Entry |
|
Symbol |
Mtor, 2610315D21Rik, AI327068, FRAP, FRAP2, Frap1, RAFT1, RAPT1, flat
|
Name |
(RefSeq) mechanistic target of rapamycin kinase
|
KO |
|
Organism |
mmu Mus musculus (house mouse)
|
Pathway |
mmu01521 | EGFR tyrosine kinase inhibitor resistance |
mmu04072 | Phospholipase D signaling pathway |
mmu04213 | Longevity regulating pathway - multiple species |
mmu04613 | Neutrophil extracellular trap formation |
mmu04919 | Thyroid hormone signaling pathway |
mmu04920 | Adipocytokine signaling pathway |
mmu04935 | Growth hormone synthesis, secretion and action |
mmu05022 | Pathways of neurodegeneration - multiple diseases |
mmu05163 | Human cytomegalovirus infection |
mmu05167 | Kaposi sarcoma-associated herpesvirus infection |
mmu05168 | Herpes simplex virus 1 infection |
mmu05170 | Human immunodeficiency virus 1 infection |
mmu05207 | Chemical carcinogenesis - receptor activation |
mmu05230 | Central carbon metabolism in cancer |
mmu05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
|
Brite |
KEGG Orthology (KO) [BR:mmu00001]
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
56717 (Mtor)
04371 Apelin signaling pathway
56717 (Mtor)
04630 JAK-STAT signaling pathway
56717 (Mtor)
04066 HIF-1 signaling pathway
56717 (Mtor)
04072 Phospholipase D signaling pathway
56717 (Mtor)
04151 PI3K-Akt signaling pathway
56717 (Mtor)
04152 AMPK signaling pathway
56717 (Mtor)
04150 mTOR signaling pathway
56717 (Mtor)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
56717 (Mtor)
04136 Autophagy - other
56717 (Mtor)
09143 Cell growth and death
04218 Cellular senescence
56717 (Mtor)
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
56717 (Mtor)
04659 Th17 cell differentiation
56717 (Mtor)
09152 Endocrine system
04910 Insulin signaling pathway
56717 (Mtor)
04920 Adipocytokine signaling pathway
56717 (Mtor)
04935 Growth hormone synthesis, secretion and action
56717 (Mtor)
04919 Thyroid hormone signaling pathway
56717 (Mtor)
09149 Aging
04211 Longevity regulating pathway
56717 (Mtor)
04213 Longevity regulating pathway - multiple species
56717 (Mtor)
09159 Environmental adaptation
04714 Thermogenesis
56717 (Mtor)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
56717 (Mtor)
05206 MicroRNAs in cancer
56717 (Mtor)
05205 Proteoglycans in cancer
56717 (Mtor)
05207 Chemical carcinogenesis - receptor activation
56717 (Mtor)
05230 Central carbon metabolism in cancer
56717 (Mtor)
05231 Choline metabolism in cancer
56717 (Mtor)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
56717 (Mtor)
09162 Cancer: specific types
05210 Colorectal cancer
56717 (Mtor)
05212 Pancreatic cancer
56717 (Mtor)
05225 Hepatocellular carcinoma
56717 (Mtor)
05226 Gastric cancer
56717 (Mtor)
05214 Glioma
56717 (Mtor)
05221 Acute myeloid leukemia
56717 (Mtor)
05215 Prostate cancer
56717 (Mtor)
05224 Breast cancer
56717 (Mtor)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
56717 (Mtor)
05168 Herpes simplex virus 1 infection
56717 (Mtor)
05163 Human cytomegalovirus infection
56717 (Mtor)
05167 Kaposi sarcoma-associated herpesvirus infection
56717 (Mtor)
05165 Human papillomavirus infection
56717 (Mtor)
09164 Neurodegenerative disease
05010 Alzheimer disease
56717 (Mtor)
05014 Amyotrophic lateral sclerosis
56717 (Mtor)
05016 Huntington disease
56717 (Mtor)
05017 Spinocerebellar ataxia
56717 (Mtor)
05022 Pathways of neurodegeneration - multiple diseases
56717 (Mtor)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
56717 (Mtor)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
56717 (Mtor)
04931 Insulin resistance
56717 (Mtor)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
56717 (Mtor)
01522 Endocrine resistance
56717 (Mtor)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:mmu01001]
56717 (Mtor)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mmu04131]
56717 (Mtor)
Enzymes [BR:mmu01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
56717 (Mtor)
Protein kinases [BR:mmu01001]
Serine/threonine kinases: Other
PIKK family [OT]
56717 (Mtor)
Membrane trafficking [BR:mmu04131]
Autophagy
Other autophagy associated proteins
mTORC1 complex
56717 (Mtor)
mTORC2 complex
56717 (Mtor)
|
SSDB |
|
Motif |
|
Other DBs |
|
LinkDB |
|
Position |
4:148533039..148642142
|
AA seq |
2549 aa
MLGTGPAVATASAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPSSDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAVQPQQPNALVGLLGYSSPQGLMGFGTSPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVASITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKEDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANITNATTAATTAASAAAATSTEGSNSESEAESNENSP
TPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVN
EALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVAS
KSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFG
ERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQA
WDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSL
QVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNL
SIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTL
MQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRH
PSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTC
HTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDG
VELGEPAHKKAGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLD
VPTQVELLIKQATSHENLCQCYIGWCPFW |
NT seq |
7650 nt +upstreamnt +downstreamnt
atgcttgggacgggtcctgccgtggccaccgccagtgccgccacatctagcaacgtgagc
gtcctgcagcagttcgccagtggactgaagagccggaatgaggagaccagggccaaagca
gccaaggagctccagcactacgtcaccatggagcttcgagagatgagtcaggaggagtct
actcgcttctatgaccagctgaaccatcacatttttgaactggtttccagctcagatgcc
aatgagaggaagggtggcatcttggccatcgccagcctcataggagtggaaggtgggaat
tccaccagaattggcagatttgccaactaccttcgaaacctcctcccctcaagcgatcca
gttgtcatggaaatggcgtccaaggccattggccgcctggcgatggcaggggacactttc
actgctgaatatgtggagtttgaagtgaagcgagccttggagtggctgggtgctgaccga
aatgagggccggagacatgccgctgtcctcgttctccgtgagctggccatcagtgtcccc
accttcttcttccagcaagttcagcccttctttgacaacatttttgtggctgtgtgggac
cccaagcaggccatccgggaaggcgctgtagcggcccttcgtgcctgtctgattctcacc
acgcagcgggaaccaaaggaaatgcagaagcctcagtggtaccggcacacatttgaagaa
gcagagaaaggttttgatgagaccctggccaaagagaagggtatgaatcgagatgatcga
atccacggagccttgctgatcctcaacgagctagttcgtatcagcagcatggagggagag
cgtctgagagaagagatggaggagatcacccagcagcagctggtgcatgacaagtactgc
aaagacctcatgggcttcgggaccaagcctcggcacatcacgcccttcaccagtttccag
gctgtgcagccccagcagccgaacgccttggtgggactgctggggtacagctcccctcaa
ggcctgatgggatttgggacgtcccccagccctgccaagtccactctggtggaaagccgc
tgttgcagagacttgatggaagagaaatttgatcaggtgtgccagtgggtgctgaagtgc
aggagcagcaagaactcgctgatccagatgacaatccttaacctgctgccccgcctggct
gcattccgaccgtccgccttcacagatacccagtacctccaggacaccatgaaccatgtc
ctgagctgtgtcaagaaggagaaggaacggactgcggcgttccaggccctggggctgctt
tctgtggccgtgaggtcggagtttaaggtctacttgccccgtgtacttgacatcatccga
gcagcgcttcctccaaaggactttgcccacaagaggcagaaaaccgtgcaggtggatgcc
accgtattcacgtgcatcagcatgttggcacgagcaatggggccgggcatccagcaggac
atcaaggagctgctggagcccatgttggcagtgggcctgagccccgcgctcactgctgtg
ctctatgacctgagccggcagattccacagctgaagaaagatattcaggacggccttctg
aagatgctgtccctggtccttatgcacaaacccctccggcacccaggcatgcccaaaggc
ctggctcaccagctggcttcccctggtctcaccaccctccctgaggccagcgacgtggcc
agcatcactcttgcccttcgaacccttggcagctttgaatttgaaggccactctctgacc
cagttcgtccgacactgcgcagatcacttcctgaacagcgagcacaaggagatccgcatg
gaagctgctcgcacctgctcccgcctgctcacaccctccatccacctcatcagcggccat
gcccacgtggttagccagactgcagtgcaggtggtggcagatgtgctcagcaagctgctt
gtggttggcataacagatcctgaccctgatatccgctactgtgtcttggcatccctggac
gagcgctttgatgcccacctggcccaggcagaaaacttacaagctctgtttgtggctctg
aatgaccaggtctttgagatccgcgagctggccatctgcactgtgggccgactaagcagc
atgaacccagccttcgtcatgcctttcctgcgcaagatgctcatccagatcctgacagag
ctggagcacagcggcattgggagaatcaaggagcagagcgcccgcatgctggggcacctg
gtgtccaacgccccccggctcatccgcccctacatggagcctatcctgaaggctttaatt
ttgaaactgaaagatccagaccctgacccaaacccgggcgtgatcaataacgtgttggcc
actataggagaactggctcaggtgagcggcctggaaatgcggaagtgggtggacgagctc
tttatcatcatcatggacatgctgcaggactcctccctgctggccaaaaggcaggtggct
ttgtggaccctgggacagttggtggccagcactggctatgtggtggagccctacaggaag
taccccactttgcttgaagtgctgctgaatttcctgaagacggagcagaaccagggcact
cggagagaggctatccgagtgttggggctccttggggctttggatccctacaagcacaaa
gtgaacatcggcatgatcgaccagtcccgggacgcttccgctgtcagcctgtcagagtcc
aagtcaagtcaggattcctctgactacagcaccagtgaaatgctggtcaacatgggaaac
ctgcccctggacgagttctaccccgctgtgtccatggtggccttgatgcggatcttccga
gatcaatccctctctcaccaccacaccatggtggtgcaggccatcaccttcatcttcaag
tccctggggctcaagtgtgtgcagttcctgccccaggtcatgcccacattccttaatgtc
atccgagtctgtgatggggccatccgggaatttctgttccagcagctggggatgctggtg
tcctttgtgaagagccacatccgtccctacatggatgaaatagtcactctcatgagagag
ttttgggtcatgaacacgtcaatccagagcacaatcattcttctcattgagcagattgtg
gtggctctcggaggggaatttaagctttatctgccccagttgatcccacacatgctgcgg
gtcttcatgcatgacaacagccaaggccgaatcgtctccatcaagctgttagccgcgatc
cagctgtttggcgccaacctggatgactatctgcacttgttgttgcctccgattgtgaaa
ttgtttgatgcccctgaagtcccgctgccatcaagaaaggcagcgctggagacggtggac
cgcctgacagagtccctagacttcactgactacgcctcccgcatcattcacccaatagtt
cgtacgctagaccagagcccagagctgcgctccacagccatggacactctgtcttcgctt
gtctttcaactggggaagaagtaccagatcttcattccaatggtgaataaagtcctcgtg
cgacaccggatcaaccaccagcgctatgatgtgcttatctgcagaatcgtcaaggggtac
acacttgctgatgaggaagaagaccctttgatttaccagcatcgaatgctaaggagcagc
cagggagatgccctggccagtggaccagttgagacaggacccatgaagaaactgcatgtc
agcaccatcaacctccaaaaggcctggggagctgccagaagggtctccaaggacgactgg
ctggagtggctgaggcgcttgagtctggagcttctgaaggactcctcatcgccctccctg
cgctcatgctgggccctggcgcaggcctacaaccccatggccagggatctcttcaatgct
gcctttgtgtcctgctggtctgagctgaatgaagaccagcaagatgagctcatcaggagt
attgagttggctctcacttctcaagacattgctgaagtcacacaaaccctcctgaacttg
gctgagttcatggaacacagtgacaagggccccctgccgctgagagatgacaatggcatc
gtgctcctgggtgagagagctgccaagtgccgggcatatgccaaagcactgcactacaaa
gaactggagttccagaaagggcccacgcctgccatacttgagtccctcatcagcattaac
aacaagctccagcagcctgaggcagcttctggggtgttggaatacgccatgaaacacttc
ggagagctggagatccaggccacctggtatgagaagctgcatgagtgggaggatgctctc
gtggcctacgacaagaagatggacacaaacaaggaagacccggagctgatgctgggccga
atgcgctgcctcgaggccttgggggaatggggccagcttcatcagcagtgctgtgaaaag
tggactctggttaatgatgagacccaggctaagatggcccggatggctgctgctgcagcg
tggggtttaggtcagtgggacagcatggaggagtacacctgcatgatcccacgggacacc
cacgatggagccttttacagggcagtgttggctctacatcaggatctcttctccttggcc
cagcagtgcattgacaaggccagggacctgctggatgcagagctgactgccatggcagga
gagagctacagccgagcctatggggccatggtttcttgccacatgctgtccgagctggaa
gaggttatccagtacaaacttgtccctgagcgtcgggagatcatccggcagatctggtgg
gagagactgcagggctgccagcgtattgttgaggactggcagaaaatcctcatggtccgg
tcccttgtggtcagccctcatgaggacatgagaacctggctcaagtacgcaagcctgtgt
ggcaagagtggcagactggctcttgctcataaaaccttagtgttgctcttgggagttgat
ccatctcggcaacttgaccatcctctgccaaccgctcaccctcaagtgacctatgcctac
atgaagaacatgtggaaaagtgctcggaagattgacgccttccagcacatgcaacacttt
gtgcagaccatgcagcagcaggcccagcatgccatcgccacagaggaccagcagcacaag
caggagctgcataagctcatggccaggtgttttctgaaacttggggagtggcagctgaac
ctccagggcatcaacgagagcaccatccccaaggtgctacagtactacagtgccgccaca
gagcatgaccgcagctggtacaaggcttggcatgcatgggcagtgatgaacttcgaagca
gtgctacactacaaacatcagaaccaagcccgtgatgagaagaagaagctgcgtcatgcc
agcggggccaacatcaccaatgccaccactgcagccaccactgcagcctctgctgctgct
gccaccagcacagagggcagcaacagtgagagtgaagctgagagcaatgagaacagcccc
accccgtcccctctgcagaagaaggtcactgaggatttatccaaaactctcttgttgtac
actgtccctgctgttcaaggcttcttccgttctatctccttgtcaagaggcaacaacctc
caggatacactaagagtcctcaccctgtggtttgattatggtcactggccagatgtcaat
gaagccttggtggaaggggtgaaggccatacagattgacacttggttacaggttatacct
cagctcattgcaagaattgacacacccagacccttggtgggccggctcattcaccagctt
ctcacagatattggtcggtaccacccacaggccctcatctaccccctgacggtggcttct
aagtctaccaccacagcccgtcacaatgcagccaacaagatcttgaagaacatgtgtgaa
cacagcaacacgctggtccagcaggccatgatggtgagtgaagagctgattcgggtagcc
atcctctggcatgagatgtggcatgaaggcctggaagaggcatctcgcttgtactttggg
gagaggaacgtgaaaggcatgtttgaggtgctggagcccctgcatgctatgatggaacgg
ggtccccagactctgaaggaaacatcctttaatcaggcatatggccgagatttaatggag
gcacaagaatggtgtcgaaagtacatgaagtcggggaacgtcaaggacctcacgcaagcc
tgggacctctactatcacgtgttcagacggatctcaaagcagctaccccagctcacatcc
ctggagctgcagtatgtgtcccccaaacttctgatgtgccgagaccttgagttggctgtg
ccaggaacatacgaccccaaccagccaatcattcgcattcaatccatagccccgtctttg
caagtcatcacatccaagcagaggcctcggaagctgactctgatgggcagcaatgggcat
gagtttgttttcctcctgaaaggccatgaagatctgcggcaggatgaacgagtgatgcag
ctctttggcctggtgaacacactcctagccaatgaccccacttctcttcgcaagaacctc
agcatccagagatacgctgtcatccctctgtccaccaactcgggcctcattggctgggtg
ccccactgtgacacactgcatgccctcatccgggactacagagagaagaagaagatcctg
ttgaacatcgagcatcgcatcatgctgcggatggctcctgactatgaccacctgacgttg
atgcagaaggtagaggtgtttgagcatgctgtcaacaacacagctggggacgacctggcc
aagctactgtggctaaaaagccccagctcggaggtgtggtttgaccgaagaaccaactat
acccgctccctggccgttatgtcgatggtcggatacattttaggccttggagacaggcac
ccatccaatctgatgctggaccggctgagtgggaagatcctgcacattgactttggggac
tgctttgaggtcgctatgaccagagagaaatttccagaaaagattccatttagactaaca
agaatgttgaccaatgctatggaggttacgggtctggatggcaactacagaaccacatgc
cacaccgtgatggaagtgctccgggaacacaaggacagtgtcatggctgtgctggaagcc
tttgtctatgacccactgctcaactggaggctgatggacacaaataccaaaggcaataag
cggtcccggacaaggacagactcctactctgccggccagtcagtagaaattttggacggt
gtagaacttggagaaccagcccataagaaagcagggaccactgtgccagaatccatccat
tcattcattggagacggtttggtgaaaccagaagccttaaacaagaaagctattcagatt
attaacagggttcgagataagctcactggtcgggatttctctcatgatgacactttggat
gttccaacccaagtggagctgcttatcaagcaggcaacatctcacgagaacctctgccag
tgctacattggctggtgtcccttctggtaa |