Oryctolagus cuniculus (rabbit): 100009497 Help Entry 100009497         CDS       T03373                                  Symbol TLR4 Name (RefSeq) toll like receptor 4   KO K10160   toll-like receptor 4 Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04064   NF-kappa B signaling pathway ocu04066   HIF-1 signaling pathway ocu04145   Phagosome ocu04151   PI3K-Akt signaling pathway ocu04217   Necroptosis ocu04613   Neutrophil extracellular trap formation ocu04620   Toll-like receptor signaling pathway ocu04621   NOD-like receptor signaling pathway ocu04936   Alcoholic liver disease ocu05132   Salmonella infection ocu05133   Pertussis ocu05134   Legionellosis ocu05135   Yersinia infection ocu05140   Leishmaniasis ocu05142   Chagas disease ocu05144   Malaria ocu05145   Toxoplasmosis ocu05146   Amoebiasis ocu05152   Tuberculosis ocu05161   Hepatitis B ocu05162   Measles ocu05164   Influenza A ocu05170   Human immunodeficiency virus 1 infection ocu05171   Coronavirus disease - COVID-19 ocu05205   Proteoglycans in cancer ocu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ocu05321   Inflammatory bowel disease ocu05323   Rheumatoid arthritis ocu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04064 NF-kappa B signaling pathway     100009497 (TLR4)    04066 HIF-1 signaling pathway     100009497 (TLR4)    04151 PI3K-Akt signaling pathway     100009497 (TLR4)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     100009497 (TLR4)   09143 Cell growth and death    04217 Necroptosis     100009497 (TLR4)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     100009497 (TLR4)    04620 Toll-like receptor signaling pathway     100009497 (TLR4)    04621 NOD-like receptor signaling pathway     100009497 (TLR4)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100009497 (TLR4)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100009497 (TLR4)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     100009497 (TLR4)    05161 Hepatitis B     100009497 (TLR4)    05171 Coronavirus disease - COVID-19     100009497 (TLR4)    05164 Influenza A     100009497 (TLR4)    05162 Measles     100009497 (TLR4)   09171 Infectious disease: bacterial    05132 Salmonella infection     100009497 (TLR4)    05135 Yersinia infection     100009497 (TLR4)    05133 Pertussis     100009497 (TLR4)    05134 Legionellosis     100009497 (TLR4)    05152 Tuberculosis     100009497 (TLR4)   09174 Infectious disease: parasitic    05146 Amoebiasis     100009497 (TLR4)    05144 Malaria     100009497 (TLR4)    05145 Toxoplasmosis     100009497 (TLR4)    05140 Leishmaniasis     100009497 (TLR4)    05142 Chagas disease     100009497 (TLR4)   09163 Immune disease    05323 Rheumatoid arthritis     100009497 (TLR4)    05321 Inflammatory bowel disease     100009497 (TLR4)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     100009497 (TLR4)   09167 Endocrine and metabolic disease    04936 Alcoholic liver disease     100009497 (TLR4)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ocu04131]     100009497 (TLR4)   09183 Protein families: signaling and cellular processes    04054 Pattern recognition receptors [BR:ocu04054]     100009497 (TLR4)    04090 CD molecules [BR:ocu04090]     100009497 (TLR4)    00536 Glycosaminoglycan binding proteins [BR:ocu00536]     100009497 (TLR4) Membrane trafficking [BR:ocu04131]  Endocytosis   Phagocytosis    Toll-like receptors     100009497 (TLR4) Pattern recognition receptors [BR:ocu04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    100009497 (TLR4) CD molecules [BR:ocu04090]  Proteins   100009497 (TLR4) Glycosaminoglycan binding proteins [BR:ocu00536]  Hyaluronan   Cell surface receptors    100009497 (TLR4) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 TIR LRR_4 TIR_2 LRR_6 LRR_9 DUF1863 Curto_V2 Motif Other DBs NCBI-GeneID:  100009497 NCBI-ProteinID:  NP_001076201 Ensembl:  ENSOCUG00000002216 UniProt:  Q8MIQ2 LinkDB All DBs Position Un Genome browser AA seq 839 aa AA seqDB search MMPRLRLAGTLVPAMAFLSYLRPEIWEPCVEVVPNITYQCMEKNLYKIPDNIPFSTKNLD LSFNLLEHLGSHSFLHVSELHFLDLSRCKIHTIEDDAYQGLKNLSTLILTGNPIQSLSPQ AFSGLSNLQKLVAVETHLTSLGDFPIGHLKTLKELNVAHNLIHSFSIPDYFSNLSSLEHL DLSNNKIQSIYHKDLRVLHQMPLGTLSLDLALNPIDFIPPGAFEAIRLHELILKSNFKST NIMKICIQGLSGLEVHRLVLGEFKNERNMKNFDKSALEGLCNLAIEEFRLAYIDDLEGNI TDLFDCLENVSVMALVHMYIDNQEIFPKDFSWKSLEFINCEFSENIFFLKLSSLRRLIFT ANKGVRTFPELNTPSLEFLDISNNGLSLQSCCSVNSLRLTQLKHLNLSFNGVITMTSNFV GLEQLEHLYFQHSNLRNINEFSIFLSLNNLLYLDISYTHIRVAFRGIFDGLYSLRVLKMA GNAFQDNRLLNIFTEMTSLTTLDLSSCQLEQVYQGAFESLPRLESLNMSHNNLLVLDTLT YKCLYSLQVLDLSFNHIGNITEPGQQHFPSNLTLLHLTKNAFVCDCEHQIFMQWIKDQRR LLVEVEQMVCITPPNMPVLSFTNATCQISKTIISVSVFSVLVVSFAVVLVYKFYFPLMLL VGRRKYGRGESVYDAFVIYSSQDEDWVRNELVKNLEEGVPPFRLCLHYRDFIPGVAIAAN IIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSHAGIIFIVLQKVEKSLLRQ RVELYRLLSRNTYLEWEDTVLGRHIFWRRLRKALLDGKTLSPEGMARAENNQQEAMTLI NT seq 2520 nt NT seq  +upstreamnt  +downstreamnt atgatgcctcgcctgcgcctggctgggactctggtcccagccatggccttcctttcctac ttgagaccagaaatctgggagccctgtgtggaggtcgttcccaatattacttaccagtgc atggagaagaatctctacaaaatccctgacaacattcccttctcaaccaagaacctggat ctgagttttaacctcctggagcatttaggcagccatagcttcttgcatgtctcagaactg cactttctggatttatccaggtgtaaaattcatacaattgaagatgatgcataccaaggc ctaaagaatctctctaccttgatattgacaggaaaccctatccaaagcttatccccacaa gctttttctggactatcaaatttgcagaaactagtggctgtggagacacacctgacctct ctaggggacttccctattggacatctcaaaaccttgaaggagcttaatgtggcccataat cttatccattccttcagtattcctgactatttttctaacctgtctagccttgagcacctg gacctttcaaataacaagattcaaagtatttatcataaagacttgcgtgttctacatcaa atgcccctaggcacactctctttagacctggctttgaaccctatagattttatccccccc ggtgcctttgaagcaattagactccacgaactgattttgaaaagtaattttaaaagtaca aatataatgaagatctgtattcaagggctgagtggtttagaagttcaccggttggttttg ggagaatttaaaaatgaaagaaacatgaaaaattttgataaatctgccctggagggactt tgcaatttggctattgaagaattccgattagcatacatagatgacctcgaaggcaatatt actgacttatttgattgtttggaaaatgtttctgtaatggctctggtgcatatgtatata gacaaccaagaaatttttcctaaagatttcagctggaaatcattagaatttattaactgt gaatttagtgaaaatattttcttcttgaagctctcatctctcagaagacttattttcact gccaacaaaggtgtgaggacttttccagaacttaacacaccaagccttgagtttctagat atcagcaataatggtttgagtctccaaagctgctgttctgtgaatagtttgagactgacc caactcaagcatttaaatctgagcttcaatggtgttattaccatgacatcaaactttgtg ggcttagaacaactggaacatctgtatttccaacattccaatttgagaaacatcaatgaa ttttcaatattcttatcactcaacaacctcctttaccttgacatttcctatactcacatc cgagttgccttccgtggcatctttgatggtttatacagtctccgagtcttaaaaatggct ggaaatgctttccaggacaacaggcttctgaatatcttcacagagatgactagcttgacc accctggacctttcttcatgtcaactagaacaggtgtaccagggagcatttgagtcactc cccagactggagtcactaaatatgagtcacaacaacctgttggtattggatacactcact tataaatgtctctactccctccaggttctggatttaagtttcaatcacataggaaatatt acagagccagggcagcagcattttccaagtaatctaactttattacatcttactaagaat gcctttgtttgtgattgtgaacatcagattttcatgcagtggatcaaagaccagaggagg ctgttggtggaagttgaacaaatggtgtgcatcacacctccaaatatgcctgtgctgagt tttacaaatgccacctgtcagataagcaagaccatcattagcgtgtcagtattcagtgtg cttgtggtatcttttgctgtagttctggtttataagttctattttcctttgatgcttcta gttggccgaagaaagtatggtaggggtgaaagcgtctatgatgcctttgttatctactca agccaggatgaggactgggtgagaaatgagttagtaaagaacttagaagaaggagtgcct ccctttcggctctgccttcactatagagactttattcctggtgtggccatcgctgccaac atcatccaggaaggtttccacaagagccggaaggttattgttgtagtgtcccagcacttc atccagagccgctggtgtatctttgaatatgagattgctcagacctggcagtttttgagc agccatgcgggtatcattttcattgtcctgcaaaaggtggagaagtccctactccggcag cgggtggagctgtatcgccttctcagcaggaacacttacttggagtgggaagatactgtc ctggggcggcatatcttctggagacggctcagaaaagccctactggatggaaaaacactg agtccagagggaatggcaagggcagaaaacaaccaacaagaagcaatgactttgatctga

Oryctolagus cuniculus (rabbit): 100009578 Help Entry 100009578         CDS       T03373                                  Symbol TLR2 Name (RefSeq) toll like receptor 2   KO K10159   toll-like receptor 2 Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04145   Phagosome ocu04151   PI3K-Akt signaling pathway ocu04613   Neutrophil extracellular trap formation ocu04620   Toll-like receptor signaling pathway ocu05132   Salmonella infection ocu05134   Legionellosis ocu05140   Leishmaniasis ocu05142   Chagas disease ocu05144   Malaria ocu05145   Toxoplasmosis ocu05146   Amoebiasis ocu05152   Tuberculosis ocu05161   Hepatitis B ocu05162   Measles ocu05168   Herpes simplex virus 1 infection ocu05169   Epstein-Barr virus infection ocu05170   Human immunodeficiency virus 1 infection ocu05171   Coronavirus disease - COVID-19 ocu05205   Proteoglycans in cancer ocu05235   PD-L1 expression and PD-1 checkpoint pathway in cancer ocu05321   Inflammatory bowel disease ocu05323   Rheumatoid arthritis ocu05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04151 PI3K-Akt signaling pathway     100009578 (TLR2)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     100009578 (TLR2)  09150 Organismal Systems   09151 Immune system    04613 Neutrophil extracellular trap formation     100009578 (TLR2)    04620 Toll-like receptor signaling pathway     100009578 (TLR2)  09160 Human Diseases   09161 Cancer: overview    05205 Proteoglycans in cancer     100009578 (TLR2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100009578 (TLR2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     100009578 (TLR2)    05161 Hepatitis B     100009578 (TLR2)    05171 Coronavirus disease - COVID-19     100009578 (TLR2)    05162 Measles     100009578 (TLR2)    05168 Herpes simplex virus 1 infection     100009578 (TLR2)    05169 Epstein-Barr virus infection     100009578 (TLR2)   09171 Infectious disease: bacterial    05132 Salmonella infection     100009578 (TLR2)    05134 Legionellosis     100009578 (TLR2)    05152 Tuberculosis     100009578 (TLR2)   09174 Infectious disease: parasitic    05146 Amoebiasis     100009578 (TLR2)    05144 Malaria     100009578 (TLR2)    05145 Toxoplasmosis     100009578 (TLR2)    05140 Leishmaniasis     100009578 (TLR2)    05142 Chagas disease     100009578 (TLR2)   09163 Immune disease    05323 Rheumatoid arthritis     100009578 (TLR2)    05321 Inflammatory bowel disease     100009578 (TLR2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     100009578 (TLR2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:ocu04131]     100009578 (TLR2)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:ocu04147]     100009578 (TLR2)    04054 Pattern recognition receptors [BR:ocu04054]     100009578 (TLR2)    04090 CD molecules [BR:ocu04090]     100009578 (TLR2)    00536 Glycosaminoglycan binding proteins [BR:ocu00536]     100009578 (TLR2) Membrane trafficking [BR:ocu04131]  Endocytosis   Phagocytosis    Toll-like receptors     100009578 (TLR2) Exosome [BR:ocu04147]  Exosomal proteins   Exosomal proteins of breast milk    100009578 (TLR2) Pattern recognition receptors [BR:ocu04054]  Membrane-bound pattern recognition receptors   Toll-like receptors    100009578 (TLR2) CD molecules [BR:ocu04090]  Proteins   100009578 (TLR2) Glycosaminoglycan binding proteins [BR:ocu00536]  Hyaluronan   Cell surface receptors    100009578 (TLR2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  LRR_8 TIR LRR_4 TIR_2 LRR_9 LRR_5 LRR_1 LRRCT Motif Other DBs NCBI-GeneID:  100009578 NCBI-ProteinID:  NP_001076250 Ensembl:  ENSOCUG00000003367 UniProt:  Q8MIQ3 LinkDB All DBs Position 15:9907319..9921223 Genome browser AA seq 784 aa AA seqDB search MPPALWTVWALGAIVSLPTEGAPDLPSLSCDPAGICDGRSRSFQSIPSGLMATVKSLDLS NNEITYIRDSDLHRCVHLRALMLMSNGIDTIDEDSFSSLGSLEHLDLSNNHLSHLSAAWF RPLSSLKFLNLLENPYRTLGETSLFSHLPHLRILKVGSLYAFANIRRMDFAGVRSLEELE IDGSNLQSYEPRGLGSIPNVSRLVLHLRQPTLLLKLFPDLLSSVECLELRETDLEDFRFS GLSVTEPNPRITRFIFRSVKITDESCNEILKLLAYVPELLDLEFDDCTLNGVGDFEVPDR DLSQDLGKVETLTIRRLHIPKFYLFYDLSTIYSLSERVKRVTVENSKVFLVPCSFSQHLK SLEYLDLSENLMVEEYLKNSACEKAWPSLQTLILRQNHLTSLEKTGETLLTLKNLTDLDI SKNTFHAMPDTCQWPERLRRLNLSSTRIHSLTYCIPQTLEILDVSNNNLNVFSLTLPRLK ELYISRNMLKTLPGASLLPMLLVMKISRNSINTFSKEQLESFQKVTALEAGGNNFICSCD FLSLTQEQPALTRVLPDWPESYLCDSPSHVRGQQVQDARLSVSECHRAAVVSGVCCALLL LTLLAVVLCRHFHGLWYLKMTWAWLQAKRKPRKAACRDVCYDAFVSYSEHDSYWVENLLV QELENSDPPFRLCLHKRDFVPGKWIIDNIIDCIEKSRKTVFVLSQNFVKSEWCKYELDFS HFRLFDENNDAAILVLLEPIEKKAIPQRFCKLRKIMNTRTYLEWPTEEAEHAGFWGNLRA AIKS NT seq 2355 nt NT seq  +upstreamnt  +downstreamnt atgccacctgcgttgtggacggtgtgggccttgggggctatagtcagcctccccacggaa ggggctcctgacctgccctctctgtcttgtgaccctgccggcatctgcgatgggcgctcc agatccttccaatccatcccctcggggctcatggcaacggtgaaaagccttgacctgtcc aacaacgagatcacctatatcagagacagtgacttgcacaggtgtgtgcacctcagggct ctgatgctgatgtccaatggaatcgacacgatagatgaagattctttctcttccctgggc agcctcgagcacctggacttatccaataaccacctatctcatttatccgccgcctggttc aggcctctctcgtccctgaaattcttaaacttgctggaaaacccttacagaacccttggg gagacatctctgttttctcacctcccacatttgcgaatcctgaaagtaggaagcctttat gcctttgcgaatattcggaggatggattttgccggagtccgctctctcgaggaacttgag attgatgggtcaaacctgcagagctacgagccacggggcttgggatccatccccaacgtg agccgcctggttctccacctgaggcagcccaccttgctgctcaagctcttcccagacctt ttaagttctgtggagtgtctggagctgagagagactgatctggaagatttccgtttttcg gggctgtctgtcaccgaaccgaatccacggattaccagatttatctttagaagtgtgaaa atcaccgatgagagttgtaatgaaatactcaaacttctggcttatgtgcctgagttactg gacttagagtttgatgactgcacccttaatggagttggtgattttgaagtaccagaccga gacctaagtcaagatctgggtaaagtcgaaacgttaacaatacggaggttgcacatcccc aagttctacttattttacgatctgagtacaatctattcactctcagaaagggtgaagagg gtcacagtggaaaacagtaaggtttttttggttccttgttcattctcacaacatttaaaa tcattagaatacttagatctcagtgaaaatctgatggtggaagaatatttgaaaaattca gcctgcgagaaggcctggccctctctgcagacgttaattttaaggcaaaatcatttgaca tcattagaaaaaaccggagagaccctgctgacgctgaaaaacctgaccgaccttgacatc agtaagaatactttccacgccatgcctgacacgtgtcagtggccggaaaggttgagacgg ctgaacctgtccagcacacggatacacagtttgacgtactgcatcccacagaccctggaa atcctagacgttagcaataacaatctcaacgtgttttctttgactctgcccagactcaaa gaactttatatttccagaaatatgttaaagaccctcccaggtgcctccttgttacctatg ctactggtcatgaaaatcagcaggaattcgataaacactttttcgaaggagcagctcgaa tcctttcagaaggtgacggccttggaagccggagggaacaacttcatctgctcctgcgac ttcctgtctttgactcaggagcagcccgcgctgaccagggtcctgccggactggccagag agctacctgtgtgactccccatcccatgtgcgtggccagcaggtgcaggacgcgcgcctg tcggtgtccgagtgccacagggcagcggtggtgtctggcgtgtgctgtgccctcctcctg ctgacgctgctcgccgtggtcctgtgccgccatttccacgggctgtggtacctgaagatg acgtgggcctggctgcaggccaagaggaagccgaggaaagcggcctgcagggacgtgtgt tacgatgcgttcgtgtcctacagcgagcacgactcctactgggtggagaacctgctggtg caggagctggagaactccgaccccccgttcaggctgtgtctgcacaagcgggactttgtg cccggcaagtggatcattgacaacatcatcgactgcatcgagaagagccgcaagaccgtc ttcgtgctctcgcagaacttcgtcaagagcgagtggtgcaagtacgagctggacttctcc cacttccgcctctttgatgagaacaacgacgccgccattctggtgctcctggagcccatt gagaaaaaggccatcccccagcgcttctgcaagctgcgcaagatcatgaacaccaggacc tacctggagtggcccacggaggaggctgagcacgccgggttctgggggaacttgagggcc gccataaagtcctag

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