KEGG   Oryctolagus cuniculus (rabbit): 100347407
Entry
100347407         CDS       T03373                                 
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ocu  Oryctolagus cuniculus (rabbit)
Pathway
ocu01521  EGFR tyrosine kinase inhibitor resistance
ocu01522  Endocrine resistance
ocu04010  MAPK signaling pathway
ocu04012  ErbB signaling pathway
ocu04014  Ras signaling pathway
ocu04015  Rap1 signaling pathway
ocu04022  cGMP-PKG signaling pathway
ocu04024  cAMP signaling pathway
ocu04062  Chemokine signaling pathway
ocu04068  FoxO signaling pathway
ocu04071  Sphingolipid signaling pathway
ocu04072  Phospholipase D signaling pathway
ocu04140  Autophagy - animal
ocu04150  mTOR signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04218  Cellular senescence
ocu04270  Vascular smooth muscle contraction
ocu04360  Axon guidance
ocu04370  VEGF signaling pathway
ocu04371  Apelin signaling pathway
ocu04510  Focal adhesion
ocu04540  Gap junction
ocu04550  Signaling pathways regulating pluripotency of stem cells
ocu04613  Neutrophil extracellular trap formation
ocu04625  C-type lectin receptor signaling pathway
ocu04630  JAK-STAT signaling pathway
ocu04650  Natural killer cell mediated cytotoxicity
ocu04660  T cell receptor signaling pathway
ocu04662  B cell receptor signaling pathway
ocu04664  Fc epsilon RI signaling pathway
ocu04666  Fc gamma R-mediated phagocytosis
ocu04720  Long-term potentiation
ocu04722  Neurotrophin signaling pathway
ocu04726  Serotonergic synapse
ocu04730  Long-term depression
ocu04810  Regulation of actin cytoskeleton
ocu04910  Insulin signaling pathway
ocu04912  GnRH signaling pathway
ocu04914  Progesterone-mediated oocyte maturation
ocu04915  Estrogen signaling pathway
ocu04916  Melanogenesis
ocu04917  Prolactin signaling pathway
ocu04919  Thyroid hormone signaling pathway
ocu04921  Oxytocin signaling pathway
ocu04926  Relaxin signaling pathway
ocu04928  Parathyroid hormone synthesis, secretion and action
ocu04929  GnRH secretion
ocu04935  Growth hormone synthesis, secretion and action
ocu05010  Alzheimer disease
ocu05022  Pathways of neurodegeneration - multiple diseases
ocu05034  Alcoholism
ocu05132  Salmonella infection
ocu05152  Tuberculosis
ocu05160  Hepatitis C
ocu05161  Hepatitis B
ocu05163  Human cytomegalovirus infection
ocu05164  Influenza A
ocu05165  Human papillomavirus infection
ocu05167  Kaposi sarcoma-associated herpesvirus infection
ocu05170  Human immunodeficiency virus 1 infection
ocu05200  Pathways in cancer
ocu05205  Proteoglycans in cancer
ocu05206  MicroRNAs in cancer
ocu05207  Chemical carcinogenesis - receptor activation
ocu05208  Chemical carcinogenesis - reactive oxygen species
ocu05210  Colorectal cancer
ocu05211  Renal cell carcinoma
ocu05212  Pancreatic cancer
ocu05213  Endometrial cancer
ocu05214  Glioma
ocu05215  Prostate cancer
ocu05218  Melanoma
ocu05219  Bladder cancer
ocu05220  Chronic myeloid leukemia
ocu05221  Acute myeloid leukemia
ocu05223  Non-small cell lung cancer
ocu05224  Breast cancer
ocu05225  Hepatocellular carcinoma
ocu05226  Gastric cancer
ocu05230  Central carbon metabolism in cancer
ocu05231  Choline metabolism in cancer
ocu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ocu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    100347407
   04015 Rap1 signaling pathway
    100347407
   04630 JAK-STAT signaling pathway
    100347407
   04068 FoxO signaling pathway
    100347407
   04072 Phospholipase D signaling pathway
    100347407
   04071 Sphingolipid signaling pathway
    100347407
   04024 cAMP signaling pathway
    100347407
   04022 cGMP-PKG signaling pathway
    100347407
   04151 PI3K-Akt signaling pathway
    100347407
   04150 mTOR signaling pathway
    100347407
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    100347407
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    100347407
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100347407
   04650 Natural killer cell mediated cytotoxicity
    100347407
   04660 T cell receptor signaling pathway
    100347407
   04662 B cell receptor signaling pathway
    100347407
   04664 Fc epsilon RI signaling pathway
    100347407
   04666 Fc gamma R-mediated phagocytosis
    100347407
   04062 Chemokine signaling pathway
    100347407
  09152 Endocrine system
   04929 GnRH secretion
    100347407
   04915 Estrogen signaling pathway
    100347407
   04917 Prolactin signaling pathway
    100347407
   04921 Oxytocin signaling pathway
    100347407
   04926 Relaxin signaling pathway
    100347407
   04935 Growth hormone synthesis, secretion and action
    100347407
   04919 Thyroid hormone signaling pathway
    100347407
   04928 Parathyroid hormone synthesis, secretion and action
    100347407
  09156 Nervous system
   04726 Serotonergic synapse
    100347407
   04720 Long-term potentiation
    100347407
   04730 Long-term depression
    100347407
   04722 Neurotrophin signaling pathway
    100347407
  09158 Development and regeneration
   04360 Axon guidance
    100347407
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100347407
   05206 MicroRNAs in cancer
    100347407
   05205 Proteoglycans in cancer
    100347407
   05207 Chemical carcinogenesis - receptor activation
    100347407
   05208 Chemical carcinogenesis - reactive oxygen species
    100347407
   05230 Central carbon metabolism in cancer
    100347407
   05231 Choline metabolism in cancer
    100347407
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100347407
  09162 Cancer: specific types
   05210 Colorectal cancer
    100347407
   05212 Pancreatic cancer
    100347407
   05225 Hepatocellular carcinoma
    100347407
   05226 Gastric cancer
    100347407
   05214 Glioma
    100347407
   05221 Acute myeloid leukemia
    100347407
   05220 Chronic myeloid leukemia
    100347407
   05218 Melanoma
    100347407
   05211 Renal cell carcinoma
    100347407
   05219 Bladder cancer
    100347407
   05215 Prostate cancer
    100347407
   05213 Endometrial cancer
    100347407
   05224 Breast cancer
    100347407
   05223 Non-small cell lung cancer
    100347407
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100347407
   05161 Hepatitis B
    100347407
   05160 Hepatitis C
    100347407
   05164 Influenza A
    100347407
   05163 Human cytomegalovirus infection
    100347407
   05167 Kaposi sarcoma-associated herpesvirus infection
    100347407
   05165 Human papillomavirus infection
    100347407
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    100347407
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    100347407
   05022 Pathways of neurodegeneration - multiple diseases
    100347407
  09165 Substance dependence
   05034 Alcoholism
    100347407
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100347407
   01522 Endocrine resistance
    100347407
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ocu01001]
    100347407
Enzymes [BR:ocu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     100347407
Protein kinases [BR:ocu01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   100347407
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 100347407
NCBI-ProteinID: XP_051707682
Ensembl: ENSOCUG00000014175
LinkDB
Position
9:complement(104701036..104792708)
AA seq 686 aa
MPVSHAASPGLSIISAASMEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRA
SDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLL
HEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNG
FRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGAPALPSLTMRRMRESVS
RMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSL
NASPRAWSRRFGLRGRDAIRSHSESGSPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGS
GTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDP
TPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQM
FQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQV
EQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG
RGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASE
PSLHRAAHTEDINACTLTTSPRLPVF
NT seq 2061 nt   +upstreamnt  +downstreamnt
atgccggtgtcccatgcagcatcaccaggtttgagcattatttcagctgcatcaatggag
cacatacagggggcttggaagacgatcagcaatggttttggattcaaagatgcagtgttt
gatggctccagctgcatctcccccacgatagttcagcagtttggctatcagcgtcgggcg
tcagatgatggcaaactcacagattcttctaagacaagcaacactatccgtgtgttcttg
ccaaataagcaacgaacagtggtcaatgtgcgaaatgggatgagcttgcatgactgccta
atgaaagcgctcaaggtgaggggcctgcagccggagtgctgtgctgtgttcagactcctc
catgaacataaaggtaaaaaagcacgtttagattggaatacggatgccgcctccttgatt
ggagaagaacttcaagtagatttcctggatcacgttcccctcaccacacacaactttgcc
cgaaagacgttcctgaagcttgccttctgtgacatttgtcaaaagttcctcctcaatgga
tttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagtacctact
atgtgtgtcgactggagtaatatcagacagctcttattgtttccaaactccaccattggt
gatagtggggccccagcactaccttctttgacgatgcgtcggatgcgagaatctgtttcc
cggatgcctgttagttcccagcacagatactccacaccccatgccttcacattcaacacc
tccagtccctcctcagaaggctccctgtcccagaggcagaggtcgacgtccacacctaat
gtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataacagcctg
aatgcttctcccagggcgtggtccagacggtttggtttgaggggaagagatgcaattcga
agtcacagtgaatcaggctcaccttcagccctatccagcagccccaacaatttgagccca
acaggctggtcacagcccaaaacccctgtgccagcacagagagaacgggcaccaggatct
ggaacacaggagaaaaacaaaattaggccccgtggacagagagattccagctattactgg
gaaatagaagccagcgaagtgatgctctccactcggattggatctggctcctttggaact
gtttataaaggcaaatggcatggagacgttgcagtgaagatccttaaggtcgtcgaccca
accccagagcagctgcaggccttcaggaacgaggtggctgtcctgcgcaaaacacggcat
gtgaacatcctactcttcatggggtacatgacaaaggacaacctggcaattgtgacccag
tggtgtgagggcagcagcctctataaacatctgcacgtccaggagaccaagttccagatg
ttccagttaattgacatcgcccgccagacagcacaaggcatggactacttgcatgcaaag
aatatcattcacagagacatgaaatccaacaatatattcctccatgaaggcctaacggtg
aaaattggagatttcggtttggcaacagtaaaatcacggtggagtggttcccagcaggtc
gaacaacctaccggctccgtcctgtggatggctccagaggtgatccgaatgcaggataac
aaccccttcagcttccagtctgacgtctactcgtacggcatcgtgttgtacgagctgatg
acaggggagcttccctactcccacatcaacaaccgggatcagatcatcttcatggtgggc
cggggctatgcctccccggatctcagcaagctctacaagaactgcccgaaagccatgaag
aggctggtggctgactgcgtgaagaaagttaaggaggagaggcctcttttcccccagatc
ctgtcctccatcgagctgctccagcactctctgccgaagatcaaccggagcgcctctgag
ccatccctccaccgggcagcccacactgaggacatcaatgcttgcacgctgaccacgtcc
ccgagactgcccgtcttctag

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