KEGG   PATHWAY: mna04672
Entry
mna04672                    Pathway                                

Name
Intestinal immune network for IgA production - Miniopterus natalensis
Description
The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes.
Class
Organismal Systems; Immune system
Pathway map
mna04672  Intestinal immune network for IgA production
mna04672

Other DBs
GO: 0002387
Organism
Miniopterus natalensis [GN:mna]
Gene
107527336  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
107527343  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
107545174  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107536419  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
107544122  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
107542667  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
107542672  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
107542674  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
107545091  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
107545092  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
107524832  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
107531685  uncharacterized protein LOC107531685 [KO:K10784]
107529760  IL2; interleukin-2 [KO:K05429]
107525027  IL4; interleukin-4 [KO:K05430]
107525025  IL5; interleukin-5 [KO:K05428]
107540295  IL6; interleukin-6 [KO:K05405]
107539442  IL10; interleukin-10 [KO:K05443]
107534176  TGFB1; transforming growth factor beta-1 [KO:K13375]
107544615  TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
107530196  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
107539194  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
107525448  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
107543987  AICDA; single-stranded DNA cytosine deaminase [KO:K10989] [EC:3.5.4.38]
107530873  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
107539933  CD40LG; CD40 ligand [KO:K03161]
107524793  ICOS; inducible T-cell costimulator [KO:K06713]
107537458  ICOSLG; ICOS ligand [KO:K06710]
107529371  CCR9; C-C chemokine receptor type 9 [KO:K04184]
107546708  ITGA4; integrin alpha-4 [KO:K06483]
107528299  ITGB7; integrin beta-7 [KO:K06590]
107532553  CXCL12; stromal cell-derived factor 1 [KO:K10031]
107531145  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
107526276  CCL28; C-C motif chemokine 28 [KO:K05513]
107528866  CCR10; C-C chemokine receptor type 10 [KO:K04185]
107529902  CCL25; C-C motif chemokine 25 [KO:K13072]
107538561  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
107543972  LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
107528876  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
107532491  IL15; interleukin-15 [KO:K05433]
107542422  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
107539473  PIGR; polymeric immunoglobulin receptor [KO:K13073]
Compound
C00777  Retinoate
C15493  9-cis-Retinoic acid
Reference
  Authors
Fagarasan S, Honjo T
  Title
Intestinal IgA synthesis: regulation of front-line body defences.
  Journal
Nat Rev Immunol 3:63-72 (2003)
DOI:10.1038/nri982
Reference
  Authors
Macpherson AJ, McCoy KD, Johansen FE, Brandtzaeg P
  Title
The immune geography of IgA induction and function.
  Journal
Mucosal Immunol 1:11-22 (2008)
DOI:10.1038/mi.2007.6
Reference
  Authors
Kunisawa J, Kiyono H
  Title
A marvel of mucosal T cells and secretory antibodies for the creation of first lines of defense.
  Journal
Cell Mol Life Sci 62:1308-21 (2005)
DOI:10.1007/s00018-005-5035-1
Reference
  Authors
Cerutti A, Rescigno M
  Title
The biology of intestinal immunoglobulin A responses.
  Journal
Immunity 28:740-50 (2008)
DOI:10.1016/j.immuni.2008.05.001
Reference
  Authors
Tsuji M, Suzuki K, Kinoshita K, Fagarasan S
  Title
Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis.
  Journal
Semin Immunol 20:59-66 (2008)
DOI:10.1016/j.smim.2007.12.003
Reference
  Authors
Corthesy B
  Title
Roundtrip ticket for secretory IgA: role in mucosal homeostasis?
  Journal
J Immunol 178:27-32 (2007)
DOI:10.4049/jimmunol.178.1.27
Reference
  Authors
Suzuki K, Fagarasan S
  Title
How host-bacterial interactions lead to IgA synthesis in the gut.
  Journal
Trends Immunol 29:523-31 (2008)
DOI:10.1016/j.it.2008.08.001
Reference
  Authors
Mora JR, von Andrian UH
  Title
Differentiation and homing of IgA-secreting cells.
  Journal
Mucosal Immunol 1:96-109 (2008)
DOI:10.1038/mi.2007.14
Reference
  Authors
Suzuki K, Ha SA, Tsuji M, Fagarasan S
  Title
Intestinal IgA synthesis: a primitive form of adaptive immunity that regulates microbial communities in the gut.
  Journal
Semin Immunol 19:127-35 (2007)
DOI:10.1016/j.smim.2006.10.001
Reference
  Authors
Cerutti A
  Title
The regulation of IgA class switching.
  Journal
Nat Rev Immunol 8:421-34 (2008)
DOI:10.1038/nri2322
Related
pathway
mna04612  Antigen processing and presentation
mna04660  T cell receptor signaling pathway
mna04662  B cell receptor signaling pathway
mna04670  Leukocyte transendothelial migration
KO pathway
ko04672   
LinkDB

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