Mus musculus (house mouse): 26398
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Entry
26398 CDS
T01002
Symbol
Map2k4, JNKK1, MAPKK_4, MEK4, MKK4, PRKMK4, Sek1, Serk1
Name
(RefSeq) mitogen-activated protein kinase kinase 4
KO
K04430
mitogen-activated protein kinase kinase 4 [EC:
2.7.12.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04010
MAPK signaling pathway
mmu04012
ErbB signaling pathway
mmu04620
Toll-like receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04668
TNF signaling pathway
mmu04912
GnRH signaling pathway
mmu04926
Relaxin signaling pathway
mmu04935
Growth hormone synthesis, secretion and action
mmu04936
Alcoholic liver disease
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05142
Chagas disease
mmu05161
Hepatitis B
mmu05166
Human T-cell leukemia virus 1 infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05169
Epstein-Barr virus infection
mmu05208
Chemical carcinogenesis - reactive oxygen species
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26398 (Map2k4)
04012 ErbB signaling pathway
26398 (Map2k4)
04668 TNF signaling pathway
26398 (Map2k4)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
26398 (Map2k4)
04664 Fc epsilon RI signaling pathway
26398 (Map2k4)
09152 Endocrine system
04912 GnRH signaling pathway
26398 (Map2k4)
04926 Relaxin signaling pathway
26398 (Map2k4)
04935 Growth hormone synthesis, secretion and action
26398 (Map2k4)
09160 Human Diseases
09161 Cancer: overview
05208 Chemical carcinogenesis - reactive oxygen species
26398 (Map2k4)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
26398 (Map2k4)
05161 Hepatitis B
26398 (Map2k4)
05167 Kaposi sarcoma-associated herpesvirus infection
26398 (Map2k4)
05169 Epstein-Barr virus infection
26398 (Map2k4)
09171 Infectious disease: bacterial
05132 Salmonella infection
26398 (Map2k4)
05135 Yersinia infection
26398 (Map2k4)
09174 Infectious disease: parasitic
05142 Chagas disease
26398 (Map2k4)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
26398 (Map2k4)
05418 Fluid shear stress and atherosclerosis
26398 (Map2k4)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
26398 (Map2k4)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26398 (Map2k4)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
26398 (Map2k4)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
STE7 family
26398 (Map2k4)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
Seadorna_VP7
Pkinase_fungal
ABC1
Haspin_kinase
APH
Motif
Other DBs
NCBI-GeneID:
26398
NCBI-ProteinID:
NP_033183
MGI:
1346869
Ensembl:
ENSMUSG00000033352
UniProt:
P47809
Q543X6
LinkDB
All DBs
Position
11:complement(65579070..65679185)
Genome browser
AA seq
397 aa
AA seq
DB search
MAAPSPSGGGGSGGGGGTPGPIGPPASGHPAVSSMQGKRKALKLNFANPPVKSTARFTLN
PNTTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK
PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS
TSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGN
IKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT
GRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELL
KHPFILMYEERTVEVACYVCKILDQMPATPSSPMYVD
NT seq
1194 nt
NT seq
+upstream
nt +downstream
nt
atggcggctccgagcccgagcggcggcggcggctccgggggcggtggcggcaccccgggg
cccatcggacctccagcttctggccacccggcggtcagcagcatgcagggtaagcgcaaa
gcactgaagttgaattttgcaaatccacctgtcaaatcgacagcacggtttactctgaat
cctaatactacaggagtccagaacccacacatagagagactgagaacacacagcattgag
tcatcaggaaaactgaagatctcccctgaacaacactgggatttcactgcagaggacttg
aaagaccttggagaaattggacgaggagcttatggttctgtcaacaaaatggtccacaaa
ccaagtgggcagataatggcagttaaaagaattcggtcaactgtggatgaaaaagaacaa
aaacaacttctcatggatttggatgtagtaatgcggagtagtgattgcccatacattgtt
cagttctatggtgcactcttcagagagggcgactgttggatctgtatggagctcatgtct
acctcgttcgataagttttacaaatatgtatatagtgtgttagatgacgttattccggaa
gagatcttaggcaaaatcactttagcaactgtgaaagcactaaaccacttaaaagaaaac
ttgaaaattattcacagagacatcaaaccttccaatattcttctggacagaagtggaaat
ataaagctctgtgatttcggcatcagtggacagcttgtggactctattgccaagacaaga
gatgctgggtgtaggccgtatatggcacctgaaagaatagacccaagtgcatcaagacaa
gggtatgatgtccgctctgatgtctggagtttggggatcacattgtacgagttggccaca
ggccgatttccttatccaaagtggaatagtgtatttgatcagctaacacaagtggtgaaa
ggagaccctccgcagctgagtaattctgaagaaagggagttctcccccagtttcatcaac
tttgtcaacttgtgccttacgaaggatgaatccaaaaggccaaagtataaagagcttctg
aaacatccctttattttgatgtatgaagaacgtactgtagaggtcgcatgctatgtttgt
aaaatcctggatcagatgccagccactcccagctcgcccatgtatgtcgactga
Mus musculus (house mouse): 26399
Help
Entry
26399 CDS
T01002
Symbol
Map2k6, MAPKK_6, MAPKK6, MEK6, MKK6, Prkmk6, SAPKK3
Name
(RefSeq) mitogen-activated protein kinase kinase 6
KO
K04433
mitogen-activated protein kinase kinase 6 [EC:
2.7.12.2
]
Organism
mmu
Mus musculus (house mouse)
Pathway
mmu04010
MAPK signaling pathway
mmu04015
Rap1 signaling pathway
mmu04218
Cellular senescence
mmu04380
Osteoclast differentiation
mmu04620
Toll-like receptor signaling pathway
mmu04664
Fc epsilon RI signaling pathway
mmu04668
TNF signaling pathway
mmu04750
Inflammatory mediator regulation of TRP channels
mmu04912
GnRH signaling pathway
mmu04935
Growth hormone synthesis, secretion and action
mmu04936
Alcoholic liver disease
mmu05014
Amyotrophic lateral sclerosis
mmu05022
Pathways of neurodegeneration - multiple diseases
mmu05132
Salmonella infection
mmu05135
Yersinia infection
mmu05145
Toxoplasmosis
mmu05161
Hepatitis B
mmu05163
Human cytomegalovirus infection
mmu05167
Kaposi sarcoma-associated herpesvirus infection
mmu05169
Epstein-Barr virus infection
mmu05170
Human immunodeficiency virus 1 infection
mmu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
mmu05417
Lipid and atherosclerosis
mmu05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
mmu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
26399 (Map2k6)
04015 Rap1 signaling pathway
26399 (Map2k6)
04668 TNF signaling pathway
26399 (Map2k6)
09140 Cellular Processes
09143 Cell growth and death
04218 Cellular senescence
26399 (Map2k6)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
26399 (Map2k6)
04664 Fc epsilon RI signaling pathway
26399 (Map2k6)
09152 Endocrine system
04912 GnRH signaling pathway
26399 (Map2k6)
04935 Growth hormone synthesis, secretion and action
26399 (Map2k6)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
26399 (Map2k6)
09158 Development and regeneration
04380 Osteoclast differentiation
26399 (Map2k6)
09160 Human Diseases
09161 Cancer: overview
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
26399 (Map2k6)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
26399 (Map2k6)
05161 Hepatitis B
26399 (Map2k6)
05163 Human cytomegalovirus infection
26399 (Map2k6)
05167 Kaposi sarcoma-associated herpesvirus infection
26399 (Map2k6)
05169 Epstein-Barr virus infection
26399 (Map2k6)
09171 Infectious disease: bacterial
05132 Salmonella infection
26399 (Map2k6)
05135 Yersinia infection
26399 (Map2k6)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
26399 (Map2k6)
09164 Neurodegenerative disease
05014 Amyotrophic lateral sclerosis
26399 (Map2k6)
05022 Pathways of neurodegeneration - multiple diseases
26399 (Map2k6)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
26399 (Map2k6)
05418 Fluid shear stress and atherosclerosis
26399 (Map2k6)
09167 Endocrine and metabolic disease
04936 Alcoholic liver disease
26399 (Map2k6)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mmu01001
]
26399 (Map2k6)
Enzymes [BR:
mmu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.12 Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
2.7.12.2 mitogen-activated protein kinase kinase
26399 (Map2k6)
Protein kinases [BR:
mmu01001
]
Serine/threonine kinases: STE group
STE7 family
26399 (Map2k6)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
ABC1
Seadorna_VP7
Pkinase_fungal
CLP1_P
Haspin_kinase
Choline_kinase
APH
DUF4344
Motif
Other DBs
NCBI-GeneID:
26399
NCBI-ProteinID:
NP_036073
MGI:
1346870
Ensembl:
ENSMUSG00000020623
UniProt:
P70236
Q543Z5
LinkDB
All DBs
Position
11:110289928..110416348
Genome browser
AA seq
334 aa
AA seq
DB search
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSK
ERPTYPELMQHPFFTVHESKAADVASFVKLILGD
NT seq
1005 nt
NT seq
+upstream
nt +downstream
nt
atgtctcagtcgaaaggcaagaagcgaaacccgggccttaagattccaaaagaagcgttt
gaacagcctcagaccagttccacgccgcctcgggatttagactccaaggcttgcatatct
attggaaaccagaactttgaggtgaaggcagatgacctggagccgatagtggagctggga
cgaggtgcgtacggggtggtggagaagatgcgtcacgtgcccagcgggcagatcatggca
gtgaagcggatacgggccacagttaatagccaggaacagaaacggctgctgatggatttg
gatgtctccatgaggacggtggactgtccattcaccgtgaccttctacggtgcactcttc
cgggagggcgacgtgtggatctgcatggagctcatggatacgtcactagataaattctac
aaacaagttattgataaaggccaaacaattccagaggatatcttaggaaagatagcagtt
tctattgtaaaagcgttagaacatttacacagtaagctgtctgttatccatcgagacgtc
aagccttctaatgtgctcattaacacactgggccaggtgaagatgtgtgactttggaatc
agtggctacctggtcgactctgttgctaaaacgatcgatgccggttgcaaaccatacatg
gctcctgaacgaataaatccagagctcaaccagaaggggtacagtgtgaagtctgacatt
tggagcctgggcatcaccatgatcgagctggccatccttcggtttccttatgattcttgg
ggaacgcccttccagcagctaaagcaggtggtcgaagagccctctcctcagctcccagca
gacaagttctccgcggactttgttgactttacctcacagtgcttgaagaaaaattccaaa
gaacggcccacatatccagagcttatgcaacatccatttttcaccgtacatgaatccaaa
gcagcagacgtggcatcttttgtaaaactgatacttggggactaa
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