KEGG   PATHWAY: ocu04612
Entry
ocu04612                    Pathway                                
Name
Antigen processing and presentation - Oryctolagus cuniculus (rabbit)
Class
Organismal Systems; Immune system
Pathway map
ocu04612  Antigen processing and presentation
ocu04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008602  IFNG; interferon gamma precursor [KO:K04687]
100009088  TNF; tumor necrosis factor precursor [KO:K03156]
100343673  proteasome activator complex subunit 1 [KO:K06696]
100344177  proteasome activator complex subunit 2 [KO:K06697]
100352610  proteasome activator complex subunit 3 isoform X2 [KO:K06698]
127493554  proteasome activator complex subunit 3-like [KO:K06698]
100338160  LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
100348873  heat shock cognate 71 kDa protein [KO:K03283]
100353534  heat shock 70 kDa protein 1-like [KO:K03283]
100354037  heat shock 70 kDa protein 1B [KO:K03283]
100354435  heat shock 70 kDa protein 1B [KO:K03283]
100356572  heat shock cognate 71 kDa protein [KO:K03283]
127488889  heat shock 70 kDa protein 1B [KO:K03283]
127488890  heat shock 70 kDa protein 1B-like [KO:K03283]
127493068  heat shock 70 kDa protein 1B-like [KO:K03283]
100352959  heat shock-related 70 kDa protein 2 [KO:K26598]
100338049  heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
100338694  heat shock protein HSP 90-alpha [KO:K04079]
100358690  heat shock protein HSP 90-beta [KO:K04079]
100328967  RLA class I histocompatibility antigen, alpha chain 19-1 precursor [KO:K06751]
100338822  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100339821  LOW QUALITY PROTEIN: RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100348995  RLA class I histocompatibility antigen, alpha chain 11/11 isoform X16 [KO:K06751]
100349085  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100349247  HLA class I histocompatibility antigen, B alpha chain isoform X2 [KO:K06751]
100349757  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100354611  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X4 [KO:K06751]
100355380  patr class I histocompatibility antigen, A-2 alpha chain isoform X2 [KO:K06751]
100356371  RLA-A3; MHC class I antigen-like precursor [KO:K06751]
100008764  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
100341645  calnexin [KO:K08054]
100350679  beta-2-microglobulin [KO:K08055]
100328685  PDIA3; protein disulfide-isomerase A3 precursor [KO:K08056] [EC:5.3.4.1]
100009050  CALR; calreticulin precursor [KO:K08057]
100350417  calreticulin [KO:K08057]
100354694  tapasin isoform X2 [KO:K08058]
100349155  antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
100351666  antigen peptide transporter 2 isoform X1 [KO:K05654] [EC:7.4.2.14]
100356269  T-cell surface glycoprotein CD8 alpha chain [KO:K06458]
100355767  T-cell surface glycoprotein CD8 beta chain [KO:K06459]
108178285  uncharacterized protein LOC108178285 [KO:K10784]
100337728  NKG2-A/NKG2-B type II integral membrane protein isoform X1 [KO:K06541]
103348990  natural killer cells antigen CD94 [KO:K06516]
100346565  legumain [KO:K01369] [EC:3.4.22.34]
100101593  cathepsin B [KO:K01363] [EC:3.4.22.1]
100328929  RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha precursor [KO:K06752]
100341358  RLA class II histocompatibility antigen, DP beta chain isoform X1 [KO:K06752]
100343144  HLA class II histocompatibility antigen, DQ alpha 1 chain [KO:K06752]
100349408  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
100349667  HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100350168  HLA class II histocompatibility antigen, DRB1 beta chain isoform X1 [KO:K06752]
100350656  RLA-DRB1; HLA class II histocompatibility antigen, DRB1 beta chain [KO:K06752]
100351163  HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752]
100351416  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
100352415  RLA-DMA; histocompatibility antigen DM heterodimer heavy chain-like precursor [KO:K06752]
100352672  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
100352927  RLA class II histocompatibility antigen, DP alpha-1 chain isoform X2 [KO:K06752]
100355948  RLA-DMB; histocompatibility antigen DM heterodimer light chain-like precursor [KO:K06752]
127482571  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
100342022  HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
100008830  cathepsin L2 isoform X1 [KO:K01365] [EC:3.4.22.15]
100344030  procathepsin L isoform X1 [KO:K01365] [EC:3.4.22.15]
100347623  procathepsin L [KO:K01365] [EC:3.4.22.15]
100356256  procathepsin L [KO:K01365] [EC:3.4.22.15]
100101598  cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
100009152  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
100338894  MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
100328902  RFX5; DNA-binding protein RFX5 [KO:K08061]
103346995  DNA-binding protein RFXANK isoform X1 [KO:K08062]
100338019  regulatory factor X-associated protein [KO:K08063]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100348746  nuclear transcription factor Y subunit alpha isoform X9 [KO:K08064]
100343385  nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
100338067  nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
ocu03050  Proteasome
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
KO pathway
ko04612   
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