KEGG   PATHWAY: ocu04061
Entry
ocu04061                    Pathway                                
Name
Viral protein interaction with cytokine and cytokine receptor - Oryctolagus cuniculus (rabbit)
Description
Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ocu04061  Viral protein interaction with cytokine and cytokine receptor
ocu04061

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100348266  CCL5; C-C motif chemokine ligand 5 [KO:K12499]
100348776  CCL3; C-C motif chemokine 3-like 1 [KO:K05408]
100348517  CCL14; C-C motif chemokine ligand 14 [KO:K21092]
103351619  CCL16; C-C motif chemokine 16 [KO:K21093]
103351523  C-C motif chemokine 15 [KO:K05511]
103351522  C-C motif chemokine 23 [KO:K05511]
100343840  CCL7; chemokine (C-C motif) ligand 7 [KO:K05509]
100009130  CCL2; chemokine (C-C motif) ligand 2 [KO:K14624]
100348869  CCL27; C-C motif chemokine ligand 27 [KO:K16598]
108176349  uncharacterized LOC108176349 [KO:K16598]
107546750  CCL11; chemokine (C-C motif) ligand 11 [KO:K16597]
100354652  C-C motif chemokine 24 [KO:K21097]
100355784  CCL24; C-C motif chemokine ligand 24 [KO:K21097]
103349663  CCL28; C-C motif chemokine ligand 28 [KO:K05513]
100303767  C-C motif chemokine 28 [KO:K05513]
103348470  CCL17; C-C motif chemokine ligand 17 [KO:K21083]
103348469  CCL22; C-C motif chemokine ligand 22 [KO:K21095]
100008984  CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
103348897  CCL20; C-C motif chemokine ligand 20 [KO:K14625]
103351518  CCL1; C-C motif chemokine ligand 1 [KO:K05514]
100337936  CCL25; C-C motif chemokine ligand 25 [KO:K13072]
100348362  CCL19; C-C motif chemokine ligand 19 [KO:K05512]
100144337  CCL21; C-C motif chemokine ligand 21 [KO:K16062]
100009192  GRO-G; GRO gamma protein [KO:K05505]
100328583  GRO-B; GRO beta protein [KO:K05505]
100009245  GRO-A; GRO [KO:K05505]
100008716  ENA-78; alveolar macrophage chemotactic factor-like [KO:K05506]
100009129  CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030]
103350825  PPBP; pro-platelet basic protein [KO:K10029]
100008921  platelet microbicidal protein 1 [KO:K05407]
103350772  CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416]
100353112  CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671]
100340593  CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672]
100144333  CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032]
103345545  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
100349255  lymphotactin [KO:K05507]
100346186  CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508]
100008701  IL10; interleukin 10 [KO:K05443]
100008733  IL6; interleukin 6 [KO:K05405]
100302458  IL2; interleukin 2 [KO:K05429]
100144338  IL18; interleukin 18 [KO:K05482]
103347619  IL37; interleukin 37 [KO:K05485]
100353950  IL19; interleukin 19 [KO:K05444]
100353705  IL20; interleukin 20 [KO:K22667]
100009088  TNF; tumor necrosis factor [KO:K03156]
100328931  LTA; lymphotoxin alpha [KO:K05468]
100347876  TNFSF14; tumor necrosis factor superfamily member 14 [KO:K05477]
100355808  TNFSF10; tumor necrosis factor superfamily member 10 [KO:K04721]
100347811  IL34; interleukin 34 [KO:K22633]
100338577  CSF1; colony stimulating factor 1 [KO:K05453]
100328940  CCR1; chemokine (C-C motif) receptor 1 [KO:K04176]
100358097  CCR2; C-C motif chemokine receptor 2 [KO:K04177]
100189557  CCR3; C-C motif chemokine receptor 3 [KO:K04178]
100347328  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
100101579  CCR5; C-C motif chemokine receptor 5 [KO:K04180]
100339537  CCR6; C-C motif chemokine receptor 6 [KO:K04181]
100345500  CCR8; C-C motif chemokine receptor 8 [KO:K04183]
100144329  CCR9; C-C motif chemokine receptor 9 [KO:K04184]
100352521  ACKR4; atypical chemokine receptor 4 [KO:K04186]
100144330  CCR10; C-C motif chemokine receptor 10 [KO:K04185]
100338432  CCR7; C-C motif chemokine receptor 7 [KO:K04182]
100328622  CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175]
100328627  CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050]
100349863  CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188]
100144335  CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190]
100346189  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
100354655  ACKR3; atypical chemokine receptor 3 [KO:K04304]
100352332  XCR1; X-C motif chemokine receptor 1 [KO:K04193]
100008874  CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192]
100354902  IL10RA; interleukin 10 receptor subunit alpha [KO:K05134]
100338351  IL10RB; interleukin 10 receptor subunit beta [KO:K05135]
100347752  IL6R; interleukin 6 receptor [KO:K05055]
100349330  IL6ST; interleukin 6 signal transducer [KO:K05060]
100358489  interleukin-2 receptor subunit alpha [KO:K05068]
100338113  interleukin-2 receptor subunit alpha [KO:K05068]
103351862  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
100303768  IL18R1; interleukin 18 receptor 1 [KO:K05173]
100343288  IL18RAP; interleukin 18 receptor accessory protein [KO:K05174]
100341271  IL20RA; interleukin 20 receptor subunit alpha [KO:K05136]
100349338  IL20RB; interleukin 20 receptor subunit beta [KO:K05137]
100344077  IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138]
100346106  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
100349872  TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141]
100346624  LTBR; lymphotoxin beta receptor [KO:K03159]
108176138  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
100340992  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
Reference
  Authors
Alcami A
  Title
Viral mimicry of cytokines, chemokines and their receptors.
  Journal
Nat Rev Immunol 3:36-50 (2003)
DOI:10.1038/nri980
Reference
  Authors
Pontejo SM, Murphy PM
  Title
Chemokines encoded by herpesviruses.
  Journal
J Leukoc Biol 102:1199-1217 (2017)
DOI:10.1189/jlb.4RU0417-145RR
Reference
  Authors
de Munnik SM, Smit MJ, Leurs R, Vischer HF
  Title
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
  Journal
Front Pharmacol 6:40 (2015)
DOI:10.3389/fphar.2015.00040
Reference
  Authors
Vischer HF, Siderius M, Leurs R, Smit MJ
  Title
Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
  Journal
Nat Rev Drug Discov 13:123-39 (2014)
DOI:10.1038/nrd4189
Reference
PMID:9325239
  Authors
Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
  Title
Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
  Journal
Virology 236:316-27 (1997)
DOI:10.1006/viro.1997.8730
Reference
PMID:9621074
  Authors
Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
  Title
Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
  Journal
J Virol 72:6104-12 (1998)
DOI:10.1128/JVI.72.7.6104-6112.1998
Reference
PMID:9600978
  Authors
Damon I, Murphy PM, Moss B
  Title
Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
  Journal
Proc Natl Acad Sci U S A 95:6403-7 (1998)
DOI:10.1073/pnas.95.11.6403
Reference
  Authors
Dewin DR, Catusse J, Gompels UA
  Title
Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
  Journal
J Immunol 176:544-56 (2006)
DOI:10.4049/jimmunol.176.1.544
Reference
  Authors
Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
  Title
Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
  Journal
Mol Pharmacol 69:888-98 (2006)
DOI:10.1124/mol.105.015222
Reference
  Authors
Wang D, Bresnahan W, Shenk T
  Title
Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
  Journal
Proc Natl Acad Sci U S A 101:16642-7 (2004)
DOI:10.1073/pnas.0407233101
Reference
  Authors
Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
  Title
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
  Journal
PLoS Pathog 8:e1002497 (2012)
DOI:10.1371/journal.ppat.1002497
Reference
  Authors
Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
  Title
A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
  Journal
Proc Natl Acad Sci U S A 103:5995-6000 (2006)
DOI:10.1073/pnas.0510462103
Reference
  Authors
Tadagaki K, Nakano K, Yamanishi K
  Title
Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
  Journal
J Virol 79:7068-76 (2005)
DOI:10.1128/JVI.79.11.7068-7076.2005
Reference
  Authors
Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
  Title
Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
  Journal
J Leukoc Biol 74:676-82 (2003)
DOI:10.1189/jlb.0503206
Reference
  Authors
Najarro P, Lee HJ, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
  Journal
J Gen Virol 84:3325-36 (2003)
DOI:10.1099/vir.0.19591-0
Reference
  Authors
Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
  Title
Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
  Journal
J Gen Virol 87:809-16 (2006)
DOI:10.1099/vir.0.81427-0
Reference
  Authors
Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
  Title
Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
  Journal
Eur J Immunol 38:763-77 (2008)
DOI:10.1002/eji.200737618
Reference
PMID:8992974
  Authors
Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
  Title
The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
  Journal
J Immunol 158:604-13 (1997)
Reference
  Authors
Yoon SI, Jones BC, Logsdon NJ, Walter MR
  Title
Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
  Journal
Structure 13:551-64 (2005)
DOI:10.1016/j.str.2005.01.016
Reference
  Authors
Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
  Title
Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
  Journal
Proc Natl Acad Sci U S A 97:1695-700 (2000)
DOI:10.1073/pnas.97.4.1695
Reference
  Authors
Chang WL, Baumgarth N, Yu D, Barry PA
  Title
Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
  Journal
J Virol 78:8720-31 (2004)
DOI:10.1128/JVI.78.16.8720-8731.2004
Reference
  Authors
Li H, Wang H, Nicholas J
  Title
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
  Journal
J Virol 75:3325-34 (2001)
DOI:10.1128/JVI.75.7.3325-3334.2001
Reference
  Authors
Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
  Title
HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
  Journal
Blood 98:823-9 (2001)
DOI:10.1182/blood.v98.3.823
Reference
  Authors
Xiang Y, Moss B
  Title
IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
  Journal
Proc Natl Acad Sci U S A 96:11537-42 (1999)
DOI:10.1073/pnas.96.20.11537
Reference
  Authors
Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
  Title
A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
  Journal
J Gen Virol 85:1401-12 (2004)
DOI:10.1099/vir.0.79980-0
Reference
PMID:9557689
  Authors
Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
  Title
The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
  Journal
J Virol 72:4015-21 (1998)
DOI:10.1128/JVI.72.5.4015-4021.1998
Reference
  Authors
Snow AL, Martinez OM
  Title
Epstein-Barr virus: evasive maneuvers in the development of PTLD.
  Journal
Am J Transplant 7:271-7 (2007)
DOI:10.1111/j.1600-6143.2006.01650.x
Reference
  Authors
Shim AH, Chang RA, Chen X, Longnecker R, He X
  Title
Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
  Journal
Proc Natl Acad Sci U S A 109:12962-7 (2012)
DOI:10.1073/pnas.1205309109
Reference
  Authors
Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
  Title
The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
  Journal
J Biol Chem 277:21730-9 (2002)
DOI:10.1074/jbc.M200113200
Reference
  Authors
Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
  Title
A secreted high-affinity inhibitor of human TNF from Tanapox virus.
  Journal
Proc Natl Acad Sci U S A 100:4831-6 (2003)
DOI:10.1073/pnas.0737244100
Reference
  Authors
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
  Title
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
  Journal
Biochem Pharmacol 76:1522-32 (2008)
DOI:10.1016/j.bcp.2008.07.030
Reference
  Authors
Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
  Title
Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
  Journal
Cell Host Microbe 13:324-35 (2013)
DOI:10.1016/j.chom.2013.02.003
KO pathway
ko04061   
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