KEGG   Microtus oregoni (creeping vole): 121443425
Entry
121443425         CDS       T08307                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
morg  Microtus oregoni (creeping vole)
Pathway
morg01521  EGFR tyrosine kinase inhibitor resistance
morg01522  Endocrine resistance
morg04010  MAPK signaling pathway
morg04012  ErbB signaling pathway
morg04014  Ras signaling pathway
morg04015  Rap1 signaling pathway
morg04022  cGMP-PKG signaling pathway
morg04024  cAMP signaling pathway
morg04062  Chemokine signaling pathway
morg04068  FoxO signaling pathway
morg04071  Sphingolipid signaling pathway
morg04072  Phospholipase D signaling pathway
morg04140  Autophagy - animal
morg04150  mTOR signaling pathway
morg04151  PI3K-Akt signaling pathway
morg04210  Apoptosis
morg04218  Cellular senescence
morg04270  Vascular smooth muscle contraction
morg04360  Axon guidance
morg04370  VEGF signaling pathway
morg04371  Apelin signaling pathway
morg04510  Focal adhesion
morg04540  Gap junction
morg04550  Signaling pathways regulating pluripotency of stem cells
morg04613  Neutrophil extracellular trap formation
morg04625  C-type lectin receptor signaling pathway
morg04630  JAK-STAT signaling pathway
morg04650  Natural killer cell mediated cytotoxicity
morg04660  T cell receptor signaling pathway
morg04662  B cell receptor signaling pathway
morg04664  Fc epsilon RI signaling pathway
morg04666  Fc gamma R-mediated phagocytosis
morg04720  Long-term potentiation
morg04722  Neurotrophin signaling pathway
morg04726  Serotonergic synapse
morg04730  Long-term depression
morg04810  Regulation of actin cytoskeleton
morg04910  Insulin signaling pathway
morg04912  GnRH signaling pathway
morg04914  Progesterone-mediated oocyte maturation
morg04915  Estrogen signaling pathway
morg04916  Melanogenesis
morg04917  Prolactin signaling pathway
morg04919  Thyroid hormone signaling pathway
morg04921  Oxytocin signaling pathway
morg04926  Relaxin signaling pathway
morg04928  Parathyroid hormone synthesis, secretion and action
morg04929  GnRH secretion
morg04935  Growth hormone synthesis, secretion and action
morg05010  Alzheimer disease
morg05022  Pathways of neurodegeneration - multiple diseases
morg05034  Alcoholism
morg05132  Salmonella infection
morg05152  Tuberculosis
morg05160  Hepatitis C
morg05161  Hepatitis B
morg05163  Human cytomegalovirus infection
morg05164  Influenza A
morg05165  Human papillomavirus infection
morg05167  Kaposi sarcoma-associated herpesvirus infection
morg05170  Human immunodeficiency virus 1 infection
morg05200  Pathways in cancer
morg05205  Proteoglycans in cancer
morg05206  MicroRNAs in cancer
morg05207  Chemical carcinogenesis - receptor activation
morg05208  Chemical carcinogenesis - reactive oxygen species
morg05210  Colorectal cancer
morg05211  Renal cell carcinoma
morg05212  Pancreatic cancer
morg05213  Endometrial cancer
morg05214  Glioma
morg05215  Prostate cancer
morg05218  Melanoma
morg05219  Bladder cancer
morg05220  Chronic myeloid leukemia
morg05221  Acute myeloid leukemia
morg05223  Non-small cell lung cancer
morg05224  Breast cancer
morg05225  Hepatocellular carcinoma
morg05226  Gastric cancer
morg05230  Central carbon metabolism in cancer
morg05231  Choline metabolism in cancer
morg05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:morg00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    121443425 (Raf1)
   04012 ErbB signaling pathway
    121443425 (Raf1)
   04014 Ras signaling pathway
    121443425 (Raf1)
   04015 Rap1 signaling pathway
    121443425 (Raf1)
   04370 VEGF signaling pathway
    121443425 (Raf1)
   04371 Apelin signaling pathway
    121443425 (Raf1)
   04630 JAK-STAT signaling pathway
    121443425 (Raf1)
   04068 FoxO signaling pathway
    121443425 (Raf1)
   04072 Phospholipase D signaling pathway
    121443425 (Raf1)
   04071 Sphingolipid signaling pathway
    121443425 (Raf1)
   04024 cAMP signaling pathway
    121443425 (Raf1)
   04022 cGMP-PKG signaling pathway
    121443425 (Raf1)
   04151 PI3K-Akt signaling pathway
    121443425 (Raf1)
   04150 mTOR signaling pathway
    121443425 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    121443425 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    121443425 (Raf1)
   04218 Cellular senescence
    121443425 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    121443425 (Raf1)
   04540 Gap junction
    121443425 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    121443425 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    121443425 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    121443425 (Raf1)
   04625 C-type lectin receptor signaling pathway
    121443425 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    121443425 (Raf1)
   04660 T cell receptor signaling pathway
    121443425 (Raf1)
   04662 B cell receptor signaling pathway
    121443425 (Raf1)
   04664 Fc epsilon RI signaling pathway
    121443425 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    121443425 (Raf1)
   04062 Chemokine signaling pathway
    121443425 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    121443425 (Raf1)
   04929 GnRH secretion
    121443425 (Raf1)
   04912 GnRH signaling pathway
    121443425 (Raf1)
   04915 Estrogen signaling pathway
    121443425 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    121443425 (Raf1)
   04917 Prolactin signaling pathway
    121443425 (Raf1)
   04921 Oxytocin signaling pathway
    121443425 (Raf1)
   04926 Relaxin signaling pathway
    121443425 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    121443425 (Raf1)
   04919 Thyroid hormone signaling pathway
    121443425 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    121443425 (Raf1)
   04916 Melanogenesis
    121443425 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    121443425 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    121443425 (Raf1)
   04720 Long-term potentiation
    121443425 (Raf1)
   04730 Long-term depression
    121443425 (Raf1)
   04722 Neurotrophin signaling pathway
    121443425 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    121443425 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    121443425 (Raf1)
   05206 MicroRNAs in cancer
    121443425 (Raf1)
   05205 Proteoglycans in cancer
    121443425 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    121443425 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    121443425 (Raf1)
   05230 Central carbon metabolism in cancer
    121443425 (Raf1)
   05231 Choline metabolism in cancer
    121443425 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    121443425 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    121443425 (Raf1)
   05212 Pancreatic cancer
    121443425 (Raf1)
   05225 Hepatocellular carcinoma
    121443425 (Raf1)
   05226 Gastric cancer
    121443425 (Raf1)
   05214 Glioma
    121443425 (Raf1)
   05221 Acute myeloid leukemia
    121443425 (Raf1)
   05220 Chronic myeloid leukemia
    121443425 (Raf1)
   05218 Melanoma
    121443425 (Raf1)
   05211 Renal cell carcinoma
    121443425 (Raf1)
   05219 Bladder cancer
    121443425 (Raf1)
   05215 Prostate cancer
    121443425 (Raf1)
   05213 Endometrial cancer
    121443425 (Raf1)
   05224 Breast cancer
    121443425 (Raf1)
   05223 Non-small cell lung cancer
    121443425 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    121443425 (Raf1)
   05161 Hepatitis B
    121443425 (Raf1)
   05160 Hepatitis C
    121443425 (Raf1)
   05164 Influenza A
    121443425 (Raf1)
   05163 Human cytomegalovirus infection
    121443425 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    121443425 (Raf1)
   05165 Human papillomavirus infection
    121443425 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    121443425 (Raf1)
   05152 Tuberculosis
    121443425 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    121443425 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    121443425 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    121443425 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    121443425 (Raf1)
   01522 Endocrine resistance
    121443425 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:morg01001]
    121443425 (Raf1)
Enzymes [BR:morg01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     121443425 (Raf1)
Protein kinases [BR:morg01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   121443425 (Raf1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 121443425
NCBI-ProteinID: XP_041501114
LinkDB
Position
Unknown
AA seq 648 aa
MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTMRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
NT seq 1947 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggactcaaagatgcg
gtgtttgatggctccagctgcatctcccctacaattgttcagcagtttggctatcagcgc
cgggcctcagatgatggcaaactcacggattcttctaagacaagcaacactatccgagtt
ttcttgccgaataagcagaggacagtggtcaatgtgcgcaatggaatgagcttgcacgac
tgccttatgaaagctctcaaagtgagaggcctgcagccggagtgttgtgcagtgttcaga
cttcttcaggaacacaaaggtaagaaagcacgcttagattggaacaccgatgctgcctct
ctgattggagaagaactgcaagtggatttcttggatcatgttccactcacaactcacaac
tttgcgcggaaaacgttcctaaagcttgcattctgtgatatctgtcaaaagttcctgcta
aatggatttcgatgtcagacttgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagcttttgctgttcccaaattccact
gttggtgatagtggagtaccagcattaccttctttgacaatgcgccggatgcgagagtct
gtttcccggatgcctgctagttcccagcacagatactccacacctcatgcctttactttc
aacacctccagcccttcctctgaaggttccctctcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccaccttgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccccaacaacctg
agtccaacaggctggtcacaacccaaaacccctgtaccagcacaaagagaacgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctgtccactcggattgggtcaggctccttt
ggcactgtgtacaagggcaagtggcacggagatgttgcagtaaagatcctaaaggtggtt
gacccaaccccagagcagctccaggccttcaggaacgaggtggctgtcttgcgcaaaaca
cggcatgttaatatcctgctgttcatggggtacatgacaaaggacaacctggccattgtg
acccagtggtgtgaaggcagcagtctctataaacatctgcatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acggtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcaa
caggttgaacagcccactggctctgtactgtggatggctccagaggtaatccgaatgcag
gataacaacccgttcagcttccagtctgacgtctactcctatggcattgtgctgtatgag
ctcatgaccggggagcttccctactcgcacatcaacaaccgagatcagatcattttcatg
gtgggccgtggatatgcttccccagatcttagcaggctctacaagaactgccccaaggca
atgaagaggttggtggcggactgtgtgaagaaagtaaaagaagagagacctctgtttccc
cagatcctgtcttccattgagctgcttcagcactctctgccgaaaatcaacaggagtgcc
tctgagccctctctgcatcgggcggcccacacggaggacatcaatgcttgcacgctgacc
acatcgccgaggctaccggtcttctag

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