KEGG   PATHWAY: ocu05203
Entry
ocu05203                    Pathway                                
Name
Viral carcinogenesis - Oryctolagus cuniculus (rabbit)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
ocu05203  Viral carcinogenesis
ocu05203

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100341599  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
127486605  GTPase HRas isoform X1 [KO:K02833]
100347487  GTPase KRas isoform X1 [KO:K07827]
127489236  GTPase KRas-like [KO:K07827]
100344241  GTPase NRas [KO:K07828]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100339383  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100357489  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127493063  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
100354475  DNA damage-binding protein 1 [KO:K10610]
100008930  YWHAQ; 14-3-3 protein theta [KO:K16197]
100342694  14-3-3 protein zeta/delta [KO:K16197]
100358299  14-3-3 protein beta/alpha [KO:K16197]
100358813  14-3-3 protein epsilon isoform X4 [KO:K06630]
100328734  YWHAH; 14-3-3 protein eta [KO:K16198]
100354276  14-3-3 protein gamma [KO:K16198]
127488492  14-3-3 protein gamma [KO:K16198]
100352594  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
100348778  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100348518  signal transducer and activator of transcription 5A [KO:K11223]
100348267  signal transducer and activator of transcription 5B [KO:K11224]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100345382  serine protease hepsin [KO:K08665] [EC:3.4.21.106]
100337822  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100345181  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100348663  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100345250  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100357841  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
127485184  transcription factor p65 isoform X1 [KO:K04735]
100355271  proto-oncogene c-Rel [KO:K09254]
100339928  nuclear factor NF-kappa-B p100 subunit [KO:K04469]
100349426  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100134864  G1/S-specific cyclin-E1 [KO:K06626]
100134867  G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
100351345  E3 SUMO-protein ligase EGR2 isoform X2 [KO:K12496]
100355500  early growth response protein 3 isoform X1 [KO:K12497]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100346624  LTBR; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159]
103348899  nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
100008849  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
100344653  heterogeneous nuclear ribonucleoprotein K-like isoform X1 [KO:K12886]
100348489  cyclin-dependent kinase inhibitor 1 [KO:K06625]
100348597  ATP-dependent RNA helicase DDX3X isoform X2 [KO:K11594] [EC:5.6.2.7]
100009013  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
100008815  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100342212  cAMP-dependent protein kinase catalytic subunit beta isoform X3 [KO:K04345] [EC:2.7.11.11]
100342379  histone H2B type 1-C/E/F/G/I [KO:K11252]
100342662  histone H2B subacrosomal variant [KO:K11252]
100343141  histone H2B type 1-C/E/F/G/I [KO:K11252]
100343938  histone H2B type 1-H [KO:K11252]
100344442  histone H2B type 1-H [KO:K11252]
100344914  histone H2B type 1-C/E/F/G/I [KO:K11252]
100344952  histone H2B type 1-C/E/F/G/I [KO:K11252]
100346201  histone H2B type 1-C/E/F/G/I [KO:K11252]
100346241  histone H2B type 1-C/E/F/G/I [KO:K11252]
100346716  histone H2B type 1-H [KO:K11252]
100347239  histone H2B type 1-C/E/F/G/I [KO:K11252]
100347785  histone H2B type 1-C/E/F/G/I [KO:K11252]
100348578  histone H2B type 1-C/E/F/G/I [KO:K11252]
100350750  histone H2B type 1-A [KO:K11252]
100351672  histone H2B type 2-E [KO:K11252]
100352266  histone H2B type 2-K1 [KO:K11252]
100352707  late histone H2B.L4 [KO:K11252]
100353468  late histone H2B.L4 [KO:K11252]
100355462  histone H2B type 2-F [KO:K11252]
103349694  histone H2B type 1-B [KO:K11252]
103351930  histone H2B type F-M-like [KO:K11252]
108176081  H2B.U histone 2 [KO:K11252]
127490211  histone H2B type 3-B [KO:K11252]
100340305  histone H4 [KO:K11254]
100340438  histone H4-like [KO:K11254]
100343903  histone H4 [KO:K11254]
100344192  histone H4 [KO:K11254]
100345719  LOW QUALITY PROTEIN: histone H4 [KO:K11254]
100346459  histone H4 [KO:K11254]
100346758  histone H3.1 [KO:K11254]
100347744  histone H4 [KO:K11254]
100349756  histone H4 [KO:K11254]
100351746  LOW QUALITY PROTEIN: histone H4 [KO:K11254]
100352498  histone H4-like [KO:K11254]
100353786  histone H4-like [KO:K11254]
100354956  histone H4 [KO:K11254]
100355675  apoptosis regulator BAX isoform X2 [KO:K02159]
100342500  growth factor receptor-bound protein 2 [KO:K04364]
100337888  tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
100352863  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100343365  TATA-box-binding protein [KO:K03120]
100346981  TATA box-binding protein-like 1 isoform X2 [KO:K03120]
100349947  TATA box-binding protein-like 2 [KO:K03120]
100358775  ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [KO:K11838] [EC:3.4.19.12]
100346517  recombining binding protein suppressor of hairless isoform X4 [KO:K06053]
100352205  recombining binding protein suppressor of hairless-like protein [KO:K06053]
100354981  SNW domain-containing protein 1 [KO:K06063]
100342919  general transcription factor IIH subunit 1 isoform X1 [KO:K03141]
100338745  general transcription factor IIH subunit 2-like protein [KO:K03142]
100347110  general transcription factor IIH subunit 3 isoform X2 [KO:K03143]
127493056  general transcription factor IIH subunit 4 isoform X1 [KO:K03144]
100343990  general transcription factor IIE subunit 1 [KO:K03136]
100338045  transcription initiation factor IIE subunit beta [KO:K03137]
100340569  staphylococcal nuclease domain-containing protein 1 [KO:K15979]
100340619  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100354135  histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100359058  transcription initiation factor IIB [KO:K03124]
100009036  G1/S-specific cyclin-D2 [KO:K10151]
100009038  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100009040  cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100352785  cyclin-A2-like [KO:K06627]
100358389  cyclin-A1 isoform X1 [KO:K06627]
100338447  S-phase kinase-associated protein 2-like [KO:K03875]
100342452  S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
100350256  28S ribosomal protein S18b, mitochondrial [KO:K16174]
100357358  LOW QUALITY PROTEIN: 28S ribosomal protein S18b, mitochondrial-like [KO:K16174]
100338847  TNF receptor-associated factor 1 [KO:K03172]
100359083  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100340005  TNF receptor-associated factor 5 isoform X1 [KO:K09849]
127486194  tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100340056  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
100345556  tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
100350157  V-type proton ATPase subunit d 1 [KO:K02146]
100350237  V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
100342825  ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
100339253  disks large homolog 1 isoform X8 [KO:K12076]
100353305  paxillin isoform X5 [KO:K05760]
100342046  bcl-2 homologous antagonist/killer [KO:K14021]
103346571  interferon regulatory factor 3 isoform X1 [KO:K05411]
100350591  26S proteasome regulatory subunit 4 [KO:K03062]
100355680  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
100357431  retinoblastoma-associated protein isoform X1 [KO:K06618]
100342365  retinoblastoma-like protein 1 isoform X1 [KO:K04681]
100339977  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
100009037  cyclin-dependent kinase inhibitor 1B [KO:K06624]
100354124  E3 ubiquitin-protein ligase UBR4 isoform X6 [KO:K10691] [EC:2.3.2.27]
100008856  JUN; transcription factor Jun [KO:K04448]
100337729  chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
100355156  histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
127482567  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
100354595  histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
100338458  histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
100358981  histone deacetylase 5 isoform X2 [KO:K11406] [EC:3.5.1.98]
103347301  histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
100354982  histone deacetylase 6 isoform X2 [KO:K11407] [EC:3.5.1.98]
103345620  nucleolar complex protein 4 homolog isoform X1 [KO:K11407] [EC:3.5.1.98]
100355860  histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
100352038  histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
100345764  histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
100352120  polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
100352253  histone deacetylase 11 isoform X6 [KO:K11418] [EC:3.5.1.98]
100008676  PKM; pyruvate kinase PKM isoform 1 [KO:K00873] [EC:2.7.1.40]
100344432  interferon regulatory factor 9 isoform X2 [KO:K04693]
100338697  dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
100344662  dnaJ homolog subfamily A member 3, mitochondrial-like isoform X2 [KO:K09504]
100346295  histone acetyltransferase KAT2B isoform X1 [KO:K06062] [EC:2.3.1.48]
100347774  histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
100353065  LOW QUALITY PROTEIN: histone acetyltransferase KAT2B-like [KO:K06062] [EC:2.3.1.48]
100357517  transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
100534011  GTF2A1L; TFIIA-alpha and beta-like factor [KO:K03122]
100355396  transcription initiation factor IIA subunit 2 [KO:K03123]
100354695  serum response factor isoform X1 [KO:K04378]
100328905  IKBKG; NF-kappa-B essential modulator [KO:K07210]
100357341  NF-kappa-B inhibitor alpha [KO:K04734]
100357503  ras GTPase-activating protein 2 isoform X2 [KO:K08053]
100008965  cell division control protein 42 homolog isoform X1 [KO:K04393]
100344482  cell division control protein 42 homolog [KO:K04393]
100339873  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100340661  transforming protein RhoA [KO:K04513]
100343368  transforming protein RhoA-like [KO:K04513]
100343680  transforming protein RhoA-like [KO:K04513]
100346856  LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100356250  transforming protein RhoA [KO:K04513]
127489660  transforming protein RhoA-like [KO:K04513]
100337841  gelsolin isoform X1 [KO:K05768]
100355795  scinderin isoform X1 [KO:K05768]
100341378  alpha-actinin-1 isoform X1 [KO:K05699]
100351066  alpha-actinin-4 isoform X1 [KO:K05699]
100009039  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100340625  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100351874  cyclin-dependent kinase 4 inhibitor B [KO:K04685]
100345729  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100354874  cell division cycle protein 20 homolog [KO:K03363]
100348625  mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
100338733  protein VAC14 homolog isoform X1 [KO:K15305]
100353385  ran-specific GTPase-activating protein isoform X1 [KO:K15306]
100348691  DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
100349330  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100101579  CCR5; C-C chemokine receptor type 5 [KO:K04180]
100345500  C-C chemokine receptor type 8 [KO:K04183]
100189557  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100347328  C-C chemokine receptor type 4 [KO:K04179]
100009438  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100348477  caspase-8 [KO:K04398] [EC:3.4.22.61]
100358587  bcl2-associated agonist of cell death [KO:K02158]
103349392  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
100009121  C3; complement C3 alpha chain [KO:K03990]
100328967  RLA class I histocompatibility antigen, alpha chain 19-1 precursor [KO:K06751]
100338822  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100339821  LOW QUALITY PROTEIN: RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100348995  RLA class I histocompatibility antigen, alpha chain 11/11 isoform X16 [KO:K06751]
100349085  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100349247  HLA class I histocompatibility antigen, B alpha chain isoform X2 [KO:K06751]
100349757  RLA class I histocompatibility antigen, alpha chain 11/11 [KO:K06751]
100354611  H-2 class I histocompatibility antigen, Q10 alpha chain isoform X4 [KO:K06751]
100355380  patr class I histocompatibility antigen, A-2 alpha chain isoform X2 [KO:K06751]
100356371  RLA-A3; MHC class I antigen-like precursor [KO:K06751]
103347105  uncharacterized protein LOC103347105
Reference
PMID:18201576
  Authors
McLaughlin-Drubin ME, Munger K
  Title
Viruses associated with human cancer.
  Journal
Biochim Biophys Acta 1782:127-50 (2008)
DOI:10.1016/j.bbadis.2007.12.005
Reference
PMID:21102637
  Authors
Moore PS, Chang Y
  Title
Why do viruses cause cancer? Highlights of the first century of human tumour virology.
  Journal
Nat Rev Cancer 10:878-89 (2010)
DOI:10.1038/nrc2961
Reference
PMID:19400863
  Authors
Kalland KH, Ke XS, Oyan AM
  Title
Tumour virology--history, status and future challenges.
  Journal
APMIS 117:382-99 (2009)
DOI:10.1111/j.1600-0463.2009.02452.x
Reference
PMID:17979705
  Authors
Boccardo E, Villa LL
  Title
Viral origins of human cancer.
  Journal
Curr Med Chem 14:2526-39 (2007)
DOI:10.2174/092986707782023316
Reference
PMID:21084867
  Authors
Saha A, Kaul R, Murakami M, Robertson ES
  Title
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.
  Journal
Cancer Biol Ther 10:961-78 (2010)
DOI:10.4161/cbt.10.10.13923
Reference
PMID:21152115
  Authors
Zheng ZM
  Title
Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses.
  Journal
Int J Biol Sci 6:730-55 (2010)
DOI:10.7150/ijbs.6.730
Reference
PMID:19956178
  Authors
Martin D, Gutkind JS
  Title
Human tumor-associated viruses and new insights into the molecular mechanisms of cancer.
  Journal
Oncogene 27 Suppl 2:S31-42 (2008)
DOI:10.1038/onc.2009.351
Reference
PMID:16459163
  Authors
Zhang X, Zhang H, Ye L
  Title
Effects of hepatitis B virus X protein on the development of liver cancer.
  Journal
J Lab Clin Med 147:58-66 (2006)
DOI:10.1016/j.lab.2005.10.003
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:21647825
  Authors
Ng SA, Lee C
  Title
Hepatitis B virus X gene and hepatocarcinogenesis.
  Journal
J Gastroenterol 46:974-90 (2011)
DOI:10.1007/s00535-011-0415-9
Reference
PMID:21966251
  Authors
Nishida N, Goel A
  Title
Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
  Journal
Curr Genomics 12:130-7 (2011)
DOI:10.2174/138920211795564359
Reference
PMID:19854353
  Authors
Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
  Journal
Adv Cancer Res 103:75-109 (2009)
DOI:10.1016/S0065-230X(09)03004-8
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Reference
PMID:9343405
  Authors
Klein NP, Schneider RJ
  Title
Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
  Journal
Mol Cell Biol 17:6427-36 (1997)
DOI:10.1128/MCB.17.11.6427
Reference
PMID:16039586
  Authors
Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC
  Title
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
  Journal
Mol Cell 19:159-70 (2005)
DOI:10.1016/j.molcel.2005.06.009
Reference
PMID:21994562
  Authors
Benhenda S, Cougot D, Neuveut C, Buendia MA
  Title
Liver cell transformation in chronic HBV infection.
  Journal
Viruses 1:630-46 (2009)
DOI:10.3390/v1030630
Reference
PMID:11099494
  Authors
Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD
  Title
X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway.
  Journal
J Biol Chem 276:8328-40 (2001)
DOI:10.1074/jbc.M006026200
Reference
PMID:10824878
  Authors
Arbuthnot P, Capovilla A, Kew M
  Title
Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways.
  Journal
J Gastroenterol Hepatol 15:357-68 (2000)
DOI:10.1046/j.1440-1746.2000.02069.x
Reference
PMID:9837909
  Authors
Gottlob K, Fulco M, Levrero M, Graessmann A
  Title
The hepatitis B virus HBx protein inhibits caspase 3 activity.
  Journal
J Biol Chem 273:33347-53 (1998)
DOI:10.1074/jbc.273.50.33347
Reference
PMID:15614436
  Authors
Zhang JL, Zhao WG, Wu KL, Wang K, Zhang X, Gu CF, Li Y, Zhu Y, Wu JG
  Title
Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease Hepsin.
  Journal
Arch Virol 150:721-41 (2005)
DOI:10.1007/s00705-004-0446-0
Reference
PMID:15105524
  Authors
Cooray S
  Title
The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival.
  Journal
J Gen Virol 85:1065-76 (2004)
DOI:10.1099/vir.0.19771-0
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DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
ocu03022  Basal transcription factors
ocu03320  PPAR signaling pathway
ocu04010  MAPK signaling pathway
ocu04062  Chemokine signaling pathway
ocu04064  NF-kappa B signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04142  Lysosome
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04630  JAK-STAT signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04810  Regulation of actin cytoskeleton
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05165  Human papillomavirus infection
ocu05166  Human T-cell leukemia virus 1 infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05169  Epstein-Barr virus infection
KO pathway
ko05203   
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