KEGG   PATHWAY: mna04630
mna04630                    Pathway                                

JAK-STAT signaling pathway - Miniopterus natalensis
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
mna04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Miniopterus natalensis [GN:mna]
107529760  IL2; interleukin-2 [KO:K05429]
107525027  IL4; interleukin-4 [KO:K05430]
107525025  IL5; interleukin-5 [KO:K05428]
107540295  IL6; interleukin-6 [KO:K05405]
107539481  IL7; interleukin-7 [KO:K05431]
107525410  IL9; interleukin-9 [KO:K05432]
107539442  IL10; interleukin-10 [KO:K05443]
107541304  IL11; interleukin-11 [KO:K05417]
107539273  IL12A; interleukin-12 subunit alpha [KO:K05406]
107537877  IL12B; interleukin-12 subunit beta [KO:K05425]
107525052  IL13; interleukin-13 [KO:K05435]
107532491  IL15; interleukin-15 [KO:K05433]
107529936  IL17D; interleukin-17D [KO:K05492]
107539452  IL19; interleukin-19 [KO:K05444]
107539124  IL20; interleukin-20 [KO:K22667]
107529740  IL21; interleukin-21 [KO:K05434]
107527220  IL22; interleukin-22 [KO:K05445]
107546155  IL23A; interleukin-23 subunit alpha [KO:K05426]
107539458  IL24; interleukin-24 isoform X1 [KO:K22668]
107531433  IFNB1; interferon beta [KO:K05415]
107527227  IFNG; interferon gamma [KO:K04687]
107541202  IFNE; interferon epsilon [KO:K05442]
107543083  IFNK; interferon kappa [KO:K05441]
107534165  IFNL1; interferon lambda-1 [KO:K05447]
107534161  interferon lambda-3-like [KO:K22669]
107534162  interferon lambda-3-like [KO:K22669]
107534163  interferon lambda-3-like [KO:K22669]
107541200  interferon omega-1-like [KO:K05440]
107541196  interferon tau-like [KO:K05440]
107541199  interferon omega-1-like [KO:K05440]
107526227  OSM; oncostatin-M [KO:K05418]
107526243  LIF; leukemia inhibitory factor [KO:K05419]
107541983  LOW QUALITY PROTEIN: cardiotrophin-2-like [KO:K24382]
107525060  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
107527702  CNTF; ciliary neurotrophic factor [KO:K05420]
107528961  CSF3; granulocyte colony-stimulating factor [KO:K05423]
107540896  EPO; erythropoietin isoform X1 [KO:K05437]
107531064  somatotropin-like [KO:K05438]
107537334  LEP; leptin [KO:K05424]
107543119  THPO; thrombopoietin isoform X1 [KO:K06854]
107533698  PRL; prolactin isoform X1 [KO:K05439]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107542420  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
107545294  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
107532895  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
107543962  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
107539670  interleukin-4 receptor subunit alpha-like [KO:K05071]
107544754  interleukin-4 receptor subunit alpha-like [KO:K05071]
107529138  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
107543721  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
107546370  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
107539642  IL9R; interleukin-9 receptor [KO:K05073]
107530781  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
107537472  interleukin-10 receptor subunit beta-like isoform X1 [KO:K05135]
107545002  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
107535370  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
107533449  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
107529345  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
107537520  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
107542422  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
107530947  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
107546079  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
107539652  IL21R; interleukin-21 receptor [KO:K05075]
107542211  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
107530946  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
107533896  IL23R; interleukin-23 receptor [KO:K05065]
107544337  IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
107527134  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
107537477  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
107530983  IFNGR1; interferon gamma receptor 1 [KO:K05132]
107537453  IFNGR2; interferon gamma receptor 2 [KO:K05133]
107541834  IFNLR1; interferon lambda receptor 1 [KO:K05140]
107545740  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
107545726  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
107543957  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
107545016  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
107543958  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
107543956  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
107545322  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
107542574  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
107533235  EPOR; erythropoietin receptor [KO:K05079]
107545625  GHR; growth hormone receptor [KO:K05080]
107533557  LEPR; leptin receptor isoform X1 [KO:K05062]
107542708  MPL; thrombopoietin receptor [KO:K05082]
107546187  PRLR; prolactin receptor [KO:K05081]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
107533604  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
107538122  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:]
107535380  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:]
107533300  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:]
107540521  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
107546189  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
107528938  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
107540906  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
107528939  STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223]
107528845  signal transducer and activator of transcription 5B-like [KO:K11224]
107546227  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
107540176  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
107525439  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
107538918  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
107532035  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
107525887  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
107540251  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
107529025  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
107536258  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
107545431  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
107539147  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
107527777  BCL2L1; bcl-2-like protein 1 [KO:K04570]
107545640  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:]
107539494  MYC; myc proto-oncogene protein [KO:K04377]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107538904  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107536896  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107545578  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
107544193  AOX1; aldehyde oxidase [KO:K00157] [EC:]
107524097  aldehyde oxidase 4-like [KO:K00157] [EC:]
107524106  aldehyde oxidase 2 isoform X1 [KO:K00157] [EC:]
107528850  GFAP; glial fibrillary acidic protein isoform X1 [KO:K05640]
107540619  STAM; signal transducing adapter molecule 1 [KO:K04705]
107531669  STAM2; signal transducing adapter molecule 2 [KO:K04705]
107525236  PTPN2; tyrosine-protein phosphatase non-receptor type 2 [KO:K18026] [EC:]
107544062  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:]
107531724  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
107535781  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:]
107531280  EP300; histone acetyltransferase p300 [KO:K04498] [EC:]
107525838  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
107546617  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
107529097  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
107525640  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X1 [KO:K16065] [EC:]
107539938  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
107529574  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
107540994  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
mna04010  MAPK signaling pathway
mna04060  Cytokine-cytokine receptor interaction
mna04110  Cell cycle
mna04120  Ubiquitin mediated proteolysis
mna04151  PI3K-Akt signaling pathway
mna04210  Apoptosis
KO pathway

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