Entry
Name
AREG-overexpression to PI3K signaling pathway
Definition
AREG* -> EGFR -> PI3K -> PIP3 -> AKT -> S6K
Expanded
374v1 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (6198,6199)
Class
Type
Variant
Pathway
Disease
Gene
1956 EGFR; epidermal growth factor receptor
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
6198 RPS6KB1; ribosomal protein S6 kinase B1
6199 RPS6KB2; ribosomal protein S6 kinase B2
Variant
374v1 (AREG*) AREG overexpression
Metabolite
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Dasari A, Messersmith WA
Title
New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways.
Journal
Reference
Authors
Hutchinson RA, Adams RA, McArt DG, Salto-Tellez M, Jasani B, Hamilton PW
Title
Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer.
Journal
Reference
Authors
Yarom N, Jonker DJ
Title
The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer.
Journal
Discov Med 11:95-105 (2011)
LinkDB
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