KEGG   PATHWAY: mna04514
mna04514                    Pathway                                

Cell adhesion molecules - Miniopterus natalensis
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Environmental Information Processing; Signaling molecules and interaction
Pathway map
mna04514  Cell adhesion molecules

Other DBs
GO: 0050839
Miniopterus natalensis [GN:mna]
107545253  CD58; lymphocyte function-associated antigen 3 [KO:K06492]
107545372  CD2; T-cell surface antigen CD2 [KO:K06449]
107545841  platelet receptor Gi24 [KO:K23268]
107527389  IGSF11; immunoglobulin superfamily member 11 [KO:K06791]
107527336  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
107538149  CD274; programmed cell death 1 ligand 1 [KO:K06745]
107524832  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
107527343  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
107524834  CTLA4; cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
107537458  ICOSLG; ICOS ligand [KO:K06710]
107524793  ICOS; inducible T-cell costimulator [KO:K06713]
107545174  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107536419  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
107544122  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107542667  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
107542672  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
107542674  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
107545091  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107545092  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
107531685  uncharacterized protein LOC107531685 [KO:K10784]
107544013  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
107538488  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
107538961  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107525813  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
107546126  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
107546127  class I histocompatibility antigen, Gogo-C*0101/C*0102 alpha chain-like [KO:K06751]
107528441  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
107528628  CD8A; T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
107528645  CD8B; T-cell surface glycoprotein CD8 beta chain isoform X1 [KO:K06459]
107538100  PDCD1LG2; programmed cell death 1 ligand 2 [KO:K06708]
107528516  CD276; CD276 antigen isoform X1 [KO:K06746]
107545307  VTCN1; V-set domain-containing T-cell activation inhibitor 1 isoform X1 [KO:K06747]
107530026  PDCD1; programmed cell death protein 1 [KO:K06744]
107530873  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
107539933  CD40LG; CD40 ligand [KO:K03161]
107523958  ALCAM; CD166 antigen [KO:K06547]
107527647  CD6; T-cell differentiation antigen CD6 [KO:K06456]
107536315  CD226; CD226 antigen [KO:K06567]
107536798  NECTIN2; nectin-2 isoform X1 [KO:K06531]
107527387  TIGIT; T-cell immunoreceptor with Ig and ITIM domains [KO:K16350]
107541988  ITGAL; integrin alpha-L [KO:K05718]
107543669  ITGB2; integrin beta-2 [KO:K06464]
107533247  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
107531104  ICAM2; intercellular adhesion molecule 2 [KO:K06523]
107533301  ICAM3; intercellular adhesion molecule 3 isoform X1 [KO:K06486]
107543399  CD22; B-cell receptor CD22 [KO:K06467]
107540236  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:]
107536400  SIGLEC1; sialoadhesin [KO:K06548]
107527328  NECTIN3; nectin-3 [KO:K06592]
107533012  CLDN34; claudin-34 [KO:K06087]
107532131  CLDN2; claudin-2 [KO:K06087]
107541283  claudin-22-like [KO:K06087]
107541286  putative claudin-24 [KO:K06087]
107541287  claudin-22-like [KO:K06087]
107526510  CLDN15; claudin-15 [KO:K06087]
107531162  CLDN19; claudin-19 [KO:K06087]
107535846  CLDN6; claudin-6 [KO:K06087]
107535847  CLDN9; claudin-9 [KO:K06087]
107526582  CLDN3; claudin-3 [KO:K06087]
107526583  CLDN4; claudin-4 isoform X1 [KO:K06087]
107527366  CLDN16; claudin-16 [KO:K06087]
107527824  CLDN20; claudin-20 [KO:K06087]
107531292  CLDN25; LOW QUALITY PROTEIN: putative claudin-25 [KO:K06087]
107544613  CLDN7; claudin-7 [KO:K06087]
107527299  CLDN1; claudin-1 [KO:K06087]
107546080  CLDN18; claudin-18 isoform X1 [KO:K06087]
107543691  CLDN14; claudin-14 [KO:K06087]
107529521  CLDN11; claudin-11 [KO:K06087]
107545903  CLDN10; claudin-10 isoform X1 [KO:K06087]
107539888  CLDN17; claudin-17 [KO:K06087]
107530497  CLDN5; claudin-5 [KO:K06087]
107537805  OCLN; occludin [KO:K06088]
107535112  F11R; junctional adhesion molecule A [KO:K06089]
107525477  JAM2; junctional adhesion molecule B [KO:K06735]
107540599  JAM3; junctional adhesion molecule C isoform X1 [KO:K06785]
107530503  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
107537188  CDH5; cadherin-5 [KO:K06533]
107530700  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
107542469  CD99; CD99 antigen [KO:K06520]
107542472  XG; glycoprotein Xg [KO:K06520]
107544165  CD99 antigen-like protein 2 [KO:K06520]
107540812  ITGAM; integrin alpha-M [KO:K06461]
107533858  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
107529070  SELP; P-selectin [KO:K06496]
107546708  ITGA4; integrin alpha-4 [KO:K06483]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107530679  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
107528299  ITGB7; integrin beta-7 [KO:K06590]
107538561  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
107529072  SELL; L-selectin [KO:K06495]
107532929  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
107524566  GLG1; Golgi apparatus protein 1 isoform X1 [KO:K06816]
107533086  NECTIN1; nectin-1 [KO:K06081]
107524183  CDH2; cadherin-2 [KO:K06736]
107525467  NCAM2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
107531317  NCAM1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
107538801  L1CAM; neural cell adhesion molecule L1 [KO:K06550]
107534007  CADM1; cell adhesion molecule 1 isoform X1 [KO:K06781]
107540087  NEGR1; neuronal growth regulator 1 [KO:K06775]
107537178  NTNG1; netrin-G1 [KO:K07522]
107525482  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
107524676  NTNG2; netrin-G2 [KO:K16359]
107537338  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
107544331  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:]
107531782  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
107546364  SDC1; syndecan-1 [KO:K06257]
107526147  SDC2; syndecan-2 [KO:K16336]
107540411  SDC3; syndecan-3 [KO:K16337]
107530912  SDC4; syndecan-4 isoform X1 [KO:K16338]
107536679  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
107540309  ITGB8; integrin beta-8 [KO:K06591]
107530252  ITGA8; integrin alpha-8 [KO:K06584]
107542696  NRXN3; neurexin 3 isoform X1 [KO:K07377]
107544280  NRXN1; LOW QUALITY PROTEIN: neurexin-1 [KO:K07377]
107542792  NRXN2; neurexin-2-beta [KO:K07377]
107544588  NLGN2; neuroligin-2 isoform X1 [KO:K07378]
107532893  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
107540418  NLGN4X; neuroligin-4, X-linked [KO:K07378]
107544258  neuroligin-1 [KO:K07378]
107541580  CADM3; cell adhesion molecule 3 isoform X1 [KO:K06780]
107526621  NRCAM; neuronal cell adhesion molecule [KO:K06756]
107528192  CNTN1; contactin-1 [KO:K06759]
107535877  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:]
107539321  CNTN2; contactin-2 isoform X1 [KO:K06760]
107538720  NFASC; neurofascin [KO:K06757]
107528928  CNTNAP1; contactin-associated protein 1 [KO:K07379]
107523799  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
107529054  MPZL1; myelin protein zero-like protein 1 [KO:K06770]
107535130  MPZ; LOW QUALITY PROTEIN: myelin protein P0 [KO:K06770]
107543404  MAG; myelin-associated glycoprotein [KO:K06771]
107527895  CDH1; cadherin-1 [KO:K05689]
107535027  VCAN; versican core protein isoform X1 [KO:K06793]
107530895  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107527894  CDH3; cadherin-3 [KO:K06796]
107529778  CDH4; cadherin-4 [KO:K06797]
107543518  CDH15; cadherin-15 [KO:K06809]
107528447  NEO1; neogenin isoform X1 [KO:K06766]
Barclay AN.
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
Semin Immunol 15:215-23 (2003)
Sharpe AH, Freeman GJ.
The B7-CD28 superfamily.
Nat Rev Immunol 2:116-26 (2002)
Grewal IS, Flavell RA.
CD40 and CD154 in cell-mediated immunity.
Annu Rev Immunol 16:111-35 (1998)
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
J Immunol 175:1558-65 (2005)
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
Cell adhesion and polarity during immune interactions.
Immunol Rev 186:68-82 (2002)
Dejana E.
Endothelial cell-cell junctions: happy together.
Nat Rev Mol Cell Biol 5:261-70 (2004)
Bazzoni G.
The JAM family of junctional adhesion molecules.
Curr Opin Cell Biol 15:525-30 (2003)
Becker BF, Heindl B, Kupatt C, Zahler S.
Endothelial function and hemostasis.
Z Kardiol 89:160-7 (2000)
Elangbam CS, Qualls CW Jr, Dahlgren RR.
Cell adhesion molecules--update.
Vet Pathol 34:61-73 (1997)
Muller WA.
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
Trends Immunol 24:327-34 (2003)
Yamagata M, Sanes JR, Weiner JA.
Synaptic adhesion molecules.
Curr Opin Cell Biol 15:621-32 (2003)
Ethell IM, Pasquale EB.
Molecular mechanisms of dendritic spine development and remodeling.
Prog Neurobiol 75:161-205 (2005)
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
Making memories stick: cell-adhesion molecules in synaptic plasticity.
Trends Cell Biol 10:473-82 (2000)
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
Mol Cell Neurosci 19:292-306 (2002)
Dunican DJ, Doherty P.
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
Mol Cell Biol Res Commun 3:255-63 (2000)
Girault JA, Peles E.
Development of nodes of Ranvier.
Curr Opin Neurobiol 12:476-85 (2002)
Arroyo EJ, Scherer SS.
On the molecular architecture of myelinated fibers.
Histochem Cell Biol 113:1-18 (2000)
Salzer JL.
Polarized domains of myelinated axons.
Neuron 40:297-318 (2003)
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
Roles and modes of action of nectins in cell-cell adhesion.
Semin Cell Dev Biol 15:643-56 (2004)
Nakanishi H, Takai Y.
Roles of nectins in cell adhesion, migration and polarization.
Biol Chem 385:885-92 (2004)
Siu MK, Cheng CY.
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
Biol Reprod 71:375-91 (2004)
Lee NP, Cheng CY.
Adaptors, junction dynamics, and spermatogenesis.
Biol Reprod 71:392-404 (2004)
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
Development 132:1525-37 (2005)
Marthiens V, Gavard J, Lambert M, Mege RM.
Cadherin-based cell adhesion in neuromuscular development.
Biol Cell 94:315-26 (2002)
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
J Cell Sci 118:2355-62 (2005)
mna04520  Adherens junction
mna04530  Tight junction
mna04610  Complement and coagulation cascades
mna04660  T cell receptor signaling pathway
mna04670  Leukocyte transendothelial migration
KO pathway

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