagacaaagcggcgg ggagacttgtattccatccagacctccctcatcgtggctgcactcaagaaaatgctgccc attggtttgaatatgtgtactccaggcgaccaggagctgatctccctcgcaaaatcgcga tacggccatagggacacagatgaagaggtcagagaacatctgcggaacaacttgcacttg caggaaaagtctgatgacccagctgtaaaatggcagctgaacctctacaaggatgttctg aagagtgaagaacctttcaatccggaaaagacagtggagcgtgtacagagaatttcagca gctgtcttccacctggaacaggtggaacagcctttgaggtccaagaaggccgtctggcac aaactgctatcaaagcaacggaaacgggcagtggtggcctgcttcaggatggcccctctc tacaacctgcccaggcaccgctctattaacctcttcctccatggctatcagagattttgg atagaaacagaggagtattcctttgaagagaaactagtacaggatttggctaaatctcca aaggtggaagaggaggaggaggaagagtccgaaaaacaacctgacccactgcatcagatc attctgtattttagccgcaacgctctcacggagaggagcaaattggaagacgaccctttg tacacctcctattccagcatgatggctaagagttgtcaaagtggtgaggacgaagaagaa gatgaagacaaggaaaaaacatttgaagagaaggagatggagaagcagaaaaccctgtat cagcaagctcggctgcatgagcgtggtgccgcggagatggtccttcagatgataagcgct agcaaaggtgacatgagccccatggtggttgagactctgaagctggggatcgccattctg aacggaggcaatgctggtgtgcaacagaaaatgctagattacctaaaggagaaaaaggat gctggattctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaat gcatttgagaggcagaataaagctgaaggcctggggatggtgactgaagaaggaacactc attgttcgtgaacgtggtgaaaaagtactccagaatgacgagttcacgcgtgatctcttt agattcctacagttactttgtgagggacataacagtgactttcagaacttcctgcggact cagatgggtaacaccaccaccgtgaatgtcatcatcagcactgtggactaccttctgcgt ctgcaggaatcaatcagtgatttctactggtattattcagggaaggacatcattgatgaa tccggacagcacaatttctccaaagctctggcagtcaccaagcagattttcaattctctt acagaatacatccagggcccttgcattggtaatcagcagagcctggctcacagcaggctg tgggacgctgtggttggcttcctccatgtctttgctaatatgcagatgaaactgtctcag gattccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtg atgcttctgtccctcctggaagggaatgtggtaaatggcaccattggcaagcagatggtt gacacactggtagaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttc ttgaaacttaaagacttaaccagctcagacaccttcaaagaatacgacccagatggtaaa ggaattatctccaaaagagaattccagaaggccatggaagggcaaaaacagtacacgcag tcagagattgactttctcctttcgtgtgcagaagctgatgagaatgacatgtttaattac attgattttgtagaccggttccatgagccggccaaggacatagggtttaatgtggctgtg ttattgacaaatctttctgaacacatgccaaacgattcccggctgaagtgtctgttggac ccagcagaaagtgtgctaaattacttcgaaccctacctaggacgcatcgagatcatgggt ggggccaagaaaattgagcgtgtttattttgaaatcagtgagtccagtcgcactcagtgg gagaagccccaggtgaaggaatctaagcgacagttcatttttgatgttgtcaacgaaggt ggggagcaggaaaagatggagctgtttgtgaacttctgtgaggacaccatctttgaaatg cagttagcatctcagatctctgaatccgattcagcggacaggccagaagaggaggaagaa gatgaagattcttcttacgtgttagaaattgcgggtgaagaggaggaagacgggtctttc gagccggcctctgcatttgcaatggcctgtgcctctgtgaagaggaacgtcgccgacttt ctgaagagggcaaccctgaagaacttcaggaagcagtacaggaacgtgaaaaagatgact gcgaaggagctggtgaaggtgctctgctcctttttctggatgctgttcctggggctgttc cagatgctcttcaccatcctgggaggaatctttcagatcctctggagcacagtgttcgga gggggcctggtagaaggggcaaagaacatcagagtgaccaagatcctgggtgacatgcct gacccaacccaatttggtatccatgatgacactatggaggctgagagggcagaggtgatg gagccaggtatcaccactgaactagtacacttcataaagggggagaagggagatacagat atcatgtcagacctctttggactccacccaaagaaagagggcagcttaaagcatgggcct gaagtgggtttgggtgacctctcagaaattattggcaaggatgaaccccctacgttagag agtactgtacagaagaagaggaaagctcaggcagcagagatgaaagcagcaaatgaagca gaaggaaaagtagaatccgagaaggcagacatggaagatggagagaaggaagacaaagcc aaagaagaggagcaagccgagtacctgtggacagaagtgacaaaaaagaagaagcggcgg tgtggtcagaaggctgagaagccggaagctttcacagccaatttctttaaagggctggac atctatcagaccaagttactgcattacctggccaggaatttctacaacctgaggttcctt gctctgtttgtagccttcgctatcaacttcatcctgcttttttataaggtcactgaagaa cctttagaagaagagacagaggatgttgcaaacctatggaattcatttaatgacgaggaa gaggaagaagcgatggtgttctttgtccttcaggagagcactgggtatatggcaccaacg ctgcgggccctggccatcatccacaccatcatctctctagtctgtgtggtgggctactac tgcctgaaggtgcctttggtggtattcaaaagggaaaaagaaatcgccaggaagctggag tttgatggcctatatatcaccgaacagccatctgaagatgacatcaaggggcaatgggac cgcttggtgatcaacacaccatcttttcctaataactactgggacaagtttgtaaagaga aaggtgatcaacaagtatggcgatctctacggagcagagcgcattgctgaacttctgggt ttggacaaaaatgctcttgacttcagcccagtagaagagaccaaagcagaggcggcttct ctggtgtcatggctaagttccatagacatgaagtaccatatctggaagcttggagttgtg tttactgacaactcctttctctaccttgcctggtatacaaccatgtcagtcctgggccac tacaataacttcttctttgctgctcacctgctggatatcgcaatgggcttcaagacactg aggaccattctgtcatctgtaactcacaatggcaaacagttggttctgacggtcggtctc ctggccgtggtggtgtatctctatactgtggtggctttcaacttcttccgcaagttctac aacaaaagcgaagacgatgacgagcctgatatgaagtgtgacgacatgatgacgtgttac cttttccacatgtacgtgggagtgagagcaggaggtggcattggtgacgagattgaagac cctgctggtgatccttatgaaatgtatcgcattgtctttgacattacctttttcttcttt gtcattgtcatcttgctggccatcattcaaggtcttattattgatgctttcggagagcta agagaccagcaggaacaagtgcgagaagatatggagaccaaatgtttcatctgtgggatt ggcaatgactactttgacacgacccctcatggttttgaaacacatacattacaagagcac aacttagccaactacttgttcttcctgatgtatttgattaataaagatgaaacagagcac acgggtcaggaatcttatgtctggaagatgtaccaagaaaggtgctgggatttcttccca gccggtgactgctttcgtaaacagtatgaagatcagcttggataa

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