Oreochromis aureus (blue tilapia): 116322306 Help Entry 116322306         CDS       T07295                                  Name (RefSeq) ryanodine receptor 3-like   KO K04963   ryanodine receptor 3 Organism oau  Oreochromis aureus (blue tilapia) Pathway oau04020   Calcium signaling pathway oau04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:oau00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     116322306    04020 Calcium signaling pathway     116322306  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:oau04040]     116322306 Ion channels [BR:oau04040]  Voltage-gated cation channels   Ryanodine receptor    116322306 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RyR RYDR_ITPR RR_TM4-6 SPRY RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  116322306 NCBI-ProteinID:  XP_039459438 Ensembl:  ENSOABG00000013801 LinkDB All DBs Position LG19:complement(21755777..21825406) Genome browser AA seq 4406 aa AA seqDB search MLTLVSNCIDRLNVYNSAAHFGECAGSEAGVAWKDILNLLYELLAALIRGNRNNCTQFSN NLDWLVSKLERLESSSGILEVLHCILIESPEALNIIQKGHIKSIISLLYKHGRNHKILDV LCSLCVCNGVAVRTNQNLICDHLLPKRDLLLQTQLVNDVQSMRPNIFLGVSEGSAQYKKW YYELMIDQVDHFVTSEPSHLRVGWANTKGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASMNQHILTSEDVVSCCLDLGAPSISFRINGQPVQGMFENFNTDGLFFPVVS FSAGVKVRFLLGGRHGDFKFLPPSSYAPCYEALLPKEKMKVEPVKEYKRDVDGVRDLLGT TQFMSQASFIPTPVETSQIVMPPHLEKVRDKLAENIHELWGMNKIELGWSYGKIRDDNKR QHPCLVDFSKLPETEKNYNLQMSTETLKTLLALGCRIVHMNPNAEDSLKKIKLPKNYMMS NGYKPSPLDLSDIKLTPGQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKSKRNPRLV PYALLDERTKKSNRDSLREAIRTLIGYGYNIEPSDQEGGQVSERLSIDKIRFFRVERTYA VKTGKWYFEFEAVTGGDMRVGWARPGCKPDVELGTDELAFVFDGYRGHCLNMGSRLFGRC WHAGDVVGCMINMEDKSMIFTLNGEILITTKGSELCFTDFETEDGFIPVCSLGLSQVGRM NLGKDASTFKYYTMCGLQEGFEPFAVNMNREVTMWFSKRLPTFVNVPKDHNHIAVTRIDG TIDSPPCLKVTHKTFGTQNSNADMVFCRLSMPVEFHSFFKISPVVDMNGVHEEETLKVKH RYPLRSVRHSDESRRVDYSSITTYYHSVRVFAGQDPACVWVGWVTPDYHYYSNNFNLSKN RTVTVTLGDERGRVHESVKRSNCYMVWGGDVTSTSHTSGRSNVDLEIGCLIDLATGLLTF TVNGKEISTSYQVEPNTKLFPAVFVRPTSPSLFQFELTKIKNAMPLSSAIFKSEHKNPVP QCPPRLDVQTINAVLWSRMPNSFLKVETARVNERHGWVVQCVEPLQMLAVHIPEENRCID VMELSEQEDMKKFHYHTLKLYCALCALGNTRVAHALCSHLDQSQLLYTIDNQYLSGMLRE GFYNVLISIHLETAKEARLMMKDEFVIPVTAETRSIRLFSDASKKHLPPGVGLSTSLKPR LNFTPPCFISTKREHLYSPQIPLDALKEKAILMLTEAVQSGGHHIRDPVGGCVEHQFVPI LKLISTLLTMGVLGSEDVRKILLLIDPNVFKEAREEGATGATDKEGLTGAEEKAVEAGEE EAIKEAQQPMEGLLEKRLPEPVKRQMCELLHYFCDCELKHRIEAIVSFSDSFVSKLQYNQ KFRYNELMLALNMSAAVTAKKTKEFRSPPQEQINMLLNFSMGEDCPCPADIQEELYDFHN QLQLHCGIPMEEDEDEQDTSIKGRLLMLVNRIKGQAHKAEEPTKMEQAAPSNLKELISQT MVSWSQECHIQDPELVRKMFSLLRRQYDSVGELLRAMRKTYTISAASVQDTINLLASLGQ IRSLLSVRMGKEEEKLMIDGLGDIMNNKVFYQHPNLMRILGMHETVMEVMVNVLGGDKSQ EIAFPKMVASCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAS SVMDNNGLALALEEPDLDKVVTYLAGCGLQSCPMLLAKGYPDIGWNPIEGERYLSFLRFA VFVNGESVEENSSVVVKLLIRRPECFGPALRGEGGNGLLAAMKEAIKISETPALDLPGSV QGVSSDVSGDGDDEEEVVHMGNAIMSFYSALIDLLGRCAPEMHLINKGKGEALRIRAILR SLVPTEDLVGIISIPLKMPITNKDGSVTEPDMSASFCPDHKAPMVLFLDRVYGVEDQSFL LHLLEVGFLPDLRAATSLDTEGLCTTETALAMNRYIGSAMLPLLTRCAPLFAGTEHYATL IDSTLHTIYRLSKGRSLTKAQRDAIEECLLSVCKHLRPSMLQQLLRRLVFDVPLLTDYCK MPLRLLTNHYEQNWKYYCLPSGWGSFGTASEDELLLTKKIFWGVFDSLSQRKYDPELFKM AMPCLSAIAGALPPDYVDASISTTVEKPVSVDAQGNFDPKPINTANIALPEKLEHFANKY AEHTHEKWSAEKVLLGWKYGDCVDEKAKTHPQLRTYKGLTEKEKDIYRWPIRESLKSMLA MGWSIDRTKDGESMSQQRETEKMRKISQASQANGFNPSPIDTSNVVLSRELQGMVEVVAE NYHNIWAKKKKSDLGSRGGGTHPLLVPYDTLTAKEKARDREKAQDLFRFLLINGYSITRG LKDLEQDSSSMEKRFAYKFLKKLLKCVDSAQEFITHLEAMAASGKTDRSPHEQEIKFFAK VLLPLIDQYFKNHSLYFLSSPNKNLSSSGYASNKEKEMVTSLFCKLAALVRHRISLFGSD STTMVSCLHILAHTLDTRTVMKSGSEQVRVGLRTFFENAAEDLEKTFENLKLGKFTHSRS QMKGVSQNINYTTAALLPILTALFEHITQHHFGVDLLLDDVQVSCYRILTSLYALGTGKN IYVERQLPALGQCLATLAGALPVAFLEPQLNPYNPCSVFNTKSARERATLGIQDSVEEMC PGMPRLDRLMKDINDMAESGARYTEMPHVIEVVLPMLCNYLSYWWERGPENQPASGGSIC CTTVTSEHLSLILGNILKILNNNLGIDEASWMKRIAVYVQPIISKARADLLKSHFLPTLE KLKKKTVKVVAEEELLKADCKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSRW LKEPDSDSNDLFRMVAEIFILWCKSHNFKREEQNFVVQNEINNLSFLTGDNKTKMSKSGG QDQERKHKKRRGEFYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKTRYLMKDTDDE VKDHIQQNLHLREKSDDPAVRWQLNLYKDIVTRTEGLSDPEKVVDRIQRISAAVFNLEQV EQPLRSKKCVWQKLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLLAYQRIWIETEEYSF EEKLVQDLAPDSCGCVQKIQPKVEEEEEEEVRKQPDPLHQLILHFSHNALTECSSLEEDP LYIAYADMMAKSCAEGEEEEGKEKTFEEKEMEKQKMLYQQARLHDRGAAEMVLQMISASK GRLGATVTVTLKLGISILNGGNILVQQKMLDYLKEKRDVGFFKSLSGLMMSCSVLDLNAF ERQNKAEGLGMVTEEGSINVSERGSKVLQNDEFTKDLFRFLQLLCEGHNNDFQNFLRTQT GNTTTVNIIISTVDYLLRLQESISDFYWYYSGKDVIDEAGQRNFSKALAVAKQVFNSLTE YIQGPCIGNQQSLAHSRLWDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLQKDMVVMM LSLLEGNVVNGTIGKQMVDTLVESSSNVEMILKFFDMFLKLKDLTTSDSFKEYDPESKGV ISKKDFQKSMENQKQYSQSEIEFLLSCAEADENDMFNYEQFVERFHEPAKDIGFNVAVLL TNLSEHMPHDARLSTFLDLAESVLSYFEPYLGRIEIMGGAKRIERVYFEISESSRTQWEK PQVKESKRQFIFDVVNEGGESEKMELFVNFCEDTIFEMQLASQISEPDPVERPEEEEDDI QTMMENQEQEDEESAMMESSSAFTIACISMRKSLCHFRQLLTLKSMRRQFRKFRKMSVKE MVRGFFSFFWMIITGLFHFVYSLIWGFFHILWTTMFGGGLVEGAKNMKVTDILGNMPDPT QFGIHGDVLETEKMEASEASALAEMGQMAQGEAAEADLMAELLNIQPKKEGKHGAEPGLG DVSEVVVGDAPSIASAVKQKKAQMAAKTRAVNGDYRSDTEKGDSEDGEKKDHDKTRDEAP PELSVEEKKAPKKRLGLKKEAPEAFMASFFAGLEVYQTKMLNYLARNFYNLRFLALFVAF AINFILLFYKVTGDYSDDEDPWNGRGRVGEEEDEGALEYFVLQESTGYMAPTLRCLAILH TIISFLCVVGYYYLKVPLVVFKREKEIARKLEFAGLYITEQPSDDDIKGQWDRLVINTPS FPNNYWDKFVKRKVIKKYGDLYGAERIAELLGLDKSALDFNPTEETVAKEASLVSWLSSI DTKYHVWKMGVVFTDNSFLYLVWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVT HNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGV RAGGGIGDEIEDPAGDPYELYRILFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVK EDMETKCFICGIGNDYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVW KMYQERCWDFFPAGDCFRKQYEDQLG NT seq 13221 nt NT seq  +upstreamnt  +downstreamnt atgctgactctggtgtccaactgtattgaccgactgaacgtctataacagcgccgcacat ttcggggagtgcgcgggctcggaggccggagtggcctggaaagacattctcaacctgctg tatgagctgctggctgcgttaatccgagggaaccgcaacaactgcacacagttctccaac aacttggactggctggtgagcaagctggagagactggagtcttcttcagggattctggaa gttctgcactgcattttaatcgagagccccgaggcgctcaatatcatccagaaaggacac attaaatccatcatatcgctgctgtacaagcatggacgcaaccacaagatactagatgtg ctctgttcactgtgtgtgtgtaacggcgtagctgtgcgaaccaatcagaacctcatctgc gatcacttgctgcccaagagagatctgctgttgcaaacccagctggtcaatgatgtccag agcatgagaccgaacatcttcctgggcgtgagtgaaggctcggctcagtacaagaagtgg tactatgaactcatgatcgaccaggtggaccactttgtgaccagcgagccctcccacctc agagtcggctgggcgaacacaaaaggctatgcaccctacccgggaggaggagagggctgg ggtggtaatggagttggtgatgatctctactcgtacggctttgatggactccacctctgg tcaggtcgtatcccgcgggcggttgcgtccatgaaccagcacattctgacctcagaggac gtggtgagctgctgcctggacctcggagcccccagcatatccttcaggatcaacggacag cccgtccagggcatgtttgaaaatttcaacacagacggactcttcttccctgtcgtcagt ttctccgcaggtgtcaaggttcgtttcctgttgggtggacggcacggtgactttaagttc ctgcctccatcaagctacgcaccgtgttatgaggctctgctgccaaaagagaagatgaag gtggagccggtgaaagagtataagagagatgtggacggagttcgagatctgctgggcacc acccagttcatgtcgcaggcctccttcatccccacacctgtggaaaccagccagattgtc atgccgcctcatttggagaaggttcgggacaagctggctgagaatatccatgagctctgg ggcatgaataagattgagcttggctggtcttatggcaagataagggatgataataagcgg cagcatccgtgcctggtggatttctccaagctgccggaaacggaaaaaaactacaatctg cagatgtcaacggagactctgaagaccctgctggcgttaggctgtcgtatagttcacatg aatccaaatgctgaggactctctcaaaaagataaaactccctaagaactacatgatgtcc aatggttataagccgtcccctctggacctgtccgatatcaaactgactccggggcaggag ctgctggtggacaaactggcagagaacgctcacaatgtgtgggccaaggaccggatcaaa cagggatggacatacgggattcagcaggatcttaaaagtaagcgtaaccctcgcctggtt ccttatgctctgctggatgaacgcaccaagaagtcaaacagggacagcttgcgggaagct atccgcactctgattggctacgggtacaacatcgagccctcggaccaggaaggcggacaa gtctcggagcgcctcagcattgataagatccgcttctttagggtagaaagaacgtacgca gtgaagactgggaagtggtacttcgaatttgaggcagttaccggtggagacatgagagtg ggctgggccagacctgggtgtaagccagatgtggagcttggcacagatgagcttgcgttt gtctttgatggatacaggggccactgcctgaacatgggcagccggctgtttgggcgctgt tggcatgctggggatgtggtgggctgcatgatcaacatggaggacaagtccatgatcttc acgctgaacggggagatcctgatcaccaccaagggctctgagctctgcttcacggacttt gaaactgaggatgggtttattccagtgtgtagcctcggtctgtcgcaggtgggtcgtatg aatctcgggaaggatgctagcacctttaagtactacaccatgtgcggcttgcaggaggga ttcgagccatttgccgtcaacatgaatcgagaggtcacgatgtggttcagcaagcgtctg cctacttttgtcaacgtgccgaaagaccacaaccacattgcggtaaccaggatcgacggc accatcgacagccctccttgtctcaaagtcacccacaagacatttgggacacagaacagt aacgccgacatggtgttttgtcgtctgagcatgcctgtggagttccactccttcttcaag atcagccctgtggtggacatgaacggtgttcatgaggaagaaacccttaaagttaaacac agatatccactgagatctgtgaggcacagcgatgaaagtagacgagtggactacagcagc atcactacgtactaccattcagtgagggtcttcgcaggtcaggaccctgcctgtgtgtgg gttggatgggttactcctgactaccattactatagcaacaacttcaacctcagcaagaat cgaacagtgactgtaaccctgggcgacgaacgtgggcgagtccacgagagcgtgaagagg agtaactgctacatggtgtggggtggtgatgtcaccagcacttcccacacctccggtcgc agcaatgtggatctggagatcggctgtctaatagatttggccactggcctgttgacattc accgtcaatggcaaagagatctctacctcctaccaggtggaaccaaacaccaagcttttc cctgctgtgtttgtgcgacccaccagccccagcctctttcagtttgaactgactaaaata aagaacgccatgcctctgtcatcagccatcttcaagagtgagcataagaacccggttcca cagtgtccgccccgactggatgtccagaccataaatgccgtgctgtggagccgcatgccc aacagtttcctcaaagtggaaacggccagggttaatgagaggcatggctgggtggttcag tgcgtggagcccctgcagatgttggcagtgcacatacctgaagagaacaggtgcattgac gtcatggagctctcggagcaggaggacatgaagaagttccactatcacaccttgaaactg tactgtgccctctgtgctctgggaaacactcgtgtggcccacgccctttgcagccacctg gaccaatcacagctcttatacacaatcgacaatcagtacctgtctggcatgttacgcgag ggcttctacaatgttctgattagcatccacctggagacagccaaagaggcgcgactcatg atgaaagatgagttcgtcattcctgtcacggccgagacacgctccattcgtctcttttct gatgcttctaaaaagcaccttccgcccggggtggggcttagcacctccctgaaacctcgc ctcaactttaccccaccgtgcttcatcagcaccaaacgggagcatctgtacagtccccaa atcccactggatgcactgaaggagaaagcgattttgatgttgacagaggctgttcaaagc ggagggcaccacatccgagatcctgtcggaggatgcgtggagcaccagtttgttccaatc ctaaagctcattagcaccttgctgacgatgggtgttttaggaagcgaggacgttcgtaag attttactgctcattgacccgaacgtcttcaaagaggcaagagaggagggagccacgggg gcaacagacaaagagggactaacaggggcagaggaaaaggcggtggaagctggagaagag gaggcaatcaaagaggctcaacagccaatggaaggactgctggagaagaggctgccagag ccggttaaacgacagatgtgcgagctgcttcactatttctgtgactgcgaactgaagcac cgtatcgaggccattgtgtccttttctgacagcttcgtgtccaagctgcagtacaaccag aagttccgctacaatgagctgatgctggccctcaatatgtctgctgctgttacagcaaag aagaccaaagagttcagatcaccgcctcaagaacagatcaacatgctgctgaacttcagt atgggagaggactgcccatgccctgcagacatccaggaggaactctatgattttcataat cagctgcagctccactgtgggatccctatggaggaagacgaagacgagcaggatacatcg attaaaggtcgcctccttatgctggtgaacaggatcaaaggccaggcgcacaaagcagag gagcccacgaagatggagcaagctgcaccctccaatctgaaagagcttatctctcagacc atggtcagctggtcccaggagtgtcacatccaggaccctgaacttgttcgcaaaatgttc agcctgctgaggaggcagtacgacagcgttggagagctcctccgggccatgaggaagacg tacaccatcagcgctgcctcggtccaggacaccatcaacctcttggcctccctgggtcag atcagatctctgctgtcagttcgaatgggaaaggaggaggaaaagctcatgattgatgga ctgggtgacattatgaacaacaaggtcttctaccagcacccgaacctcatgagaatactg ggcatgcatgagactgtcatggaggtcatggtcaatgtcctcggaggagacaagtcccag gaaattgcctttcccaagatggtggccagctgttgtcgcttcctgtgctacttctgccgg atcagccgtcagaatcagaaggccatgtttgaccacctcagttacctactggagaacagc agcgtgggcctagcttcgccagctatgaggggctccactcctctagatgtggctgcttcc tcagtgatggacaataacgggctggctctggcactggaagaacctgacctggacaaggtg gtcacctacttggctggctgtggtcttcagagttgtccaatgcttctggctaaaggttat ccagacatcggctggaaccccattgagggagagcgctatctgtccttcttgcggtttgct gtctttgtgaacggcgagagtgtggaggagaactcgagcgttgtggtgaagctgctgatc cgtcgtccggagtgtttcggacctgctctgagaggagagggagggaacggtctcctggct gccatgaaggaagctattaagatctctgagacgcccgctttggacctcccaggctccgtc cagggagttagctctgatgtgtctggtgatggtgacgatgaagaggaagtggtccacatg ggcaatgccatcatgtcgttctactctgctctcatcgacctgttaggacgttgtgcccct gagatgcatctcatcaacaaagggaaaggcgaagctctgcgcattcgtgctatcctgcgc tctctggtgcctaccgaggacctcgtgggaatcattagcataccgctcaaaatgcccatt accaacaaagatgggtcagtgacagagccggacatgtcggcgagcttctgtccggaccac aaggcccccatggtgctgtttttagacagagtgtatggtgtggaagaccagagctttcta cttcacctgcttgaagttggcttcctccctgacctgagggctgctacttctctggacacg gagggtctgtgtaccacggagacagccctggctatgaaccgctacatcggttcagccatg ctgcccctcctcacccgctgcgcccctctcttcgctggcaccgagcactacgccaccctc atagactccaccctgcacaccatctaccgcctatccaagggccgttcgctgaccaaggcg cagagagatgcgatagaggagtgcttgctgtctgtttgcaagcaccttcgtccctccatg ctgcagcagctcctgcgccgcctcgtctttgatgtgcccttgttgactgattactgcaag atgcctctaaggctgctaaccaaccactatgagcaaaactggaagtactactgcctccct tcaggctggggcagctttggaacagcctctgaagatgaactactgcttaccaagaagatc ttctggggagtgtttgactctttgtctcagaggaagtacgaccccgagctgttcaagatg gccatgccttgtctcagtgccatagctggagctttgccgccagactatgtggatgcctcc attagtaccactgtggaaaagcctgtttctgtggatgctcagggcaactttgaccccaaa ccaatcaatacggctaacatcgctcttccagagaaacttgagcattttgccaacaagtac gccgagcatacccatgagaaatggtctgcagagaaggtgctgctggggtggaaatatgga gactgtgttgatgagaaggcgaagactcatcctcagctgaggacctacaaaggcctgacg gagaaggagaaggatatttacagatggcctattagagagtccctgaagagtatgctggca atggggtggagtattgataggaccaaagatggagagagcatgtctcaacagagggagact gagaaaatgagaaagatatctcaggcctcacaggctaacggcttcaatccgagcccaata gacacaagcaacgtggttctatccagagagctgcaagggatggtggaggtggtggctgaa aattaccataacatctgggccaagaagaagaaaagtgaccttggaagtcgaggaggggga acacatcctctgttggtgccctacgacacgctgacggccaaggagaaggcccgcgatcga gagaaggctcaggacctttttcgcttcctgctaatcaatggatatagcatcacaagaggt ttgaaggacttggagcaggattcctcctccatggagaaaaggtttgcctacaaattcctc aagaagctgctgaaatgtgttgactcagcccaggaattcattacccacttagaagccatg gctgccagcggcaagacagacaggtcacctcatgagcaagaaatcaagttttttgccaaa gtgctcctcccactcattgaccagtactttaagaaccactctctctacttcctgtcctcc cctaataagaatctaagcagcagcggctatgcctccaacaaggagaaagaaatggtcacc agcctcttttgtaaactggcagctcttgtcagacataggatttcactttttgggagtgac tccaccaccatggtcagctgtctgcatatcctggcacacacactcgataccaggacagtg atgaagtcgggctctgagcaggtgagggtggggctgaggacgttcttcgagaacgccgca gaggatctggagaaaacgttcgagaacctgaagctggggaagttcacccactcccgctcg cagatgaaaggagtgtcacagaatatcaactacaccaccgcagctctgcttcccatccta actgctctgtttgaacacattactcaacaccactttggagtcgacctgctcctggatgac gtccaagtgtcctgctatcgaatcctgaccagcctctatgctctgggcactgggaaaaac atctatgtagaaagacagctgccagctctcggtcagtgtctggcaactctggccggcgcc ttgcccgttgccttcctagagccgcaactcaacccgtacaacccctgctcagtttttaat acgaagagcgccagagaacgagccaccctaggaatacaagactcagtggaggagatgtgt cctggcatgccacggctggaccgcctcatgaaggacatcaatgacatggcagagtctgga gcgcggtacacagagatgccccatgtgattgaggtggtgctgcccatgctgtgtaactat ctgtcctactggtgggaaaggggtcctgaaaaccaaccggccagcgggggaagcatctgc tgtaccacagtcacctcggagcacctcagtctgattctcggcaacatcctcaagatcctc aacaacaacctgggcatcgatgaggcttcgtggatgaagagaattgcagtgtacgtacag cccatcatcagcaaggcccgtgcagacctgctgaagagccacttcctgcccacgctggag aaactaaagaagaagacagtgaaagtggtggctgaggaagagctcctcaaggccgactgt aaaggagacactcaggaggccgagctgctcatcctggacgagtttgccgtactctgcagg gacctgtacgcgttttaccctatgctcattcgttatgtggacaacaacaggtcaaggtgg ctgaaagaaccagattcggactccaatgacctcttcaggatggtcgcagagatatttatc ctttggtgcaagtcacataatttcaaaagagaagaacaaaactttgtggtccagaatgaa atcaacaacctttcattcttgactggagataataaaacaaagatgtccaagtctggggga caagatcaggagaggaagcacaagaagaggcgaggtgagttctactccatccaaacctca ctgattgtagccgccctgaagaagatgctgcctatcggtcttaacatgtgcaccccggga gatcaggagctcatctctctggctaagacacgctacctcatgaaagatacagatgatgaa gttaaagaccacattcagcagaacctgcaccttcgcgaaaagtctgatgaccctgccgtg aggtggcagctcaacctgtacaaggacatagtgacgaggactgaggggctttcagacccc gagaaggtggtggatcgtatccagaggatctctgctgccgtctttaacttggagcaggtg gaacaaccactgagatccaaaaaatgtgtatggcagaagttgctgtccaagcagaggaag cgcgccgttgtcgcctgcttccgaatggctccgctttacaatctgccgaggcatcgctct attaacctcttcctcctggcctatcagagaatatggatagaaacagaagagtactctttt gaagagaaactagtgcaggaccttgcacctgactcatgtggctgtgtccagaaaatacag cctaaagtggaggaagaggaggaggaggaggtgagaaagcagccagaccctcttcaccag ctcattctgcatttcagccataacgctctgactgaatgcagttctctggaagaggatccc ttgtatattgcctatgcagatatgatggcaaagagttgtgctgaaggtgaagaagaggaa ggaaaagagaaaacatttgaggaaaaggaaatggagaagcaaaagatgctgtatcagcag gccagacttcatgaccgaggggctgcagagatggtgcttcaaatgatcagcgccagcaaa ggtcgactgggtgctacggtaactgtcacgctcaagctgggcatctccattctcaatgga gggaacatcctggttcaacagaaaatgctggattatctcaaggaaaaaagagatgttggc ttctttaaaagcttgtccgggctcatgatgtcatgcagcgttctggacttgaacgctttt gaaaggcaaaacaaagctgaaggtctgggtatggtaactgaagagggatcaatcaacgtg agtgagcggggttccaaggtactgcagaatgatgaattcactaaggatctttttaggttt ctgcagcttctctgcgagggacataacaatgattttcaaaacttcctaaggacgcagaca gggaacacaactacagtcaatataatcattagtactgtggactacctgctaagactgcag gaatccattagtgatttctactggtactactctggcaaggatgtcattgatgaggccggt cagaggaacttctccaaagcactagcagtggccaaacaggtgttcaactctttaacagag tatatacagggtccgtgtatagggaatcagcagagtctggctcacagcaggctgtgggat gcagtggtgggcttcttgcatgtttttgccaatatgcagatgaagttatctcaggactcc agtcagattgaattactaaaggagctgctggacctgcagaaggacatggtcgtcatgatg ctctcgctacttgaaggtaatgttgtgaatggaactatcggcaaacagatggtggacacc ttggtggaatcttccagtaacgtggagatgatcctgaaatttttcgacatgttcctcaag ttgaaggacttgaccacttcggacagcttcaaggagtacgaccccgagagcaaaggcgtc atctcaaagaaggatttccagaagtccatggagaaccagaagcagtattctcagtctgag attgagtttcttctctcctgcgctgaggctgacgagaacgacatgttcaactacgagcag tttgttgagaggtttcacgaaccggcaaaagacatcggctttaacgtcgccgtgttgcta accaatctttcagagcacatgcctcacgatgcccgcctctcaactttcctggacctggcc gaaagcgtcctcagctacttcgagccttacttgggtcgcattgagatcatgggcggagcc aagcgcatcgagagagtgtacttcgagatcagcgagtcgagtcgcacgcagtgggagaag cctcaggtgaaagagtcgaagcggcagttcatctttgacgtggtcaacgagggcggagag agcgagaagatggagctgtttgtaaatttctgcgaggacacgatcttcgagatgcagctg gcctctcagatttcagagccagaccccgttgagcgcccggaggaagaagaggatgacatc cagaccatgatggagaaccaggaacaggaagacgaggagagtgcaatgatggagtcttcc tcggcatttacaatcgcatgcatctccatgaggaagagcttgtgtcacttccgccagctg cttactcttaaaagcatgcggcggcaattcaggaaattcaggaagatgagcgtgaaggag atggtgcggggcttcttctccttcttctggatgatcatcacgggcctctttcactttgtt tacagcctaatttggggattcttccacatcttgtggacaactatgtttgggggtggcctc gttgaaggggctaagaacatgaaggttacagatattttgggaaacatgcctgaccccact cagttcgggatccacggagatgtgttagaaacggaaaagatggaggcaagcgaagcgtca gcgttggcggagatgggtcagatggctcaaggggaagcagcagaggcggatctgatggct gagctactcaacatacagccgaagaaggagggcaagcatggggccgagccaggtttgggg gatgtgtctgaggtggtggtgggagatgccccatcaatagccagtgcggtcaagcagaag aaggcacagatggctgcaaagacgagggctgtgaacggagactacagatctgatacagag aagggagattcagaagatggtgagaagaaggaccacgacaagactagagacgaagctcct ccagagttgtctgtggaggagaagaaagccccgaagaaaaggctcggcttgaagaaggag gcaccggaggctttcatggcgagcttcttcgctggcttggaagtctaccagactaagatg ctgaactacctggcaagaaatttctacaatctccgcttcttggcactttttgttgccttt gctatcaactttattcttctcttctacaaagtgacgggtgattactcggatgatgaagac ccctggaacggtcgaggcagagttggggaggaggaagacgagggagcgcttgagtatttc gtcttgcaggagagcacaggttacatggcaccaacacttcgctgtctggcaatactacac accatcatatctttcctgtgtgtagtgggatactactacctgaaggtgcctttggtagtg ttcaagcgggagaaggagatagcaaggaagttggagtttgcgggcctctacatcaccgag cagccgtctgatgacgacattaaaggacagtgggacagactggtcatcaacactccctcc tttcccaacaactactgggataaatttgtcaagcgcaaagtgataaaaaagtatggagac ctttacggagcagagaggatagcagagctgctggggttggacaagagtgccctggatttc aaccctacagaggaaactgttgccaaggaggcttcactggtgtcatggttgagctcaatc gatacgaagtaccacgtctggaaaatgggagttgtgtttacagataattcattcttgtat ctagtttggtacaccaccatgtccatcctgggtcactacaacaacttcttctttgccgcc catctgctggacatcgccatgggcttcaagaccctccgcaccatcctttcgtctgtcacg cacaacggcaaacagctggtgctgacagtgggcctgctagctgttgtggtctatctctac actgtggtggccttcaacttcttcaggaagttttacaacaagagtgaggatgaggatgag ccggacatgaagtgcgacgacatgatgacgtgctacctattccacatgtatgttggggta agagcaggaggcgggataggggatgagatcgaggacccagctggcgacccctatgagctc taccgcatcctgtttgacatcacgttcttcttctttgttattgtcatcctcttggccatc atccagggtttgatcattgatgcctttggagagttaagagaccaacaggagcaggtcaaa gaggacatggagaccaaatgtttcatctgtgggatcgggaacgattacttcgacacaacc ccccacggctttgagacccacaccttacaagagcacaatttggccaactatctgtttttc ctgatgtacctcatcaacaaggatgagacagagcacactggacaggagtcctacgtgtgg aagatgtatcaggagcgctgctgggactttttcccagctggagattgcttccgcaaacag tacgaagatcagcttggatag

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