KEGG   PATHWAY: ngi00330
Entry
ngi00330                    Pathway                                
Name
Arginine and proline metabolism - Nannospalax galili (Upper Galilee mountains blind mole rat)
Class
Metabolism; Amino acid metabolism
Pathway map
ngi00330  Arginine and proline metabolism
ngi00330

Module
ngi_M00015  Proline biosynthesis, glutamate => proline [PATH:ngi00330]
ngi_M00047  Creatine pathway [PATH:ngi00330]
ngi_M00134  Polyamine biosynthesis, arginine => ornithine => putrescine [PATH:ngi00330]
ngi_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA [PATH:ngi00330]
ngi_M00970  Proline degradation, proline => glutamate [PATH:ngi00330]
ngi_M00972  Proline metabolism [PATH:ngi00330]
Other DBs
GO: 0006525 0006560
Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103724470  Got1l1; glutamic-oxaloacetic transaminase 1-like 1 [KO:K14454] [EC:2.6.1.1]
103724501  Nos2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
103724707  Aldh4a1; aldehyde dehydrogenase 4 family member A1 [KO:K00294] [EC:1.2.1.88]
103724817  Aldh3a2; aldehyde dehydrogenase 3 family member A2 [KO:K00128] [EC:1.2.1.3]
103724937  Arg1; arginase 1 [KO:K01476] [EC:3.5.3.1]
103725076  Ckmt1a; creatine kinase, mitochondrial 1A [KO:K00933] [EC:2.7.3.2]
103725109  Pycr2; pyrroline-5-carboxylate reductase family member 2 [KO:K00286] [EC:1.5.1.2]
103725333  Agmat; agmatinase [KO:K27001]
103725369  Sat1; spermidine/spermine N1-acetyltransferase 1 [KO:K00657] [EC:2.3.1.57]
103725587  Carns1; carnosine synthase 1 [KO:K14755] [EC:6.3.2.11]
103727612  Ckb; creatine kinase B [KO:K00933] [EC:2.7.3.2]
103728564  [KO:K14454] [EC:2.6.1.1]
103728874  Lap3; leucine aminopeptidase 3 [KO:K11142] [EC:3.4.11.1 3.4.11.5]
103729941  Prodh2; proline dehydrogenase 2 [KO:K11394] [EC:1.5.5.3]
103730144  Sms; spermine synthase [KO:K00802] [EC:2.5.1.22]
103730168  Pycr1; pyrroline-5-carboxylate reductase 1 [KO:K00286] [EC:1.5.1.2]
103730902  Azin2; antizyme inhibitor 2 [KO:K01583] [EC:4.1.1.19]
103732590  Maob; monoamine oxidase B [KO:K00274] [EC:1.4.3.4]
103732919  Srm; spermidine synthase [KO:K00797] [EC:2.5.1.16]
103733179  Got1; glutamic-oxaloacetic transaminase 1 [KO:K14454] [EC:2.6.1.1]
103733196  Hoga1; 4-hydroxy-2-oxoglutarate aldolase 1 [KO:K18123] [EC:4.1.3.16]
103733219  Aldh18a1; aldehyde dehydrogenase 18 family member A1 [KO:K12657] [EC:2.7.2.11 1.2.1.41]
103735119  Got2; glutamic-oxaloacetic transaminase 2 [KO:K14455] [EC:2.6.1.1]
103735286  Pycrl; pyrroline-5-carboxylate reductase-like [KO:K00286] [EC:1.5.1.2]
103736403  Smox; spermine oxidase [KO:K12259] [EC:1.5.3.16 1.5.3.-]
103736955  P4ha1; prolyl 4-hydroxylase subunit alpha 1 [KO:K00472] [EC:1.14.11.2]
103737328  Gamt; guanidinoacetate N-methyltransferase [KO:K00542] [EC:2.1.1.2]
103739192  L3hypdh; trans-L-3-hydroxyproline dehydratase [KO:K18384] [EC:4.2.1.77]
103740420  Aldh7a1; aldehyde dehydrogenase 7 family member A1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
103742046  Prodh; proline dehydrogenase 1 [KO:K00318] [EC:1.5.5.2]
103742177  Maoa; monoamine oxidase A [KO:K00274] [EC:1.4.3.4]
103743662  Aldh16a1; aldehyde dehydrogenase 16 family member A1 [KO:K00128] [EC:1.2.1.3]
103744272  Oat; ornithine aminotransferase [KO:K00819] [EC:2.6.1.13]
103745300  [KO:K11182] [EC:1.4.3.22]
103745301  [KO:K11182] [EC:1.4.3.22]
103745303  Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
103745358  [KO:K11182] [EC:1.4.3.22]
103745360  [KO:K11182] [EC:1.4.3.22]
103745361  [KO:K11182] [EC:1.4.3.22]
103745523  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
103745571  Aldh2; aldehyde dehydrogenase 2 family (mitochondrial) [KO:K00128] [EC:1.2.1.3]
103745707  Aldh1b1; aldehyde dehydrogenase 1 family member B1 [KO:K00128] [EC:1.2.1.3]
103746122  Aldh9a1; aldehyde dehydrogenase 9 family member A1 [KO:K00149] [EC:1.2.1.47 1.2.1.3]
103746689  Dao; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
103746955  Gatm; glycine amidinotransferase [KO:K00613] [EC:2.1.4.1]
103747022  P4ha2; prolyl 4-hydroxylase subunit alpha 2 [KO:K00472] [EC:1.14.11.2]
103747615  Odc1; ornithine decarboxylase 1 [KO:K01581] [EC:4.1.1.17]
103748118  Cndp2; CNDP dipeptidase 2 (metallopeptidase M20 family) [KO:K08660] [EC:3.4.13.18]
103748140  Cndp1; carnosine dipeptidase 1 [KO:K05604] [EC:3.4.13.20]
103749186  Ckm; creatine kinase, M-type [KO:K27382]
103749295  Arg2; arginase 2 [KO:K01476] [EC:3.5.3.1]
103749544  Amd1; adenosylmethionine decarboxylase 1 [KO:K01611] [EC:4.1.1.50]
103749825  P4ha3; prolyl 4-hydroxylase subunit alpha 3 [KO:K00472] [EC:1.14.11.2]
103750267  Ckmt2; creatine kinase, mitochondrial 2 [KO:K00933] [EC:2.7.3.2]
103751576  [KO:K01611] [EC:4.1.1.50]
103752119  Sat2; spermidine/spermine N1-acetyltransferase family member 2 [KO:K00657] [EC:2.3.1.57]
Compound
C00012  Peptide
C00019  S-Adenosyl-L-methionine
C00022  Pyruvate
C00025  L-Glutamate
C00048  Glyoxylate
C00062  L-Arginine
C00077  L-Ornithine
C00086  Urea
C00134  Putrescine
C00148  L-Proline
C00179  Agmatine
C00213  Sarcosine
C00223  p-Coumaroyl-CoA
C00300  Creatine
C00315  Spermidine
C00334  4-Aminobutanoate
C00406  Feruloyl-CoA
C00431  5-Aminopentanoate
C00436  N-Carbamoylputrescine
C00441  L-Aspartate 4-semialdehyde
C00533  Nitric oxide
C00555  4-Aminobutyraldehyde
C00581  Guanidinoacetate
C00750  Spermine
C00763  D-Proline
C00791  Creatinine
C00884  Homocarnosine
C00986  1,3-Diaminopropane
C01035  4-Guanidinobutanoate
C01043  N-Carbamoylsarcosine
C01110  5-Amino-2-oxopentanoic acid
C01137  S-Adenosylmethioninamine
C01157  Hydroxyproline
C01165  L-Glutamate 5-semialdehyde
C01250  N-Acetyl-L-glutamate 5-semialdehyde
C01682  Nopaline
C02305  Phosphocreatine
C02565  N-Methylhydantoin
C02647  4-Guanidinobutanal
C02714  N-Acetylputrescine
C02946  4-Acetamidobutanoate
C03078  4-Guanidinobutanamide
C03166  Phosphoguanidinoacetate
C03287  L-Glutamyl 5-phosphate
C03296  N2-Succinyl-L-arginine
C03375  Norspermidine
C03415  N2-Succinyl-L-ornithine
C03564  1-Pyrroline-2-carboxylate
C03771  5-Guanidino-2-oxopentanoate
C03912  (S)-1-Pyrroline-5-carboxylate
C04137  Octopine
C04281  L-1-Pyrroline-3-hydroxy-5-carboxylate
C05147  trans-3-Hydroxy-L-proline
C05931  N-Succinyl-L-glutamate
C05932  N-Succinyl-L-glutamate 5-semialdehyde
C05933  N(omega)-Hydroxyarginine
C05936  N4-Acetylaminobutanal
C05938  L-4-Hydroxyglutamate semialdehyde
C05945  L-Arginine phosphate
C05946  (4R)-4-Hydroxy-2-oxoglutarate
C05947  L-erythro-4-Hydroxyglutamate
C10497  Feruloylputrescine
C15699  gamma-L-Glutamylputrescine
C15700  gamma-Glutamyl-gamma-aminobutyraldehyde
C15767  4-(L-gamma-Glutamylamino)butanoate
C18172  Carboxyspermidine
C18174  Carboxynorspermidine
C18326  p-Coumaroylputrescine
C19706  cis-3-Hydroxy-L-proline
C20560  N1-(3-Aminopropyl)agmatine
C22886  N1-[(S)-3-amino-3-carboxypropyl]agmatine
Reference
PMID:5288244
  Authors
Haake P, Allen GW.
  Title
Studies on phosphorylation by phosphoroguanidinates. The mechanism of action of creatine: ATP transphosphorylase (creatine kinase).
  Journal
Proc Natl Acad Sci U S A 68:2691-3 (1971)
DOI:10.1073/pnas.68.11.2691
Reference
PMID:16499623
  Authors
Kurihara S, Oda S, Kumagai H, Suzuki H.
  Title
Gamma-glutamyl-gamma-aminobutyrate hydrolase in the putrescine utilization pathway of Escherichia coli K-12.
  Journal
FEMS Microbiol Lett 256:318-23 (2006)
DOI:10.1111/j.1574-6968.2006.00137.x
Reference
PMID:15590624
  Authors
Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H.
  Title
A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12.
  Journal
J Biol Chem 280:4602-8 (2005)
DOI:10.1074/jbc.M411114200
Related
pathway
ngi00020  Citrate cycle (TCA cycle)
ngi00220  Arginine biosynthesis
ngi00250  Alanine, aspartate and glutamate metabolism
ngi00260  Glycine, serine and threonine metabolism
ngi00270  Cysteine and methionine metabolism
ngi00310  Lysine degradation
ngi00410  beta-Alanine metabolism
ngi00470  D-Amino acid metabolism
ngi00480  Glutathione metabolism
ngi00630  Glyoxylate and dicarboxylate metabolism
ngi00650  Butanoate metabolism
ngi00770  Pantothenate and CoA biosynthesis
KO pathway
ko00330   

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