Entry |
|
Name |
HCMV gB to PDGFR-RAS-ERK signaling pathway
|
Definition |
UL55 -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK |
Expanded |
K22773 -> (5156,5159) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
Class |
nt06167 Human cytomegalovirus (HCMV)
|
Type |
Pathogen
|
Pathway |
hsa05163 | Human cytomegalovirus infection |
|
Disease |
H00368 | Cytomegalovirus infection |
|
Gene |
5156 | PDGFRA; platelet derived growth factor receptor alpha |
5159 | PDGFRB; platelet derived growth factor receptor beta |
2885 | GRB2; growth factor receptor bound protein 2 |
6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
|
Perturbant |
K22773 (UL55) | gB; Betaherpesvirinae envelope glycoprotein B |
|
Reference |
|
Authors |
Price P (ed). |
Title |
Manifestations of Cytomegalovirus Infection |
Journal |
|
Reference |
|
Authors |
Roy S, Arav-Boger R |
Title |
New cell-signaling pathways for controlling cytomegalovirus replication. |
Journal |
|
LinkDB |
|