Mus musculus (house mouse): 12675
Help
Entry
12675 CDS
T01002
Symbol
Chuk, Chuk1, Fbx24, Fbxo24, IKBKA, IKK_alpha, IKK1, Ikka, NFKBIKA
Name
(RefSeq) conserved helix-loop-helix ubiquitous kinase
KO
K04467
inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:
2.7.11.10
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01523
Antifolate resistance
mmu04010
MAPK signaling pathway
mmu04014
Ras signaling pathway
mmu04062
Chemokine signaling pathway
mmu04064
NF-kappa B signaling pathway
mmu04068
FoxO signaling pathway
mmu04150
mTOR signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04380
Osteoclast differentiation
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04623
Cytosolic DNA-sensing pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04668
TNF signaling pathway
mmu04920
Adipocytokine signaling pathway
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05171
Coronavirus disease - COVID-19
mmu05200
Pathways in cancer
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05212
Pancreatic cancer
mmu05215
Prostate cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05222
Small cell lung cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
12675 (Chuk)
04014 Ras signaling pathway
12675 (Chuk)
04064 NF-kappa B signaling pathway
12675 (Chuk)
04668 TNF signaling pathway
12675 (Chuk)
04068 FoxO signaling pathway
12675 (Chuk)
04151 PI3K-Akt signaling pathway
12675 (Chuk)
04150 mTOR signaling pathway
12675 (Chuk)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
12675 (Chuk)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
12675 (Chuk)
04621 NOD-like receptor signaling pathway
12675 (Chuk)
04622 RIG-I-like receptor signaling pathway
12675 (Chuk)
04623 Cytosolic DNA-sensing pathway
12675 (Chuk)
04625 C-type lectin receptor signaling pathway
12675 (Chuk)
04660 T cell receptor signaling pathway
12675 (Chuk)
04658 Th1 and Th2 cell differentiation
12675 (Chuk)
04659 Th17 cell differentiation
12675 (Chuk)
04657 IL-17 signaling pathway
12675 (Chuk)
04662 B cell receptor signaling pathway
12675 (Chuk)
04062 Chemokine signaling pathway
12675 (Chuk)
09152 Endocrine system
04920 Adipocytokine signaling pathway
12675 (Chuk)
09158 Development and regeneration
04380 Osteoclast differentiation
12675 (Chuk)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
12675 (Chuk)
05208 Chemical carcinogenesis - reactive oxygen species
12675 (Chuk)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
12675 (Chuk)
09162 Cancer: specific types
05212 Pancreatic cancer
12675 (Chuk)
05221 Acute myeloid leukemia
12675 (Chuk)
05220 Chronic myeloid leukemia
12675 (Chuk)
05215 Prostate cancer
12675 (Chuk)
05222 Small cell lung cancer
12675 (Chuk)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
12675 (Chuk)
05170 Human immunodeficiency virus 1 infection
12675 (Chuk)
05161 Hepatitis B
12675 (Chuk)
05160 Hepatitis C
12675 (Chuk)
05171 Coronavirus disease - COVID-19
12675 (Chuk)
05164 Influenza A
12675 (Chuk)
05162 Measles
12675 (Chuk)
05168 Herpes simplex virus 1 infection
12675 (Chuk)
05163 Human cytomegalovirus infection
12675 (Chuk)
05167 Kaposi sarcoma-associated herpesvirus infection
12675 (Chuk)
05169 Epstein-Barr virus infection
12675 (Chuk)
05165 Human papillomavirus infection
12675 (Chuk)
09171 Infectious disease: bacterial
05132 Salmonella infection
12675 (Chuk)
05135 Yersinia infection
12675 (Chuk)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
12675 (Chuk)
05142 Chagas disease
12675 (Chuk)
09164 Neurodegenerative disease
05010 Alzheimer disease
12675 (Chuk)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
12675 (Chuk)
05418 Fluid shear stress and atherosclerosis
12675 (Chuk)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
12675 (Chuk)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
12675 (Chuk)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
12675 (Chuk)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
12675 (Chuk)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: Other
IKK family [OT]
12675 (Chuk)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
Pkinase_fungal
Kdo
TBK1_ULD
YrbL-PhoP_reg
Motif
Other DBs
NCBI-GeneID:
12675
NCBI-ProteinID:
NP_001155882
MGI:
99484
Ensembl:
ENSMUSG00000025199
UniProt:
E9Q605
Q8CBT3
Q3TPN9
LinkDB
All DBs
Position
19:complement(44061773..44095940)
Genome browser
AA seq
719 aa
AA seq
DB search
MERPPGLRPGAGGPWEMRERLGTGGFGNVSLYQHRELDLKIAIKSCRLELSSKNRERWCH
EIQIMKKLDHANVVKACDVPEELNFLINDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQ
ILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKTIHKIIDLGYAKDVDQGSLCTS
FVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPK
CIFACEEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLNWDPQQRGGPIDLTLKQPRC
FALMDHILNLKIVHILNMTSAKIISFLLPCDESLHSLQSRIERETGINTGSQELLSETGI
SLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPI
IQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKL
EFFRKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYSEVGVIGYLEDQIMSLHTE
IMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPPDHLYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQ
SSARSLVGYSLEGTVTPPVSAWLPPTLADREHPLTCVRDVSTNDRRKSELSWPFKYYYS
NT seq
2160 nt
NT seq
+upstream
nt +downstream
nt
atggagcggcccccggggctgcggccgggcgcgggcggcccctgggagatgcgggaacgg
cttggcaccggcggtttcgggaacgtcagtctgtaccagcaccgggaacttgatctcaaa
atagcaattaagtcttgtcgtttagagctaagttccaaaaacagagagcgatggtgccat
gaaatccagatcatgaaaaagttggaccatgcgaatgttgtaaaggcctgtgatgtccct
gaggaattgaactttttaattaacgatgtgcctcttctggcaatggagtactgttctgga
ggggacctccggaagctactcaacaaaccagaaaattgttgtggacttaaagaaagccag
atactttctttactgagtgacataggatctgggatccgatatctgcatgaaaacaaaatt
atacatcgagatctaaaacctgaaaatatagttcttcaagatgttggtgggaagacaata
cataaaataattgatttgggttatgccaaagatgttgatcaaggaagtctctgtacatct
tttgtgggaacattgcagtatttggccccagagctctttgaaaataagccgtacacagcc
actgtggattattggagctttgggaccatggtgtttgaatgtattgctggatataggcct
tttttgcatcatctgcagccatttacctggcatgagaagattaagaagaaagatccaaag
tgtatatttgcatgtgaagagatgactggagaagttcggtttagtagccatttacctcag
ccaaacagcctttgtagtttaatagtagagccaatggaaagctggctccaattgatgctg
aattgggacccacagcagagagggggacctattgatcttactttgaagcagccaagatgt
tttgcattaatggatcacattctcaatttaaagatagtgcacatcctaaatatgacttct
gcaaaaatcatttcttttctgttaccatgtgatgaaagtcttcattcactacagtctcga
attgagcgtgaaacaggaataaatacaggttctcaggagcttctgtcagagacagggatt
tctctggatcctcggaaaccagcctctcagtgtgttctagatggagttagaggctgtgat
agctacatggtttatttgtttgataaaagtaagactgtatatgaaggaccatttgcatcc
agaagtttatctgattgtgtaaattatattgtacaagacagcaaaatacaactgccaatt
atacagctgcggaaagtatgggctgaagcagtgcactacgtatctgggctaaaggaagac
tacagcaggctcttccagggacaaagagcagcaatgttaagtcttcttagatataatgct
aacttgacaaaaatgaagaatactttgatctcagcatcacagcaactcaaagctaaattg
gagttttttcgaaaaagcattcagcttgacttggagagatatagtgagcagatgacttat
gggatatcttcagaaaaaatgttaaaagcatggaaagaaatggaagaaaaggccattcac
tattctgaggttggtgtcattggttatcttgaggatcaaattatgtctttgcacactgaa
atcatggagctgcagaagagcccctatggacgacgccagggagacttgatggagtctctg
gagcagcgtgccattgatctctataagcagctaaagcacagacctcctgatcacttgtac
agcgacagcacagagatggtgaagatcatcgtgcacaccgtgcagagtcaggaccgtgtt
ctcaaggagctgtttggtcacctgagcaagttgttgggctgcaagcagaagattattgat
ctactccccaaggtggaagtggccctcagtaacatcaaagaagctgacaatactgtcatg
tttatgcagggaaagaggcagaaagaaatttggcacctccttaaaattgcctgtacacag
agttctgcccgctctcttgtaggatacagtctagaaggcacagtaacccctccagtatca
gcatggctgccccctacattagcagaccgtgaacatcctctgacatgtgtgagagacgtt
agcacaaatgatagaagaaaatctgaactgtcttggccatttaagtactattattcgtga
Mus musculus (house mouse): 16150
Help
Entry
16150 CDS
T01002
Symbol
Ikbkb, IKK-2, IKK-beta, IKK2, IKK[b], IKKbeta
Name
(RefSeq) inhibitor of kappaB kinase beta
KO
K07209
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:
2.7.11.10
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01523
Antifolate resistance
mmu04010
MAPK signaling pathway
mmu04014
Ras signaling pathway
mmu04062
Chemokine signaling pathway
mmu04064
NF-kappa B signaling pathway
mmu04068
FoxO signaling pathway
mmu04150
mTOR signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04380
Osteoclast differentiation
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04623
Cytosolic DNA-sensing pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04668
TNF signaling pathway
mmu04722
Neurotrophin signaling pathway
mmu04910
Insulin signaling pathway
mmu04920
Adipocytokine signaling pathway
mmu04930
Type II diabetes mellitus
mmu04931
Insulin resistance
mmu04932
Non-alcoholic fatty liver disease
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05171
Coronavirus disease - COVID-19
mmu05200
Pathways in cancer
mmu05206
MicroRNAs in cancer
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05212
Pancreatic cancer
mmu05215
Prostate cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05222
Small cell lung cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
16150 (Ikbkb)
04014 Ras signaling pathway
16150 (Ikbkb)
04064 NF-kappa B signaling pathway
16150 (Ikbkb)
04668 TNF signaling pathway
16150 (Ikbkb)
04068 FoxO signaling pathway
16150 (Ikbkb)
04151 PI3K-Akt signaling pathway
16150 (Ikbkb)
04150 mTOR signaling pathway
16150 (Ikbkb)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
16150 (Ikbkb)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
16150 (Ikbkb)
04621 NOD-like receptor signaling pathway
16150 (Ikbkb)
04622 RIG-I-like receptor signaling pathway
16150 (Ikbkb)
04623 Cytosolic DNA-sensing pathway
16150 (Ikbkb)
04625 C-type lectin receptor signaling pathway
16150 (Ikbkb)
04660 T cell receptor signaling pathway
16150 (Ikbkb)
04658 Th1 and Th2 cell differentiation
16150 (Ikbkb)
04659 Th17 cell differentiation
16150 (Ikbkb)
04657 IL-17 signaling pathway
16150 (Ikbkb)
04662 B cell receptor signaling pathway
16150 (Ikbkb)
04062 Chemokine signaling pathway
16150 (Ikbkb)
09152 Endocrine system
04910 Insulin signaling pathway
16150 (Ikbkb)
04920 Adipocytokine signaling pathway
16150 (Ikbkb)
09156 Nervous system
04722 Neurotrophin signaling pathway
16150 (Ikbkb)
09158 Development and regeneration
04380 Osteoclast differentiation
16150 (Ikbkb)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
16150 (Ikbkb)
05206 MicroRNAs in cancer
16150 (Ikbkb)
05208 Chemical carcinogenesis - reactive oxygen species
16150 (Ikbkb)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
16150 (Ikbkb)
09162 Cancer: specific types
05212 Pancreatic cancer
16150 (Ikbkb)
05221 Acute myeloid leukemia
16150 (Ikbkb)
05220 Chronic myeloid leukemia
16150 (Ikbkb)
05215 Prostate cancer
16150 (Ikbkb)
05222 Small cell lung cancer
16150 (Ikbkb)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
16150 (Ikbkb)
05170 Human immunodeficiency virus 1 infection
16150 (Ikbkb)
05161 Hepatitis B
16150 (Ikbkb)
05160 Hepatitis C
16150 (Ikbkb)
05171 Coronavirus disease - COVID-19
16150 (Ikbkb)
05164 Influenza A
16150 (Ikbkb)
05162 Measles
16150 (Ikbkb)
05168 Herpes simplex virus 1 infection
16150 (Ikbkb)
05163 Human cytomegalovirus infection
16150 (Ikbkb)
05167 Kaposi sarcoma-associated herpesvirus infection
16150 (Ikbkb)
05169 Epstein-Barr virus infection
16150 (Ikbkb)
05165 Human papillomavirus infection
16150 (Ikbkb)
09171 Infectious disease: bacterial
05132 Salmonella infection
16150 (Ikbkb)
05135 Yersinia infection
16150 (Ikbkb)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
16150 (Ikbkb)
05142 Chagas disease
16150 (Ikbkb)
09164 Neurodegenerative disease
05010 Alzheimer disease
16150 (Ikbkb)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
16150 (Ikbkb)
05418 Fluid shear stress and atherosclerosis
16150 (Ikbkb)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
16150 (Ikbkb)
04936 Alcoholic liver disease
16150 (Ikbkb)
04932 Non-alcoholic fatty liver disease
16150 (Ikbkb)
04931 Insulin resistance
16150 (Ikbkb)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
16150 (Ikbkb)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
16150 (Ikbkb)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.10 IkappaB kinase
16150 (Ikbkb)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: Other
IKK family [OT]
16150 (Ikbkb)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
IKBKB_SDD
Pkinase
PK_Tyr_Ser-Thr
IKKbetaNEMObind
Pkinase_fungal
Kdo
ubiquitin
YrbL-PhoP_reg
APH
Glyco_hydro_65m
TBK1_ULD
Motif
Other DBs
NCBI-GeneID:
16150
NCBI-ProteinID:
NP_034676
MGI:
1338071
Ensembl:
ENSMUSG00000031537
UniProt:
O88351
Q5D0E0
A0A0R4J0T4
LinkDB
All DBs
Position
8:complement(23149221..23196605)
Genome browser
AA seq
738 aa
AA seq
DB search
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQATGEQIAIKQCRQELSPKNRDRWCL
EIQIMRRLNHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRRYLNQFENCCGLREG
AVLTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEKRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
VDIVVSEDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPQYGPNGCF
RALDDILNLKLVHVLNMVTGTVHTYPVTEDESLQSLKTRIQEDTGILETDQELLQEAGLV
LLPDKPATQCISDSKTNEGLTLDMDLVFLFDNSKINYETQITPRPQPESVSCILQEPKRN
LSFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMSLLRNNSCLSKMKNAMASTAQQLK
AKLDFFKTSIQIDLEKYKEQTEFGITSDKLLLAWREMEQAVEQCGRENDVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDERTVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNVSRLSHPGQLMSQPSSACDSLPESDKKSEELVAEAHALCSRLE
SALQDTVKEQDRSFTVTA
NT seq
2217 nt
NT seq
+upstream
nt +downstream
nt
atgagctggtcaccgtccctcccaacccagacatgtggagcctgggaaatgaaagaacgc
ctggggaccgggggatttggaaacgtcatccggtggcacaatcaggcgacaggtgaacag
atcgccatcaagcaatgccgacaggagctcagcccaaagaacagagaccgctggtgcctc
gaaatccagatcatgagaaggctgaaccatcccaatgtggtggctgcccgggatgtccca
gaggggatgcagaacctggcacccaatgatttgccactgctggccatggagtactgccaa
ggaggagatctccgaagatacttgaaccagttcgagaactgctgtggcctgcgggaagga
gctgtccttaccctgctgagtgacatcgcatcggctcttagataccttcacgaaaacaga
atcatccatcgagacctgaagccagaaaacatcgttctgcagcaaggagagaaaagatta
atacacaaaattattgatctaggatatgccaaggagctggatcagggcagtctgtgcacg
tcatttgtggggactctgcaatacctggcgccagagcttctggagcagcagaagtacacc
gtgaccgttgactactggagcttcggcaccctggccttcgagtgcatcactggcttccgg
cccttcctccctaactggcagcctgtgcagtggcactccaaagtccggcagaagagcgaa
gtggacatcgttgttagtgaagacttgaatggagcagtgaagttttcaagttcgctaccc
ttccccaataatcttaacagtgtcttggctgaacggctggagaagtggctgcagctgatg
cttatgtggcaccctcggcaaaggggcacggatccccagtatggccccaacggctgcttc
agagccctggatgacatcttgaacttgaagctggttcatgtcttgaacatggtcacaggc
accgttcacacataccccgtgacggaggatgagagtctgcagagcttaaaaaccagaatc
caggaagacacggggatcctggagacagaccaggagctgctgcaagaggcagggctggtg
ctgctccctgacaagcctgctactcagtgcatctcagacagcaagacaaacgagggcctc
acgttggacatggatcttgtttttctctttgacaacagtaaaatcaactatgagactcag
atcaccccccgaccccaaccggaaagtgtcagctgtatccttcaggagcccaagcggaac
ctctccttcttccagctgaggaaagtgtggggccaagtctggcacagcatccagacgctg
aaggaagactgtaaccggctgcagcagggacagcgagcagccatgatgagtctcctccgg
aataacagctgcctctctaagatgaagaacgccatggcctccacggcccagcagctcaag
gccaagctggacttcttcaaaaccagcatccagatcgacctggagaagtataaagagcag
accgagtttgggatcacctcagataaattgctgctggcttggcgggagatggagcaggct
gtggagcagtgtgggcgggagaatgacgtgaagcatctagtagagcggatgatggcactg
cagactgacattgtggacctgcagaggagcccgatgggtcggaagcaggggggcaccctg
gatgacctagaggaacaagcgagggagctctaccgaagactcagggagaagccaagagac
caaaggacagaaggtgacagccaggagatggtacggctgctgcttcaggcaatccaaagc
tttgagaagaaagttcgggtgatttatacacagctcagtaagaccgtggtttgtaagcag
aaggcactggagttgctgcccaaggtagaagaggtagtgagccttatgaacgaggacgag
aggaccgtggtccggcttcaggagaagcggcagaaggaactctggaacctcctgaagatc
gcctgtagcaaagtccgaggtcccgtgagtggaagcccagacagcatgaatgtgtctcga
ctcagtcaccctggtcagctaatgtcccagccttccagtgcctgtgacagcttacctgaa
tcagacaagaaaagtgaagaactggtggccgaagcccacgccctctgctcccggctagaa
agtgcgctgcaggacactgtgaaggagcaagacagaagcttcacggtaaccgcctga
Mus musculus (house mouse): 16151
Help
Entry
16151 CDS
T01002
Symbol
Ikbkg, 1110037D23Rik, IKK[g], NEMO
Name
(RefSeq) inhibitor of kappaB kinase gamma
KO
K07210
inhibitor of nuclear factor kappa-B kinase subunit gamma
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu01523
Antifolate resistance
mmu04010
MAPK signaling pathway
mmu04014
Ras signaling pathway
mmu04062
Chemokine signaling pathway
mmu04064
NF-kappa B signaling pathway
mmu04151
PI3K-Akt signaling pathway
mmu04210
Apoptosis
mmu04380
Osteoclast differentiation
mmu04620
Toll-like receptor signaling pathway
mmu04621
NOD-like receptor signaling pathway
mmu04622
RIG-I-like receptor signaling pathway
mmu04623
Cytosolic DNA-sensing pathway
mmu04625
C-type lectin receptor signaling pathway
mmu04657
IL-17 signaling pathway
mmu04658
Th1 and Th2 cell differentiation
mmu04659
Th17 cell differentiation
mmu04660
T cell receptor signaling pathway
mmu04662
B cell receptor signaling pathway
mmu04668
TNF signaling pathway
mmu04920
Adipocytokine signaling pathway
mmu04936
Alcoholic liver disease
mmu05010
Alzheimer disease
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05145
Toxoplasmosis
mmu05160
Hepatitis C
mmu05161
Hepatitis B
mmu05162
Measles
mmu05163
Human cytomegalovirus infection
mmu05164
Influenza A
mmu05165
Human papillomavirus infection
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05168
Herpes simplex virus 1 infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05171
Coronavirus disease - COVID-19
mmu05200
Pathways in cancer
mmu05203
Viral carcinogenesis
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05212
Pancreatic cancer
mmu05215
Prostate cancer
mmu05220
Chronic myeloid leukemia
mmu05221
Acute myeloid leukemia
mmu05222
Small cell lung cancer
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05340
Primary immunodeficiency
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
16151 (Ikbkg)
04014 Ras signaling pathway
16151 (Ikbkg)
04064 NF-kappa B signaling pathway
16151 (Ikbkg)
04668 TNF signaling pathway
16151 (Ikbkg)
04151 PI3K-Akt signaling pathway
16151 (Ikbkg)
09140 Cellular Processes
09143 Cell growth and death
04210 Apoptosis
16151 (Ikbkg)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
16151 (Ikbkg)
04621 NOD-like receptor signaling pathway
16151 (Ikbkg)
04622 RIG-I-like receptor signaling pathway
16151 (Ikbkg)
04623 Cytosolic DNA-sensing pathway
16151 (Ikbkg)
04625 C-type lectin receptor signaling pathway
16151 (Ikbkg)
04660 T cell receptor signaling pathway
16151 (Ikbkg)
04658 Th1 and Th2 cell differentiation
16151 (Ikbkg)
04659 Th17 cell differentiation
16151 (Ikbkg)
04657 IL-17 signaling pathway
16151 (Ikbkg)
04662 B cell receptor signaling pathway
16151 (Ikbkg)
04062 Chemokine signaling pathway
16151 (Ikbkg)
09152 Endocrine system
04920 Adipocytokine signaling pathway
16151 (Ikbkg)
09158 Development and regeneration
04380 Osteoclast differentiation
16151 (Ikbkg)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
16151 (Ikbkg)
05208 Chemical carcinogenesis - reactive oxygen species
16151 (Ikbkg)
05203 Viral carcinogenesis
16151 (Ikbkg)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
16151 (Ikbkg)
09162 Cancer: specific types
05212 Pancreatic cancer
16151 (Ikbkg)
05221 Acute myeloid leukemia
16151 (Ikbkg)
05220 Chronic myeloid leukemia
16151 (Ikbkg)
05215 Prostate cancer
16151 (Ikbkg)
05222 Small cell lung cancer
16151 (Ikbkg)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
16151 (Ikbkg)
05170 Human immunodeficiency virus 1 infection
16151 (Ikbkg)
05161 Hepatitis B
16151 (Ikbkg)
05160 Hepatitis C
16151 (Ikbkg)
05171 Coronavirus disease - COVID-19
16151 (Ikbkg)
05164 Influenza A
16151 (Ikbkg)
05162 Measles
16151 (Ikbkg)
05168 Herpes simplex virus 1 infection
16151 (Ikbkg)
05163 Human cytomegalovirus infection
16151 (Ikbkg)
05167 Kaposi sarcoma-associated herpesvirus infection
16151 (Ikbkg)
05169 Epstein-Barr virus infection
16151 (Ikbkg)
05165 Human papillomavirus infection
16151 (Ikbkg)
09171 Infectious disease: bacterial
05132 Salmonella infection
16151 (Ikbkg)
05135 Yersinia infection
16151 (Ikbkg)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
16151 (Ikbkg)
05142 Chagas disease
16151 (Ikbkg)
09163 Immune disease
05340 Primary immunodeficiency
16151 (Ikbkg)
09164 Neurodegenerative disease
05010 Alzheimer disease
16151 (Ikbkg)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
16151 (Ikbkg)
05418 Fluid shear stress and atherosclerosis
16151 (Ikbkg)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
16151 (Ikbkg)
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
16151 (Ikbkg)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
16151 (Ikbkg)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: Other
IKK family [OT]
16151 (Ikbkg)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
NEMO
CC2-LZ
zf_C2H2_10
Nairovirus_NSm
PKC_C2
LLC1
Motif
Other DBs
NCBI-GeneID:
16151
NCBI-ProteinID:
NP_001154895
MGI:
1338074
Ensembl:
ENSMUSG00000004221
UniProt:
O88522
Q8VC91
Structure
PDB
LinkDB
All DBs
Position
X:73436883..73498013
Genome browser
AA seq
412 aa
AA seq
DB search
MNKHPWKNQLSEMVQPSGGPAEDQDMLGEESSLGKPAMLHLPSEQGTPETLQRCLEENQE
LRDAIRQSNQMLRERCEELLHFQVSQREEKEFLMCKFQEARKLVERLSLEKLDLRSQREQ
ALKELEQLKKCQQQMAEDKASVKAQVTSLLGELQESQSRLEAATKDRQALEGRIRAVSEQ
VRQLESEREVLQQQHSVQVDQLRMQNQSVEAALRMERQAASEEKRKLAQLQAAYHQLFQD
YDSHIKSSKGMQLEDLRQQLQQAEEALVAKQELIDKLKEEAEQHKIVMETVPVLKAQADI
YKADFQAERHAREKLVEKKEYLQEQLEQLQREFNKLKVGCHESARIEDMRKRHVETPQPP
LLPAPAHHSFHLALSNQRRSPPEEPPDFCCPKCQYQAPDMDTLQIHVMECIE
NT seq
1239 nt
NT seq
+upstream
nt +downstream
nt
atgaacaagcacccctggaagaaccagctgagtgagatggtgcagcccagtggtggccca
gcagaggaccaggacatgctgggtgaagaatcttctctggggaagcctgcaatgctacat
ctgccttcagagcagggtactcctgagaccctccagcgctgcctggaagagaatcaagag
ctccgagacgctatccggcagagcaatcagatgctgagggaacgctgtgaggagctgctg
catttccaggtcagccagcgggaggagaaggagttccttatgtgcaaattccaggaagcc
cggaagctggtggagagactgagcttggagaagcttgatcttcggagtcagagggaacag
gccttaaaggagttggagcaactgaagaaatgccaacagcagatggctgaggacaaggcc
tctgtgaaagctcaggtgacatcattgctcggagaactccaggagagccagagccgtttg
gaggctgccaccaaggatcggcaagctttagagggaaggattcgagcagttagtgagcag
gtcagacagctggagagtgagcgggaggtgctacagcagcagcacagcgtccaggtggac
cagctgcgtatgcagaaccagagcgtggaggctgccttgcgaatggagcggcaggctgct
tcagaggagaagcggaagctggctcagttgcaggcagcctatcaccagctcttccaagac
tacgacagccacattaagagcagcaagggcatgcagctggaagatctgaggcaacagctc
cagcaagctgaggaggccctggtagccaaacaggaattgattgataagctgaaagaggag
gctgagcagcacaagattgtgatggagactgtgccagtcttgaaggcccaggcggatatc
tacaaggctgacttccaagctgagaggcatgcccgggagaagctggtggagaagaaggag
tatttgcaggagcagctggagcagctgcagcgcgagttcaacaagctgaaagttggctgc
catgagtcagccaggattgaggatatgaggaagcggcatgtagagactccccagcctcct
ttactccctgctccagctcaccactcctttcatttggccttgtccaaccagcggaggagc
cctcctgaagaacctcctgacttctgttgtccgaagtgccagtatcaggctcctgatatg
gacactctacagatacatgtcatggagtgcatagagtag
DBGET
integrated database retrieval system
