Oreochromis aureus (blue tilapia): 116311265 Help Entry 116311265         CDS       T07295                                  Symbol ryr3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism oau  Oreochromis aureus (blue tilapia) Pathway oau04020   Calcium signaling pathway oau04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oau00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116311265 (ryr3)    04020 Calcium signaling pathway     116311265 (ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oau04040]     116311265 (ryr3) Ion channels [BR:oau04040]  Voltage-gated cation channels   Ryanodine receptor    116311265 (ryr3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_8 Med16_bridge Motif Other DBs NCBI-GeneID:  116311265 NCBI-ProteinID:  XP_039454626 Ensembl:  ENSOABG00000000409 LinkDB All DBs Position LG15:complement(16861670..16978060) Genome browser AA seq 4854 aa AA seqDB search MAEGGEGEDEIQFLRTDDEVVLQSVATIQKEHRKFCLAAEGLGNRLCYLESTSEAKYVPP DLCICNFVLEQSLSVRALQEMLANTGQNSEGSADHEKWAGQGGGHRTLLYGHAILLRHSF SGMYLTCLKTSRSLTDKLSFDVGLQEDSIGESCWWTIHPASKQRSEGEKVRIGDDLILVS VSTERYLHLSISNGNIQVDASFMQTLWNVQPTCSSSNMAVGYLTGGHVMRLCHGHDESLT IPGADKNEEEQRIVNYEAGKGASKARSLWRVEPLRISWSGSHIRWGQPFRLRHLSTGHYL ALTEDRGLVLQDRVKSDTTATAFCFRASKEKGDTGPKRDIDGMGMPEIKYGDSVCFIMHV ATGLWLSYQAPDAKSSRLGPLKRRACLHSEGHMDDGLILQRCQHEESRAARIIRNTTFLF TNFIKALDSIAAGESTAVAGYVEEVLQTLNDLIEYFKQPDSELEHEEKQCLLRSLIKRQD LFKEEGMLSLLSKCIDRMNLYDSAAHFGEVAGEEAGAAWKDILNLLYELLAALIRGNRNN CTQFSRKLDWLVSKLERLESSSGILEVLHCILVESPEALNIIQKGHIKSIVSLLYKHGRN HKILDVLCSLCVCNGVAVRANQNLICDNLLPNRDLLLQTRLVNDVQSMRPNIFLGIAEGS AQYKKWYYELVIDQVDHFVTSEPTHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYSF DGLHLWSGRIPRAVASINQHLLNSDDVVSCCLDLGAPSMSFRINGQPVQGMFEDFNTDGF FFPVVSFSAGVKVRFLLGGRHGDFKFLPPAGYSPCYEALLPKEKMHVEPVKEYKRDHDGV RDLLGTTQFLSQASFIPTPVDTSQIVLPPHLENIRDKLAENIHELWGMNKIELGWTYGKV RDDNKRQHPCLVDFAKLPETERNYNLQMSSETLKTLLALGCHVAQVNIHAEDDLKKIKLP KNYMMSNGYKPAPLDLSDVRLNAGQEVLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSR RNPRLVPYALLDERTKKSNRDSLREAIRTMVGYGYEIDPPDQEVVHVLDDQSVETIRFFR VEQTYAVKTGKWYFEFEALSGGDMRVGWARPGCRPDVELGVDDQAFVFDGYRGRRMHAGS RYFGHPWKKGDVVGCMINMEDKSMIFTLNGELLITNKGSELCFTDFETEDGFIPVCSLSM SQIGRMNLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFFNVPQEHPDIE VTRIDGTVDSPPCLKVTHKTYGTQNSNNDMVYCRLSMPVEFYSADKLLDESLKLSHPPKE DGSIDFGSITTYYYSVRVFAGQDPACVWVGWVTPDYHYYSKNFSLSKTRTVTVTLGDERG RVHESVQRSNCYMVCVADAATPSSSSRSSSDLEIGCLADLATGLVSFTANGKELPTSYQV EPNTKLFPAVFVLPTSANLFQFEFVKIKDAMPLSSAIFKSEHRNPVPQCPPRLDVQTIVA VLWSRMPNTFLNVETARVSERHGWVVQCLEPMQMMAVHIPEENRCLDIMELSEHEDLRKF HYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLREGFYNVLISIHLET AKEARLMMNNEFIIPVTDETRSIKLFPDESKRHSLPGVDLSTSLKPRVNFSPVGIINTKR QQYLYSPQIPLGILKEKAISMLTEAVQGGGTHIRDPVGGSLEYQFVPILKLIGTLLIMGV LTSDEVRLILLLIDPNVFGETKEGEEVKGDEVAVSGEKEEVSKNEEKAVEAGEEETKESK PQVKGLLEKSLPESVKRQMCELLHYFCDCELKHRIESIVSFSDSFVSKLQYNQKFRYNEL MLALNMSAAVTAKKTKEFRSPPQEQINILLNFSAGEDCPCPEEIQDELNSFHEELRLHCG IPVEEEEEEQDTSIKGRLLALLYKIKGPPQKTEQEPTETEQAAPTNLKELISQTITSWAQ ESHIQDPELVRVMFSLLRRQYDGIGELLRAMKKSYTISAASVQDAINLLASLGQIRSLLS VRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGGDKSQEIAFPK MVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASEAMRGSTPLDVAASSVMDNN GLALALEEPDLEKVVTYLAGCGLQSCAMLVAKGYPDLGWNPIEGERYLSFLRFAVFCNGE SVEENANVVVKLLIRRPECFGPALRGEGGQGLLAAMEEAIKISEDPALDLPKTPAGVTTG SGEEEGEVIHMGNAIMSFYSALIDLLGRCAPEMHLINAGKGEALRIRAILRSLVPTSDLV GVISIPLKMPVVNKDGTVTEPDMSACFCPDHKAPMVLFLDRVYGIEDQSFLLQMLEVGFL PDLRASASLDTEALSTTETALAMNRYIGSALLPLLTRCAALFGSTEHHAQLVDSTLQTIY RLSKGRSLTKAQRDAIEECLLAICKHLRPSMMQQLLRRLVFDVPVLNEYCKIPLRLLTNH YEQNWKYYCLPSGMGSFGTASEEELLLTKKLFWGIFDSLSHKKYDAELFKMAKSCLCAIA GALPPDFVDSSLGATLEKQASMDAQGNFDPKPISTANISLPEKLEYIANKYAEHSHDKWS SEKMSVGWKHGDTVDEQAKTHPLLKPYKSLSEKERETYRWPVRESLKSMLSMGWNIERTK EGEAMFQQRESEKQRKISESQINGFSPAPMDLHNVTLSRELQGMVEVVAENYHNIWAKKK KTELVSKGGGTHPLLVPYDTLTAKEKYRDREKAQELFKFLQISGYAITRGLKDMEQDSSS MEKRFSYKFLKRLLKNVDSAQEFIAHLEAMATSGKTDKSPHDQEIKFFAKVLLPLTDQTF KNHCLYFLSTPSKNLSSCGCASNKEKEMVTSLFCKLAALVRHRISLFGSDSAMMVSCLHI LTHSLDTRTVMKTGSELVKVGLKTFFENAAEDLDKLLEMLKLGKFMQSRAQMKSVSQSIN YVTVALLPILTALFEHIKTYEFGVDLLLDDVQLSCYRILTCLYSLGTGKNVFVERHLPAL GESLATLVGAMPVAFLEPHLNAHNPLSVFNTKTPRERAILSMPDTVEEMCPEMPRLDKLL KDVNDVSESGARYSDMPQVIEVILPMLCNYLSYWWEKGPENSPPDTHCCTMVTSEHLSII LGNILKILNSNLGIDDAPWMKRIAVYSQPIICKAGADLLRTHFLPTLDKLKKKTVKVVAE EELLKADSKGDNQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRWLKEPDGDSTELF RMVAEIFILWCKSHNFKREEQNFVVQNEINNLGFLTGEGKTKMSKTGGDQERKHKRRRGE YYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKIRYSLKDTDDEVKEHLRQNLHLQD KSDDPAVQWQMNLYKDVVVKIEEPANPEHTVDRVQSISAAVFHLEQVEQPLRNKKCVWQK LLSKQRKRAVVACFRMAPLYNLPRHRAINFFIPAYERLWIEAEEYSFEEKLVQDLAKTPM KIVEEEEEEVAEIQPDPLHQLILHFSHNALTERSHLEEDPLYIAYADMMAKSCAEDEEEE EEEGKEKTFEEKEMEKQKILYQQARLHARGAAEMVLQMISASKGRLGPMVTCTLKLGISI LNGGNVQVQQKMLDYLKEKRDAGFFKSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS IHTERGSKVLQNDEFTKDLFRFLQLLCEGHNGDFQNFLRTQTGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKEIIDETGKLNFSKALSVAKQIFNSLTEYIQGPCIGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDASQIELLKELMDLQKDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSSNVEMILKFFDMFLKLKDLTTSDNFKEYDPECKGIISKKEFQKSMESQKQYIQ SEIEFLLSCVEADENDMFNYKEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLATFLD LAESVLSYFEPYLGRIEIMGSAKRIERVYFEISESSREQWEKPQVKESKRQFIFDVVNEG GESEKMEMFVNFCEDTIFEMQLASQISEPEVVEQPEEDEEEDGHSILEELTAEEEHALES ASAFTTACRSVSGKISHVRQMFSIKSMRKKFKKLKKLSIKEIITGFFAFFWMLFTGFFKG IYSLIFGFFHVIWSSMFGGGLVEGAKNIKVTDILGNMPDPTQFGIHGDVIEGEKVEAIES LGNLDIAMAPTGDIVEVDMMMEMLNAPKKEGGKHVEPGLGDVSELSAEPATDHKKKAAAK KVETPENEPEKADTENQEKEDKPKEEAAKEPVTEEKPKTRSSQPKEPAPAFMSSIFAVLD VYLNKTVNYLARNFYNLRFLALFVCFAINFILLFYKVTGETDEETEGENRWGADEEDDEN TLFDMDEFVLQESTGYMLPTLRFLAIFHTVISLVCLVGYYCLKVPLVVFKREKEIARKLE FDGLYITEQPSDDDIKGQWDRLVINTPSFPNNYWDKFIKRKVINKYGDLYGAERIAELLG LDKSALDFDPTVETVEKEASLVSWLSSIDTKYHIWKLGVVLTDNSFLYLIWYTTMSIFGH FNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFY NKSEDEDEPDMKCDDMMTCYMFHMYVGVRAGGGIGDELEDPAGDPYELYRILFDITFFFF VIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDRTPHGFETHTLQEH NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPTGDCFRKQYEDQLG NT seq 14565 nt NT seq  +upstreamnt  +downstreamnt atggctgagggcggagaaggggaagatgagatccagttcttgagaactgacgatgaggtg gtgctccagagtgtggccaccatccagaaggagcatcgtaagttctgcctggccgccgag ggacttggaaaccgtctatgttacctggaatcaacatctgaagctaagtatgttcctccg gacctttgtatctgtaactttgtgctggagcagtcactgtcagtgcgagccctgcaggag atgctggctaacactgggcagaacagcgaagggagcgctgaccatgaaaaatgggcgggt caggggggtggacaccggaccctgctctacggtcacgccatcctcctacgccactccttc agtggcatgtacttgacctgtttgaagacatcaaggtctctgacagacaagctgtcattt gatgtcggactgcaagaagattcaataggagagtcctgctggtggaccattcaccctgca tccaagcagagatctgagggagagaaagtccgcattggagacgacctgattcttgtcagt gtgtcgacggagagatatctacatctctctatttccaatggcaacattcaagtggatgcc tccttcatgcagaccctgtggaatgtccagcctacctgctcatcaagcaacatggcagta ggttatttaactggtggacatgtgatgcgtctctgtcatgggcatgatgagagcctgacc atccctggagcagacaagaatgaagaggagcagaggatagtcaactatgaggctggtaag ggagcatcaaaggcccgttcactgtggagagtggagccgctgaggatcagctggagtggt agccacatccggtggggccagcccttccgactacgccatctctctactggccattatctt gctctgactgaagaccgtggactggtcctgcaggacagagtgaagtctgacaccacggcc actgctttctgctttagggcctccaaggaaaagggagatactggcccaaagagggacatt gatggcatgggcatgccagagatcaagtacggagactctgtgtgcttcatcatgcatgtg gcaacaggactttggctgtcctaccaggcgccagatgccaaatcatctcgtcttggtccc ctaaaaagaagggcctgcctacattctgagggccacatggatgacgggctcatcctccag cgctgtcagcatgaggagtctcgggctgcacgcatcatccgtaacaccacgttcctcttt accaacttcatcaaagctttggacagcattgcagcaggagagtctacagcggtggccggg tacgttgaagaggtgctacagacactgaatgatttgattgagtactttaagcagcccgat tctgagctggagcatgaagagaagcagtgtcttctccgttcactcatcaaacgtcaggac ctcttcaaagaggagggtatgctgagtcttctgtccaaatgcattgatcgaatgaacctg tacgacagtgcagcccacttcggggaggtggctggggaggaagctggcgcagcgtggaag gacattctcaacctgctttatgaactcttagctgcactgattcgtggaaaccggaacaac tgtacccagttttcccgaaaattggactggttggtcagcaaactcgaaagactggagtct tcatcaggtattctggaagtcctccactgtatcttggtagaaagcccagaagctctgaac atcatccagaaaggtcacattaaatccatcgtctctctgctctacaagcatggacgcaac cacaagatcctggatgtcctttgttccctctgtgtatgcaatggagtggcagtgagagcc aatcagaatctgatctgtgacaacctccttcccaatagggacctgctgcttcagactcga ttggtcaatgatgttcagagtatgagaccaaatatcttcctgggcatagctgaaggttca gctcagtataagaagtggtattatgagctggtcattgaccaagtggaccactttgtaacc agtgagccgacccacctgagggtaggctgggccaacactaaaggctatgctccgtacccc ggtggaggagaagggtggggaggcaacggtgttggagatgacctgtactcttacagcttt gatggactgcatctctggtcaggccgaatcccaagggccgtggcctccattaaccagcac ctgctgaactcagacgatgtggtcagctgctgtctggatttgggagctcccagtatgtcc ttcaggatcaacgggcagcctgtccagggcatgttcgaggacttcaacacagacgggttc ttcttccctgtagtcagcttttctgcaggtgtaaaggtccggttcctgctaggcggtcgc catggagatttcaagttcttgccacctgccggttactctccgtgttatgaagcactgttg cccaaagagaagatgcatgtagagcctgtgaaggagtacaagagggaccatgatggggtc cgtgatttgctgggaaccacccagttcctctctcaggcctcctttatccccactcctgtt gacaccagtcagattgttcttccccctcacttggagaacatccgggacaagctggcagaa aacattcacgaactgtgggggatgaacaagattgaactgggctggacctatggcaaggtt cgtgatgacaacaagaggcagcacccttgccttgtggatttcgccaagctgcctgaaact gaaaggaactacaacttgcagatgtccagtgaaaccctaaagacccttttagccctggga tgccatgttgcccaggttaatattcacgctgaagacgatctgaagaaaatcaaattaccc aaaaactacatgatgtccaatggatataagcctgcgccactggacctctctgatgtgaga ctgaatgctggtcaggaggttctagttgataaactggccgaaaatgcgcacaatgtgtgg gccaaagatagaattaaacaaggatggacctatggcatccagcaggatttgaagagcagg cgtaatcctcgcctggtgccatatgctttactggatgaacgcaccaagaaatctaacagg gacagtctgagagaggccatcaggactatggttggatatggatatgagatcgacccccca gatcaagaggttgtgcacgtgcttgatgatcagagcgtcgagacgatacgcttcttccgt gtggagcagacctacgcggtgaagacggggaagtggtactttgagtttgaggctctgagt ggaggagacatgagggttggctgggccagaccaggctgcagacctgatgtggagctcgga gtggacgaccaagccttcgtctttgatggatatcggggacgacgtatgcatgcaggcagc cgctactttggacatccttggaaaaagggcgacgtggttggctgcatgatcaacatggag gacaaatcgatgattttcacccttaacggagaactgctgatcaccaataaaggatccgag ctttgcttcactgactttgagacagaggatggtttcatccccgtgtgcagtctcagcatg tctcagatcggccgtatgaacttgggcaaggacgccagtactttcaagtactacaccatg tgtggtctacaggagggttttgagccctttgctgttaacatgaacagagaggtcaccatg tggttcagcaagcgcctgcccacttttttcaatgtacctcaggaacaccctgatattgag gtgacgaggattgacggaacagtcgacagccctccttgccttaaggtcactcacaagacg tatggcactcaaaacagcaacaatgacatggtctactgtagactgagcatgcccgtggag ttttattctgcagacaagctcctggatgaatcactgaagctcagccatcctccaaaagaa gatggaagtattgactttggaagcatcacaacttattactactcagtgcgagtgtttgct ggacaggaccctgcttgtgtgtgggtgggctgggtcacacccgactatcattattatagc aagaacttcagcctcagcaaaacccgcacggtcacagtgacgctgggagatgagagggga agggtccatgagagtgttcagaggagtaactgctacatggtgtgtgtagcagacgcagct accccgtcttcctccagccgctctagctccgacctggagattggctgtctggctgacctg gccactggccttgtctccttcactgccaatggcaaagagctccccacatcatatcaggtg gaaccaaataccaagctcttccctgctgtgtttgtcctccccaccagtgcaaacctcttc cagtttgaatttgttaagataaaggatgccatgccactctcatcagccatattcaagagc gagcacaggaacccggtgccacagtgtccgccacggttggatgtgcagacaattgtggca gtgctttggagccggatgcccaatacctttctcaatgtggagacggctcgcgttagtgaa agacatggctgggtggtccagtgtctggagcctatgcagatgatggctgtacacatacct gaagaaaacaggtgtttggacataatggagttatctgagcacgaagacttgaggaagttc cactaccacacactaaagctgtattgtgccctttgtgcactgggaaacactcgtgtagct cacgccctctgcagccatttggaccaatcacagcttctctacacaatcgacaatcagtac ctctctggcatgctgagagagggcttctacaatgtcctcatcagcattcatctcgagaca gcaaaggaagcccgtctaatgatgaacaacgagttcattatccctgtgacggatgaaacg cgctccatcaagctgttcccagatgagtccaagcgacattcacttcctggggtggaccta agcacctcccttaaacctcgggtcaatttctcccctgtgggaatcatcaacaccaaacgc cagcagtacctctacagcccccagatcccattgggcatcctaaaggaaaaagccatcagc atgctaaccgaggcagtgcaaggtggagggacccacatccgagacccagtaggcgggagt cttgagtaccagtttgttcccattttgaaactgattggaacactgttaataatgggagtc ctgaccagtgatgaggtgaggctgattctcctcctgatcgaccccaatgtgtttggagag accaaagagggcgaggaagttaagggggatgaggtggccgtgtcgggggagaaggaggag gtgagcaagaatgaggagaaggctgtagaagcaggggaggaggagaccaaggagagcaaa ccgcaagttaaaggcctgctggagaagtctctgccggagtctgtcaaacgccagatgtgt gagctgctccactacttctgtgactgcgagctgaagcaccgcatcgaatccattgtttcc ttctccgacagcttcgtatccaagctgcagtacaatcagaagttccgctacaatgagcta atgctggctctcaacatgtctgccgctgtcactgccaagaagaccaaagagtttcgttca cctccgcaggagcagataaacatcctgttgaatttcagcgcaggtgaggactgcccctgc cccgaggagatccaggatgagctcaactcgttccatgaagaactgcggctgcattgtgga attccagtggaggaggaagaagaagaacaggacacttcaattaaaggccgtcttctggct ttactgtataagatcaagggcccaccacagaagacagagcaggaacccacagagactgaa caggctgcccccaccaacctgaaggagcttatctcccagaccataaccagctgggctcag gagtctcacattcaggacccagagctggtcagagtgatgttcagcctgctgaggagacag tatgacggcatcggggaactgcttcgggccatgaagaagtcgtacaccatcagtgccgca tccgtgcaagatgctattaacctgctggcatctctgggtcaaatcagatctctgctatca gtgcgaatgggcaaggaagaggagaaactcatgattgatgggctcggcgacatcatgaac aacaaggttttctaccagcatcctaatctgatgagagtgctgggcatgcatgagacggtc atggaggtcatggtgaacgtgcttgggggagacaagtcacaggagatcgccttccccaag atggtagctagctgttgtcgcttcctgtgttatttctgccgtattagccggcaaaaccag aaagccatgtttgaccacctgagctacctgctggagaacagcagtgtcggattggcctct gaagctatgcggggctccactccgctggatgtcgcagcgtcttcggtgatggacaacaac ggtctggcgctggccctggaggagcctgatctggagaaggtggtgacatacctagcaggc tgtggtcttcagagctgcgccatgctggtggctaagggatacccagacctcggctggaac cccatagagggagagcgctacctctcattcctgaggttcgccgttttctgcaacggtgag agcgtggaggaaaatgccaacgtggtggtgaagctgctcatcagacgtccagagtgtttc ggccccgccttgaggggcgaggggggtcagggtctgctggctgccatggaagaggcgatc aagatctctgaagatcctgccctggacctgcccaagactcctgctggagtcactactggg tctggtgaggaggaaggggaagtgattcacatgggcaacgccatcatgtccttctactct gccctcattgacctgctgggacgctgtgctcctgagatgcatcttatcaatgcaggtaaa ggtgaggcgctgcgtatcagagccatcctgcgctctctggttcccacttcagacctggtg ggcgtcatcagcatccccctcaaaatgcctgtcgttaataaagatggcacagtgaccgaa ccggacatgtcagcttgtttctgtcccgaccacaaggcccccatggtgctcttcctggac agagtttatggcatcgaggaccagagcttcctgctccagatgttggaggttggcttcctg cctgacctccgagcctcggcatctctggatacggaggcgttgagcactacagagactgcc ctggccatgaacaggtacatcggctcagctctgctgcctctgctgacccgctgtgccgct ctctttggcagcacagagcaccacgcacagctggttgactccacgttgcagactatctac aggctgtcaaaaggccgctcactcaccaaagcccaaagggatgccattgaagagtgtctg ctggcaatctgcaaacacctgcgtccctccatgatgcagcagctgctcagacgtctggtg tttgacgttccagtgctcaatgaatattgcaagatacctctccggctgctgaccaatcac tacgagcagaactggaagtactactgcctgccatctggtatgggcagctttggcactgcc tctgaggaggagctccttctcaccaagaaactcttctggggaatctttgactccctttct cataagaaatatgatgctgaacttttcaaaatggccaagtcatgcctgtgtgcaatcgct ggggccctgcctccagactttgtggattccagtttaggtgcaacgctggagaagcaggca tcaatggacgcacagggtaactttgaccccaaacccatcagcactgccaatatctccctt cctgaaaaacttgagtacattgccaacaaatatgcagagcattcccatgacaagtggtcc tcagagaagatgtcagtgggctggaaacatggagacactgtggatgagcaggccaaaacc catccactcctgaagccctataaatctctgagtgagaaggagagagaaacgtatcgctgg ccagtgagagagtcactgaagagcatgttgtctatgggctggaacattgagaggaccaaa gagggtgaggcgatgttccagcaacgagagagcgaaaaacagcggaagatctccgagtcc cagattaatggattcagtcccgctccaatggatctgcacaatgtcaccttgtcgagagag ctgcagggcatggtggaggtggttgcagaaaattaccacaacatctgggccaagaagaag aaaactgagcttgtcagcaaaggaggagggacccacccactgctggtaccctatgatacc ttgacagctaaagagaagtacagagacagagagaaggcccaggagctcttcaagttcctg cagattagcggctatgccatcacaagaggcttgaaggacatggagcaggattcatcatca atggaaaaacgtttttcttacaagttccttaagaggctgctgaagaatgttgactctgcc caggagttcattgctcatcttgaggcgatggccaccagcgggaagaccgacaaatcccct catgaccaggaaatcaagttctttgccaaggtgttgcttcccctgactgatcaaacattt aaaaaccactgtctgtacttcctgtctacacctagtaagaacctgagcagttgtggttgt gcctccaataaagagaaggagatggtcaccagtctgttctgtaagctggcagctcttgtc agacacaggatttctctctttggaagtgattcagcaatgatggtgagctgtctgcacatc cttactcactcacttgacactagaacagtgatgaagactggctcggagctggtaaaagtc gggttaaagactttctttgagaatgcagcagaagacttggacaagctgctggagatgctg aaactgggaaagttcatgcaatcccgtgcccagatgaagagcgtcagtcaaagcataaac tatgtgacagtggcactgctgcctatcctcactgctctctttgaacatatcaaaacatac gagtttggagtggacttgcttttggatgacgtccagctgtcttgctacagaattctgaca tgtttgtactctctgggaacaggaaagaacgtgtttgtggagaggcatctgccagcactg ggggagagcctggcgactctggttggagccatgcctgtagctttcctggagcctcatcta aacgctcacaacccactctcagtcttcaacaccaagacccctcgagagcgagccatcctg agtatgcctgacacagtggaggagatgtgcccagagatgcctcgtcttgacaaacttctc aaagacgtcaatgatgtgtcagagtctggtgctcgctatagtgacatgccacaggttata gaggtaatccttcccatgctgtgtaactatctctcctactggtgggagaaaggtccagag aactcgcccccagatactcactgctgcaccatggtgacctctgaacacctcagcatcatt ctgggaaatatcctcaagatcctcaacagcaacctgggcatcgatgatgctccttggatg aagaggattgccgtctattctcagccaatcatctgcaaagctggagcagatctgctcaga acccatttcctgcccacactggataaattaaagaagaagacagtgaaggtggtggctgaa gaggagctgctgaaagctgacagcaaaggtgacaaccaggaggcagaactgctcatcttg gatgagtttgctgtgctctgcagggacctctatgctttctaccccatgctcattcgttat gtggacaacaacaggtccaggtggctgaaggagccggacggagactccactgagctcttt aggatggtggctgagatcttcatcctctggtgcaagtcacataactttaagcgtgaggag caaaactttgtggttcagaatgaaatcaacaatttgggcttcctaactggtgaaggcaag actaagatgtccaagacaggtggggaccaggagaggaaacacaagcgccggcgtggggaa tactactccattcaaacgtctctaattgtagccgccctgaagaagatgctacccatcggc cttaacatgtgcaccccaggagaccaggagctcatctctttggccaagatacgctacagc ttgaaagacacagatgatgaggtgaaggagcatttgcgtcagaatctccatctccaggac aagtctgacgacccagcggtccagtggcagatgaacctgtacaaagatgttgtggtgaag attgaggaaccagcaaacccagagcacacagtggacagagtccagagcatctctgctgca gtcttccatctggagcaggtggagcaaccacttaggaataaaaagtgtgtgtggcagaag ctgctatcgaaacagcgtaaacgtgctgtagtggcttgtttccgcatggctccactctac aatttacccaggcatcgtgctatcaacttcttcatcccggcctatgagagactttggata gaggcagaggagtactcctttgaggagaagctagttcaggatctggcaaaaacaccaatg aagattgtggaggaggaggaagaggaggtggctgagatccagcccgaccctctccaccaa ctcattctccacttcagccacaacgctctgacagaaagaagtcacttggaagaagatcct ttgtatattgcgtatgcagacatgatggcaaagagctgtgcagaggatgaggaagaagaa gaggaagaagggaaagaaaagacattcgaggagaaggagatggaaaagcagaagatcctt tatcagcaggcgaggctgcacgctcgtggggctgctgaaatggtgctgcagatgatcagc gccagtaaaggtcgtctgggccccatggtgacctgcaccctcaaactgggcatctccatc ctaaatggaggcaacgtgcaagttcagcagaaaatgctcgattacttgaaagaaaaaaga gatgcaggctttttcaagagtctttcaggactaatgcagtcctgcagtgtcctggacttg aatgcatttgagagacagaacaaagcagaaggactcggcatggtgacagaggaaggttct atccacactgagcggggctccaaggtgctacagaatgatgagtttactaaagatcttttc cggtttttgcaacttctgtgcgagggccacaatggagatttccagaactttctgagaacc caaactggaaacacaaccacagtcaacatcattatcagcactgtggactatctgctccgt cttcaggaatctatcagtgacttctactggtactactctggcaaagaaataattgatgaa accggaaagctcaacttttccaaagctttatctgtagcaaagcagatatttaactcgctg actgagtacatccagggtccatgtattgggaaccagcagagtttagcacacagcagactg tgggatgcagtggtgggcttcttgcatgttttcgcaaacatgcagatgaagctgtctcag gatgccagtcaaattgagctgctgaaggaactgatggacttacagaaagacatggtggtc atgctgctgtctctgcttgagggtaatgtggttaatggaacaattggaaagcagatggtt gacaccctggtggagtcttccagcaatgtggagatgattctcaagttcttcgacatgttc cttaaattgaaggatctcacgacctctgacaacttcaaggagtatgaccctgagtgtaaa ggcatcatttctaagaaggagttccagaagtccatggagagccagaagcagtacatccag tctgagatcgaattcttgctctcgtgtgtagaggcggacgagaatgacatgttcaactac aaggagtttgtggagcgattccacgagccggccaaagacatcggtttcaatgtggcagtc ctgttgaccaacctgtctgaacacatgccgcatgactcccgacttgccactttcttagat ctggctgaaagtgtgcttagttactttgagccttacctgggtcgtattgaaatcatgggc agtgcaaagcgaatcgagagggtttactttgagatcagcgagtcgagccgtgagcagtgg gaaaagccgcaggtgaaagaatccaagcgtcagttcatctttgacgtggtgaacgagggc ggagagagcgagaagatggagatgtttgtgaatttctgcgaagacaccatttttgagatg cagctggcctcacagatctctgagccagaagtggttgaacagcccgaagaggacgaagag gaagatggacacagcatcctggaggagctgactgcagaggaagagcacgccctggagtct gcctctgccttcaccaccgcatgtcgctcagtcagtggcaagatttcacacgtccgccag atgttttccattaaaagcatgcgcaagaagtttaagaaactcaagaagctgagcatcaag gagataatcacaggcttctttgccttcttctggatgctcttcactggcttttttaagggt atctacagcctcatctttggtttcttccacgtcatctggtcctccatgtttggtggaggt ttagtcgagggagccaagaacataaaggtgacggacatcctcggaaacatgcctgacccg actcagttcggcatccacggagatgtgatagagggagagaaagtggaggctatagaatca ttaggaaacctggacatagccatggcaccaacaggggacattgtagaggttgacatgatg atggagatgctgaacgcgcctaaaaaagaaggaggaaaacatgtggagccaggcctgggg gatgttagcgagctgagtgctgagcccgccactgatcataagaagaaagctgctgccaag aaggttgaaacccctgagaatgaaccagaaaaagcagacacagagaaccaagagaaggag gataaaccaaaggaggaggcggctaaggagccagtgacagaggagaagcccaagaccagg tcaagtcagcctaaagagccagcaccggcgttcatgtccagtatttttgcagttctggat gtctatctgaacaagacggtgaactacctggctcgtaacttctataacctccgcttcctg gccctgtttgtgtgttttgccatcaacttcattctgctcttctacaaggtcactggtgaa actgatgaagaaactgaaggtgaaaaccgctggggtgctgacgaagaagatgacgagaac acgctctttgacatggatgagtttgtgcttcaggagagcaccggctacatgttaccaacg ctgcgcttcttggctatattccacaccgtcatctcgctcgtctgcctggtcgggtactac tgcctgaaggttcctttggtggtttttaagagggagaaggaaattgccagaaagcttgaa tttgatgggctgtacatcactgagcagccatctgacgatgatatcaaaggccagtgggat cgacttgtcatcaacaccccatccttcccaaacaactactgggacaaatttatcaagcgc aaggttattaataaatatggtgatctctatggagcagaacgcattgctgagcttttaggc ctagataagagcgctttggactttgaccccacagtggaaactgtcgagaaggaagcgtcc ctggtctcctggctgagctccattgatacaaagtaccacatctggaaactgggcgtggtc ttgactgacaattctttcctgtatctcatctggtacaccaccatgtctatttttggacac ttcaacaacttcttctttgctgctcatctgctggacatcgccatgggattcaagaccctt cgcaccatcctgtcatctgttactcacaatggcaagcagctcgtgctgactgtgggtttg ctggctgtggtcgtctatctctacaccgtggtggccttcaacttcttcaggaagttttac aataagagcgaggatgaagacgagcccgacatgaagtgcgacgatatgatgacgtgctat atgttccacatgtacgtgggtgtgagagctggaggaggtattggagatgagttagaggac ccagctggagatccatacgagctctaccgcatcctgttcgacatcaccttcttcttcttt gtcatcgtcatcctgctggccatcattcagggtttaatcattgatgcctttggtgagctg agagaccaacaggagcaggtgaaagaggacatggagaccaaatgtttcatctgtggaatt gggaatgattactttgaccggacgcctcatggctttgaaactcacaccttacaagaacac aacctagccaactacctgttcttcctgatgtatctgattaacaaggatgagactgagcat acgggtcaggagtcatacgtgtggaagatgtaccaggagagatgctgggacttcttcccc actggagactgcttccgtaagcaatatgaggaccagctgggttag

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