Oryctolagus cuniculus (rabbit): 100009545 Help Entry 100009545         CDS       T03373                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism ocu  Oryctolagus cuniculus (rabbit) Pathway ocu04020   Calcium signaling pathway ocu04371   Apelin signaling pathway ocu04713   Circadian entrainment ocu04921   Oxytocin signaling pathway ocu04970   Salivary secretion ocu05010   Alzheimer disease ocu05012   Parkinson disease ocu05020   Prion disease ocu05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:ocu00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100009545 (RYR3)    04020 Calcium signaling pathway     100009545 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     100009545 (RYR3)   09154 Digestive system    04970 Salivary secretion     100009545 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     100009545 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     100009545 (RYR3)    05012 Parkinson disease     100009545 (RYR3)    05020 Prion disease     100009545 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     100009545 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ocu04040]     100009545 (RYR3) Ion channels [BR:ocu04040]  Voltage-gated cation channels   Ryanodine receptor    100009545 (RYR3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR Ins145_P3_rec SPRY RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  100009545 NCBI-ProteinID:  NP_001076231 Ensembl:  ENSOCUG00000011459 UniProt:  Q9TS33 LinkDB All DBs Position 17:39452330..40047439 Genome browser AA seq 4872 aa AA seqDB search MAEGGEGGEDEIQFLRTEDEVVLQCIATVHKEQRKFCLAAEGLGNRLCFLEPTSEAKFIP PDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLLLQDRGKADTKSTAFSFRPSKETKEKLDSSHKRDIEGMGVPEIKYGDSVCFVQHIAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTAAPVTLPIEEVLQTLHDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEVLSLLYKLLAALIRGNRNTCAQFSN NLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSAQYKKW YFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVRDLLGT TQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKMRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKKVKLPKNYMMS NGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFRVERSY AVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGPMTKPLCLKAAGASVGTKVVGILGV PWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIGR MNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIEVVRID GTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQEI LSHTTTQCFYSIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVHE SVKRSNCYMVWGGDVVASSQRSSRSNVDLEIGCLVDLAMGMLSFSANGKELGTCYQVEPN TKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTIQPVLW SRMPNSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHYH TLRLYSAVCALGNSRVAYALCSHVDLSQLFHAIDNKYLPGLLRSGFYDLLISIHLANAKE RKLMMKNEYIIPITSTTRNIRLYPDESKKHGLPGVGPRTCLKPGFKFSTPCFVVTNEERQ KQSPEIPLEILKMKALSMLTEAVQCSGAHIRDPVGGSVEFQFVPVLKLVGTLLVMGVFCD DDVRQILLLIDPSVFGEHSADTEEGAEKEEVSQVEEKAVEAGEKTSKEARKEAPVRGLLQ TRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSA ALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLVHCGVPLEEEEE EEEDTSWTGKLRTLVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQDA ELVRMMFNLLRRQYDSIGELLQALRKTYTISHASVSDTINLLAALGQIRSLLSVRMGREE ELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRF LCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEE PDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASV VVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISESPALDLPSQGYKREVPEDGEEEEE IVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPL KLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASA SLDTVALSTTESALALNRYICSAVLPLLTRCAPLFAGTEHYTSLIDSTLQTIYRLSKGRS LTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNDYCKMPLKLLTNHFEQCWKY YCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMSLPCLSAIAGALPPDY LDTRITATLEKQVSVDADGNFDPKPINTINFSLPEKLEYIVTKYAEHSHDKWACEKSQSG WKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQ LRENEKLRSVSQTSQGNSYNPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELES KGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGVIVSRGMKDMELDAFSMEKRFA YKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLY FLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLD TRTVMKSGSELVKAGLRAFFESAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVAL LPILTSIFEHVAQHQFGVDLLLGDVQISCYRILCSLYSLGTGKNIYVERQRPALGECLAS LAAAIPVAFLEPTLNRYNALSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEINDL AESGARYTEMPHVIEVILPMLCNYLSYWWERGPENLSPSTGPCCSKVTSEHLSLILGNIL KIINNNLGIDEASWMKRIAVYAQPIISKARPDLLRSHFIPTLEKLKKKAVKTVQEEEQLK ADGKGDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSNWLKSPDGDSDQLFRMVAE VFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRG DLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHLQ EKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWHK LLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKSPK VEEEEEEEMEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEEE DKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNG GNAGVQQKMLDYLKVKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIV RERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNVIISTVDYLLRLQ ESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWD AVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDT LVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQSE IDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPA ESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGE QEKMELFVNFCEDTIFEMQLASQISESDSADRPEEEEGDEESSYVLEINGEEEEDKSFES ASAFAMACASLKRNITNLLRKATLKNLRKQYRNVKKMTAKELVKVFFSFFWMLFVGLFQL FFTIVGGIFQILWSTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMEAERAEVAEA GITTELVHFVKGERGDTELMSDLFGLHPKKEGGVKHGPEVGLGDLSEIIGKDEPPTLEST VRKKRKAQAAETKAEHEAEGKVESEKADLEDGEKEDKAKEEERAEYLWAEVTKKKKRRRG QKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPL EEETEDVANLWNSLNDEEEEEAMVFFVLQESTGYMAPTLRALAVVHTIISLVCVVGYYCL KVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPHNYWDKFVKRKV INKYGDLYGAERIAELLGLDKNALDFSPVEETTAEAASLVSWLSSIDMKYHIWKLGVVFT DNSFLYLAWYTTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLA VVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPA GDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGN DYFDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAG DCFRKQYEDQLG NT seq 14619 nt NT seq  +upstreamnt  +downstreamnt atggccgaaggcggagaaggaggcgaggacgaaatccagttcctgcggactgaagatgaa gtggtcctccagtgcatcgcaactgtccacaaggagcagaggaagttctgcctggcagcc gagggacttggcaatcgcctgtgcttcctggaacccacttcagaagccaagtttattcct ccagatctctgcgtctgcaatttcgtgttggaacagtccctctctgtccgagccctgcag gaaatgcttgccaacacaggtgaaaatggtggcgaaggggcagcacaaggagggggccac aggactctgctctatggccacgccattcttctgcgccactctttcagcggaatgtatctg acatgtttgactacatcaagatcccagacagataaacttgcctttgatgtgggtctgcgg gagcatgccacaggagaagcctgttggtggaccatacatcctgcttctaaacagagatct gagggagagaaagttcgaattggtgatgacctcatcctcgtcagtgtgtcctctgaaaga taccttcatctctcgatatcgaatggcaacatacaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacctgctcaggaagtagcatcgaagaaggatacctacttggt gggcacgtggtacgtcttttccatggccatgatgagtgtctgacaataccatcaacagac cagaatgattcccagcacaggaggatattctacgaagctgggggagctgggacccgagcc aggtctctatggagagtggaaccccttcggataagctggagtggcagtaacatcagatgg ggccaggccttccgactccggcatctcaccacaggccactatctagccttgacagaggac caaggcctcctgctgcaagaccggggaaaagcagacaccaagtccacagccttctctttc cggccatcaaaggaaaccaaggagaaattggattccagtcacaagcgagatatagaaggc atgggagttccagaaatcaaatatggggactctgtctgctttgttcagcacatagccagt ggtctatgggtaacctacaaagcacaagacgccaaaacatcccgcctgggacctctcaaa aggaaggtcatactccatcaggaaggtcacatggatgacggattaacactgcagagatgc cagcgtgaggagtcccaggctgctcgtatcatccggaacacgactgccttattcagccag tttgtcagtgggaacaatcgcacagctgcccctgtcaccctgcctatagaagaggtcctg cagaccctccacgacttgattgcgtacttccagcccccggaggaggagatgcagcatgaa gacaagcaaaacaagctccgctccctcaaaaacagacagaatcttttcaaggaagaggga atgttggccttggtgttgaattgcattgatcgcttaaatatctacaatagtgtggcacac ttcgcagggattgcaagggaagagagtggcatggcttggaaagaagtcctcagcctcctg tacaagctgctggctgctctcatccgtggaaacagaaacacctgtgctcaattctccaat aaccttgattggcttatcagtaaattggacagactagaatcttcctcaggtatcctggaa gttttgcactgcatcttgattgaaagcccagaagccttaaatctgatagcagagggccac atcaagtccatcatctccctgctggataagcatgggcggaatcacaaggttctggatgtc ctgtgctccctctgtctctgcaatggggtcgcagtgagagccaaccagaacctgatctgt gacaacttgctgccccggagaaacctgctcctgcagacgagactgattaatgatgtcacg agtatccggcctaacatcttcctgggagtcgctgagggctcagctcagtacaagaagtgg tacttcgagctcatcattgaccaggtggaccccttcctaacggcagagcccacacacctg cgggtgggctgggcctcctcctcaggctatgccccctacccaggaggtggagaaggatgg ggaggcaatggtgttggtgatgacctgtactcctatggttttgatggacttcacctgtgg tcaggccggatacccagagccgtggcctccatcaaccagcacctcctcaagtcggatgat gtggtaagctgctgccttgacctgggagtgcccagcatctccttccgcatcaatgggcag cctgtgcaggggatgtttgagaacttcaacacggatgggctcttcttccccgtgatgagc ttttcagcaggtgtcaaggtacgattcctcatgggtggacgtcatggagaatttaaattc ttgcctccttctggctatgccccttgctatgaagccttacttccaaaagagaagatgaga ttggagcctgtcaaagaatataaacgtgatgccgagggcgttagagatctgttgggcacc acccagttcctctcccaagcttccttcatcccatgccccatagacaccagtcaggttgtt ttgccacctcacctagagaagatccgagacaggctggctgaaaacatccacgagctttgg ggaatgaataagatagagctcggctggacctttggcaagatgcgggatgacaataaaaga caacacccctgcctggtggagttttcaaaactccctgaaactgagaagaattataacctg caaatgtcaactgaaaccttaaaaaccctcctggccctgggatgccacattgctcatgtt aacccagctgccgaggaggatctcaaaaaggtcaagttgcccaaaaactacatgatgtcc aatggctataagccagcccctttggatttgtctgatgtgaagctgttaccgccccaagaa attttagtggataaacttgcagaaaatgcacacaatgtttgggctaaagatagaataaaa caaggatggacctatggcattcagcaggatttgaagaacaaaagaaatccccgtctggtg ccatatgcattactggatgagcgaactaagaagtcaaacagggacagtctgcgtgaagca gttcggacgttcgttggttatgggtataacattgagccatcagaccaagaactagctgac ccagctgtggagaaagtcagcatagacaagatccgatttttccgggtagagcggtcttac gcagtgagatctggaaagtggtattttgagtttgaggtggtgactggaggagacatgcgg gtcggctgggccaggccaggctgtcggcctgacattgagctggggccgatgaccaagcct ttgtgtttgaaggcagcaggggccagcgttggcaccaaggtagtgggtattttgggcgta ccctggcagccaggagatgtggtcggatgtatgattaacctggatgatgcctcaatgatt ttcacgctgaatggggagctgctgatcaccaataaaggctctgaacttgcctttgctgac tacgagattgaaaatggctttgtgcccatctgctccctggggctatctcaaatcggccgc atgaatctcgggacagacgccagtaccttcaaattttataccatgtgtggtctccaagag ggctttgagcccttcgccgtcaacatgaaccgagatgttgcaatgtggttcagcaagcgc ctcccaacgtttgtcaatgtgccaaaggatcatccacacatcgaggtcgtgaggattgat ggcaccatggacagccctccatgcctcaaggtgacccacaagacgtttggcacacagaac agcaatgccaacatgatctactgccggctgagcatgcccgtcgagtgccattcctccttc agccatagtccctgtctggacagtgaggctttccagaaaaggaaacagatgcaagaaata ctctctcatacaacaacacagtgcttctactccatccgcatctttgccggacaggacccc tcctgcgtctgggttggctgggtgactccggactatcacctgtacagtgagaagtttgac ctgaataaaaactgtacagtgaccgtcaccctgggggacgaaagaggccgggtccatgaa agtgttaagcgcagcaactgctacatggtctggggtggggacgttgtggccagttcccaa agatcaagtcggagcaacgtggacctggagattggctgcctcgtggatcttgcaatgggc atgttgtccttctcagccaatgggaaagaacttggcacgtgctaccaggtggagcctaat accaaagtgtttccagcggtcttcctgcaacccacaagcacatctttgtttcagtttgaa cttggcaagctgaagaatgcaatgcccttgtccgcggccatatttaagagtgaagagaag aacccggtcccccagtgcccacctcggctggatgtccagaccatccagccagtgctctgg agccgcatgcccaacagtttcctgaaggtggagacggagcgggtgagcgagcgccatggt tgggtggtgcagtgcctggagcccctgcagatgatggccctccacatcccagaggagaac aggtgtgtggacattctggagctctgtgagcaggaggacctgatgcagttccattatcac acactgagactgtacagcgcggtgtgtgccctggggaacagccgagtagcgtacgccctg tgcagtcacgtggacctctcccagctcttccatgccattgacaacaagtacctccccggc ctcctgcggtctggtttctacgacctgctcatcagcatccacctggccaatgcgaaggag aggaagctgatgatgaagaacgagtacatcatccccattaccagcaccaccaggaatatt cgcctgtaccctgatgagtccaagaagcatggactgcctggggtgggcccgaggacgtgc ctcaagcccggcttcaagttctctaccccttgctttgtcgtgaccaatgaggagcgccag aagcaaagccctgagattcccttggagattctcaagatgaaggccctgagcatgctgacg gaggcagtgcagtgcagtggggcccacatccgagaccccgttgggggttctgtagagttc cagtttgtgcctgtgctgaaactggttggaaccctgctggtcatgggtgtgttttgcgat gatgacgttcggcagatcctcctcctcatcgatccctctgtgtttggcgaacacagtgca gacacggaggagggagcagaaaaggaagaagtgagccaggtagaggagaaggcagtggag gctggggaaaagaccagcaaagaggccaggaaggaggctccagtcagaggcctgctgcag acccgattgcctgagtccgtcaagctgcagatgtgtgagctcctcagctatctctgtgac tgtgagctgcagcaccgagtggaagccattgtggcatttggtgacatttatgtctccaag ctgcaggccaatcagaagttccgctacaatgagctcatgcaggccctgaacatgtctgca gccctgacagcccggaagaccagggagttccggtcgcccccacaggagcagatcaacatg cttcttaacttccaactgggagagaactgtccctgcccagaggagatccgagaggagctg tacgacttccatgaggaccttctcgttcactgtggggttcccttggaggaagaagaggag gaggaggaggatacttcctggacaggaaaactccgtaccttggtgtataaaatcaaaggc ccacccaagccagagaaggagcagccaacagaggaagaggagagatgccctacaacactg aaggaactcatctcacagacaatgatccgctgggcccaggaggaccagatccaggatgca gagctggtccgaatgatgtttaacctcctccggcggcagtacgacagcatcggggagctg ctgcaggccctgcgcaagacctacaccatcagccacgcctctgtgagcgacaccatcaac ctgctggctgccctgggccagatccgctccctcctgagcgtcaggatgggcagggaggag gagttgctcatgatcaatgggctgggggacataatgaacaataaggtgttttaccagcat cccaacctcatgagagtccttggcatgcatgagacagtgatggaggtgatggtgaatgtg ttgggtaccgagaagtctcagattgcttttccaaagatggttgcgagctgctgccgcttc ctttgctatttctgtcgcattagccgacaaaatcagaaggccatgtttgagcatctgagt tacctgctggagaacagcagtgttggcctagcctccccgtcgatgagagggtccacccca ttggatgtggcagcctcctccgtgatggacaacaacgagttagcactgggcttagaggaa ccggaccttgagaaggtggtgacctacttggcaggctgtggcctacagagctgtcccatg ctactggccaaaggataccctgatgttggctggaaccctattgaaggggagcgctacctg tccttcctgaggtttgccgtcttcgtgaacagtgaaagtgtggaagaaaacgccagcgtc gtggtcaagctgctcatcaggcgcccagagtgcttcggccctgccctgcggggtgaaggg ggaaacggcctcctggcagccatgcagggtgccattaaaatctccgagagcccggcgctt gacctcccctcccagggatacaagcgggaagtcccggaagatggagaagaggaagaagag attgtgcacatgggcaatgcaattatgtccttttactcagctcttatagatctgctgggc cgctgcgctcctgaaatgcacctcatccagacgggaaagggggaagccatccggatccgg tccatcctgcgctccctggtgcccacagaggacctcgtcgggatcatcagcatccccttg aaactgccctccctaaacaaagatggatcagtcagtgagccagatatggcagccaacttc tgccctgaccacaaggcccccatggtactgttcttggaccgtgtttatggcattaaggat caaacttttcttctccacttgctggaggttgggtttttacctgacttaagagcttctgcc tccctagatacggttgccctcagcaccacagagtcggcgctggcactcaacaggtacata tgctctgccgtgctcccgctgcttacaaggtgtgcccctctctttgctgggacggaacac tacacctctctgatcgattctacactgcagacaatatacaggctctccaagggccgatcc ctcaccaaagcacagagggacaccatagaagaatgtctgcttgccatttgcaatcacctg aggccttccatgttacagcaactcctgcgacgtctcgtctttgatgtgccacagctcaat gattactgcaaaatgcctcttaagcttctgaccaaccacttcgagcagtgctggaagtat tactgtctgccttcaggctggggcagctacggccttgccgtggaggaagaactgcaccta acagagaagctcttctggggcatcttcgactccctttcccataagaaatacgaccctgat cttttccgcatgtccctgccttgtctcagtgctatagccggggcattgccaccagattat ttagataccagaatcacagccacgctggagaaacaggtctcagtggatgcagatggcaac ttcgaccccaaacctatcaacaccataaatttttccttgcctgaaaaattggaatacatt gtcaccaagtatgctgagcattcacatgataaatgggcctgtgaaaagagccagagcgga tggaaatacggaatttccctggatgaaaacgtgaagacccacccgctgatcaggcctttc aagaccctgacggagaaggagaaagaaatttatcggtggcctgccagggagtccctgaaa accatgctggctgtgggctggaccgtggagaggaccaaagagggtgaagccttggttcag ctgcgggaaaatgagaaacttcgaagtgtgtcccagaccagccagggtaacagctacaac cctgctcccctcgacctctcaaacgttgtgctctccagagaactccaggggatggtggag gtcgtggctgagaactatcacaatatctgggccaagaagaagaagctggagctggagagc aaaggtggcggcagtcatcctcttctggtgccatatgacaccttaactgccaaggaaaag ttcagagaccgagagaaggcacaggacctgttcaaattcctgcaagtgaatggtgttata gtttctagaggtatgaaggatatggagctggatgccttctccatggaaaagaggtttgcc tataagttcttgaagaagatcctgaaatacgtcgattctgctcaagagtttattgcacat ttggaagccattgtcagcagtgggaaaactgagaagtctccccatgaccaggagatcaaa ttctttgccaaagttctcctcccactggttgaccagtacttcaccaatcaccgcctctac ttcctgtcatctcctctgaagccccttagcagcagtgggtatgcctcccataaagagaaa gaaatggttgccagcctgttctgcaaacttgctgctcttgttagacacaggatttccctc ttcgggagcgattcgactacaatggtgagctgtcttcacatcttagctcagacacttgac acaaggactgtcatgaagtccggctcagagctggtgaaggctggcttacgagcgttcttt gaaagtgctgccgaggacttggagaagacttcggaaaacctgaagctggggaagttcacc cattcccgaacgcagatcaaaggcgtctctcagaatattaactacaccaccgtggctctg ctccccatactgacgtccatctttgagcacgtcgctcagcaccagtttggggtggatctc ctcttgggtgacgtgcagatttcatgctaccgcatcctgtgcagcctgtactcccttggg acaggaaaaaacatctatgttgagagacaacgccctgcccttggagagtgtctggcttca ctggcagctgccatacctgtggcgttcctggagcctactcttaaccgctataatgctctc tcagtcttcaacaccaaaacccccagagaaaggtctattctggggatgccagacacagtg gaagagatgtgccctgacatcccccagctggaaggcctaatgaaggaaatcaatgacctg gctgagtcaggggcccgctacacggagatgcctcatgtcatcgaggtgatcttgcccatg ctctgcaactacctgtcctactggtgggagcggggccctgagaacctgtcccccagcaca gggccctgctgcagcaaggtcacctctgaacacctcagtctcatcctgggcaacatcttg aagatcatcaacaacaacctgggcatcgacgaggcctcctggatgaagcgcattgcagtg tacgcccagccgatcatcagcaaagcgaggccagacctgctgagaagccacttcatccca actctggagaagctgaagaagaaggccgtcaagaccgtgcaggaggaggagcagctgaaa gccgatggcaaaggagacacccaggaggcagagctgctcatcctggatgagtttgccatc ctctgcagagatctctatgccttctaccccatgctgatccgctatgtggacaacaacaga tccaactggctcaaaagccctgatggggattctgaccaactcttccgcatggtggcagag gtcttcatcctgtggtgtaaatcacataacttcaagagggaagaacaaaattttgtgatt cagaatgaaattaataacttggcatttttaactggagacagcaaaagcaagatgtcaaaa gccatgcaagtaaagtctggaggacaggaccaggagcggaagaagacaaagcggagggga gacctgtattccatccagacctccctcatcgtggctgcactcaagaaaatgctgcccatc ggcttgaatatgtgcactccaggcgaccaggagctgatctcccttgccaaatcccgatac agctacagggacacagatgaagaggtcaaggaacatctgcggaataacttgcacttgcaa gaaaagtctgatgacccagctgtaaaatggcaactgaatctctacaaggatgttctgaaa agtgaagagccttccaatccagaaaagactgtggagcgtgtgcagagaatttcagcagct gtcttccacctggaacaggtagaacagcctttgagatccaagaaggccgtctggcacaaa ctattgtcaaagcaacggaaacgggcagtggtggcctgtttcaggatggcccctctctat aacctgcccaggcaccgctctattaacctcttcctccatggctatcagagattttggata gaaacagaggaatattcctttgaagagaaactagtacaggatttggctaaatctccaaag gtggaagaggaggaggaggaagagatggaaaagcaaccagacccgttgcatcagatcatt ctccatttcagccgcaatgctctcactgagaggagcaaattggaagatgaccctctgtac acttcttactccagcatgatggccaagagttgtcagagtggtgaggatgaagaagaagaa gacaaggagaagacatttgaagagaaagagatggagaagcagaaaaccctctatcagcag gctcggctgcatgagcgcggtgccgccgagatggtccttcagatgataagtgccagcaaa ggtgagatgagccccatggtggttgagaccctgaagctgggcatcgccattctgaatgga ggcaacgccggtgtgcaacagaaaatgctagattatctaaaggtgaaaaaggatgctggg ttctttcaaagcctttctggtcttatgcagtcttgcagtgtccttgatttgaatgcgttt gagaggcagaataaagctgaaggcctgggaatggttactgaagaaggaacactcattgtt cgtgagcgtggtgaaaaggtactccagaatgatgagttcacacgagatctctttaggttt ctacagttactttgtgaaggacataacagtgactttcagaacttcttgcgaactcagatg ggaaacactaccaccgtgaatgtcatcatcagcacagtggactatctgctgcgtctacag gaatccatcagtgatttctactggtattactcagggaaagacatcattgatgaatctgga cagcacaatttttccaaagctctagcagtcaccaagcagattttcaattctcttacagaa tatatccagggcccttgtattggaaaccagcagagcctggctcacagtcggctgtgggat gcagtggtcggcttcctccatgtgtttgctaacatgcagatgaaactctctcaggattcc agtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtgatgctt ctgtccctcctggaagggaatgtggtaaatggaaccattggcaagcagatggttgacaca ctggtagaatcatctaccaatgtagaaatgatcttgaaattctttgacatgttcttgaaa cttaaagacttaaccagctcagataccttcaaagaatatgacccagatggtaaagggatt atctccaagaaagaattccagaaggccatggaaggccaaaaacagtatacacagtcagag attgactttctcctctcatgtgcagaagctgatgagaatgacatgtttaattacattgat tttgtagaccggttccatgagccggccaaggacataggctttaatgtggcggtgttactg acaaatctttctgaacacatgccaaatgattctcgcctgaagtgtctgttagacccagca gaaagtgtgctgaattactttgagccatacctagggcgaattgagatcatgggtggggcc aagaaaattgaacgtgtgtattttgagatcagtgaatccagtcgaactcaatgggagaag ccgcaagtgaaggaatctaagcgacagttcattttcgatgttgtcaacgaaggtggagaa caagaaaagatggaactgtttgtgaatttctgtgaggataccatttttgaaatgcaatta gcatcccagatctctgagtctgactcagctgacaggccagaagaagaggaaggagatgaa gaatcctcttatgtgttagaaattaatggggaagaggaggaagacaaatcttttgagtcc gcctctgcatttgccatggcctgtgcctcgttaaagagaaatatcaccaaccttctgagg aaggcaaccctcaagaacctcaggaagcaatacaggaatgtgaaaaagatgaccgcgaag gaactggtgaaagtcttcttctcttttttctggatgctatttgtggggctgtttcagttg ttcttcaccatagtggggggaatcttccagatcctctggagcacagtgttcggagggggc ctcgtagaaggggcaaagaacatcagagtgactaagatcctgggtgatatgcctgaccca acccagtttggtatccacgatgatgcgatggaagctgagagggcagaagtggcagaggca ggcatcacgactgaactagtgcacttcgtcaagggagagaggggagatacagaactcatg tcagacctctttggactccacccaaagaaggaaggtggcgtaaagcatgggcccgaagtg ggtttgggtgacctctccgaaatcatcggcaaggatgaaccccctaccttagagagcact gtacggaagaagaggaaagcacaggcagcagagacgaaggcagaacatgaagcagaagga aaagtagaatctgagaaggcagacttggaagatggggaaaaggaagacaaagccaaagaa gaggagcgagccgagtacctgtgggcagaagtgacaaaaaagaagaagcggcggcgtggt cagaaagttgagaagcctgaagccttcatggccaatttttttaaggggttggaaatctat cagactaagttactgcactacctggccaggaatttctacaacctgaggttccttgctctg tttgtagccttcgctatcaacttcatcctgcttttttataaggtcacagaagaaccgtta gaggaagagactgaggatgttgcaaacctgtggaattccttgaatgatgaggaagaggaa gaagcgatggtgttctttgtcctgcaggagagcactgggtatatggcgccaacactgcgg gccctggccgttgtccacaccatcatctctctggtctgtgtggtgggctattactgcctg aaggtgcctttggtggtattcaaaagggaaaaagaaattgccaggaagctggagtttgat ggcctctatatcactgaacagccatcggaggatgacatcaagggacagtgggaccgcttg gtgatcaacacaccatcttttcctcataactactgggacaagtttgtaaagagaaaggtg atcaacaagtatggagatctgtatggagcagagcgcattgctgaactcctgggcttggac aaaaatgcccttgacttcagtccagttgaagagaccacggcagaggcggcttctctggtg tcatggctgagttccatcgacatgaagtaccacatctggaagctgggggttgtttttact gacaattcctttctctaccttgcctggtacacaaccatgtcagtcctgggccactacaac aacttcttctttgctgctcatctactggatattgcaatgggcttcaagacactaaggacc attctgtcatctgtaacccacaatggcaaacagttggttctgactgtcggtctcctggca gtagttgtttatctctataccgtggtggctttcaacttcttccgcaagttctacaacaaa agtgaggatgatgacgagcctgacatgaagtgtgacgacatgatgacgtgctaccttttc cacatgtacgtgggagtgagggcaggaggcggcatcggcgatgaaattgaggaccctgct ggtgatccttatgaaatgtatcgcattgtatttgacatcacctttttctttttcgtcatt gtcatcttgctggccatcattcaaggtctcattattgacgcttttggagagctgagagac cagcaggaacaagtgagagaagatatggagactaaatgcttcatctgtggcattggcaat gactactttgacacaacccctcatggctttgaaacacatacattacaagagcacaacttg gccaactacctgttctttctgatgtatttgattaataaagatgaaacagagcacacgggt caggaatcctatgtctggaagatgtaccaggaaaggtgttgggatttcttcccagcaggc gactgctttcgcaaacagtatgaagatcagcttggataa

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