Microtus oregoni (creeping vole): 121465671 Help Entry 121465671         CDS       T08307                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism morg  Microtus oregoni (creeping vole) Pathway morg04020   Calcium signaling pathway morg04371   Apelin signaling pathway morg04713   Circadian entrainment morg04921   Oxytocin signaling pathway morg04970   Salivary secretion morg05010   Alzheimer disease morg05012   Parkinson disease morg05020   Prion disease morg05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:morg00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     121465671 (Ryr3)    04020 Calcium signaling pathway     121465671 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     121465671 (Ryr3)   09154 Digestive system    04970 Salivary secretion     121465671 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     121465671 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     121465671 (Ryr3)    05012 Parkinson disease     121465671 (Ryr3)    05020 Prion disease     121465671 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     121465671 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:morg04040]     121465671 (Ryr3) Ion channels [BR:morg04040]  Voltage-gated cation channels   Ryanodine receptor    121465671 (Ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_5 EF-hand_8 Motif Other DBs NCBI-GeneID:  121465671 NCBI-ProteinID:  XP_041534932 LinkDB All DBs Position Unknown AA seq 4871 aa AA seqDB search MAEAGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTVENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLLLQDRGKSDTKSTAFSFRASKEIKEKSDSSHKRDMEGMGVPEIKYGDSVCFVQHVAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPIEEVLQTLHDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYHSVAHFAGIAREESGMAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSPQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLTSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKRVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYVLLDERTKKSNRDSLREAIRTFVGYGYNIEPSDQELVTDPTVEKVSIDKIRFFRVERS YAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFG RTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIG RMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRI DGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQE ILSQTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVH ESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEP NTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPTPQCPPRLDVQTIQPVL WSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHY HTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRAGFYDLLISIHLANAK ERKLMMKNEYIIPITNTTRNIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTNEEH QKQSPEIPLEILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFD DDDVRQILLLIDPSVFGEHSRETEEGAEKEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHEDLLVHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKEQPTEEEERYPTTLKELVSQTMIRWAQENQIQDAELVR IMFSLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKTEVTEDDEEEEEIVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTESALALNRYICSAVLPLLTRCAPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYCKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDLDLFRMALPCLSAIAGALPPDYLDTR ITATLEKQVSVDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTREGEALVQQREN EKLRCVSNQVNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGG GSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKF LKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLS SPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRT VMKSGSELVKAGLRSFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPI LTSIFEHIAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAA AIPVAFLEPNLNRYNPLSVFNTKTPRERSILGMPDKVEEMCPDIPQLEGLMKEINSLAES GARYMEMPHVIEVILPMLCNYLSYWWERGPENLPPSTGPCCTKVTSEHLSLILGNILKII NNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLDKLKKKAVKTVQEEEQLKTDG KGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDTDSDQLFRMVAEVFI LWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLY SIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKS DDPAVKWQLNLYKDVLRNDEPSNPEKTVERVQRISAALFHLEQVEQPLRSKKAVWHKLLS KQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAYSFEEKLVQDLAKSPRVEE EEEEETEKQPDPLHQIILYFSRNALTERSKLEDDPLYTSYSSMMAKSCQSAEDEDEDEER EKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGN AGVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRE RGEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQES ISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAV VGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLV ESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQSEID FLLSCTEADENDMFNYIDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAES VLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQE KMELFVNFCEDTIFEMQLASQISESDSTDRPEEEEEEGEESAYTMEMEGEAEEDKSMEPA SAFAMACASAKRNVTNFLKRATLKNLRKQYRNVKKMSAKELVKVFVSFFWMLSVGLFQLL LSILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEADRADMIEPG VTTELVHFVKGEPGDSDIMSDLFGIHSKKDSGLKQGPEVGLGDLSEIIGKDEPPTLESTV RKKRKAQAAEMKAVREAEGKAESEKADMEDREKEDKIKEDGQAEYLWAEVTVKKTRRRGQ KAEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLE EETEDVANLWNSFNDEDEDEAMVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLK VPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVKRKVI NKYGDLYGAERIAELLGLDKNALDFSPVEETKVEAASLVSWLSSIDMKYHIWKLGVVFTD NSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAG DPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGND YFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGD CFRKQYEDQLG NT seq 14616 nt NT seq  +upstreamnt  +downstreamnt atggccgaagccggagaaggaggcgaggatgagatccagttcctgcggactgaggatgaa gtggtactccagtgcatagcaaacatccacaaggagcagcggaagttctgcctggcagct gaaggccttgggaatcgcctgtgcttcttggaacccacctcagaagccaagtacatccct ccagatctctgtgtctgcaatttcgtgctggaacagtccttatctgtcagagcactgcaa gaaatgcttgccaacaccgttgaaaatggcggagaaggggcagcacaagggggtggccac aggaccctgctgtacggtcacgcaattctcctgaggcactctttcagtggaatgtatcta acatgcttgaccacgtcaagatcccagacagataaacttgcctttgatgtaggtctgcgg gaacatgccacaggagaagcctgctggtggaccatacatcccgcctccaaacagaggtct gaaggagagaaagtgcgaatcggagatgacctgatcctcgtcagtgtgtcctctgaaaga taccttcatctctcgatatcaaatggtagcatacaggtggatgcctcctttatgcaaaca ctctggaatgtgcatcctacgtgttcgggaagcagcatcgaagaaggatacttacttggt gggcacgtagttcgtcttttccatggtcatgatgagtgtttgacgataccgtcgacagac cagaatgactctcagcacaggagggtgttctatgaagctggaggagctgggaccagagcc aggtctctatggagagtggaaccccttcggataagctggagtggcagtaacatcaggtgg ggccaggctttccgtctccggcatctcactaccggccattacttggccttgacagaagac caaggccttcttctacaagaccggggaaaatcggataccaagtccacagccttctccttc cgggcgtcaaaggaaatcaaggagaaatcggattccagtcacaagagagatatggaaggc atgggcgttccagaaatcaagtatggtgattctgtctgctttgtccagcatgtagccagt ggcctttgggtcacctacaaagcacaagatgccaaaacttcccgcctgggacctctaaag aggaaggtcatactccatcaggaaggccacatggatgatggattaacactgcagaggtgc cagcgggaggagtcccaggctgctcgcatcatcaggaacacaacagccttattcagccag ttcgtcagtggaaacaaccgcacagctgctcctgtcaccttgccaatcgaagaggtcctg cagaccctacatgacttgattgcctacttccagccaccagaggaggagatgcaacatgaa gacaaacagaataagctccggtctctcaaaaacagacagaatcttttcaaggaggaggga atgttggccctggtattgaattgcattgatcgcttaaatatctaccatagcgtagcacac tttgcagggatcgcaagggaagagagtggcatggcctggaaagaaattctaaacctgctc tacaagttgctagctgctctcatccgtggaaacagaaacaactgtgctcaattctccaat aaccttgattggttaattagtaaactggacagactagaatcttcctcaggtatcttggag gtcttgcactgcatcttgattgaaagcccagaagccttaaacctgatagcagagggtcac atcaagtccatcatctccctcctggacaagcacgggcggaatcacaaggttctcgatgtc ctatgttccctctgtctctgcaatggggtcgcagtaagagccaaccagaatctgatctgt gacaacctactaccccggaggaacctgctcctgcagacacggctaattaatgatgtcacc agtatccggccaaacatcttcctgggagtggctgaaggctcgccacagtacaagaagtgg tactttgagttgattatcgaccaggtggaccctttcctaaccgcagagcccacgcatctg cgagtgggctgggcctcctcctctggctatgctccctaccctggaggtggagaaggatgg ggaggcaatggtgttggcgatgacctgtactcctatggctttgacggacttcatctttgg tcaggccggatacccagagcagtggcctccatcaaccagcatctgctgacgtcagatgac gtggtgagctgctgccttgaccttggagtacccagcatttctttccgaatcaacgggcaa cctgtgcaggggatgtttgagaatttcaacacagatggactcttcttccctgtgatgagc ttttcagctggtgtcaaagtacgcttcctgatgggtggtcggcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccctactgccaaaggagaaaatgaga ttggagcctgtcaaagaatataaacgtgatgcagatggtgtcagggatctgttgggtacc actcagttcctctcccaagcctctttcatcccttgtcccatagacaccagtcaggttgtt ttgccacttcacctagagaagatccgagacaggctggctgaaaatatccacgagctttgg ggaatgaataaaattgaacttggctggacttttggcaaaatacgggatgacaacaaaaga caacacccctgccttgtagagttttcaaagctccctgaaactgagaagaactacaacctg caaatgtcaacggaaaccttgaaaaccctgctggccctggggtgccacattgctcacgtt aacccggctgctgaagaggatctcaagagagtcaaactgcccaaaaactatatgatgtcc aatgggtacaagccagctcctttggatttatctgatgttaagctgttaccacctcaagaa attttagtggataagcttgctgagaatgcacacaatgtttgggcaaaggacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtg ccatatgtattactggatgagcgcaccaagaaatcaaatagggacagcctgcgggaagct atacggacatttgttggttatggatataacatcgagccatcggaccaagaactagtaact gaccccactgttgagaaggtcagcatagacaagattcgatttttccgggtagagcggtca tatgcagtaaagtctggaaagtggtactttgaatttgaagtggtaaccggaggagatatg cgtgtcggctgggccaggccaggctgtcgtcctgacattgaactgggggctgatgaccaa gcctttgtgtttgaaggcagcaggggtcagcgttggcatcaaggtagcggatattttgga cgaacttggcagccaggagatgtggttgggtgtatgattaacctggatgatgcttccatg atcttcacactgaatggggagctactgatcaccaacaaaggctctgaacttgccttcgct gactatgagattgagaacgggtttgtgcccatttgctctctggggctgtcacagattggc cgcatgaatcttgggacagatgccagtaccttcaaattttataccatgtgtggcctccag gagggctttgagcctttcgcggtaaatatgaaccgagacgtggcagtttggttcagcaag cgcctcccaacattcgtgaatgtgcccaaggatcatcctcacatagaggttgtaaggatt gatggcaccatggacagccctccgtgcctcaaggtgacccacaagacattcggcacacag aacagcaatgccaacatgatctactgccgcctgagcatgcctgtcgaatgtcactcctct ttcagccacagcccttgtctagacagtgaagccttccagaagaggaaacagatgcaagaa atactttctcaaacaacaacgcaatgctactacgctatccgcatttttgctgggcaggat ccatcatgtgtctgggttggatgggtgactccagactaccatttgtacagcgaaaagttt gacctgaataaaaactgtaccgtgactgtcactctgggagatgaaagaggccgggtccat gaaagtgtgaaacgcagcaactgctacatggtctggggtggggacattgttgctagttcc caaagatcaagtcgaagcaatgtagacctagagattggctgccttgtagatctggcaatg ggcatgttgtccttctcagctaatgggaaggaactcggtacctgctaccaggtggagcct aacaccaaagtattcccagcagtcttcctccagcctacaagcacttctttgtttcagttt gaacttggaaaactgaagaatgcaatgcccttgtcagcagccatatttaagagtgaagag aagaaccctaccccacagtgtccacctcggctggatgtccaaaccatccagcctgtgctg tggagtcgcatgcccagcagcttcctcaaagtggagacagagcgggtgagcgagcgccat ggctgggtggtgcagtgcctagaacccctgcaaatgatggcactccacatcccggaggag aacaggtgtgtggacatccttgagctctgtgagcaggaggacctgatgcagttccattac cacacacttaggctctacagtgccgtgtgtgccctggggaacagccgggttgcctatgcc ctgtgcagccacgtggacctctctcagctcttctatgccattgacaacaagtacttgcct ggcctactccgagccggtttctatgacctgctcattagcattcacctggccaacgctaag gagaggaagctgatgatgaagaatgagtacatcatccccatcaccaacaccaccaggaat atccgcctatacccagatgagtccaagaggcatgggctgcccggggtgggcctgaggacg tgccttaagccaggcttcaggttctcgactccttgcttcgtggtgactaatgaggagcat cagaagcagagccctgagattcccctggagatcctcaaaaccaaggctctgagcatgctg acggaggccgtgcactgtagcggggcccacatccgagaccctgttggtggttcagtggag ttccagtttgtgcctgtgctgaagctcattggaaccctgctagtcatgggcgtttttgat gatgatgatgttcgtcagatcctcctcttgattgatccctctgtgtttggggagcacagc agggagacagaagagggagcagaaaaagaagtgacccaagtcgaggaaaaggcagtggag gctggagaaaaggccagcaaggaggccccggtcaaaggcttgctgcagacccgattgccc gagtctgtcaagctgcagatgtgtgaactcctcagctacctctgtgactgtgaactgcag catcgagtagaggctattgtggcatttggtgacatttatgtgtccaagcttcaggcaaat cagaaattccgctacaatgagctcatgcaggccctgaacatgtctgcagccctaactgcc cggaagacacgggagttccgctcaccacctcaggagcagatcaacatgctcctcaacttt cacctgggagagaactgcccctgcccggaggagatccgcgaggagctgtacgacttccat gaggaccttctggtgcactgtggggttcccttggaggaagaagaagaggaggaggaggac acttcctggacaggaaaactgcgtgctttggtgtataaaatcaagggtccacccaagcca gagaaagagcaaccaacagaggaagaggaacggtatcctacaacactgaaggaactagtc tcccagacaatgatccgctgggcccaggagaaccaaatccaggatgcagagttggtgagg attatgttcagcctcctccggagacagtatgacagcattggggagttactacaggccttg cggaagacctacaccatcagccaggcctccgtgagcgacaccatcaacctgctggctgcc ctgggccagattcggtccctcctcagtgtcaggatgggcaaggaagaggagcttctcatg atcaacgggctgggggacataatgaacaacaaggtgttttaccagcaccccaacctaatg agagtccttggcatgcatgagacggtgatggaggtgatggtgaacgtgttgggtacagag aaatcacagattgccttccccaaaatggttgctagctgctgtcgcttcctttgctatttc tgtcgaattagccggcaaaatcagaaggccatgtttgagcatctaagctacctgctggag aacagcagcgtgggcctagcttccccatcgatgagggggtccaccccactggacgtggca gcctcctcggtgatggacaacaacgagttagcactgggcttggaagaaccggatcttgag aaggtggtaacctacttggcaggttgtggccttcagagctgccccatgcttctggccaaa ggatacccggacgttggctggaaccccattgaaggggaacgttacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtagaggaaaacgccagtgttgtggtcaagctg ctcatccgacgtcctgagtgctttgggccagctctgaggggtgaaggaggaaacggactg ctggcggccatgcagggggctattaagatctcagagaacccggccctcgacctcccctcc cagggttacaagacagaagtcacagaggatgacgaggaggaggaagagattgtgcacatg ggcaatgccattatgtcgttttattcggctcttatagatctactgggccgctgtgctcct gaaatgcatctcattcaaacagggaaaggggaagccatccggatccgctccatcctgcgc tccttggtccccacagaagacctggttggaatcatcagcatccccctgaaactgccctcc ctaaacaaagatggatcagtcagcgagccggacatggcagccaacttctgccctgaccac aaggcacccatggtgctgttcttggaccgtgtgtatggcattaaagatcaaaccttcctg ctccacttgctggaagttgggtttttgcctgacctacgagcatctgcatccctagataca gtgtccctcagcaccaccgagtctgcgctggcactcaacaggtacatatgttcggctgtg ctcccactccttactagatgcgcccctctcttttctgggacagagcactgcacctctctg attgattctacactgcaaacaatatacaggctttccaaaggacggtccctcaccaaggcg cagagggacaccatagaagaatgtttgcttgccatttgcaatcacttgagaccttccatg ttacagcaactcctacgacgtctggtttttgatgtgccgcagctcagcgagtactgcaaa atgcctcttaagcttctgaccaatcactatgagcagtgctggaagtattactgcctgcct tcgggatgggggagctatgggctagccgtggaggaggaactgcacctcactgagaagctc ttctgggggatttttgactccctctcccacaagaaatatgacctggatcttttccgaatg gccctgccgtgtctcagtgcgattgctggggccttgccaccagactatttagatacaaga atcacagccactttggagaaacaggtctcagtggatgcagatgggaactttgacccgaaa cctattaacaccatgaacttttccttgcctgaaaaattggaatacattgtcaccaagtat gctgagcattctcatgataaatgggcctgtgacaagagtcacagtggatggaaatatggg atttccctggatgaaaacgtgaagacccacccactgatacggcccttcaagacattaaca gagaaggagaaggaaatttatcgctggcctgccagagaatccctgaaaaccatgctcgct gtgggctggacagtggaaaggaccagagaaggagaagctttggtccaacaaagagagaat gagaaacttcgatgtgtgtcgaatcaggtcaaccagggtaacagctacagcccagccccg ctggatctctcaaatgtggtgctgtccagggagctccagggaatggtggaggtggtggct gagaactatcacaacatctgggccaagaagaagaagctggagctggagagtaaaggtggt ggcagtcaccctctcttggtaccatatgacaccttgactgccaaggaaaagttcagggat cgagaaaaggcacaggacctgttcaaattcctccaggtgaatggcattatagtttctaga ggtatgaaggacatggagctggacgcctcctccatggaaaagagatttgcctataagttt ttgaagaagatcctgaaatacgttgactctgctcaagagtttattgctcacttggaagcc attgtcagcagtgggaaaaccgaaaagtctccccacgaccaggagatcaaattctttgcc aaagttctcctccccctggttgaccagtacttcaccaaccaccgcctttacttcttgtca tctcctctgaagccacttagcagcagtgggtatgcttcccataaagagaaagaaatggta gccagcctgttctgcaagctggcggctctcgtgagacacaggatctctctctttgggagt gattcaactacgatggtgagctgccttcacatcttagctcagacgcttgacacaaggacc gtcatgaagtcgggctcagagctggtgaaagctgggttacgctccttctttgaaaacgca gcagaagacttagagaagacctccgaaaacctgaagctggggaagtttacccattccaga acgcagatcaaaggtgtttctcagaatattaactacaccacagtggccctgcttcccatc ctgacatccatctttgagcacatcgctcagcatcagtttggggtggatctactcttgggt gacgtgcagatttcatgctaccacattctgtgcagcctctattccctcgggactgggaaa aacatctacgttgaaaggcaacgtcccgctcttggagaatgtctggcttccctggcggct gccatcccagtggcattcctggagcccaaccttaaccgctataatcccctctcagtcttc aacaccaagactcctagggagcggtctattctggggatgccagacaaggtggaagagatg tgtcctgacatcccccagctggaaggcctgatgaaggaaatcaatagcttggccgagtca ggtgcccggtacatggagatgccccatgtcattgaagtgatcttgcctatgctctgcaac tacctgtcttactggtgggagcgggggcctgagaacctgccgcccagcacagggccctgc tgcaccaaggtcacatctgaacacctcagcctcatcctgggcaacatcctgaaaatcatc aacaacaacctgggcattgatgaggcctcctggatgaagcgcatcgcagtgtacgcacag ccaatcatcagcaaagccaggcctgacctgctgcgaagccacttcatccccaccctggac aagctaaagaagaaggcggtcaagactgtgcaggaggaggagcagctgaagacagacggc aagggggacactcaggaggccgagctgctcatcctggacgagtttgcggtcctctgcagg gacctctacgccttctaccccatgctgatccgctacgtggacaacaacagatctaactgg ctcaaaagcccagacactgattctgaccagctcttccgcatggtggctgaagtcttcatt ctgtggtgtaaatctcacaacttcaagagggaagagcaaaactttgtgattcaaaatgaa attaataacttggcatttttaaccggagacagcaaaagcaagatgtcaaaagccatgcaa gtaaagtctggaggacaggaccaggagcggaagaagacaaagaggcgaggagacttgtat tccatccagacctccctcatcgtggctgctctcaagaaaatgctacccattggtttgaac atgtgtactccaggcgaccaggagctcatctcactggcaaaatcacgctacagctgtagg gacaccgatgaagaggtcaaggaacatctgcggaataacctgcacctgcaggaaaagtca gatgacccggctgtgaaatggcaactgaacctctacaaagatgttctgaggaacgacgaa ccttctaatccggaaaagacggtggagcgagtgcagaggatctcagccgctctcttccac ctggagcaggtggaacagcctttgaggtccaaaaaggctgtgtggcacaaattattgtca aagcaacggaaacgggcagtggtggcctgtttcaggatggctcctctctacaatttgccc aggcaccgctctattaacctcttcctccatggctatcagagattttggatagaaacagag gcgtattcctttgaagagaaactagtacaggatttggctaaatctcccagggttgaagag gaggaagaggaagagacagaaaagcaacctgatccgcttcaccaaatcatcctgtatttt agccgcaacgccctcacagagaggagcaaattggaagatgaccctttgtacacctcctac tccagtatgatggccaagagttgtcagagtgctgaggatgaagacgaagatgaagagagg gaaaaaacatttgaagagaaagagatggagaagcagaaaacactgtatcagcaagcgcgc ttgcacgaacgtggtgccgcagagatggtccttcagatgataagtgccagcaaaggtgag atgagtcccatggtggttgagacgctgaagctgggaattgccattctcaatggaggcaat gctggcgtgcaacagaaaatgctagattacttaaaagagaaaaaagatgccgggttcttt caaagcctttctggtcttatgcagtcttgtagtgtccttgatttgaatgcatttgagagg cagaataaagctgaaggcctgggaatggttacagaagaaggaacactcattgttcgtgag cgtggtgaaaaagtgctccagaatgatgagttcacacaggatctcttccggttcctacag ctgctttgtgaaggacacaacagcgactttcagaactttctgaggactcagatgggcaac accaccactgtgaacatcataatcagcaccgtggactaccttctgcgtctgcaggaatcc atcagcgatttctattggtactactcgggaaaggacatcattgatgaatctggacagcac aatttctctaaagctctggcagtcaccaagcagatctttaattctcttacagagtacatc cagggcccttgcatcgggaaccagcagagcctggctcacagtaggctgtgggatgcagtg gttggattcctccatgtgtttgctaacatgcagatgaagctgtctcaggattccagtcag atcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcc ctactggaaggaaatgtggtaaacggaactattggaaagcagatggttgacacactggta gaatcatccactaatgtagagatgatcttgaaattctttgacatgttcttgaaacttaaa gacttaaccagctcagacaccttcaaagaatatgacccggatggtaaagggatcatctcc aggaaagaattccagaaggccatggaaggtctaaagcaatacacacagtcagagatcgac ttcctcctttcgtgtacggaggctgacgagaatgacatgtttaattatattgattttgta gaacggttccacgagccagccaaggacatagggttcaatgtggccgtgttactgaccaat ctctctgaacacatgcccaatgattctcgcttgaagtgcctgttggacccagcagaaagt gtgctaaattactttgaaccatacctgggtcgaatcgagatcatgggtggggccaagaaa attgaacgtgtttattttgagatcagcgaatccagtcgaactcagtgggaaaagcctcaa gtgaaggagtccaagcgacagttcatttttgatgtcgtcaatgaaggtggggaacaggag aagatggagctgtttgtgaacttctgcgaggacacaatcttcgagatgcagttagcatct cagatctcagaatccgactcaaccgacagaccggaagaggaagaggaagagggtgaagag tctgcttatacgatggaaatggagggggaggcggaggaggacaagtctatggagcctgcc tctgcctttgccatggcctgtgcctcagcaaagagaaatgtcaccaactttctgaagagg gcaacgctgaagaacctcaggaaacagtaccgaaatgtcaaaaagatgagtgcgaaggag ttggtgaaggttttcgtctctttcttctggatgctgtctgtgggcctcttccagctgctc ctctctatcttgggaggcatctttcagatcctctggaacacagtgtttggtgggggcctc gtcgaaggagcaaagaacatccgagtgaccaagatcctaggcgacatgcctgaccccacc cagtttgggatccatgatgacgccatggaggcggacagagcagacatgattgagccgggt gtcaccactgaactggtccacttcgtaaagggggagccgggagattcagacatcatgtcc gacctctttggaatccactcaaagaaagacagtggcttaaagcaagggcctgaagtggga ttgggtgacctctctgaaatcatcggcaaggatgagccccctacgttagagagtactgtg cggaagaaaaggaaagcacaggctgcagagatgaaagcagtgcgtgaagccgaaggaaag gctgaatctgagaaagctgacatggaagacagagaaaaggaagacaaaatcaaggaggac ggacaagccgagtacctgtgggcagaggtgacagtgaagaagacacggcggcgtggccag aaggctgagaagccagaagccttcatggccaatttcttcaaggggctggaaatctatcag accaagttactgcactacctggccaggaatttctacaacctgaggttccttgctctgttt gtagccttcgctatcaacttcatcctgcttttttataaggtcactgaagaacctttggaa gaagagacggaggatgttgcaaacctgtggaactcctttaatgatgaagatgaggacgaa gcaatggtattctttgttcttcaggagagcactgggtatatggccccaacactgcgtgcc ctggccattgtccacaccatcatctctctggtctgtgtggtgggatattactgcctgaag gtgcctctggtagtcttcaaaagggagaaagaaattgccaggaagctagagtttgatggt ctgtatatcaccgaacagccatctgaagatgacatcaaggggcagtgggaccgcttggtg atcaacacaccatcttttcctaataactattgggacaagtttgtgaagaggaaggtaatc aacaagtatggagatctctacggagcagagcgcatcgctgaactcctgggtttggataag aatgccctcgacttcagcccagtagaagagaccaaagtggaggcggcctctctggtgtca tggctaagttccatcgacatgaagtaccatatttggaagctgggggtggttttcactgac aattcctttctctaccttgcctggtatacaaccatgtctgtcctgggccactacaacaac ttcttcttcgctgctcatctgttggatattgcaatgggctttaaaaccttgaggacaatc ctgtcatctgtaactcacaatggcaaacagctggttctgactgttggcctcctggctgtg gttgtttacctctatactgtggtggctttcaacttcttccgcaagttctataacaaaagt gaagatgatgacgagccggatatgaagtgtgacgacatgatgacatgctacctcttccat atgtatgtgggagtgagagcgggtggcggcattggtgatgaaatcgaagaccctgctggt gacccttacgagatgtatcgcatcgtctttgacattaccttcttcttctttgtcattgtc atcttgctggccatcattcaaggtctgattattgatgcttttggagagctgagagaccag caggaacaagtacgtgaagacatggagacgaaatgcttcatctgtggcattggcaatgac tattttgacacaacccctcatggttttgaaacacatacactgcaagagcacaacttggcc aattacttattctttctgatgtatttgattaataaggatgaaacagaacacacgggtcag gaatcttatgtgtggaagatgtaccaggaaaggtgttgggacttcttcccagctggcgac tgctttcgtaagcaatatgaagatcagcttgggtaa

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