Marmota marmota marmota (Alpine marmot): 107137664 Help Entry 107137664         CDS       T09644                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism mmma  Marmota marmota marmota (Alpine marmot) Pathway mmma04020   Calcium signaling pathway mmma04371   Apelin signaling pathway mmma04713   Circadian entrainment mmma04921   Oxytocin signaling pathway mmma04970   Salivary secretion mmma05010   Alzheimer disease mmma05012   Parkinson disease mmma05020   Prion disease mmma05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mmma00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     107137664 (Ryr3)    04020 Calcium signaling pathway     107137664 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     107137664 (Ryr3)   09154 Digestive system    04970 Salivary secretion     107137664 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     107137664 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     107137664 (Ryr3)    05012 Parkinson disease     107137664 (Ryr3)    05020 Prion disease     107137664 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     107137664 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mmma04040]     107137664 (Ryr3) Ion channels [BR:mmma04040]  Voltage-gated cation channels   Ryanodine receptor    107137664 (Ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 DUF2281 Motif Other DBs NCBI-GeneID:  107137664 NCBI-ProteinID:  XP_015335616 Ensembl:  ENSMMMG00000021724 LinkDB All DBs Position Unknown AA seq 4888 aa AA seqDB search MQGVLGILEEKKITYIEDFLHYRPFNFHDPGFQMQEDEVVLQCIASIHKEQRKFCLAAEG LGNRLCFLEPTSEAKYIPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRT LLYGHAILLRHSFSGMYLTCLTTSRSQTDKLAFDVGLQEQATGEACWWTIHPASKQRSEG EKVRIGDDLILVSVSSERYLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGH VVRLFHGHDECLTIPSTDQNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQ AFRLRHLTTGHYLALTEDQGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDMEGMG VPEIKYGDSVCFVQHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQR EESQAARIIRNTTALFSQFVSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMRHEDK QNKLRSLKNRQNLFKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYK LLAALIRGNRNNCAQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIK SIISLLDKHGRNHKVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSI RPNIFLGVAEGSAQYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGG NGVGDDLYSYGFDGLHLWSGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPV QGMFENFNTDGLFFPVMSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLE PVKEYKRDADGVRDLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGM NKIELGWTFGKIRDDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNP AAEDDLKKVKLPKNYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQG WTYGIQQDLKNKRNPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPSDQELADPA VEKVSIDKIRFFRVERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGVDDQAFV FEGSRGQRWHQGSGYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYE IENGFVPICSLGLSQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLP TFVNVPKDHPHIEVVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECYSSFSH SPCLDSEAFQKRKQMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLN KNCTVTVTLGDERGRVHESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLVDLAMGML SFSANGKELGTCYQVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNP VPQCPPRLDVQTIQPVLWSRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRC VDILELCEQEDLMQFHYHTLRLYSAVCALGNSRVAYALCSHVDLSQLFYTIDNKYLPGLL RSGFYDLLISIHLANAKERKLMMKNEYIIPITSTTRNIHLYPDESKRHGLPGVGLRTCLK PGFRFSTPCFVVTSEEHQKQSPEIPLEILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQF VPVLKLIGTLLVMGVFDDDDVRQILLLIDPSVFGEHSGESEEGAEKEEVTQVEEKAVEAG EKTSKEPPIKGLLQTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQVNQK FRYDELMQALNMSAALTARKTKEFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHED LLAHCGVPWEEEEEEDEDTTWAGKLCALVHKIRGPPKQEKEPPTEEEERCPTTLKELVSQ TMICWAQENQIQDAELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALG QIRSLLSVRMGKEEELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKS QIAFPKMVASCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAS SVMDNNELALGLEEPDLEKVVTYLAGCGLQSCPMLVAKGYPDVGWNPIEGERYLSFLRFA VFVNSESVEENASVVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQG YKRDVPDEEEEEEEIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSL VPTEDLVGIISIPLKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQIFLLH LLEVGFLPDLRASASLDTVSLSTTESALALNRYICSAVLPLLTRCAPLFAGTEHYTSLID STLQTIYRLSKGRSLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMP LKLLTNHYEQCWKYYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMAL PCLSAIAGALPPDYLDTRITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAE HSHDKWACDKSQSGWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVG WTVERTKEGEALVQQRENEKLRSVSQTSQGNSYSPAPLDLSNVVLSRELQGMVEVVAENY HNIWAKKKKLELESKGGGSHPLLVPYDTLTAKEKYRDREKAQDLFKFLQVNGIIVSRGMK DLELDASSMEKRFAYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVL LPLVDQYFTNHRLYFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDST TMVSCLHILAQTLDTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQI KGVSQNINYTTVALLPILTSIFEHVAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIY VERQRPALGECLASLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPD IPQLEGLMKEINDLAESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTK VTSEHLSLILGNILKIINNNLGIDEASWMKRIAVFAQPIISKARPDLLRSHFIPTLEKLK KKAVKTVQEEEQLKADGKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKS PDADSDQLFRMVAEVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKS GGQDQERKKTKRRGDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTD EEVKEHLRNNLHLQEKSDDPAVKWQLNLYKDVLRSEEPSNPEKTVERVQRISAAVFHLEQ VEQPLRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAYS FEEKLVQDLAKSPKVEEEEEEEMEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSM MAKSCQSGEDEEEDEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSP MVVETLKLGIAILNGGNAGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNK AEGLGMVTEEGTLIVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTT VNIIISTVDYLLRLQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGP CIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLE GNVVNGTIGKQMVDTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKE FQKAMEGQKQYTQSEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSE HMPNDSRLKCLLDPAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKE SKRQFIFDVVNEGGEQEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEEEDEDSPY MLEIEGEEEEDRSFESSSAFAMACASAKRNIANFLKKATVKNLKKQYRNVKKMTAKELVK VFFSFFWMLFMGLFQLFFTVLGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFG IHDDAVEAEKVEVTEPGIPTELVHFVKGEKGDADIMSDLFGLHPKKEGGLKHGPEVGLGD LSEIIGKDEPPTLESTVQKKKKAQAAEMKAACEAEGKVESEKADMEDGEKEDKAKEEMQA EDLWAEVTKKKKRRRGQKVEKPEALMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAF AINFILLFYKVTEEPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAV VHTIISLVCVVGYYCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINT PSFPNNYWDKFVKRKVINKYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLS SIDMKYHIWKLGVVFTDNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSS VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYV GVRAGGGIGDEIEDPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQ VREDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESY VWKMYQERCWDFFPAGDCFRKQYEDQLG NT seq 14667 nt NT seq  +upstreamnt  +downstreamnt atgcagggtgttcttggtattttggaagaaaaaaaaataacgtacattgaggacttctta cattatagaccatttaacttccacgatcccgggttccaaatgcaagaagatgaagtggta ctccagtgcatcgcaagcattcacaaggagcaaaggaaattctgcctggctgccgaggga cttgggaatcgcctctgcttcttggaacccacctcagaagccaagtatattcctccagat ctctgtgtctgcaattttgtgctggaacagtccctctctgtcagagcccttcaggaaatg cttgccaacacaggtgaaaatggcggtgaaggggcagcacaagggggtggccacaggacc ctgctctatggtcatgcaatcctcctgaggcactctttcagcggaatgtatctaacttgt ttgacgacatcaagatcccagacagataagcttgcctttgatgtaggtctacaggagcaa gccacaggagaagcctgttggtggaccatacatcctgcttccaaacaaaggtcagaggga gagaaggttcgaattggcgatgacctaatcctcgtcagtgtgtcctctgaaagatacctc catctctcgatatcaaatggtaacatacaagtggatgcctccttcatgcaaacactctgg aatgtacatcctacgtgctcaggaagtagcatcgaagaaggctacctacttggtggacac gtggtacgtcttttccatggtcatgacgagtgtctgacgataccatctacagaccagaat gattcccagcacaggagagtattctatgaagccgggggagctgggaccagagccaggtct ctgtggagagtggaaccccttcggataagctggagtggcagtaatatccgatggggccag gctttccgactccggcatctcaccacagggcactacctggctttgacggaggaccagggc cttctgctacaagaccggggaaagtcggacaccaagtccacagccttctccttccgggca tcaaaggaaatcaaggagaaattggattccagtcacaagcgagatatggaaggcatggga gttccagaaatcaagtatggggattccgtctgctttgtccagcacatagccagcggtctg tgggtcacctacaaagcacaagatgccaaaacatcccgcctgggacctctgaaaagaaag gtcatcctccatcaggaaggccacatggatgacggactaacactgcagagatgccagcgt gaggagtcccaggctgctcggatcatccggaacacgacagccttattcagccagttcgtc agtggaaacaatcgcacagctgccccggtcaccctgccaatagaagaggtcctgcagacc ctacaggacttgatagcctacttccagcccccagaggaggagatgcggcatgaagataag cagaacaaacttcgatccctcaaaaacagacagaatctttttaaggaagagggaatgttg gcccttgtgttaaactgcattgatcgcttaaatatctacaatagtgtggcacactttgct gggattgcaagggaggagagtggtatggcctggaaggaaattctgaacctcctgtacaag ttgctagctgctctcattcgtggcaacaggaacaattgtgctcagttctccaataacctt gactggctgatcagcaaattggacagactagaatcttcctcaggtatcttggaagttttg cactgcattttgattgaaagcccagaagccttaaatctgatagccgagggtcacatcaag tccatcatctccctgctggataagcacgggcggaatcacaaggttctggatgtcctgtgc tccctctgtctctgcaatggggttgcagtaagagccaaccagaatctcatctgtgacaac ttgctgcctcggagaaacctgctcctgcagacacggctaattaatgatgtgaccagtatc cggccaaacatcttcctgggagttgctgagggctcagcccaatacaagaagtggtacttt gagctaattattgaccaggtggaccccttcctaacagcagagcccacacatctgcgggtt ggctgggcctcctcctcaggctatgcgccataccctggaggtggagaaggatggggaggc aatggtgttggtgatgacctgtattcctatggttttgatggacttcatctttggtcaggc cggatacccagagccgtggcttccatcaaccagcatctgctgaagtcagatgatgtggtg agctgctgccttgaccttggagtgcccagtatctctttccgcatcaatgggcagcctgtg caggggatgtttgagaacttcaacacggacgggctcttcttccctgtgatgagcttttca gcaggtgttaaagtacgtttcctgatgggtggacgtcatggggagtttaagttcctgcct ccctcgggatatgccccttgctatgaagccttacttcccaaagagaagatgagattggag cctgtcaaagaatataaacgtgatgctgatggcgttagagatctgttgggtaccacccag ttcctctcacaagcttcttttatcccatgccctatagacaccagtcaggttgttttgcca cctcacctggagaagatccgagacagactggctgaaaacattcatgagctttgggggatg aataaaatagagctcggctggacttttggcaaaatacgggatgacaataaaagacaacat ccctgccttgtggagttttcaaagctccctgaaactgagaagaattataacctgcagatg tcaactgaaaccttaaaaaccctgctggccctggggtgccacattgctcatgttaaccca gctgctgaagatgatctgaagaaggtcaaactgcccaaaaactacatgatgtccaatggc tacaagccagcccctttggatttgtctgatgtgaagctgttgcctcctcaagaaatttta gtggacaaacttgcagaaaatgcacacaatgtttgggcaaaagacagaataaaacaagga tggacctatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtgccttat gcgttactggatgagcgcaccaagaagtccaacagggacagcctgcgagaagctgttcgg acgttcattggttatgggtataacattgagccatcagaccaagagctagctgatccagct gtggagaaagtcagcatagacaagatccgatttttccgggtggagcggtcatatgcagta aggtctggaaaatggtattttgagtttgaagtggtgaccggaggagacatgcgagtcggc tgggcaaggccaggctgtcggcctgacattgagctgggggttgatgaccaagccttcgtg tttgaaggcagcaggggccaacgttggcatcaagggagtgggtattttgggcgaacctgg cagccaggggatgtagttggttgtatgattaacctggatgatgcctccatgatctttaca ctgaacggggagctgctgatcaccaacaaaggctctgaacttgcctttgctgactacgag attgagaatggcttcgtgcccatctgctctctggggctgtctcagatcggtcgcatgaat ctcgggatggatgccagtaccttcaagttttataccatgtgtggcctccaagagggcttt gagccttttgctgtcaacatgaaccgagatgttgcaatgtggttcagcaagcgcctccca acgtttgtcaatgtaccgaaggatcatccacacatcgaggttgtgaggattgatggcacc atggatagccctccatgcctcaaggtgacccacaagacgtttggaacacagaatagtaat gccaacatgatctactgccggctgagcatgcccgttgagtgctactcctccttcagccac agcccctgtctggacagtgaagctttccagaaaaggaaacagatgcaagaaatactctct catacaacaacacagtgctactatgccattcgcatcttcgctggacaggacccgtcctgc gtctgggttggatgggtgactccagactatcacttgtacagtgaaaagtttgacctgaac aaaaactgcacagtcactgtcactctgggggatgaaagaggccgggtccatgaaagtgtg aaacgcagcaactgctacatggtctggggcggggacattgtggccagttcccaaagatca agtcggagtaacgtggacctggagattggctgcctcgtggatctggcgatgggcatgttg tccttctcagccaatgggaaagaactcggcacctgctaccaggtggagcccaataccaaa gtatttccagcagtcttcctgcagcctacaagcacttctttgtttcagtttgaacttggg aagctgaagaatgcaatgcccttgtctgcggccatatttaagagtgaagagaagaatcca gtcccacagtgtccacctcggctggatgtccaaaccatccagcctgtgctctggagtcgc atgccaaacagcttcctgaaagtagagacagagcgggtgagcgagcgccatggctgggtg gtgcagtgcctggagcccctgcagatgatggcactccacatccctgaggagaacaggtgt gtggacatcctggagctctgtgagcaggaggacctgatgcaattccattaccacacactg aggctgtacagcgccgtgtgtgccctgggaaatagccgggtagcctatgccctgtgcagc cacgtggacctctcgcagctcttctataccattgacaacaagtacctccctggcctcctt cgatccggattctatgacctgctcattagcatccacctggccaatgctaaggagaggaaa ctgatgatgaagaatgaatacatcatccccatcaccagcaccaccaggaacatccacctg tacccagatgagtccaagaggcacggactgccaggggtgggcctgcggacgtgcctcaag ccaggcttcaggttctccaccccttgtttcgtggtaaccagtgaggagcaccagaagcag agccccgagattcccctggagattctcaagacaaaggcactgagtatgctaaccgaggcg gtgcactgtagtggagcccacatccgagaccctgtggggggttctgtggagttccagttt gtgcctgtgctgaagctcattggaaccctgttggtcatgggcgtgtttgatgatgatgat gtccgtcagattctcctcctgattgatccctctgtgtttggggagcacagtggagagtca gaagagggagcagaaaaggaggaagtgacccaggtggaagagaaggcagtggaggctggg gagaagaccagcaaggagcctccaatcaaaggcctgctgcagacccgattgccagagtcc gtcaagctgcagatgtgtgagcttctcagctatctctgcgattgtgagctgcagcaccga gtagaggccatcgtggcatttggtgacatttatgtctccaagctgcaagttaatcagaag ttccgctatgatgagctcatgcaggccctgaacatgtctgctgccctgactgcccggaag accaaggagttccgctcacccccacaggagcagatcaacatgcttcttaactttcaactg ggagagaactgcccctgcccagaggagatccgggaggaactgtacgacttccatgaggac cttcttgctcactgtggagttccctgggaagaagaggaggaggaagatgaggacaccacc tgggcaggaaaactgtgtgccttggtacacaaaatcagaggtccacccaagcaagagaag gagccaccaacagaggaggaggagagatgccctacaacactgaaggagctagtctcgcag acaatgatctgctgggcccaggaaaaccagattcaggacgcagagctggtgaggatgatg ttcaacctcctccggaggcagtacgacagcattggggagctgctgcaggccctgcgaaag acatacaccatcagccaggcctccgtgagcgacaccatcaacctgctggccgccctgggc cagattcggtccctcctcagcgtcaggatgggcaaggaggaggagctgctcatgatcaat gggctgggggacataatgaataacaaggtgttttaccagcatcccaacctcatgagagtc ctgggcatgcacgagacagtgatggaggtgatggtgaatgtgctgggtacagagaaatca cagattgctttcccaaagatggttgctagctgctgccgcttcctttgctatttctgtcga attagccggcaaaatcagaaggccatgtttgagcatctaagttacctgctagagaacagc agcgtgggcctagcctccccatcgatgagggggtccaccccactggatgtagcagcctcc tccgtgatggacaacaacgagttagcactgggcttggaggaaccagacctcgagaaggtg gtgacctacttggcaggctgtggcctacagagctgccccatgcttgtggccaaaggatac cctgacgttggctggaaccccattgaaggggagcgctatctctccttcctgaggtttgcc gtcttcgtgaacagtgagagtgtggaagagaacgccagtgtggtggttaagctgctcatc agacgcccagagtgctttggcccagccctgcggggtgaaggaggaaacggcctgttggca gccatgcagggcgccatcaagatctctgagaatccggcccttgacctcccctctcaggga tacaagagagacgtcccggacgaggaggaggaggaagaagagatcgtgcatatgggcaat gcaattatgtcattttattcggctcttatagatctgctgggccgctgtgctcctgaaatg catctcatccagacaggaaaaggggaagccatccggatccggtccattctgcgctccctg gtccccacagaggacctagttgggatcatcagcatccccctgaaactgccctccctgaac aaagatgggtcagtcagtgagcctgatatggcagccaacttctgccctgaccacaaggca cccatggtgctgttcctggaccgtgtttatggcattaaggatcaaatttttctgctccac ttgctggaggttggatttttacccgacttaagagcctctgcctctctagatacagtgtcc ctcagcaccacagagtcggcgctggcactgaacaggtatatatgctccgctgtgctccca ctccttacaagatgcgcccctctctttgccgggacagagcactacacctctctgattgat tccacactgcagaccatatacaggctttccaagggacgatccctcaccaaagcacagagg gataccatagaagaatgtttgcttgccatttgcaatcacttgaggccttccatgctgcag cagctcctgcggcggctggtgtttgatgtgccacaactcaatgaatactgcaaaatgcct cttaagcttctgacgaatcactatgagcagtgctggaagtattactgtctgccttcagga tgggggagctacgggctggctgtggaggaagaactgcacctcacagagaagctcttctgg gggatttttgactccctttcccacaagaaatatgacccagatcttttccgaatggccctg ccttgtctcagtgctattgctggggccttgccaccagactatcttgataccagaatcaca gccacattggagaaacaagtttcggtggatgcagatggcaattttgatcccaaacctatc aacacaatgaatttttccttgcctgagaaattggaatacatcgtcaccaagtatgctgaa cattcacatgataaatgggcctgtgacaagagtcagagtggatggaaatatggaatttcc ctggatgaaaacgtgaagacccacccactgataaggcctttcaagacgttaacagagaag gagaaggaaatttatcgctggccagccagagagtccctgaaaaccatgctggctgtgggc tggaccgtggagaggaccaaagaaggagaagctttggttcaacaacgggaaaatgagaaa cttcgaagtgtgtcccagaccagccagggcaacagctacagccctgctcctctggacctc tcaaatgttgtgctctccagagaactccagggaatggtggaagtagtagctgagaactat cacaatatctgggccaagaagaagaaattggagctggagagcaaaggtggcggcagtcac cctcttttggtaccatatgatactttgactgccaaagaaaagtacagggaccgagagaag gcacaagacctgtttaaattcctccaagtgaatggtattatagtttctagaggtatgaag gatttggagctggatgcttcctccatggaaaagaggtttgcctacaagtttttgaagaag atcctcaagtatgttgattctgctcaagagtttattgcccacttagaagccattgtcagc agtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaagttctt ctgccactggttgaccagtacttcacaaatcaccgcctctacttcctatcctctcctcta aagccccttagcagcagtgggtatgcctcccataaggagaaagaaatggtggccagccta ttctgcaaacttgctgctcttgttagacacaggatttccctctttgggagtgattctacc acaatggtgagctgtcttcacatcttagctcagacacttgacacaaggactgtcatgaag tcaggctcagagctggtgaaggctgggttgcgagcattctttgaaaatgctgcggaagac ctagagaagacttcggaaaacctgaagctcgggaagtttacccattccagaacacagatc aaaggcgtttctcagaacatcaactacaccaccgtggctctgctccccatcctgacatcc atctttgagcatgttgcccagcaccagtttggggtggatctgctcttgagtgacgtgcag atttcatgctaccacatactgtgcagcctctactccctcgggacaggaaaaaacatctat gttgaaaggcaacgtcctgcccttggagaatgtctggcttcactggcagctgccattcca gtggcattcctggagcccaccctcaaccgttataatcctctctcagtcttcaacaccaaa acccccagggagagatctattctggggatgccagacactgtggaagagatgtgtcctgac atcccccagctggaaggcctgatgaaggaaatcaatgacctggctgaatcaggggcccgg tacacagagatgccccatgtcatcgaggtgatcttgcccatgctgtgcaactacctgtcc tattggtgggagcgggggcctgagaacctgccccccagcacagggccttgctgcaccaag gtgacctctgaacacctcagtctcatcctgggcaacatcctaaaaatcatcaacaataac ctggggatcgacgaggcctcctggatgaagcgcattgcagtgttcgcccagccgatcatc agcaaagctaggcctgacctgctgagaagccacttcatcccaactctggagaagttaaag aagaaggcggtcaagacggtacaagaggaggagcagctgaaagctgatggcaaaggggac acacaggaggcagagctgctcatcctggacgagtttgcagttctctgcagagatctctat gccttctaccccatgctcatccgctatgtggacaacaacagatctaactggctcaaaagc cccgatgcagattctgaccagctcttccgcatggtggcagaggtcttcatcctgtggtgt aaatctcacaacttcaagagggaagagcaaaattttgtgattcagaatgaaattaataat ttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagtaaagtct ggaggacaggaccaggaacggaagaagacaaagaggaggggagacttgtactccatccag acatccctcatcgtggccgcgctgaagaaaatgctgcccattggtttgaatatgtgcaca ccaggcgaccaggagctgatctctctggcaaaatcacgctacagctgtagggacacggat gaagaggttaaggaacatctgcggaataacttgcacttgcaggaaaagtctgatgaccca gctgtaaaatggcaactgaacctctacaaggatgttctgaggagtgaagaaccttcaaat ccagaaaagacagtggaacgtgtacagagaatttcagcagctgtcttccacctggagcag gtggaacaacctttaaggtccaagaaggctgtctggcacaaactgttgtcaaagcagcgg aaacgggcagttgtggcctgtttcaggatggctcctctctacaacctacccaggcaccgc tctattaacctcttcctccatggctatcagagattttggatagaaacagaggcgtattcc tttgaagagaaactagtacaggatttggctaagtctcccaaggtggaagaggaggaggag gaagaaatggaaaagcaaccagacccacttcatcagatcattctccattttagccgcaat gctctcacagagaggagcaaattggaagatgatcctttgtacacctcctattccagcatg atggccaagagctgtcagagtggtgaggatgaagaagaggatgaagacaaggaaaaaaca tttgaggagaaagagatggagaagcagaaaaccctctatcagcaagctcgactgcatgag cgaggtgctgcagaaatggtgcttcagatgataagcgccagcaaaggtgagatgagcccc atggtggtcgagactctgaagctggggattgccattctgaatggaggcaacgctggtgta caacagaaaatgctagattacttaaaggagaaaaaagatgctggattcttccaaagcctt tctggtcttatgcaatcgtgcagtgtccttgatttgaatgcctttgaaaggcagaataaa gcggaaggcctggggatggttactgaagagggaacactcattgttcgtgagcgtggtgaa aaggtgctccagaatgatgagttcacccgagatctcttcagattcctgcagttactgtgt gaaggacataacagtgactttcagaacttcctgaggactcagatgggcaacaccaccact gtgaacatcattatcagcactgtggactaccttctccgcctgcaggaatcaatcagtgat ttctactggtactattcagggaaggatatcattgatgaatctggacagcacaatttttct aaagctctggcagtcaccaagcaaattttcaattctcttactgagtatattcagggcccc tgcatcgggaaccagcagagcctggctcacagccggctgtgggacgcagtggttggcttc ctccatgtgtttgctaacatgcagatgaaactctctcaggattccagtcagatcgagctg ctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctcctggaa gggaatgtggtaaatggaactattggcaagcagatggttgacacactggtagaatcatct actaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagacttaacc agctcagacaccttcaaagaatatgacccagatggtaaagggattatctccaaaaaagaa ttccagaaggccatggaagggcaaaagcaatatacacagtcagagattgactttctcctt tcatgtgcagaagctgacgagaatgacatgtttaactacattgattttgtagaccggttc catgagccagccaaagacatagggtttaatgtggctgtgttattgacaaatctttctgag cacatgccaaatgattctcgcctgaagtgtctgttggacccggcagaaagtgtgctaaat tactttgagccatacctaggacgaattgagatcatgggtggggccaagaaaattgagcgt gtttactttgaaatcagcgaatccagtcgaactcagtgggagaagcctcaggtgaaggaa tctaagcgacagttcatttttgatgttgtgaatgaaggtggggagcaagaaaagatggag ttgtttgtgaacttctgtgaggataccatctttgaaatgcagttagcatctcagatctct gaatccgattcagctgacaggccagaagaggaggaggaagaagatgaagattctccttat atgttagaaattgagggtgaggaggaggaggacaggtcttttgagtcttcctctgcgttt gccatggcctgtgcctcagcaaagagaaatattgccaacttcctgaagaaggcaaccgtg aagaacctcaagaagcagtacagaaatgtgaaaaagatgactgccaaggaactggtgaag gtgttcttctcttttttctggatgttgttcatgggattgttccaactgttcttcaccgta ttgggaggaatcttccagatcctctggaacacagtatttggagggggcctagtagaaggg gcaaagaacatcagagtgaccaagatcttgggtgacatgccagacccaactcagtttggt atccatgatgatgctgtggaggctgagaaggtggaagtaactgagcctggtatcccaacc gaactagtacactttgtcaagggcgagaagggagatgcagacatcatgtcagacctcttt ggattgcacccaaagaaagaaggtggcttaaagcatgggcctgaagtaggtttgggggac ctgtccgaaattattggcaaagatgaacccccaacgttagagagtactgtacagaagaaa aagaaagcacaggcagcagagatgaaggcagcatgtgaagcagaaggaaaagtagaatca gagaaggcagatatggaagacggagaaaaggaggacaaagccaaagaggagatgcaagcc gaggacctgtgggctgaagtgacaaagaagaagaagcgacgacgtggtcagaaggttgag aagcccgaagccctaatggccaacttctttaaagggctagaaatctaccagaccaagtta ttgcactacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttc gctatcaacttcatcctgcttttttataaggtcactgaagaaccattagaggaagaaacc gaggatgtggcaaacctgtggaattcctttaatgatgaggaagaggaagaagcgatggtg ttctttgtcctgcaggaaagcactgggtatatggcaccaacactgcgggcccttgctgtt gtccacaccatcatctctctagtctgtgtggtgggctattactgcctgaaggtccctttg gtggtattcaaaagggaaaaagaaattgccagaaagctggagtttgatggtttgtatatc actgaacaaccatctgaagatgacatcaaggggcagtgggaccgcttggtaatcaacaca ccatcttttcctaataactactgggacaagtttgtgaagagaaaggtgatcaacaagtat ggagatctctatggggcagagcgcatcgctgaactcctgggtttggacaaaaatgccctt gactttagcccagtggaagagaccaaagcagaggcggcttctctggtatcctggctgagt tccatcgacatgaagtaccatatctggaaactgggggttgtttttactgacaattccttt ctctaccttgcctggtacaccaccatgtcagtcctgggtcactacaacaacttcttcttt gctgctcatctattggatattgcaatgggcttcaagaccttgaggactattctgtcatct gtaacccacaatggcaaacagttggttctgactgttggtctcctggccgtggtggtttac ctctataccgtggtggctttcaacttcttccgcaagttctacaacaaaagtgaagatgac gatgagcctgacatgaagtgtgatgacatgatgacgtgctaccttttccacatgtatgtg ggagtgagagcagggggcggcattggtgatgaaattgaagaccctgctggtgatccttat gaaatgtaccgcattgtctttgacattacctttttcttcttcgtcattgtcatcttgctg gccatcattcaaggtcttattattgatgcttttggagaactcagagaccagcaggaacaa gtacgagaagatatggagactaaatgtttcatctgtggcattggcaatgactactttgac acaactcctcatggttttgagacacacacattacaagagcacaacttagccaactacttg ttctttctgatgtatttgattaacaaagatgaaacagagcacacgggtcaggaatcttat gtatggaagatgtaccaagaaaggtgctgggatttcttccccgctggcgactgttttcgg aagcaatatgaagatcagctgggataa

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