Oryctolagus cuniculus (rabbit): 100347407
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Entry
100347407 CDS
T03373
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
KO
K04366
RAF proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
ocu
Oryctolagus cuniculus (rabbit)
Pathway
ocu01521
EGFR tyrosine kinase inhibitor resistance
ocu01522
Endocrine resistance
ocu04010
MAPK signaling pathway
ocu04012
ErbB signaling pathway
ocu04014
Ras signaling pathway
ocu04015
Rap1 signaling pathway
ocu04022
cGMP-PKG signaling pathway
ocu04024
cAMP signaling pathway
ocu04062
Chemokine signaling pathway
ocu04068
FoxO signaling pathway
ocu04071
Sphingolipid signaling pathway
ocu04072
Phospholipase D signaling pathway
ocu04140
Autophagy - animal
ocu04150
mTOR signaling pathway
ocu04151
PI3K-Akt signaling pathway
ocu04210
Apoptosis
ocu04218
Cellular senescence
ocu04270
Vascular smooth muscle contraction
ocu04360
Axon guidance
ocu04370
VEGF signaling pathway
ocu04371
Apelin signaling pathway
ocu04510
Focal adhesion
ocu04540
Gap junction
ocu04550
Signaling pathways regulating pluripotency of stem cells
ocu04613
Neutrophil extracellular trap formation
ocu04625
C-type lectin receptor signaling pathway
ocu04630
JAK-STAT signaling pathway
ocu04650
Natural killer cell mediated cytotoxicity
ocu04660
T cell receptor signaling pathway
ocu04662
B cell receptor signaling pathway
ocu04664
Fc epsilon RI signaling pathway
ocu04666
Fc gamma R-mediated phagocytosis
ocu04720
Long-term potentiation
ocu04722
Neurotrophin signaling pathway
ocu04726
Serotonergic synapse
ocu04730
Long-term depression
ocu04810
Regulation of actin cytoskeleton
ocu04910
Insulin signaling pathway
ocu04912
GnRH signaling pathway
ocu04914
Progesterone-mediated oocyte maturation
ocu04915
Estrogen signaling pathway
ocu04916
Melanogenesis
ocu04917
Prolactin signaling pathway
ocu04919
Thyroid hormone signaling pathway
ocu04921
Oxytocin signaling pathway
ocu04926
Relaxin signaling pathway
ocu04928
Parathyroid hormone synthesis, secretion and action
ocu04929
GnRH secretion
ocu04935
Growth hormone synthesis, secretion and action
ocu05010
Alzheimer disease
ocu05022
Pathways of neurodegeneration - multiple diseases
ocu05034
Alcoholism
ocu05132
Salmonella infection
ocu05152
Tuberculosis
ocu05160
Hepatitis C
ocu05161
Hepatitis B
ocu05163
Human cytomegalovirus infection
ocu05164
Influenza A
ocu05165
Human papillomavirus infection
ocu05167
Kaposi sarcoma-associated herpesvirus infection
ocu05170
Human immunodeficiency virus 1 infection
ocu05200
Pathways in cancer
ocu05205
Proteoglycans in cancer
ocu05206
MicroRNAs in cancer
ocu05207
Chemical carcinogenesis - receptor activation
ocu05208
Chemical carcinogenesis - reactive oxygen species
ocu05210
Colorectal cancer
ocu05211
Renal cell carcinoma
ocu05212
Pancreatic cancer
ocu05213
Endometrial cancer
ocu05214
Glioma
ocu05215
Prostate cancer
ocu05218
Melanoma
ocu05219
Bladder cancer
ocu05220
Chronic myeloid leukemia
ocu05221
Acute myeloid leukemia
ocu05223
Non-small cell lung cancer
ocu05224
Breast cancer
ocu05225
Hepatocellular carcinoma
ocu05226
Gastric cancer
ocu05230
Central carbon metabolism in cancer
ocu05231
Choline metabolism in cancer
ocu05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:
ocu00001
]
09130 Environmental Information Processing
09132 Signal transduction
04014 Ras signaling pathway
100347407
04015 Rap1 signaling pathway
100347407
04630 JAK-STAT signaling pathway
100347407
04068 FoxO signaling pathway
100347407
04072 Phospholipase D signaling pathway
100347407
04071 Sphingolipid signaling pathway
100347407
04024 cAMP signaling pathway
100347407
04022 cGMP-PKG signaling pathway
100347407
04151 PI3K-Akt signaling pathway
100347407
04150 mTOR signaling pathway
100347407
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
100347407
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
100347407
09150 Organismal Systems
09151 Immune system
04613 Neutrophil extracellular trap formation
100347407
04650 Natural killer cell mediated cytotoxicity
100347407
04660 T cell receptor signaling pathway
100347407
04662 B cell receptor signaling pathway
100347407
04664 Fc epsilon RI signaling pathway
100347407
04666 Fc gamma R-mediated phagocytosis
100347407
04062 Chemokine signaling pathway
100347407
09152 Endocrine system
04929 GnRH secretion
100347407
04915 Estrogen signaling pathway
100347407
04917 Prolactin signaling pathway
100347407
04921 Oxytocin signaling pathway
100347407
04926 Relaxin signaling pathway
100347407
04935 Growth hormone synthesis, secretion and action
100347407
04919 Thyroid hormone signaling pathway
100347407
04928 Parathyroid hormone synthesis, secretion and action
100347407
09156 Nervous system
04726 Serotonergic synapse
100347407
04720 Long-term potentiation
100347407
04730 Long-term depression
100347407
04722 Neurotrophin signaling pathway
100347407
09158 Development and regeneration
04360 Axon guidance
100347407
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
100347407
05206 MicroRNAs in cancer
100347407
05205 Proteoglycans in cancer
100347407
05207 Chemical carcinogenesis - receptor activation
100347407
05208 Chemical carcinogenesis - reactive oxygen species
100347407
05230 Central carbon metabolism in cancer
100347407
05231 Choline metabolism in cancer
100347407
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
100347407
09162 Cancer: specific types
05210 Colorectal cancer
100347407
05212 Pancreatic cancer
100347407
05225 Hepatocellular carcinoma
100347407
05226 Gastric cancer
100347407
05214 Glioma
100347407
05221 Acute myeloid leukemia
100347407
05220 Chronic myeloid leukemia
100347407
05218 Melanoma
100347407
05211 Renal cell carcinoma
100347407
05219 Bladder cancer
100347407
05215 Prostate cancer
100347407
05213 Endometrial cancer
100347407
05224 Breast cancer
100347407
05223 Non-small cell lung cancer
100347407
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
100347407
05161 Hepatitis B
100347407
05160 Hepatitis C
100347407
05164 Influenza A
100347407
05163 Human cytomegalovirus infection
100347407
05167 Kaposi sarcoma-associated herpesvirus infection
100347407
05165 Human papillomavirus infection
100347407
09171 Infectious disease: bacterial
05152 Tuberculosis
100347407
09164 Neurodegenerative disease
05010 Alzheimer disease
100347407
05022 Pathways of neurodegeneration - multiple diseases
100347407
09165 Substance dependence
05034 Alcoholism
100347407
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
100347407
01522 Endocrine resistance
100347407
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
ocu01001
]
100347407
Enzymes [BR:
ocu01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
100347407
Protein kinases [BR:
ocu01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
100347407
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
RBD
C1_1
Kinase-like
ABC1
zf-RING-like
Pkinase_fungal
C1_2
Motif
Other DBs
NCBI-GeneID:
100347407
NCBI-ProteinID:
XP_051707682
Ensembl:
ENSOCUG00000014175
LinkDB
All DBs
Position
9:complement(104701036..104792708)
Genome browser
AA seq
686 aa
AA seq
DB search
MPVSHAASPGLSIISAASMEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRA
SDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
HEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNG
FRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGAPALPSLTMRRMRESVS
RMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSL
NASPRAWSRRFGLRGRDAIRSHSESGSPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGS
GTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDP
TPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQM
FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV
EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG
RGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASE
PSLHRAAHTEDINACTLTTSPRLPVF
NT seq
2061 nt
NT seq
+upstream
nt +downstream
nt
atgccggtgtcccatgcagcatcaccaggtttgagcattatttcagctgcatcaatggag
cacatacagggggcttggaagacgatcagcaatggttttggattcaaagatgcagtgttt
gatggctccagctgcatctcccccacgatagttcagcagtttggctatcagcgtcgggcg
tcagatgatggcaaactcacagattcttctaagacaagcaacactatccgtgtgttcttg
ccaaataagcaacgaacagtggtcaatgtgcgaaatgggatgagcttgcatgactgccta
atgaaagcgctcaaggtgaggggcctgcagccggagtgctgtgctgtgttcagactcctc
catgaacataaaggtaaaaaagcacgtttagattggaatacggatgccgcctccttgatt
ggagaagaacttcaagtagatttcctggatcacgttcccctcaccacacacaactttgcc
cgaaagacgttcctgaagcttgccttctgtgacatttgtcaaaagttcctcctcaatgga
tttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagtacctact
atgtgtgtcgactggagtaatatcagacagctcttattgtttccaaactccaccattggt
gatagtggggccccagcactaccttctttgacgatgcgtcggatgcgagaatctgtttcc
cggatgcctgttagttcccagcacagatactccacaccccatgccttcacattcaacacc
tccagtccctcctcagaaggctccctgtcccagaggcagaggtcgacgtccacacctaat
gtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataacagcctg
aatgcttctcccagggcgtggtccagacggtttggtttgaggggaagagatgcaattcga
agtcacagtgaatcaggctcaccttcagccctatccagcagccccaacaatttgagccca
acaggctggtcacagcccaaaacccctgtgccagcacagagagaacgggcaccaggatct
ggaacacaggagaaaaacaaaattaggccccgtggacagagagattccagctattactgg
gaaatagaagccagcgaagtgatgctctccactcggattggatctggctcctttggaact
gtttataaaggcaaatggcatggagacgttgcagtgaagatccttaaggtcgtcgaccca
accccagagcagctgcaggccttcaggaacgaggtggctgtcctgcgcaaaacacggcat
gtgaacatcctactcttcatggggtacatgacaaaggacaacctggcaattgtgacccag
tggtgtgagggcagcagcctctataaacatctgcacgtccaggagaccaagttccagatg
ttccagttaattgacatcgcccgccagacagcacaaggcatggactacttgcatgcaaag
aatatcattcacagagacatgaaatccaacaatatattcctccatgaaggcctaacggtg
aaaattggagatttcggtttggcaacagtaaaatcacggtggagtggttcccagcaggtc
gaacaacctaccggctccgtcctgtggatggctccagaggtgatccgaatgcaggataac
aaccccttcagcttccagtctgacgtctactcgtacggcatcgtgttgtacgagctgatg
acaggggagcttccctactcccacatcaacaaccgggatcagatcatcttcatggtgggc
cggggctatgcctccccggatctcagcaagctctacaagaactgcccgaaagccatgaag
aggctggtggctgactgcgtgaagaaagttaaggaggagaggcctcttttcccccagatc
ctgtcctccatcgagctgctccagcactctctgccgaagatcaaccggagcgcctctgag
ccatccctccaccgggcagcccacactgaggacatcaatgcttgcacgctgaccacgtcc
ccgagactgcccgtcttctag
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