KEGG   Microcebus murinus (gray mouse lemur): 105868083
Entry
105868083         CDS       T07238                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mmur  Microcebus murinus (gray mouse lemur)
Pathway
mmur01521  EGFR tyrosine kinase inhibitor resistance
mmur01522  Endocrine resistance
mmur04010  MAPK signaling pathway
mmur04012  ErbB signaling pathway
mmur04014  Ras signaling pathway
mmur04015  Rap1 signaling pathway
mmur04022  cGMP-PKG signaling pathway
mmur04024  cAMP signaling pathway
mmur04062  Chemokine signaling pathway
mmur04066  HIF-1 signaling pathway
mmur04068  FoxO signaling pathway
mmur04071  Sphingolipid signaling pathway
mmur04072  Phospholipase D signaling pathway
mmur04114  Oocyte meiosis
mmur04140  Autophagy - animal
mmur04148  Efferocytosis
mmur04150  mTOR signaling pathway
mmur04151  PI3K-Akt signaling pathway
mmur04210  Apoptosis
mmur04218  Cellular senescence
mmur04270  Vascular smooth muscle contraction
mmur04370  VEGF signaling pathway
mmur04371  Apelin signaling pathway
mmur04380  Osteoclast differentiation
mmur04510  Focal adhesion
mmur04540  Gap junction
mmur04550  Signaling pathways regulating pluripotency of stem cells
mmur04613  Neutrophil extracellular trap formation
mmur04620  Toll-like receptor signaling pathway
mmur04650  Natural killer cell mediated cytotoxicity
mmur04660  T cell receptor signaling pathway
mmur04662  B cell receptor signaling pathway
mmur04664  Fc epsilon RI signaling pathway
mmur04666  Fc gamma R-mediated phagocytosis
mmur04668  TNF signaling pathway
mmur04720  Long-term potentiation
mmur04722  Neurotrophin signaling pathway
mmur04725  Cholinergic synapse
mmur04726  Serotonergic synapse
mmur04730  Long-term depression
mmur04810  Regulation of actin cytoskeleton
mmur04910  Insulin signaling pathway
mmur04912  GnRH signaling pathway
mmur04914  Progesterone-mediated oocyte maturation
mmur04915  Estrogen signaling pathway
mmur04916  Melanogenesis
mmur04917  Prolactin signaling pathway
mmur04919  Thyroid hormone signaling pathway
mmur04921  Oxytocin signaling pathway
mmur04926  Relaxin signaling pathway
mmur04928  Parathyroid hormone synthesis, secretion and action
mmur04929  GnRH secretion
mmur04934  Cushing syndrome
mmur04935  Growth hormone synthesis, secretion and action
mmur05010  Alzheimer disease
mmur05022  Pathways of neurodegeneration - multiple diseases
mmur05034  Alcoholism
mmur05132  Salmonella infection
mmur05135  Yersinia infection
mmur05160  Hepatitis C
mmur05161  Hepatitis B
mmur05163  Human cytomegalovirus infection
mmur05164  Influenza A
mmur05165  Human papillomavirus infection
mmur05166  Human T-cell leukemia virus 1 infection
mmur05167  Kaposi sarcoma-associated herpesvirus infection
mmur05170  Human immunodeficiency virus 1 infection
mmur05200  Pathways in cancer
mmur05205  Proteoglycans in cancer
mmur05206  MicroRNAs in cancer
mmur05207  Chemical carcinogenesis - receptor activation
mmur05208  Chemical carcinogenesis - reactive oxygen species
mmur05210  Colorectal cancer
mmur05211  Renal cell carcinoma
mmur05212  Pancreatic cancer
mmur05213  Endometrial cancer
mmur05214  Glioma
mmur05215  Prostate cancer
mmur05216  Thyroid cancer
mmur05218  Melanoma
mmur05219  Bladder cancer
mmur05220  Chronic myeloid leukemia
mmur05221  Acute myeloid leukemia
mmur05223  Non-small cell lung cancer
mmur05224  Breast cancer
mmur05225  Hepatocellular carcinoma
mmur05226  Gastric cancer
mmur05230  Central carbon metabolism in cancer
mmur05231  Choline metabolism in cancer
mmur05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmur00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    105868083 (MAP2K1)
   04012 ErbB signaling pathway
    105868083 (MAP2K1)
   04014 Ras signaling pathway
    105868083 (MAP2K1)
   04015 Rap1 signaling pathway
    105868083 (MAP2K1)
   04370 VEGF signaling pathway
    105868083 (MAP2K1)
   04371 Apelin signaling pathway
    105868083 (MAP2K1)
   04668 TNF signaling pathway
    105868083 (MAP2K1)
   04066 HIF-1 signaling pathway
    105868083 (MAP2K1)
   04068 FoxO signaling pathway
    105868083 (MAP2K1)
   04072 Phospholipase D signaling pathway
    105868083 (MAP2K1)
   04071 Sphingolipid signaling pathway
    105868083 (MAP2K1)
   04024 cAMP signaling pathway
    105868083 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    105868083 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    105868083 (MAP2K1)
   04150 mTOR signaling pathway
    105868083 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    105868083 (MAP2K1)
   04148 Efferocytosis
    105868083 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    105868083 (MAP2K1)
   04210 Apoptosis
    105868083 (MAP2K1)
   04218 Cellular senescence
    105868083 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    105868083 (MAP2K1)
   04540 Gap junction
    105868083 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    105868083 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    105868083 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    105868083 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    105868083 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    105868083 (MAP2K1)
   04660 T cell receptor signaling pathway
    105868083 (MAP2K1)
   04662 B cell receptor signaling pathway
    105868083 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    105868083 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    105868083 (MAP2K1)
   04062 Chemokine signaling pathway
    105868083 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    105868083 (MAP2K1)
   04929 GnRH secretion
    105868083 (MAP2K1)
   04912 GnRH signaling pathway
    105868083 (MAP2K1)
   04915 Estrogen signaling pathway
    105868083 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    105868083 (MAP2K1)
   04917 Prolactin signaling pathway
    105868083 (MAP2K1)
   04921 Oxytocin signaling pathway
    105868083 (MAP2K1)
   04926 Relaxin signaling pathway
    105868083 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    105868083 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    105868083 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    105868083 (MAP2K1)
   04916 Melanogenesis
    105868083 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    105868083 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    105868083 (MAP2K1)
   04726 Serotonergic synapse
    105868083 (MAP2K1)
   04720 Long-term potentiation
    105868083 (MAP2K1)
   04730 Long-term depression
    105868083 (MAP2K1)
   04722 Neurotrophin signaling pathway
    105868083 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    105868083 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    105868083 (MAP2K1)
   05206 MicroRNAs in cancer
    105868083 (MAP2K1)
   05205 Proteoglycans in cancer
    105868083 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    105868083 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    105868083 (MAP2K1)
   05230 Central carbon metabolism in cancer
    105868083 (MAP2K1)
   05231 Choline metabolism in cancer
    105868083 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    105868083 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    105868083 (MAP2K1)
   05212 Pancreatic cancer
    105868083 (MAP2K1)
   05225 Hepatocellular carcinoma
    105868083 (MAP2K1)
   05226 Gastric cancer
    105868083 (MAP2K1)
   05214 Glioma
    105868083 (MAP2K1)
   05216 Thyroid cancer
    105868083 (MAP2K1)
   05221 Acute myeloid leukemia
    105868083 (MAP2K1)
   05220 Chronic myeloid leukemia
    105868083 (MAP2K1)
   05218 Melanoma
    105868083 (MAP2K1)
   05211 Renal cell carcinoma
    105868083 (MAP2K1)
   05219 Bladder cancer
    105868083 (MAP2K1)
   05215 Prostate cancer
    105868083 (MAP2K1)
   05213 Endometrial cancer
    105868083 (MAP2K1)
   05224 Breast cancer
    105868083 (MAP2K1)
   05223 Non-small cell lung cancer
    105868083 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    105868083 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    105868083 (MAP2K1)
   05161 Hepatitis B
    105868083 (MAP2K1)
   05160 Hepatitis C
    105868083 (MAP2K1)
   05164 Influenza A
    105868083 (MAP2K1)
   05163 Human cytomegalovirus infection
    105868083 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    105868083 (MAP2K1)
   05165 Human papillomavirus infection
    105868083 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    105868083 (MAP2K1)
   05135 Yersinia infection
    105868083 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    105868083 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    105868083 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    105868083 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    105868083 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    105868083 (MAP2K1)
   01522 Endocrine resistance
    105868083 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmur01001]
    105868083 (MAP2K1)
Enzymes [BR:mmur01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     105868083 (MAP2K1)
Protein kinases [BR:mmur01001]
 Serine/threonine kinases: STE group
  STE7 family
   105868083 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Seadorna_VP7 Haspin_kinase
Other DBs
NCBI-GeneID: 105868083
NCBI-ProteinID: XP_012614062
Ensembl: ENSMICG00000004393
UniProt: A0A8B7FX99
LinkDB
Position
3:complement(98965313..99046678)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSAY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagttgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaatctggaggccttgcagaagaagctggaggagctg
gagcttgatgaacagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttccggactggttatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccatacatcgttggcttctatggtgcattctacagcgatggcgagatcagt
atctgcatggagcatatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaaacacaagattatgcacagagatgtcaagccctccaacatcctagttaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaagatcctacatgtcgccagaaagactccaagggactcattac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcagttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttggatgccaggtggag
ggagatgcagctgagaccccacccaggccgagaacccctgggaggcccctcagtgcatat
ggaatggacagccgacctcccatggcgatttttgagttgttggattacatagtcaatgag
cctcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcggagagagcagatttgaaacaacttatggttcatgctttt
atcaagagatcggatgctgaggaagtagatttcgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaactcacgcggctggtgtctaa

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