KEGG   PATHWAY: ocu04914
Entry
ocu04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Oryctolagus cuniculus (rabbit)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
ocu04914  Progesterone-mediated oocyte maturation
ocu04914

Other DBs
GO: 0001556
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008668  IGF1; insulin-like growth factor I precursor [KO:K05459]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100009094  PGR; progesterone receptor [KO:K08556]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100144342  insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100337999  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100338014  ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
100338391  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100338694  heat shock protein HSP 90-alpha [KO:K04079]
100338921  anaphase-promoting complex subunit 15-like [KO:K25228]
100338989  G2/mitotic-specific cyclin-B1 [KO:K05868]
100339066  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100340312  anaphase-promoting complex subunit 15-like [KO:K25228]
100340437  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100341373  cytoplasmic polyadenylation element-binding protein 3 isoform X3 [KO:K02602]
100341695  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
100341883  LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100341906  membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2 [KO:K06633] [EC:2.7.11.1]
100342147  anaphase-promoting complex subunit 16 isoform X1 [KO:K25229]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100342311  anaphase-promoting complex subunit 10 [KO:K03357]
100342664  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
100342681  anaphase-promoting complex subunit 15 isoform X3 [KO:K25228]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100343198  cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
100343351  anaphase-promoting complex subunit 11 [KO:K03358]
100343361  speedy protein E4 [KO:K08694]
100343637  M-phase inducer phosphatase 3 isoform X1 [KO:K05867] [EC:3.1.3.48]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100344161  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100344451  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100345196  cell division cycle protein 27 homolog isoform X2 [KO:K03350]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100345632  aurora kinase A [KO:K11481] [EC:2.7.11.1]
100345665  cell division cycle protein 23 homolog [KO:K03355]
100346436  speedy protein A isoform X1 [KO:K08694]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100346929  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100347487  GTPase KRas isoform X1 [KO:K07827]
100348299  anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100348625  mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100349186  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
100350229  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
100350286  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
100350614  mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
100351062  cytoplasmic polyadenylation element-binding protein 2 isoform X1 [KO:K02602]
100351136  mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
100351964  serine/threonine-protein kinase B-raf isoform X6 [KO:K04365] [EC:2.7.11.1]
100352234  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
100352519  anaphase-promoting complex subunit 13 [KO:K12456]
100352785  cyclin-A2-like [KO:K06627]
100352820  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
100352863  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100354280  M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
100354882  mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100356287  serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
100356406  LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B3 [KO:K21771]
100356433  proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100357094  anaphase-promoting complex subunit 11 [KO:K03358]
100357348  anaphase-promoting complex subunit 7 isoform X1 [KO:K03354]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100357416  G2/mitotic-specific cyclin-B2 [KO:K21770]
100357455  speedy protein C [KO:K08694]
100357502  LOW QUALITY PROTEIN: fizzy-related protein homolog [KO:K03364]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100358334  serine/threonine-protein kinase 10 isoform X1 [KO:K08837] [EC:2.7.11.1]
100358389  cyclin-A1 isoform X1 [KO:K06627]
100358690  heat shock protein HSP 90-beta [KO:K04079]
100358702  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
100358835  anaphase-promoting complex subunit CDC26 [KO:K03359]
100358916  cytoplasmic polyadenylation element-binding protein 1 isoform X9 [KO:K02602]
100359101  cell division cycle protein 16 homolog isoform X1 [KO:K03353]
100359147  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
103346035  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103347105  uncharacterized protein LOC103347105
103347509  putative speedy protein E7 [KO:K08694]
103348219  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
127483727  anaphase-promoting complex subunit 15-like [KO:K25228]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486895  LOW QUALITY PROTEIN: anaphase-promoting complex subunit 2-like [KO:K03349]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
127488420  anaphase-promoting complex subunit 5 isoform X1 [KO:K03352]
127488989  kinesin-like protein KIF22 [KO:K10403]
127489236  GTPase KRas-like [KO:K07827]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
127491459  LOW QUALITY PROTEIN: kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
ocu04010  MAPK signaling pathway
ocu04110  Cell cycle
KO pathway
ko04914   
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