Mirounga leonina (Southern elephant seal): 118001480
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Entry
118001480 CDS
T07472
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
mlx
Mirounga leonina (Southern elephant seal)
Pathway
mlx00270
Cysteine and methionine metabolism
mlx00480
Glutathione metabolism
mlx01100
Metabolic pathways
mlx01240
Biosynthesis of cofactors
mlx04216
Ferroptosis
Module
mlx_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
mlx00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
118001480 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
118001480 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
118001480 (GCLC)
Enzymes [BR:
mlx01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
118001480 (GCLC)
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Paralog
GFIT
Motif
Pfam:
GCS
GCS2
RE_TdeIII
Motif
Other DBs
NCBI-GeneID:
118001480
NCBI-ProteinID:
XP_034847494
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All DBs
Position
Unknown
AA seq
637 aa
AA seq
DB search
MGLLSQGSPLSWEETKRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDH
ENKKVRLVLSGEEVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMRKRRKEATSLLGENQALCTITSFPRLGCPGFTLPEFKPSPVEGGASKSLFFPDEAI
NKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIEAFPEDEEATKASKPDHIYMDA
MGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVI
SASVDDRTREERGLEPLKNNNYRISKSRYDSIDSYLSECGEKYNDIDLTIDKEIYEQLLQ
EGIDRLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDI
GWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQKRDAVL
QGMFYFRKDICKGGTTMVDGYSKAQNSTEQAVEEYTLMSIDTIINGKEAVFPGLIPILNS
YLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEMNYS
LILKCNQIANELCECPELLGPAFRKVKYSGSKTDSSN
NT seq
1914 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcccagggctcgccgctgagctgggaggagaccaagcgccacgccgac
cacgtgcggcggcacgggatcctccagttcctgcacatctaccacgccgtcaaggaccgg
cacaaggacgtgctcaagtggggcgacgaggtggaatacatgttggtgtcttttgatcat
gaaaataagaaagtccggttggtcctgtccggagaggaagttcttgaaactctacaagaa
aagggggaaaggacaaacccaaaccatcctaccctgtggagaccagagtatggcagttac
atgattgaaggtacacccggacagccgtatggaggaacaatgtccgagttcaacacagtc
gaagacaacatgaggaaacgtcggaaggaagcgacttctttattaggagaaaaccaggct
ctctgcacaataacttcatttcccagattaggctgtcctgggttcacgctgccagagttc
aaacccagtccagttgaaggaggagcttccaagtccctcttctttcctgatgaagccata
aacaagcacccccgcttcagtaccctaacaagaaatatccgacacaggagaggagaaaag
gttgtcatcaatgtaccaatatttaaggacaagaatacaccctctccatttatagaagca
tttcctgaggatgaggaggcaaccaaggcttctaagcctgatcatatttacatggatgcc
atgggatttgggatgggcaattgctgtcttcaggtaacgttccaagcctgcagcatatct
gaagccagatacctgtacgatcagttggccactatctgtccaattgtcatggctttgagc
gctgcatctcccttttaccgaggctatgtgtctgacattgattgtcgctggggagtgatt
tctgcatctgtagatgatagaactcgggaggagagaggactggagccactgaagaacaat
aactataggatcagtaagtcccgatacgattcgatagacagttacttatctgagtgtggt
gagaagtacaatgacatcgacttgacgatagataaagaaatctacgaacaactgttgcag
gaaggcattgatcgtctcctggcccagcatgttgctcatctcttcattagagacccactg
actctgttcgaagagaaaatacacttggatgatgccaatgaatctgaccattttgagaat
attcagtccacaaattggcagacgatgagatttaaaccccctcctccaaactcagatatt
ggatggagagtagaattccgacccatggaggttcagttaacagactttgagaactctgca
tatgtggtgtttgtggtgctgcttaccagagtgatcctttcatacaaactggattttctc
attccactatcaaaggttgatgaaaacatgaaagttgcacagaaacgcgatgctgtcttg
cagggaatgttttatttcaggaaagatatttgcaaaggtggcaccaccatggtggacggc
tacagcaaggcccagaacagcacggaacaggcagtagaggagtacaccctgatgagcata
gacaccatcatcaacgggaaggaagctgtgtttcctggactgatcccaattctgaactct
taccttgaaaacatggaagtggatgtggacaccagatgcagtattctgaactacctaaag
ctaattaagaagagagcatctggagaactaatgacagttgccaggtggatgagagagttt
atcgcaaaccatcctgactacaagcaagacagtgtgataactgatgaaatgaactatagc
cttattttaaagtgtaaccaaattgcaaatgaattatgtgaatgcccagagttacttgga
ccagcatttaggaaagtaaaatacagtggaagtaaaactgactcttccaactag
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