Microcebus murinus (gray mouse lemur): 105859221 Help Entry 105859221         CDS       T07238                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism mmur  Microcebus murinus (gray mouse lemur) Pathway mmur04020   Calcium signaling pathway mmur04371   Apelin signaling pathway mmur04713   Circadian entrainment mmur04921   Oxytocin signaling pathway mmur04970   Salivary secretion mmur05010   Alzheimer disease mmur05012   Parkinson disease mmur05020   Prion disease mmur05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:mmur00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     105859221 (RYR3)    04020 Calcium signaling pathway     105859221 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     105859221 (RYR3)   09154 Digestive system    04970 Salivary secretion     105859221 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     105859221 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     105859221 (RYR3)    05012 Parkinson disease     105859221 (RYR3)    05020 Prion disease     105859221 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     105859221 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mmur04040]     105859221 (RYR3) Ion channels [BR:mmur04040]  Voltage-gated cation channels   Ryanodine receptor    105859221 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 Motif Other DBs NCBI-GeneID:  105859221 NCBI-ProteinID:  XP_020141528 Ensembl:  ENSMICG00000005736 LinkDB All DBs Position 3:complement(85892562..86411805) Genome browser AA seq 4868 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLLLQDRGKSDTKSTAFSFRPSKEIKEKLDSSHKREMEGMGLPEIKYGDSICFVQHVAS GLWVTYKAQDAKTPRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPTEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRTGKWYFEFEVVTGGDMRVGWARPGCRPDVELGADDQAFVFEGSRGQRWHQGSGYFGR TWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPRDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNADMIYCRLSMPVECHSSFSHSPCLDGEAFQKRKQMQEL LSHTTTQCYYAVRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLLDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEESRCVDVLELCEQEDLMQFHYH TLRLYSALCALGNSRVAYALCSHVDLSQLFYVIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNIRLYPDESKRHGLPGVGLRTCLKPEFRFSTPCFVTTSEEHQ QQSPEIPLETLKTKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFDD DDVRQILLLIDPSVFGEHGGEAEEGAEKEEVTQVEEKAVEAGEKASKEAPIRGLLQTRLP ESVKVQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLLHCGVPLEEEEEEEED TSWTGKLCTLMCKIKGSPEPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDAELVR MMFNLLRRQYDSIGELLQALRKTYTISQVSVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGEIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVTEDDEEEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVIEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYICSAVLPLLTRCAPLFAGTEHCTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQRLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWKYYCLP SGWGGYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPDYLDTR IAATLEKQISVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKTQSGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN EKLRSMPQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVLVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSSTMVSCLHILAQTLDTRTV MKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHVAQHQFGVDLLLSDVQISCYHILCSLYALGTGKNIYVERQRPALGECLASLAAA IPVAFLEPTLNRYNPLSVFNTKTPRERSIMGMPDTVEEMCPDIPQLEDLMKEINDLAESG ARYMEMPHVIEVVLPMICNYLSYWWERGPENLPPSMGPCCTKVTSEHLSLILGDILKIIN NNLGIEEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAIKTVQEEEQLKADGR GDTQEAELLILDEFAVLCRDLYAFYPILIRYVDNSRSNWLKSPDADSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYGYRDTDEEVKEHLRNNLHLQEKSD DPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPKVEEE EEEEMEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYCSMMAKSCQSGEDEEEEEDKE KTFEEKEMEKQKTLYQQARLHERGTAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNT GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESI SDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCVGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSTNVEMILKFFDMFLKLKDLTSSDTFKDYDPDGKGIISKKEFQKAMEGQKQYTQSEIDF LLSCAEADENDMFNYMDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEITESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDSADRPEEEEEEDAPYTLEIEGEEEEDKCFESPSAF AMACASMKRSVTSFLKKATLKNVRKQYRNVKKMSAKELVKVFFSFFWTLFLGLFQLFFGI LGGIFQVLWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHEDAVEMERAEVTEPGITA DLAHFVKGEKGDADMIPDLFGLHPKKEGGLKHGPEVGLGDLSEIIGKDEAPTLENTVRKK RKAQAAEMKTAHEVEGKVDSEKADTEDGEKADRAKEEEQAEYLWAEVTKRRKRRHGQKVE KPEAFTANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEEET EDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPTLRALAIIHTIISLVCVVGYYCLKVPL VVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVINKY GDLYGAERIAELLGLDKNALDFSPIEETTAEAASLVSWLSSIDMKYHIWKLGVVFTDNSF LYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVY LYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDPY EMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDYFD TTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFR KQYEDQLG NT seq 14607 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggaggagaaggaggcgaggacgagatccagttcctgcggactgaagatgaa gtggtgctccagtgcatcgccaccattcacaaggagcagaggaagttctgcctggccgcc gagggacttggcaatcgcctgtgcttcttggaacccacttcagaagccaagtatattcct ccagatctctgcgtctgcaactttgtgctggagcagtccctctctgtcagagccctgcag gaaatgctggccaacacaggtgaaaatggcggcgaaggggcagcacaagggggtggccac aggaccctgctatatggacatgcgattctcctgaggcactccttcagcggaatgtatcta acatgtttgactacatcaagatcccaaacagataaacttgcctttgatgtaggtctacgg gaacatgccacaggagaagcctgttggtggactatacatcctgcttccaaacagaggtct gagggagagaaagttcgaattggcgacgatctcatcctcgtcagtgtatcctctgaaaga taccttcatctgtcaatatctaacggtaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacatgctcaggaagtagcattgaagaaggatacctacttggt ggacatgtagtacgtctcttccacggtcatgatgagtgtttgacgatcccatctacagac cagaatgattcccagcacaggagaatattctatgaagctgggggagctgggacacgagcc aggtctctgtggagagtggaaccccttcggataagctggagtggcagcaacatcagatgg ggccaggctttccgactccgacatctgaccacaggccactacctggccttgacggaggac caaggccttctcctgcaagaccggggaaagtcagacaccaagtccacggccttctctttc cgaccatccaaggaaatcaaggagaaattggattccagtcacaagcgagagatggaaggc atgggccttccagagatcaagtatggagattccatctgctttgtccagcatgtagccagt ggtttgtgggtgacgtacaaagcacaagatgccaaaacaccccggctgggacctctgaaa agaaaggtcatactgcatcaggaaggccacatggacgatgggttaacactgcagagatgc cagcgtgaggagtcccaggccgctcggatcatccggaacacgacagccttgttcagccag tttgtcagtggaaacaatcgcacagccgctcccgtgaccctgcctacggaagaggtcctg cagaccctgcaggacttgattgcctacttccagcccccggaggaggagatgcagcatgaa gacaaacagaacaagctccgctcgctcaaaaacagacagaatcttttcaaggaagaggga atgttggcccttgtcttaaattgcatcgatcgcttgaatatctacaatagcgtagcacac tttgcagggattgccagggaagagagtggcatggcctggaaagaaattctgaacctcctc tacaaattgctggctgctctcattcgcggaaacagaaacaactgcgctcaattctccaat aaccttgattggctaatcagtaaattggacagactagaatcttcctcaggtatcttggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgttggataagcatgggcgaaatcacaaggttctagatgtc ctgtgctccttatgcctctgcaatggggttgcagtgagagccaaccagaatctgatctgt gacaacttgctgccccggagaaacctgctcctgcaaacacgactgattaacgatgttacc agtattcggccaaacatcttcctgggagttgctgaaggctcagcccagtacaagaagtgg tactttgagctgattatcgaccaagtggaccccttcctaacagcagagcccacacatctg cgggtgggctgggcctcttcctcgggctatgccccgtacccaggaggtggagaaggatgg ggaggcaatggtgttggtgatgacctgtactcctatggctttgatggacttcacctttgg tcaggacggatacccagagctgtggcctccatcaaccagcacctcctgaaatcagatgac gtggtcagctgctgccttgacctcggagtgcccagcatctctttccgcatcaacgggcag cccgtgcaggggatgtttgagaacttcaacacagacgggctcttcttcccggtgatgagc ttttcagcaggtgtcaaagtacgtttcctgatgggtggacgtcatggagaatttaagttc ctgcctccctctggctacgccccttgctatgaagccttacttccaaaagagaaaatgaga ttggagcctgtcaaagaatataaacgtgatgctgaaggggttagagatctactgggcacc acccagttcctctcccaagcctccttcatcccctgccccatagacaccagtcaggttgtt ttgccacctcacctagagaagatccgagacagactggctgaaaacatccacgagctctgg ggaatgaataagatagagctcggctggactttcggcaagatacgagatgacaacaaaaga caacacccttgccttgtggagttttcaaaactccctgaaactgagaagaattataacttg caaatgtcaaccgaaaccttaaaaaccctcctggccctggggtgccacattgctcacgtc aatccagctgctgaggaggatctcaagaaggtcaaactgcccaaaaactacatgatgtcc aatggctataagccagcccctttggacttgtctgacgtgaagctcttacctcctcaagaa attttagtggataagcttgcagaaaacgcacacaatgtttgggcaaaagacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaagaaatccccgcctggtg ccatatgcattactggatgagcgtaccaagaagtcaaacagggacagcctgcgtgaagct gttcgcacatttgttggttacgggtataatattgagccatcagaccaagaactagctgac ccggctgtggagaaagtgagcatagacaagatccgattcttccgggtggagcggtcctat gcagtgagaactggaaagtggtattttgagttcgaggtggtgaccggaggggacatgcgg gtcggctgggccaggccaggctgtcgacctgacgtcgagctgggtgctgacgaccaggcc ttcgtgtttgaaggcagcaggggccagcgttggcatcaagggagtgggtattttgggcgt acctggcagccaggagatgtggttggatgtatgattaacctggatgatgcttcgatgatc ttcacactgaatggggagctgctgatcaccaacaaaggctctgaacttgcctttgctgac tacgagattgagaatggcttcgtgcccatctgctctctggggctgtctcagatcggccgc atgaatctggggacagatgccagtaccttcaagttttataccatgtgcggcctccaagag ggctttgagccttttgctgtcaacatgaaccgagacgttgccatgtggttcagcaagcgc ctcccgacgtttgtcaacgtgccgagagatcacccacacatagaggtcgtgaggattgat ggcaccatggacagcccgccttgcctcaaggtgacccacaagacgtttggcacacagaat agcaatgccgacatgatctattgccgtctaagcatgcctgtcgagtgccactcctccttc agccacagcccctgtctggacggtgaagctttccagaagaggaaacagatgcaagaacta ctctctcatacaacaacacagtgctactatgctgtccgcatctttgctggacaagacccc tcctgcgtctgggtcggatgggtgactccagactatcacttgtacagtgaaaaatttgac ctgaataaaaactgcacagtgactgtcacgctgggggatgaaagaggccgggtgcatgaa agtgtgaaacgcagcaactgctacatggtctggggtggggacattgtggccagttcccag agatccagtcggagcaacgtggacctggagatcggctgtctcttggatctggcgatgggc atgttgtccttctcagccaacgggaaagaacttggcacctgctaccaggtggagcccaat accaaagtattcccagcagtcttcctgcagcctacaagtacttctttgtttcagtttgaa ctgggaaagctgaagaacgcgatgcccctgtcggcggccatattcaagagcgaagagaag aaccccgtcccgcagtgtccgcctcggctggatgtccagaccatccagcccgtgctctgg agccgcatgcccagcagcttcctgaaggtggagacggagcgggtgagcgagcgccacggc tgggtggtgcagtgcctggagcccctgcagatgatggcgctccacatccccgaggagagc aggtgtgtggatgtcctggagctctgtgagcaggaggacctgatgcagttccactaccac acgctacggctgtacagcgccttgtgtgccctgggaaacagccgggtggcctacgccctg tgcagccacgtggacctctcccagctcttctacgtcattgacaacaagtacctccccggc ctccttcgatcgggtttctatgacctgctcatcagcatccacctggccaacgctaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcacgaccaggaatatc cgcctgtaccctgatgagtccaagaggcacggactgcccggggtgggcctgagaacgtgc ctcaagccagagttccggttctccaccccttgctttgtcacgaccagtgaggagcaccaa cagcagagccccgagatccccttggagaccctcaagacgaaggcactgagcatgctgaca gaggcggtgcagtgcagcggggcccacatccgggaccctgttggagggtccgtggagttc cagtttgtgcccgtgctgaaactcatcggaaccctgctggtcatgggggtgtttgatgac gacgatgttcggcagatcctcctcctgatcgatccctctgtgtttggggagcacggcggg gaggcggaggagggagcagaaaaggaggaggtgacccaggtggaggagaaggcagtggag gctggagagaaggccagcaaggaggctcccatcagaggcttgttgcagacacgcttacca gagtccgtcaaagtgcagatgtgtgagctcctcagctatctctgtgactgtgagctacaa caccgagtggaggccatcgtggcatttggtgacatttatgtctccaagctacaggcaaat cagaagttccgctacaatgagctcatgcaggccctgaacatgtctgcagccctgactgct cggaagaccagggagttccgctcacccccacaggagcagatcaacatgcttcttaacttt caactgggagagaactgcccctgcccagaggagatccgggaggagctatatgacttccat gaggaccttctccttcactgtggggttcccttggaggaagaggaagaagaggaggaggac acctcctggacaggaaaactgtgtaccctgatgtgtaaaatcaaaggctcacctgagcca gaaaaggagcagccaacagaggaggaggagagatgccctacaacactgaaggaactcatc tcacagacaatgatccgctgggcgcaagaggaccagatccaggacgcggagctggtccgg atgatgttcaacctgctccgcaggcagtacgacagcatcggggagctgctgcaggcgctg cggaagacctacaccatcagccaggtctccgtgagcgacaccatcaacctgctggccgcg ctgggccagattcgctccctcctcagcgtcaggatgggcaaggaggaggagctactcatg atcaatgggctgggagagataatgaacaacaaggtattctaccagcatcccaacctcatg agagtccttggcatgcatgagacagtgatggaggtgatggtgaacgtgctggggacagag aagtctcagattgctttcccaaagatggttgctagctgctgccgcttcctttgctatttt tgtcgaattagccggcagaatcagaaggccatgtttgagcatctgagttacctgctggag aacagcagtgtcggcctagcctccccatcaatgaggggatccactccgctggatgtggcc gcttcctccgtgatggacaacaacgagttagcgctgggcttagaggaaccagacctcgag aaggtggtgacctacttggcaggctgtggcctgcagagctgccccatgcttctggccaaa ggataccctgacgtcggctggaaccccattgaaggggaacgctacctgtccttcctgagg tttgctgtcttcgtgaacagtgaaagtgtggaagaaaatgcgagcgtcgtggtcaagctg ctcatcagacgcccagagtgcttcggcccagcgctgcggggcgagggaggaaacgggctc ctggcggccatgcagggcgccattaagatctctgagaacccagcgctcgacctcccctct caggggtacaagagggaagtcacggaggacgatgaagaggaggaagaaattgtgcacatg ggcaatgcaattatgtcattttattcagcccttatagatctactgggccgctgtgctcct gaaatgcacctcatccagacgggaaaaggggaagccatccgcatcaggtccatcctgcgc tctctggtccccaccgaggacctggttggcattatcagcatccccttgaaactgccctcc ctgaacaaagatgggtcagtcatcgagccagacatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggaccgagtttatggcattaaggatcaaacttttctg ctgcatttactagaggttggatttttacctgacttaagagcctctgcctctctagataca gtttccctcagcaccacagaggctgcgctcgcactcaacaggtacatatgttctgctgtg ctcccgctccttacgagatgtgcccctctctttgccggaacagaacattgcacctctctg atcgattctacgctgcagacaatatacaggctttccaagggacgttccctcaccaaagca cagagggacactatagaagaatgtttgcttgccatttgcaatcacctgaggccttccatg ttacagcgactcctgcgacgtcttgtttttgatgtgccacaactcaatgagtactgcaaa atgcctctcaagcttctgacgaatcactatgaacagtgctggaagtactactgtctgcct tcaggctgggggggctatggcctcgcagtggaagaagaactgcacctaacggagaagctc ttctggggcatttttgactccctctcccataagaaatatgacccagatcttttccggatg gctctgccttgtctcagtgctatagctggggccttgccaccagattatttagataccaga atcgcagccacgttggagaagcagatctcggtggatgcagatggcaactttgaccccaaa cctatcaacaccatgaatttttccttacctgaaaaattggaatacatcgtcaccaagtac gctgagcattcacatgataaatgggcctgtgacaagactcagagcgggtggaagtatggc atttccctggatgagaacgtcaagacccacccactgataaggcctttcaagacattaacg gaaaaggagaaggaaatttatcgctggcctgccagagagtccctgaaaaccatgctggct gtgggctggactgtggagaggaccaaagagggggaagctttggttcaacagcgggaaaat gagaagcttcgaagcatgccccaggccagccagggcaacagctacagccctgcccccctc gacctctcaaacgtcgtgctctccagagagctccagggcatggtggaggtcgtggctgag aactatcataatatctgggccaagaagaaaaagctggaactggagagcaaaggtggtggc agtcaccctcttctggtgccatatgacaccttgactgccaaggaaaagttcagggaccga gagaaggcacaggacctgtttaaattcctccaagtgaatggcgttctagtttctagaggt atgaaggacatggaactggatgcctcctccatggaaaagagatttgcctataagtttctg aagaagatcttgaaatacgttgattctgctcaagagtttattgcccatttggaagccatt gtcagcagtgggaaaactgaaaagtctccccatgaccaggagatcaaattctttgccaaa gtcctcctcccactggttgaccaatacttcaccaatcaccgcctctacttcctgtcgtcc cctctgaagccccttagcagcagcgggtatgcctcccataaggagaaagaaatggtggcc agcctgttctgcaaacttgctgctcttgttagacacaggatttccctctttgggagtgat tcttccacaatggtgagctgtcttcacatcttagctcagacacttgacacgaggaccgtc atgaagtcgggctcagagctggtgaaggctgggttgcgagcattctttgaaaatgctgca gaagacttagagaagacttcagaaaacctgaagcttgggaagttcacccattcccggacg cagattaaaggcgtttcacagaatattaactacaccacggtggccctactccccatcctg acatccatctttgagcatgtcgctcagcatcagtttggggtggatctgctcttgagcgat gtgcagatttcgtgctaccacatactgtgcagcctctatgcccttgggacaggaaagaac atctatgtcgagaggcaacgtcctgcccttggagaatgcctggcctcactggcagctgcc ataccagtggcgttcctggagcccacccttaaccgctacaatccgctctcagtcttcaac accaaaacccccagggagaggtctattatggggatgccggacacggtggaagagatgtgt cctgacatcccccagctggaagacctgatgaaggaaatcaatgacctggctgagtcaggg gccaggtacatggagatgccacacgtcatcgaggtggtcttgcccatgatctgcaactac ctgtcctactggtgggagcgggggcccgagaacctgccccccagcatggggccctgctgc accaaagtcacctctgaacacctcagtctcatcctgggcgacatcttgaagatcatcaac aacaacttgggcatcgaggaagcctcctggatgaagcgcatcgcagtgtacgcccagccg atcatcagcaaagccaggcctgacctgctgagaagccacttcatcccgactctggagaag ctgaagaaaaaggccatcaagactgtgcaggaggaggagcagctgaaagccgacggcaga ggggacacccaggaggcggagctcctcatcctggacgagttcgcggtcctctgcagggat ctctacgccttctaccccatattgatccgctatgtggacaacagcagatctaactggctt aaaagccctgatgccgattctgaccagctcttccgcatggtggcagaggtcttcatcctg tggtgtaaatcgcacaacttcaagagggaagaacagaattttgtgattcagaatgaaata aataatttggcatttttgactggagacagcaaaagcaagatgtccaaagccatgcaagta aagtctggaggacaggaccaggaacgaaagaagacaaagcgaaggggagacttgtattcc atccagacctccctcatcgtggctgctctcaagaaaatgctgcccattggtttgaatatg tgcaccccaggcgaccaggagctgatctccctagcgaaatcacgctacggctatagggac acagatgaagaggtcaaggaacatctgcggaataacttgcacttgcaggaaaagtctgat gacccagctgtaaaatggcagctgaacctctacaaggatgttctgaagagtgaagaacct tctaatccagaaaagacagtagagcgtgtgcagagaatttcagcagctgtcttccacctg gagcaggtggagcagcctttgaggtccaagaaggctgtctggcacaaactgttgtcaaag cagcggaaacgggcagtcgtggcctgtttcaggatggcccctctctacaacctgcccagg caccgctctattaacctcttcctccatggctatcagagattttggatagaaacagaggag tattcctttgaagagaaactagttcaggatttggctaaatctcccaaggtggaagaggag gaagaggaagagatggaaaagcaacctgacccgctgcatcagatcatcctccatttcagc cgcaacgctctcacagagaggagcaaattggaagatgaccctttgtacacctcctattgc agcatgatggccaagagttgtcaaagtggtgaggatgaagaagaggaggaagacaaggaa aaaacttttgaagagaaggagatggagaaacagaaaaccctctatcagcaagctcggctg cacgagcgtggtaccgccgagatggtccttcagatgataagcgccagcaaaggtgagatg agccccatggtggttgagactctgaagctggggatcgccattctgaatggaggcaacact ggcgtgcagcagaaaatgctagattacctcaaggagaaaaaggatgccggattctttcaa agcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcatttgagaggcag aacaaagctgaaggcctgggaatggtgactgaagaaggaacactcattgttcgtgagcgt ggtgaaaaagtactccagaatgacgagttcacgcgtgatctctttagattcctgcagtta ctttgtgagggacataacagtgacttccagaacttcctgcggactcagatgggcaacacc accaccgtgaacatcatcatcagcaccgtggactaccttctgcgtctgcaggaatcaatc agtgatttctactggtattattcagggaaggacatcattgatgaatctggacagcacaat ttttccaaagctctggcagtcaccaagcagatttttaactctcttacagaatacatccag ggcccttgcgtcgggaaccagcagagcctggcccacagccggctgtgggacgcagtggtt ggcttcctccacgtgttcgctaacatgcagatgaagctctctcaggattccagtcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtccctc ctggaagggaatgtggtaaatggaactattggcaagcagatggtcgatacactggtagaa tcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaacttaaagac ttaaccagctcagataccttcaaagactatgacccagatgggaaagggattatctccaag aaagaattccagaaggccatggaagggcaaaaacagtacacgcagtcagagattgacttt ctcctttcgtgtgcagaagctgatgagaatgacatgtttaattacatggactttgtagac cggttccatgagccggccaaggacatagggttcaatgtggcggtgttgctgacaaacctt tctgaacacatgccaaatgactctcgcctgaagtgtctgctggacccggcagaaagtgtg ctgaattacttcgaaccgtacctgggaaggatcgagatcatgggtggggccaagaaaata gagcgtgtttattttgagatcactgagtccagtcggactcagtgggagaagccccaggtg aaggaatctaagcggcagttcattttcgatgtcgtcaacgaaggtggggagcaggagaag atggagctgttcgtgaacttctgcgaggacacgatctttgagatgcagttagcgtctcag atttctgaatctgactcagcagacaggccggaggaggaggaggaggaagacgctccttac acattggaaattgaaggcgaagaggaggaagacaagtgttttgagtctccctcagcattt gccatggcctgtgcctccatgaagagaagtgtcaccagctttctaaagaaggccaccctg aagaacgtcaggaagcagtacaggaatgtgaaaaagatgtctgccaaggagctggtgaag gtgttcttctcttttttctggacactgttcctggggctcttccagctgttcttcggcata ttgggagggatctttcaggtcctgtggagcacggtgtttggagggggcctcgtagaaggg gcaaagaacatcagagtgaccaagatcctgggtgacatgcctgacccgacccaatttggt attcatgaggatgctgtggagatggagagggcggaggtgaccgagccggggatcacagct gacctggcccacttcgtaaagggtgagaagggagatgcagacatgatcccagacctcttt ggactgcacccaaagaaagaaggtggcttaaagcacgggcccgaagtgggtttgggtgac ctctctgaaattattggcaaggatgaagcccccacgttagagaatactgttcgcaagaaa aggaaagcacaggcagcagagatgaaaacagcgcatgaagtggaaggaaaagtagactct gagaaggcagacacggaagatggagaaaaagcggacagagccaaagaggaggaacaagcc gagtacttgtgggcagaagtgacaaaaaggaggaagcgacggcacggtcagaaggttgag aagccagaagccttcacagccaatttctttaaagggctggaaatctatcagaccaagcta ctgcattacctggccaggaatttctacaacctgaggttccttgctctgtttgtagccttc gctatcaacttcatcctgcttttttataaggtcactgaagaacctttagaagaagaaaca gaggatgttgcaaacctgtggaattcctttaatgatgaggaagaggaggaagcgatggtg ttcttcgttctgcaagagagcactggatatatggcacccacgctgcgggccctggccatc atccacacgatcatctctctagtctgtgtggtgggctactactgcctgaaggtccctttg gtggtattcaaaagggaaaaagaaattgccaggaagctggagtttgatggcctgtatatc acagaacagccatccgaagatgacatcaaggggcagtgggaccgcttggtgatcaacaca ccgtcttttcctaataactactgggacaagtttgtaaagagaaaggtaatcaacaagtat ggagatctctatggagcagagcgcattgctgaactcctgggtttggacaaaaatgccctt gactttagcccaatagaagagactacagcagaggcagcttctctggtatcatggctaagt tccatcgacatgaagtaccatatctggaagctgggggttgtttttaccgacaactccttt ctctaccttgcctggtacacaaccatgtcagtcctgggccactacaacaacttcttcttt gctgctcatctactggatattgccatgggcttcaagacgttgaggaccatcctgtcatct gtaactcacaatggcaaacagttggttctgaccgtcggtctgctggctgtggtggtttat ctctacactgtggtggccttcaacttcttccgcaagttctacaacaagagtgaagacgac gacgagccggatatgaagtgtgacgacatgatgacttgttaccttttccacatgtacgtg ggcgtgagagcaggaggcggcattggcgatgaaatcgaagaccctgctggtgacccttat gaaatgtatcgcatcgtcttcgacattaccttcttcttcttcgtcattgtcatcttgctg gccatcattcaaggtcttattattgatgcctttggagagctaagagaccagcaggaacaa gtgcgagaagacatggagactaaatgtttcatctgcgggattggcaatgactactttgac acaacccctcatggttttgaaacacatacgctacaagagcacaacttagccaactacctg ttctttctgatgtatttgattaacaaagatgaaaccgagcacacgggtcaggaatcctat gtctggaagatgtaccaagaaaggtgttgggatttcttcccggctggcgactgctttcgt aaacaatatgaagatcagctgggctaa

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