KEGG   PATHWAY: mtr04120
Entry
mtr04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Medicago truncatula (barrel medic)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
mtr04120  Ubiquitin mediated proteolysis
mtr04120

Other DBs
GO: 0016567
Organism
Medicago truncatula (barrel medic) [GN:mtr]
Gene
11421243  polyubiquitin isoform X1 [KO:K08770]
25501783  polyubiquitin 4 [KO:K08770]
11422346  LOW QUALITY PROTEIN: polyubiquitin-like [KO:K08770]
25492931  polyubiquitin [KO:K08770]
11444753  ubiquitin-60S ribosomal protein L40 [KO:K02927]
25499401  ubiquitin-60S ribosomal protein L40 [KO:K02927]
11430063  ubiquitin [KO:K02927]
25483801  ubiquitin-60S ribosomal protein L40 [KO:K02927]
11413825  ubiquitin-40S ribosomal protein S27a [KO:K02977]
112418693  polyubiquitin-like [KO:K02977]
11416846  ubiquitin-40S ribosomal protein S27a [KO:K02977]
11416586  ubiquitin-40S ribosomal protein S27a [KO:K02977]
11409554  ubiquitin-activating enzyme E1 1 [KO:K03178] [EC:6.2.1.45]
112421986  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
25502012  SUMO-activating enzyme subunit 1A [KO:K10684] [EC:6.2.1.45]
25501072  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
11436326  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
25502755  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
11444344  ubiquitin-conjugating enzyme E2 2 isoform X1 [KO:K10573] [EC:2.3.2.23]
11438138  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
11436215  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
11406985  probable ubiquitin-conjugating enzyme E2 C isoform X1 [KO:K06688] [EC:2.3.2.23]
11432845  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
11437634  ubiquitin-conjugating enzyme E2-17 kDa isoform X1 [KO:K06689] [EC:2.3.2.23]
25501549  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
11443623  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
11436401  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
11420397  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
11405204  constitutive photomorphogenesis protein 10 [KO:K20217] [EC:2.3.2.23]
11422025  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
25487868  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
25500869  ubiquitin-conjugating enzyme E2 5 [KO:K10576] [EC:2.3.2.23]
25502069  ubiquitin-conjugating enzyme E2 4 isoform X2 [KO:K10576] [EC:2.3.2.23]
11407971  ubiquitin-conjugating enzyme E2-23 kDa [KO:K10576] [EC:2.3.2.23]
25493475  SUMO-conjugating enzyme SCE1 [KO:K10577]
11410591  SUMO-conjugating enzyme SCE1 [KO:K10577]
11414701  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
11443912  ubiquitin-conjugating enzyme E2 34 [KO:K04554] [EC:2.3.2.23]
11424383  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
11408646  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
120575836  ubiquitin-conjugating enzyme E2 36-like isoform X1 [KO:K10580] [EC:2.3.2.23]
25487247  ubiquitin-conjugating enzyme E2 35 [KO:K10580] [EC:2.3.2.23]
11443820  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
25485624  probable ubiquitin-conjugating enzyme E2 23 [KO:K10581] [EC:2.3.2.24]
11411910  probable ubiquitin-conjugating enzyme E2 25 isoform X1 [KO:K10581] [EC:2.3.2.24]
25491186  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
11408487  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
25498138  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
25498140  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
25499949  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
120577350  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
120577652  probable ubiquitin-conjugating enzyme E2 25 [KO:K10581] [EC:2.3.2.24]
25487342  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
112417997  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
112418640  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
11446955  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
25493164  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
25487341  probable ubiquitin-conjugating enzyme E2 26 [KO:K10581] [EC:2.3.2.24]
120575827  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
11432679  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
11412171  LOW QUALITY PROTEIN: probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
25499357  E3 ubiquitin-protein ligase UPL7 [KO:K10588] [EC:2.3.2.26]
11415955  E3 ubiquitin-protein ligase UPL6 [KO:K10589] [EC:2.3.2.26]
25484050  E3 ubiquitin-protein ligase UPL4 isoform X1 [KO:K10590] [EC:2.3.2.26]
11439680  E3 ubiquitin-protein ligase UPL3 [KO:K10590] [EC:2.3.2.26]
25493427  E3 ubiquitin-protein ligase UPL1 isoform X1 [KO:K10592] [EC:2.3.2.26]
25489905  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
11442326  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
25493428  E3 ubiquitin-protein ligase UPL1 [KO:K10592] [EC:2.3.2.26]
11412513  probable ubiquitin conjugation factor E4 isoform X1 [KO:K10597] [EC:2.3.2.27]
11421224  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
11433994  peptidyl-prolyl cis-trans isomerase CYP65 isoform X1 [KO:K10598] [EC:5.2.1.8]
11431087  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
11444084  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
25499082  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
25483069  polyubiquitin 9 [KO:K04506] [EC:2.3.2.27]
11437704  putative E3 ubiquitin-protein ligase SINA-like 6 [KO:K04506] [EC:2.3.2.27]
11418807  E3 ubiquitin-protein ligase DIS1 [KO:K04506] [EC:2.3.2.27]
25500674  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
11446457  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
25499735  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
120578306  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
120580680  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
120580681  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
25493350  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
11425847  E3 ubiquitin-protein ligase SINA-like 7 [KO:K04506] [EC:2.3.2.27]
11418747  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
11436875  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
11423170  E3 ubiquitin-protein ligase SINAT5 [KO:K04506] [EC:2.3.2.27]
11445862  E3 ubiquitin-protein ligase SINA-like 10 isoform X1 [KO:K04506] [EC:2.3.2.27]
25483070  E3 ubiquitin-protein ligase SINA-like 10 isoform X3 [KO:K04506] [EC:2.3.2.27]
25483549  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
11418493  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
11420758  E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
11446119  E3 ubiquitin-protein ligase MIEL1 [KO:K10144] [EC:2.3.2.27]
25499342  E3 ubiquitin-protein ligase RZFP34 isoform X1 [KO:K10144] [EC:2.3.2.27]
25481902  probable E3 ubiquitin-protein ligase RZFP34 isoform X1 [KO:K10144] [EC:2.3.2.27]
25483138  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
11429978  probable E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
11412063  E3 ubiquitin-protein ligase RZFP34 [KO:K10144] [EC:2.3.2.27]
25498559  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
25502457  E4 SUMO-protein ligase PIAL2 [KO:K04706] [EC:2.3.2.-]
11437221  E4 SUMO-protein ligase PIAL2 isoform X2 [KO:K04706] [EC:2.3.2.-]
11441665  ERAD-associated E3 ubiquitin-protein ligase HRD1A [KO:K10601] [EC:2.3.2.27]
11433721  ERAD-associated E3 ubiquitin-protein ligase HRD1B [KO:K10601] [EC:2.3.2.27]
11413962  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
25492127  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
11425891  cullin-1 [KO:K03347]
25494069  cullin-1 [KO:K03347]
25488176  cullin-1 [KO:K03347]
11443849  SKP1-like protein 11 [KO:K03094]
25485612  SKP1-like protein 1A [KO:K03094]
25499072  SKP1-like protein 1A [KO:K03094]
25499080  SKP1-like protein 1B [KO:K03094]
11446057  SKP1-like protein 14 [KO:K03094]
11424737  SKP1-like protein 14 [KO:K03094]
11426194  SKP1-like protein 1A [KO:K03094]
11434250  SKP1-like protein 1A [KO:K03094]
25491809  SKP1-like protein 1B [KO:K03094]
25502753  SKP1-like protein 1A [KO:K03094]
25499058  SKP1-like protein 1 [KO:K03094]
25499060  SKP1-like protein 1B [KO:K03094]
25499062  SKP1-like protein 1B [KO:K03094]
25499079  SKP1-like protein 1B [KO:K03094]
11414605  SKP1-like protein 1A [KO:K03094]
11429668  SKP1-like protein 1A [KO:K03094]
11432881  SKP1-like protein 1A [KO:K03094]
11433393  SKP1-like protein 1A [KO:K03094]
11423233  SKP1-like protein 1A [KO:K03094]
11425732  SKP1-like protein 1A [KO:K03094]
25491492  SKP1-like protein 1A [KO:K03094]
25491808  SKP1-like protein 14 [KO:K03094]
11430287  SKP1-like protein 1B [KO:K03094]
11429415  SKP1-like protein 1B [KO:K03094]
25490092  SKP1-like protein 1A [KO:K03094]
11425582  SKP1-like protein 1B [KO:K03094]
11435518  SKP1-like protein 14 [KO:K03094]
11408483  SKP1-like protein 1A [KO:K03094]
11445600  SKP1-like protein 1B [KO:K03094]
11438280  SKP1-like protein 1B isoform X1 [KO:K03094]
11418787  SKP1-like protein 1 [KO:K03094]
25489745  F-box protein SKP2A [KO:K03875]
25482432  F-box protein SKP2A [KO:K03875]
25492546  elongin-C [KO:K03872]
25486618  polyubiquitin 9 [KO:K03873]
11410449  cullin-3A [KO:K03869]
11408876  cullin-3A [KO:K03869]
11427751  cullin-3A [KO:K03869]
25495296  cullin-3A [KO:K03869]
25495298  cullin-3A-like [KO:K03869]
25498090  cullin-3B [KO:K03869]
25498104  cullin-3A [KO:K03869]
120580095  cullin-3A-like [KO:K03869]
25482929  cullin-3A-like [KO:K03869]
25482923  cullin-3A [KO:K03869]
11417557  LOW QUALITY PROTEIN: cullin-3B [KO:K03869]
11411434  cullin-3A [KO:K03869]
11437813  cullin-4 [KO:K10609]
11435521  DNA damage-binding protein 1 [KO:K10610]
11405495  protein DAMAGED DNA-BINDING 2 [KO:K10140]
25489968  WD repeat-containing protein ATCSA-1 isoform X2 [KO:K10570]
11442566  light-mediated development protein DET1 isoform X2 [KO:K10571]
11405363  anaphase-promoting complex subunit 11 [KO:K03358]
11440309  anaphase-promoting complex subunit 2 [KO:K03349]
11443923  anaphase-promoting complex subunit 2 [KO:K03349]
25492960  anaphase-promoting complex subunit 2 isoform X1 [KO:K03349]
11432673  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
25499951  cell division cycle 20.1, cofactor of APC complex [KO:K03363]
11419561  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
11444276  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
25498018  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
25499528  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
11439957  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
25498169  cell division cycle 20.2, cofactor of APC complex [KO:K03363]
25489317  protein FIZZY-RELATED 3 [KO:K03364]
25493638  protein FIZZY-RELATED 1 [KO:K03364]
11424985  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
25497685  cell division cycle protein 27 homolog B [KO:K03350]
25495529  cell division cycle protein 27 homolog B [KO:K03350]
11421313  anaphase-promoting complex subunit 4 [KO:K03351]
11432455  anaphase-promoting complex subunit 5 [KO:K03352]
11405324  anaphase-promoting complex subunit 6 [KO:K03353]
11440839  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
11428624  anaphase-promoting complex subunit 8 [KO:K03355]
25485211  anaphase-promoting complex subunit 8 [KO:K03355]
25501636  anaphase-promoting complex subunit 10 [KO:K03357]
11442064  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
mtr03050  Proteasome
KO pathway
ko04120   
LinkDB

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