Nanorana parkeri (Xizang Plateau frog): 108785164 Help Entry 108785164         CDS       T04897                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism npr  Nanorana parkeri (Xizang Plateau frog) Pathway npr04020   Calcium signaling pathway npr04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:npr00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     108785164 (RYR3)    04020 Calcium signaling pathway     108785164 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:npr04040]     108785164 (RYR3) Ion channels [BR:npr04040]  Voltage-gated cation channels   Ryanodine receptor    108785164 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  108785164 NCBI-ProteinID:  XP_018409702 LinkDB All DBs Position Unknown AA seq 4871 aa AA seqDB search MAEGGEVEDEIQFLRTDDEVVLQCIATIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTMAHGNEGASQGGGHRTLLYGHAILLRHSFSGMYLT CLTTSRSLTDKLAFDVGLQDTATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSERY LHLSISNGMGNIQVDASFMQTLWNVHPTCSGSSVEEGYLLGGHVVRFFHGHDECLTIPST DPAEAQHRKVNYEAGGAGVRARSLWRVEPLRISWSGSHIRWGQTFRLRHITTGQYLALTE DQGLVLQGRAKSDTKSSAFCFRASKEKLDSGPKRDIDGMGVAEIKYGDSICFIQHVDSGL WLTYKAQDAKTARLGPLKRRAILHQEGHMDDGVTLQKCQHEESQAARIIRNTTGLFSQFI SDLDSLTGNNRTVTAPIALPIEEVVQTLQDLIAYFQPPEEDLEHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNVYSSAAHFAEIIGEKTGPAWKEILNLFYELLAALIRGNRSNC AQFSNNLDWLISKLERLESSSGILEVLHCILIESPEALNLIEKGHIRSIISLLDKHGRNH KVLDVLCSLCVCNGVAVRTNQNLICDNLLPRRDLLLQTRLVNDVTSMRPNIFLGVAEGSA QYKKWYFEMIIDQVDPYLTPEPTHLRVGWASTSGYAPYPGGGEGWGGNGVGDDLFSYGFD GLHLWSGRVPRAVASSNQHLLASDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTEGLF FPVVSFSAGVKVRFILGGRHGEFKFLPPAGYAPCYEALLPKEKMRVEPVKEYKRDCEGVR DLLGTTHFLSQASFIPCPIDTSQIVLPPHLEKIRDKLAENIHELWGMNKIELGWIYGKVR DDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCLIVHSNQTAEENLKKVKLPK NYMMSNAYKPAPLDLSDVKLLPAQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFIGYGYNIEPPDQEITDQMMERISIDKIRFFR VEQTYAVKSGSWYFEFEVVTGGDMRVGWARPNCRPDIQLGADDRAFVFEGSRGQCWNMGS SFFGRNWQPGDVVGSMINMDDKSMIFTLNGELLITNQGSELAFADFEIENGFVPVCSLGL CQIGRMNLGKDASTFKYYTMCGLQEGFQPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIE VTRKDGTVEIPPCLKVTHKTFGTQNSNEDMIYCRLSMPVEFHSAFNNEEHFQKRNQLHDA SSHTATLYYYSVRIFAGQDPSSVWIGWVTPDYHFYSKNFDLSKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDLSTGSQRSGRSNVDIDIGCLVDLATGLLSFTANGKDLGTCYQVEPN TKLFPAVFLQPTSTNLFQFELGKLKNTMPLSAAIFKSEEKNPVPQCPPRLDVQSITPVLW SRMPNIFLKVETERVSERHGWVVQCLEPLQMLALHIPEENRCIDILELSEQEDLMKFHYH TLKLYCAVCALGNNRVAHALCSHVDQSQLLYTIDNQYLPGLLRSGFYNLLISIYLESAKE GKLMMNNEFIIPITDETRQIQLFPDESKRHGLPGVGRSTCLKSDLYFTAPCFVLTGEERQ QHGPEIPVDILKSKAIGMLTEAVQSSGDHIRDPVGGKVEFQFVPVLKLIATLLIMGVFED EDVRQILLLIDPNVFGDHKEEEIEENGEKEDIAQDEEKAVEAGEKATRDDKAPAKGLLQT RLPESVKLQMCELLHYFCDCELKHRVESNVAFSDKFVSKLQYNQKFRYNELMLALNMSAA LTAKKTREFRSPPQEQINMLLNFQMQEDSPCPEEIRGELYEYHEDLLMHCGIPLEEEKEE EEDKSWTGRLRSLVYKIKGRPRAEEQDPAEEEEKSPTTLKELISQTMVRWAQEDHIQDPE LVRIMFSLLRRQYDSIGELLHAMRKTYTISAASVEDTINLLASLGQIRSLLSVRMGKEEE MLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQQIAFPKMVASCCRF LCYFCRISRQNQKAMFEHLGYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALQE PDLEKVVTYLAGCGLQSCPMLIAKGYPDIGWNPIEGERYLSFLRFAVFVNCESVEENASV VVKLLIRRPECFGPSLRGEGGNGLLAAMQEAINISENPALDLPSQGYQREVVEEDEEEEI VHMGNAIMSFYSALIDLLGRCAPEPHLIQAGKGEAIRIRAILRSLVPTEDLVGIISIPLK LPAFNKDGTVFEPDMAASFCPDHKAPMVLFLDRVYGIRDQRFLLHLLEVAFLPDLRASAS LDTASLSVTEMALALNRYICSAVLPLLTRCAPLFSGTEHYAALIDSTLHTIYRLSKGRSL TKAQRDTIEECLLSICHHMRPSMLQQLLRRLVFDVPLLSEYCKMPLKLLTNHYEQCWKYY CLPSGWGSYGLASEEELHLTEKLFWGIFDSLSHKKYDAELFRMCMPCLSAIAGGLPPDYV DTRIKATPEKQMSVDAEGNFDPKPINTANLTLPEKLEYIVNKYAEHSHDKWAYDKLHSGW KYGTTLDENTKSHPLLRPFKTLTEKEKEIYRWPVRESVKTMLAIGWSVERTKEGEALALH RENEKMRSISQTSQGNGYTPASIDLSNVVLSRELQGMVEVMAENYHNIWAKKKKTELETK GAGSHPLLVPYDTLTAKEKARDREKAQELFKFLQVNGYAISRGLKDMELDASSMEKRFAF KFLKKVLHYVDSAQEFIAHLEAVVGSGKSEKSPHEQEIKFFAKVLLPLVDQYFKNHCLYF LSSPIKTLSSSGYASNKEKEMVASLFCKLAALVRHRISLFGSDSATMVSCLHILAQTLDT RTVMKSGSELVKAGVRAFFENAAEDLEKTLENLKLGKFTHSRTQMKGVSQNINYTTVALL PILTSIFEHVARHQFGVDLLLDDVQVSCYRILCSLYLLGTGKNIYVERQRPALGECLAAL AGAIPVAFLEPSLNHNNPLSVFNTKSPRERAILGMPDTVEEMCSEMPHLEGLMKEINDLA ESGARYTEMPHVIEVVLPMLCNYLSYWWERGTENVPENARPCCTQVTSEHLSVILGNILK IINNNLGIDEASWMKRIAVYAQPIISKAQPDLLKSHFIPTLEKLKKKAIKIVQEEEQLKA DSKTDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKKPDADSDDLFRMVAEV FILWCKSHNFKREEQNFVIQNEINNLAFLTGNNKSKMSKPIQVKSGGQDQERKRTKRRGD LYSIQTSLIVAALKKMLPIGLNMCSPGDQELISLAKSRYCLKDTDEEVKEHLRSNLHLQE KSEDPAVKWQLDLYKDILKSEETDPEKAVERVQKISAAVFHLEQVEQPLRSKKAVWHKLL SKQRKRAVVACFRMAPLYNLPRHRCINLFLHGYQRFWIQTEENSFEETLIQDLAKPKRKD EDEEEETEKNPDPLHQIILHFSRNALTERSKLEDDPLYTAYAAMMAKSCQNEEEEDEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGISILNGGNT VVQQKMLDYLKEKKDAGFFQSLSGLMMSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTRDLFRFLQLLCEGHNNDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESI SDFYWYYSGKDVIDESGQRNFSKSLAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSSQIELLKQLLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSSNVEMILKFFDMFLKLKDLTSSDAFKEYDPEGKGIISKKEFQKAMEGQKQYAQSEIEF LLSCAEADENDMFNYVEFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLQCLLDPANSV LNYFSPYLGRIEIMGGAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDTTDRPEEEEEEEPHHVLEVGEEDEEEKSLESSSAF IVACTALRKNTSNFLKMLTLKNISKQFRKVKKMTIKELVKVFFSFFWTLFVGLFQFVFTI IWGIFQILWSTVFGGGLVEGAKNIKVTKILGDMPDPTQFGIHDDVLETEKADAPEHATSA ELAHLVKVEKGEIDMPDIFGIQSKKESSKHGQEIGLGDFSEHVGTERTTSLESAVHKKRK TLEAEIAKEIAKEHEDNSKAESEKADMEDGEKKDKAKAEEQSEFLESKAETRSKKRRGQK KEESEAFMANFLAGLEIYQTKTLNYLARNFYNLRFLALFVAFAINFILLFYKVTEDPVSD DTDNEQNLWNPYQEDEEAEEGAVYFVLQESTGYMAPTLRILAVIHTIISFVCVIGYYCLK VPLVVFKREKEIARNVEFDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFVKRKVI NKYGDLYGADRIAELLGLDKNALDFSPVEKTKIEAGSLVSWLSSIDMKYHIWKLGVVFTD NSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAV VVYLYTVVAFNFFRKFYNKSEDEDDPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAG DPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGND YFDTTPHGFETHTLQEHNLANYLFFLMYIINKDETEHTGQESYVWKMYQERCWDFFPAGD CFRKQYEDLLG NT seq 14616 nt NT seq  +upstreamnt  +downstreamnt atggctgaagggggcgaagtggaggatgagatacaattcctccgcactgatgatgaagtt gtccttcagtgcattgccaccatccataaggaacagaggaaattttgtctggcagctgag ggacttgggaatcgactttgcttcttggagccaacatcagaagccaagtatgtccctcct gacctgtgcatttgtaattttgtgctggagcagtccctctctgttagagcccttcaggaa atgttggcaaacacaatggcacatggcaatgaaggggcatcgcaaggaggcggacacagg actttactctatggccatgctatcttactaagacattcatttagtggaatgtacttgaca tgtttgaccacatccagatcactcacagacaaacttgcatttgatgttggactgcaagac acagcaacgggagaagcctgttggtggacaatacatcctgcatccaaacagagatctgag ggagaaaaggttcggattggagatgatcttattttagtcagtgtgtcttctgaaagatac ctacatctctccatatccaatggaatgggcaatattcaggtggatgcttccttcatgcag acactgtggaatgtccatcctacatgctctgggagtagtgtggaagaagggtatctcctt ggtggacatgttgttcggtttttccatggtcatgatgagtgtttgacaataccatccacc gacccagccgaggcccagcataggaaagtaaattatgaagcaggtggagcaggtgttcgc gccaggtcgttatggagagtggaacctctcagaatcagttggagcggaagccacatccga tgggggcagacatttcgccttcgccatattacaactgggcaatatttggcactaacagag gaccaaggactagtgctacaaggccgagcaaagtcggatactaaatcatcagctttctgc ttcagagcatccaaagaaaaactggactctgggccaaagcgagacatagatggaatggga gtagcagaaattaaatatggagattccatttgctttatccagcatgtagacagtggcttg tggctcacctacaaagcccaagatgccaaaacagcaagactgggaccacttaaaagaaga gcaattctgcaccaggaaggtcatatggatgatggcgtcactttacagaagtgtcagcat gaagagtcccaggctgctagaatcattcgtaacaccacaggcctcttcagtcaatttatt agtgatttggattctctaacggggaacaatcggacagtaacagcccccatcgccctgcct attgaggaggtagttcaaaccctgcaagacttgattgcttatttccagcctccagaggaa gatctagaacatgaagataaacagaataaactccgttcactgaaaaacaggcagaacctt ttcaaagaagagggaatgctggctctggtactaaattgtattgatcgcctaaatgtgtac agcagtgcggcacactttgctgaaattattggggaaaaaactgggccagcatggaaagaa atactgaacctcttctatgaattgctagctgctctgattcgtggaaatagaagcaactgt gcacaattttccaataatctcgattggcttataagtaagctagagcgtcttgagtcatct tcaggaatattggaggttctgcactgtatcttgattgaaagccctgaggctttaaactta atagagaaaggacacatacgctctatcatttccctgttggacaagcatggaaggaaccac aaggtcctggatgtcctctgctctctgtgtgtttgcaatggtgttgcagttcgtacaaat cagaacctcatttgtgacaacctgctgcccagaagagatttattgttacaaacccgcttg gttaatgatgttaccagcatgagaccgaacatcttcctcggtgtggcagagggctcagct caatacaaaaagtggtactttgagatgatcattgatcaagtagatccctatttgacacca gagccaactcatttgcgcgttggctgggcttcaacctcgggttacgctccatatcctgga ggaggtgaaggatggggaggcaacggtgtaggtgatgatcttttctcctatggttttgat ggtcttcacttatggtctggtcgagtaccaagggcagtggcttcaagtaatcagcactta ctggcttctgatgatgttgtcagctgctgcttggaccttggagtgcccagcatttcattt cgcattaatggccaaccggtccaaggcatgtttgaaaacttcaatacagaaggattattt tttccagtagtgagcttctctgctggagtcaaggttcgctttattcttggtggccgccat ggtgagttcaagtttttacctccagctggctatgccccatgctatgaagccttgttacca aaagagaagatgagagtggagcctgtgaaagagtacaagagggattgtgaaggcgttcga gatttgttgggaacaacacactttctttcacaagcctcattcatcccgtgtcctattgat accagccagattgttttaccaccccaccttgaaaagattcgagataagttagcagaaaat attcatgaactatgggggatgaacaagattgagcttggatggatttatggaaaggtacga gacgacaataaacgccagcatccctgtttggtggaattctcaaagctaccagaaacagag aagaactacaatctacaaatgtctacagagactttaaaaaccttacttgctttgggatgc ctcattgttcactcaaatcaaacagctgaagaaaatcttaagaaagtaaaactcccaaaa aattatatgatgtccaatgcttacaaacctgccccgttggacctgtctgatgtaaaactg ttaccagcccaggaagttcttgttgataaacttgcagagaatgcacacaatgtctgggct aaagacagaataaaacaaggatggacctatggcattcagcaggacctgaagaacaaacga aatcctcgcttggtgccatatgctttacttgatgaacggactaaaaagtctaatagagac agcttgcgtgaagctgtgagaacatttattggctatggctataatattgaaccaccagac caagaaatcactgaccaaatgatggagcgcatcagcattgataagattcgcttctttagg gtggagcagacatatgctgtcaaatctgggagttggtattttgagtttgaagtggtgact ggaggtgatatgcgagtaggctgggctcgacccaactgcaggccggacattcaactcgga gcagatgatcgggcatttgtatttgaaggaagcagaggccagtgctggaacatgggaagc tctttctttggtcgcaactggcagccaggagatgtggtgggatccatgattaatatggat gataaatctatgatcttcacgttaaatggagaactgctcattactaaccaagggtctgaa ctggcatttgctgattttgaaattgaaaatggttttgttccggtctgctctttgggactg tgtcagattggtcgcatgaacctaggtaaagatgccagcaccttcaaatactacacaatg tgtggtctgcaggagggcttccagccatttgctgtgaacatgaacagagatgttgccatg tggttcagcaaacgcttacctacctttgtcaatgtgccaaaagatcatcctcacattgag gtgacaaggaaagatggtactgtagaaatccctccatgcttaaaggttacacataaaacc tttggaacccagaacagtaatgaagacatgatatactgcaggctgagtatgccagttgag ttccattctgcgttcaacaatgaagaacatttccaaaagagaaaccaacttcatgatgca tcttcacatactgccacgttgtattattactccgtgcgaatatttgctggtcaggatccc tcttctgtgtggataggatgggtgactcctgactaccacttctacagtaaaaattttgac ttgagcaagaactgcactgtgactgtcactttaggagatgaaagaggcagagtgcatgaa agtgtaaaacgtagcaattgttacatggtgtggggaggtgacctctccactggctctcag aggtcaggccgcagcaatgtagatatagacattgggtgccttgttgacctggccacagga ctgctttccttcacagctaatggaaaagacctaggaacctgctaccaggttgaaccaaat accaagctgtttccagcagtttttctgcagccaactagcactaatctctttcagtttgaa cttggaaaattaaagaacaccatgccactatcagctgcaatatttaagagtgaagaaaag aatcctgttccacagtgtccacctcgtttggatgtgcaatctataaccccagtactatgg agtcgcatgccaaatattttcttaaaagtggaaacagaacgtgtgagcgagcggcatggc tgggtggtgcaatgcctagaacccctgcagatgttggccttgcatatacctgaggagaat cggtgtattgacatcctggaactctctgagcaagaagatctcatgaaatttcattaccac actcttaaattatactgcgctgtatgtgcactgggtaacaaccgtgttgcacatgccttg tgcagtcacgttgatcagtcccagctactgtatacgattgataaccagtaccttcctggc ctcctgcgttctggtttctacaaccttcttatcagcatttacctggagtctgccaaggag ggcaagctgatgatgaacaatgagtttatcatacccatcactgatgagactcggcaaatt caactgttccctgatgagtcaaagaggcatggcttgcccggggttggtcgtagtacctgt ctgaagtctgacctttattttacagcaccttgctttgtgctgactggagaggagaggcaa cagcatggcccagagattccagtggatattcttaagtccaaagctattggcatgcttaca gaggccgtgcaaagcagtggggatcacatcagagaccctgttggaggaaaagtagagttc cagtttgtgccagtactcaagcttattgccactcttcttattatgggagtgtttgaggat gaggatgtgcgtcagattctactgctcattgacccaaatgtttttggcgaccacaaagaa gaggaaatagaagagaatggggagaaagaagacattgctcaggatgaagagaaagctgta gaggctggtgagaaagcaactagagacgacaaggctcctgccaagggcttactgcagact cgccttccagagtctgtcaaactccagatgtgcgaacttcttcattacttctgtgactgt gagctgaaacatcgtgtggaatccaatgttgccttctctgacaaatttgtttctaagctg caatacaaccagaagttccgatacaatgaacttatgctggcactgaacatgtcagctgct ctaactgccaaaaagacgagggagttccgctctcctccacaggaacagattaacatgctt ctgaatttccaaatgcaagaagacagcccttgcccagaggaaatacggggtgagctatat gagtaccatgaagatcttctcatgcactgtggtattcctcttgaggaagaaaaagaggag gaggaagataaatcatggacaggtcgtcttcgatcactagtatacaagatcaagggccgg ccaagggcagaagagcaagatcctgcagaggaggaggagaagtctcctaccacacttaaa gagctcatctcacaaacaatggtgcgctgggcacaagaagaccacatccaagaccccgag cttgtgcgtatcatgtttagcctcctacgtcgacagtatgatagtattggagagttacta catgccatgcggaaaacctatacaatcagtgctgcctctgtggaagataccattaacctg ttggcttctttgggtcaaatacgatcccttttaagtgtgcgaatgggcaaggaagaggaa atgcttatgattgatggcttaggtgacatcatgaacaacaaggtcttctatcagcatccg aacctgatgcgtgttttagggatgcatgagactgttatggaggtcatggtgaatgttcta gggggagacaagtctcagcaaattgcttttcccaagatggtggcaagctgttgcagattc ctctgctatttttgtagaattagtcggcaaaatcaaaaggccatgtttgagcatctaggt tacttattggagaacagtagtgttggtttagcatctccgtctatgaggggatctacacct ctagatgtcgctgctgcatctgtaatggacaacaatgagcttgctttggctttgcaagaa ccagacttggagaaggttgtgacatatttggcaggttgtggactgcagagctgtccaatg ttaatagccaaaggatacccagatattggatggaatcccatagagggagagcgttaccta tcattcctacgctttgctgtctttgtaaactgtgagagtgttgaagaaaatgccagtgtg gtggtgaagctattaatccgtcgaccagagtgttttgggccttctcttagaggagaaggg ggaaatggtttgctggcagctatgcaggaggctattaacatctctgagaacccagctctg gatcttccttctcagggctatcagagggaagtggtcgaagaagatgaagaagaagagatt gtacacatgggaaatgctataatgtccttttattctgcactcatagacttgctggggcgt tgtgcaccagagccacatttgatccaggctggtaaaggtgaagctatacgaatacgcgcc atcctccgatcacttgtgcctacagaagatcttgttgggattattagtatccccctaaag ctgcctgcttttaacaaagatggcacagtgtttgaaccagacatggctgctagcttttgc cctgatcacaaggctcccatggtgcttttcctggaccgtgtctatggcattagggaccaa cgcttcctccttcatctgctagaggtggcctttttacctgacctaagagcatcagcatca cttgatacagcttccctgagtgtcactgagatggctcttgctttgaaccgatatatctgc tctgcggtactcccattgcttactcgttgtgctcccctcttttccggcaccgaacactat gcagcactaatagattccaccctgcataccatatacagactatccaaggggcgttctcta accaaagctcagagagacacaattgaagagtgtctgctgtcaatatgccatcatatgcgg ccttctatgcttcagcagctcctgcggcgtctcgtttttgatgttcccttgctcagcgaa tactgcaaaatgccactgaagcttttgacaaaccattatgaacagtgctggaaatattat tgcctcccttctggatggggcagctacggtttggcctcagaggaagaactgcatctgact gaaaagctgttctgggggatttttgattccctttcccacaagaagtatgatgctgaactc ttcagaatgtgcatgccctgtctcagtgcaatagctggaggtctaccaccagattatgtt gataccagaattaaagcaacacctgagaagcaaatgtcagtggacgctgaaggaaacttt gacccaaaacccattaatactgccaatcttacattacccgagaagctggaatatattgtc aataaatacgcagagcattcccatgataaatgggcttatgacaagctacacagtggatgg aaatatggaactacccttgatgaaaatacaaaatcccacccgctgctgagaccatttaag acactaactgaaaaggagaaagaaatatatcgttggcctgtaagggaatctgtgaaaacc atgctagcaattggatggagtgtggaaagaactaaagaaggagaagccctggcactgcac cgggaaaatgaaaagatgcgcagtatatcccagactagccagggaaatggctacactcct gcttcaattgatctgagtaatgttgtcctctcccgagagctccagggaatggtggaagta atggcagaaaactaccacaatatatgggcaaaaaagaagaagacggagttggagactaaa ggtgcagggagccacccactgttggtgccctatgataccttaacagcaaaagaaaaggca agggaccgtgaaaaagcccaggaacttttcaaatttcttcaagtgaatggatatgccata tccagaggattaaaagatatggagttagatgcttcttccatggagaagagatttgccttc aaatttctgaagaaagttctgcattacgttgattcggctcaggaattcattgcacattta gaggcggttgttggcagcggtaaaagtgagaagtcaccacacgaacaagaaatcaagttt tttgccaaagttcttttgccactcgttgaccaatactttaagaaccactgcttgtatttc ctctcttctccaattaaaaccctcagcagtagtggctatgcatccaacaaagagaaagaa atggtggcaagtctgttctgcaaactggcagctcttgtcagacataggatctcactgttt ggaagtgattctgccaccatggtgagctgtttgcacattctggcccagacgcttgacaca cgcactgtaatgaagtctggatctgagctggtgaaagctggagttcgtgctttctttgaa aatgctgcagaagatttggaaaagacattagaaaatctgaagctggggaaatttactcac tctaggactcagatgaaaggagtctcccagaacattaactacaccacagtggccctcctt cctatactgacatccatttttgaacatgtggctcgtcaccagtttggagttgatttgctg ttggatgatgttcaagtttcctgctaccggatcctctgcagcctttatttacttggaacc ggaaaaaacatctatgttgaaaggcagcggcccgccctgggagaatgtctggcagctctg gctggagctattcccgtggcttttcttgagccatcactaaaccacaacaatccactctct gttttcaataccaaatctccacgggagagagctattttaggtatgccagatacagtggaa gagatgtgttcagaaatgccacacctagagggtcttatgaaagagattaatgacttggct gaatctggagctaggtacacggagatgccacatgtcattgaggtcgtccttccaatgcta tgcaactatctttcttattggtgggagagaggcacagagaatgtgccagaaaatgccagg ccatgctgtactcaagtgacttcagaacacctcagtgtcatactgggcaacatcctgaaa atcattaacaacaatctgggaatagatgaagcatcttggatgaagagaattgcagtctac gctcagccaattatcagcaaggctcaaccagacctcctaaagagccattttattcccaca ctggagaaactgaagaagaaagcaataaagattgtgcaagaggaggagcagctgaaagca gacagcaagactgacactcaggaagcagagttgctcattcttgatgagtttgcggtttta tgtagagatctgtatgctttctatcctatgctaatccgatatgtagacaacaacaggtcg aactggctcaaaaaaccagatgctgattctgatgatctgttcagaatggtggcggaagtt tttattctttggtgtaaatcacataattttaaaagagaagaacagaattttgtgattcag aatgagatcaataatttggcattcctgaccggaaacaacaagagtaagatgtctaaaccc atacaagtgaagtctggagggcaagaccaggagaggaagagaacaaagcgcagaggagac ctttactccatacagacttccctgattgtggctgccttgaaaaagatgctacccattggg ctgaatatgtgctccccgggggatcaggaactcatttcacttgcaaagagccgatattgc cttaaagacacagacgaagaagtaaaagaacacttacgcagcaacctccacctgcaggaa aaatctgaagatcctgcagttaaatggcagctggatttgtacaaggatattctgaaaagt gaggagaccgaccctgagaaagctgtagaacgtgttcagaaaatatctgctgctgtcttc catcttgaacaggtggagcagcccttgagatctaagaaagctgtctggcacaaactcctg tcgaagcagaggaagcgagctgttgtggcctgttttcgcatggcccctttgtacaatctg ccaaggcaccgttgtattaacctcttcctccatggttatcagagattttggatacaaaca gaggaaaattcctttgaggagacactaattcaggatttggctaaacccaaaaggaaagat gaagacgaagaggaggagacagagaaaaatccagatcctcttcaccagataattttacat ttcagtcgcaatgcccttactgagaggagtaagttggaggatgacccactgtatacagca tatgcagcaatgatggcaaagagctgtcaaaatgaagaagaagaagatgaggacaaagag aaaacatttgaagaaaaagaaatggaaaaacaaaagacattataccagcaggctcgtcta catgagaggggggctgctgagatggtgcttcagatgatcagtgcaagtaaaggtgaaatg agccctatggttgtggaaacactcaaacttggaatatcgattctaaacggcggcaatacc gtagtacaacagaaaatgttagactacttgaaagagaaaaaagatgctggattcttccag agtttgtctggcctaatgatgtcatgcagtgttcttgacttgaatgcatttgaaaggcag aacaaagcagaaggccttggaatggttacggaagaaggaacactcattgtccgtgaacga ggtgagaaggttttacagaatgatgaatttacaagggacctctttagattcctgcaacta ctgtgtgaaggacacaacaatgactttcagaatttcctcagaacccagatgggaaatacc accacagtaaatattatcattagcaccgtggattatcttctccgtctccaggaatctatc agtgacttctactggtactactcggggaaggatgtgattgatgaatctggacagcgcaac ttttccaaatctctggctgttaccaaacaaatatttaactcgctcactgaatacattcag ggtccatgcataggaaatcagcagagtttggcacacagtaggctatgggatgctgtggtt gggtttctccatgtctttgcaaacatgcagatgaaactgtcacaggactctagccagatt gaactgcttaaacagcttcttgatctccttcaagacatggtggtcatgctgctgtctctc ctagaaggcaatgtggttaatggaactattggaaaacaaatggttgacactcttgtagaa tcgtccagcaatgttgaaatgatccttaagttctttgacatgttcctaaagctgaaagac ctaactagctctgatgcatttaaagagtatgacccagaagggaaaggaattatctccaag aaagagtttcaaaaagccatggaggggcaaaagcaatatgcccagtctgaaattgaattc cttctttcttgtgctgaagcagatgaaaatgacatgtttaactatgttgaatttgtagac agatttcatgaaccagctaaagatattggatttaatgtggccgttttgttgactaatctc tcagagcatatgccaaatgattcacggctccagtgtttgttggatcctgcaaacagtgtt ctaaactacttttctccatacttgggtcgtattgaaattatgggtggagcaaaaagaata gagagagtatatttcgagataagtgagtcaagccggacacagtgggagaagccacaagtc aaagagtcaaagagacaatttatttttgatgtagtcaatgaaggcggagagcaggaaaaa atggaactctttgttaacttctgtgaggacacaatttttgagatgcagctggcctctcag atttctgagtcagacacaacagatagacctgaagaagaagaagaggaggaacctcaccat gtgcttgaagttggtgaagaagatgaggaagaaaaatctttggaatcttcttctgctttt attgtagcttgcacagcgctgaggaaaaacacttccaattttttaaaaatgctaactttg aaaaacattagcaaacagtttaggaaggtgaaaaaaatgaccattaaagaattagtgaaa gtcttcttctcatttttctggactctatttgttggtctgttccaatttgtgtttaccatt atatggggaatattccagattctttggagcactgtgtttggaggtggcctagttgaaggg gccaaaaacattaaagttaccaaaatattaggagacatgcctgatcccactcagtttgga atccacgatgatgtcctggaaaccgaaaaagcagatgcccctgaacatgctacatcagca gaactggcccatcttgttaaagtagagaaaggagagattgacatgcctgatatatttggt atacaaagcaaaaaagaaagctctaagcatggtcaagaaatcggtctgggtgatttctcc gagcatgtaggaacagagcgcacaaccagcttggaaagtgctgtccacaaaaagagaaaa actcttgaagcagaaatagctaaagaaattgctaaagaacatgaagacaactctaaagct gaatctgagaaggccgatatggaagatggtgagaaaaaggacaaagctaaagctgaggaa cagtctgaattcttggaaagcaaagcagaaacgagaagcaagaaaagacgtggacagaaa aaagaggaatctgaagcatttatggcaaattttctggcaggattggagatctaccaaacc aaaacgctaaattatctggcaagaaatttctataatctacgattccttgctctgtttgtt gcattcgccattaacttcattttattgttctacaaggtaactgaggatcctgtcagcgat gacacagataatgaacaaaacctatggaacccatatcaggaagatgaggaagcagaggag ggagccgtttactttgttctacaagaatccactggctacatggctccaacactacgtatc ctggctgttattcacaccatcatttctttcgtctgtgttattggatattactgtctaaag gttcctctggtggtatttaaacgtgagaaggaaattgctcgtaatgtagagtttgatgga ctatatatcacagagcagccctcagatgatgacattaaaggacaatgggatcgccttgtc atcaatactccgtctttccctaataattattgggataaatttgttaagaggaaggtcatc aataaatatggagacctatatggagcagatagaattgctgaactgcttggattggataaa aatgctctggatttcagccctgtagaaaagaccaaaatcgaggcgggatcacttgtatca tggctgagttccattgacatgaagtaccatatctggaagcttggagtggtttttactgac aattccttcctttaccttgcttggtacacaaccatgtcaatacttggacactacaacaac ttcttctttgcagctcatctcctggatattgcaatgggcttcaagaccttaagaaccatt ctttcctcagttacccacaatggaaaacagctggtgctcacagttggacttctggcggta gttgtttatctttacactgttgtggccttcaacttcttccggaagttttacaataagagt gaagacgaagatgaccctgatatgaagtgtgatgacatgatgacgtgttacctgttccac atgtatgtgggagtgagagctggaggtggcattggagatgagattgaagaccctgccggt gacccttatgagatgtatcgtattgtgttcgacatcaccttcttcttctttgttattgtc atacttctggccattattcaaggtttgatcattgatgcttttggagaactgagagaccaa caagaacaagtgagagaagacatggagacaaaatgtttcatttgtggaattggaaatgat tactttgacacgacaccgcatggctttgaaacacacaccttacaagagcacaatttggcg aactatctgttcttcctcatgtatataattaataaagatgaaaccgaacacactggccag gaatcgtatgtctggaaaatgtatcaggagagatgttgggacttcttcccagcaggtgac tgtttccgcaagcagtatgaagacctactcggataa

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