KEGG   PATHWAY: mmt00540Help
Entry
mmt00540                    Pathway                                

Name
Lipopolysaccharide biosynthesis - Methylomonas methanica
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
mmt00540  Lipopolysaccharide biosynthesis
mmt00540

Ortholog table
Module
mmt_M00063  CMP-KDO biosynthesis [PATH:mmt00540]
mmt_M00064  ADP-L-glycero-D-manno-heptose biosynthesis [PATH:mmt00540]
Other DBs
BSID: 218975
GO: 0009103
Organism
Methylomonas methanica [GN:mmt]
Gene
Metme_2639  Acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
Metme_3961  acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase [KO:K00677] [EC:2.3.1.129]
Metme_0252  UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase [KO:K02535] [EC:3.5.1.108]
Metme_2562  UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase [KO:K02536] [EC:2.3.1.191]
Metme_3952  UDP-2,3-diacylglucosamine hydrolase [KO:K03269] [EC:3.6.1.54]
Metme_3005  Lipid-A-disaccharide synthase [KO:K00748] [EC:2.4.1.182]
Metme_2668  Tetraacyldisaccharide 4'-kinase [KO:K00912] [EC:2.7.1.130]
Metme_0702  KpsF/GutQ family protein [KO:K06041] [EC:5.3.1.13]
Metme_3408  2-dehydro-3-deoxyphosphooctonate aldolase [KO:K01627] [EC:2.5.1.55]
Metme_0703  3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family [KO:K03270] [EC:3.1.3.45]
Metme_2666  3-deoxy-manno-octulosonate cytidylyltransferase [KO:K00979] [EC:2.7.7.38]
Metme_3721  Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein [KO:K02527] [EC:2.4.99.15 2.4.99.14 2.4.99.13 2.4.99.12]
Metme_4556  Phosphoheptose isomerase [KO:K03271] [EC:5.3.1.28]
Metme_0214  Bifunctional protein hldE [KO:K03272] [EC:2.7.7.70 2.7.1.167]
Metme_4538  histidinol-phosphate phosphatase family protein [KO:K03273] [EC:3.1.3.83 3.1.3.82]
Metme_1549  ADP-L-glycero-D-manno-heptose-6-epimerase [KO:K03274] [EC:5.1.3.20]
Metme_2567  lipopolysaccharide heptosyltransferase I [KO:K02841] [EC:2.4.-.-]
Metme_2568  lipopolysaccharide heptosyltransferase II [KO:K02843] [EC:2.4.-.-]
Metme_4048  glycosyl transferase family 9 [KO:K02849] [EC:2.4.-.-]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00199  D-Ribulose 5-phosphate
C00229  Acyl-carrier protein
C01112  D-Arabinose 5-phosphate
C01187  3-Deoxy-D-manno-octulosonate
C04121  CMP-3-deoxy-D-manno-octulosonate
C04478  3-Deoxy-D-manno-octulosonate 8-phosphate
C04652  UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine
C04738  UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine
C04824  Lipid X
C04919  2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
C04932  Lipid A disaccharide
C05223  Dodecanoyl-[acyl-carrier protein]
C05382  Sedoheptulose 7-phosphate
C05761  Tetradecanoyl-[acp]
C06022  UDP-3-O-(3-hydroxytetradecanoyl)-D-glucosamine
C06024  3-Deoxy-D-manno-octulosonyl-lipid IV(A)
C06025  KDO2-lipid IVA
C06026  KDO2-lipid A
C06251  Lauroyl-KDO2-lipid IV(A)
C06397  ADP-D-glycero-beta-D-manno-heptose
C06398  ADP-L-glycero-beta-D-manno-heptose
C07836  D-glycero-beta-D-manno-Heptose 7-phosphate
C07838  D-glycero-beta-D-manno-Heptose 1-phosphate
C11472  D-glycero-beta-D-manno-Heptose 1,7-bisphosphate
C19877  4-O-Phospho-alpha-Kdo-(2->6)-lipid IVA
C19878  D-glycero-alpha-D-manno-Heptose 7-phosphate
C19879  D-glycero-alpha-D-manno-Heptose 1,7-bisphosphate
C19880  D-glycero-alpha-D-manno-Heptose 1-phosphate
C19881  GDP-D-glycero-alpha-D-manno-heptose
Reference
PMID:9791168
  Authors
Heinrichs DE, Yethon JA, Whitfield C.
  Title
Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica.
  Journal
Mol Microbiol 30:221-32 (1998)
DOI:10.1046/j.1365-2958.1998.01063.x
Reference
  Authors
Kneidinger B, Marolda C, Graninger M, Zamyatina A, McArthur F, Kosma P, Valvano MA, Messner P.
  Title
Biosynthesis pathway of ADP-L-glycero-beta-D-manno-heptose in Escherichia coli.
  Journal
J Bacteriol 184:363-9 (2002)
DOI:10.1128/JB.184.2.363-369.2002
Reference
PMID:9587193
  Authors
Wyckoff TJ, Raetz CR, Jackman JE.
  Title
Antibacterial and anti-inflammatory agents that target endotoxin.
  Journal
Trends Microbiol 6:154-9 (1998)
DOI:10.1016/S0966-842X(98)01230-X
Reference
PMID:9765561
  Authors
Shibayama K, Ohsuka S, Tanaka T, Arakawa Y, Ohta M.
  Title
Conserved structural regions involved in the catalytic mechanism of Escherichia coli K-12 WaaO (RfaI).
  Journal
J Bacteriol 180:5313-8 (1998)
Reference
  Authors
Raetz CR, Whitfield C
  Title
Lipopolysaccharide endotoxins.
  Journal
Annu Rev Biochem 71:635-700 (2002)
DOI:10.1146/annurev.biochem.71.110601.135414
Reference
  Authors
Rubin EJ, O'Brien JP, Ivanov PL, Brodbelt JS, Trent MS
  Title
Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity.
  Journal
Mol Microbiol 91:887-99 (2014)
DOI:10.1111/mmi.12501
Reference
  Authors
Stead CM, Zhao J, Raetz CR, Trent MS
  Title
Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface.
  Journal
Mol Microbiol 78:837-52 (2010)
DOI:10.1111/j.1365-2958.2010.07304.x
KO pathway
ko00540   
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