Otolemur garnettii (small-eared galago): 100960499
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Entry
100960499 CDS
T07855
Symbol
KMT2A
Name
(RefSeq) histone-lysine N-methyltransferase 2A
KO
K09186
[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:
2.1.1.354
]
Organism
oga
Otolemur garnettii (small-eared galago)
Pathway
oga00310
Lysine degradation
oga01100
Metabolic pathways
oga04934
Cushing syndrome
oga05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
oga00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100960499 (KMT2A)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100960499 (KMT2A)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
100960499 (KMT2A)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
oga03000
]
100960499 (KMT2A)
03036 Chromosome and associated proteins [BR:
oga03036
]
100960499 (KMT2A)
Enzymes [BR:
oga01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
100960499 (KMT2A)
Transcription factors [BR:
oga03000
]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
100960499 (KMT2A)
Chromosome and associated proteins [BR:
oga03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100960499 (KMT2A)
HMT complexes
MLL-HCF complex
100960499 (KMT2A)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
SET
FYRC
FYRN
zf-CXXC
PHD
zf-HC5HC2H
zf-HC5HC2H_2
PHD_2
PHD_4
Bromodomain
Motif
Other DBs
NCBI-GeneID:
100960499
NCBI-ProteinID:
XP_023373056
LinkDB
All DBs
Position
Unknown
AA seq
2963 aa
AA seq
DB search
MLAQADKLPMTDKRVASLLKKAKAQLCKIEKSKSLKQTDPPRAQGQESDSSETSVRGPRI
KHVCRRAAVALGRKRAVFPDDMPTLSALPWEEREKILSSMGNDDKSSIAGSEDAEPLAPP
IKPIKPVTRNKAPQEPPVKKGRRSRRCGQCPGCQVPEDCGICTNCLDKPKFGGRNIKKQC
CKMRKCQNLQWMPSKAYLQKQAKAVKKKEKKSKTSEKKESKESSVAKNVVDSSQKLAPST
REDPAPKKSSSEPPPRKPIEEKSEEGNAPAPGPESKQATIPASRKSSKQVSQPAAPVVPQ
QPPSTGPPRKEVPKTTPSEPKKKQPPPPESGPEQSKQKKVAPRPSIPVKQKPKEKEKPPP
VNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWDMGGLGILTSVP
ITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGR
QHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDA
QWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTED
EMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQTSLKQVLTALLNSRTTSHLLRYR
QAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYISVL
EFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSS
NSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPP
TPPILSTDRSREDSPELNPPPGIEDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCA
LWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCLKPGATVGCCLTSCTSNYHFMCSRAKNC
VFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIG
SMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVIEPDIN
STVEHDENRTIAHSPTSCTESSSKESQNTAEIVSPPSPDRPHSQTSGSCYYHVISKVPRI
RTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRS
KLRIMSPMRTGSTYSRNSVSSVSTIGTAADLESSAKGVEHVLGPLSSSTNLGQNTPTSSN
LQRTAVTGGTKTSHLDGSSSSEMKQPNTSDLTSKSSSLKGEKTKMLSSKSSEGPAHNVAY
PGIPKLASQVHNTTSGELNVSKIGTFAEPSAVSFSSKEALSFPQLHLRGQRNDRDQHTDS
TQSANPSPNEETEVKTLKLSGMSNRSSIINEHVGSSSRDRRQKGKKSCKETFKEKHSSKS
FLEPGQVTTGEEGNLKPEFGDEVLAPEFMGQRPCNNVSSDKIGDKALSIPGVPKAPPMQI
EGSVKESQAPRKRTVKVTLTPLKMEGENQSKSALKESSAASPLQMESASPTEPIPASESP
GNGPVAQPSPNNTSSQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARS
NMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFT
RTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNG
KENGTENLKIDRPDDSGEKEHVIKSTVGHKNEPKMDNCHPVSRVKTQGQDSLEAQLSSLE
SSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGE
SPESSSSELLNLGEGLDLDSNREKDMGLFGVFSQQLPTTETVDSSVSSSISAEEQFELPL
ELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSEGDPALLSPGVDPTP
EGHMTPDHFIQGHMDADHISSPPCGPVEQGHGNNQDLTRNSNTPGLQVPVSPTVPIQNQK
YVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLT
SSVSSTPSVMETNTSVLGPMGSGLTLTTGLNPSLPASQSLFPPASKGLLPMPHHQHLHSF
PAATQSSFPPSISNPPSGLLIGVQPPPDPQLLVSEASQRTDLSTTVATPSSGLKKRPISR
LQARKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLSNHPNLLDLGSLNTSSHRTVPNI
IKRSKSGIMYFEQAPLLPQSVGGTAATAAGTSTISQDTSHLASGPVSALASGSSVLNVVS
MPTTTAPTSSTSVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQEQPVALPPSSGM
FPQLGTSQTPSTAAMTAASSICVLPSTQTTGITAASPSGEAEEHYQLQHVNQLLASKTGI
LSTQCDLDSASGPQVSNFTQTVDAPNSGGLEQNKALSSAVQARSSSPGSSPSSAQQSASP
SVPGPTKPKPKIKRIQLPLDKGNGKKHKVSHLRTSSSEAHIPDQEANTTSLTSATGTPGT
EAEQQNTASVEQSSQKECGQPAGQVAGLPEIQVTQNPANEPESTEPKTVEEEESNFSSPL
MLWLQQEQKRKESIAEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARL
KQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARA
EVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKT
SKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFR
IDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKF
PIEDASNKLPCNCGAKKCRKFLN
NT seq
8892 nt
NT seq
+upstream
nt +downstream
nt
atgttggctcaggcagacaagctcccaatgactgacaagagggttgccagcctcctaaaa
aaggccaaagcccagctctgcaagatcgagaagagcaagagtctgaagcagaccgaccca
cccagagcacagggtcaagaaagtgattcatcagagacctctgtgagaggacctcggatt
aaacatgtctgcagaagagcagctgttgcccttggccgaaaacgagctgtgtttcctgat
gacatgcccaccctgagtgccttaccatgggaagaacgagaaaagattttgtcttccatg
gggaatgatgacaagtcatcaattgctggctcagaagatgctgaacctcttgctccaccc
atcaaaccaattaaacctgttaccagaaacaaggcacctcaggaacctccagtaaagaag
ggacggcgatcacggcggtgtgggcagtgtcctggctgccaggtgcctgaggactgtgga
atttgtactaactgcttagacaagcccaagtttggtggccgcaatataaagaagcagtgc
tgcaagatgaggaagtgtcagaatctacaatggatgccttccaaagcctaccttcaaaag
caagctaaagctgtgaaaaagaaagagaaaaagtccaagaccagtgaaaagaaagaaagc
aaagagagcagtgttgcaaagaatgtggtggactctagtcagaaacttgccccttcaaca
agagaggatcctgccccaaagaaaagcagtagcgagcctcctccacgaaagcccatcgag
gaaaagagtgaagaagggaatgcccctgctcccgggcctgaatccaaacaagccaccatt
ccagcttccaggaagtccagcaagcaggtctcccagccagcagcaccagtcgtcccccag
cagccacctagcacaggcccaccaagaaaagaagttcccaagaccactcctagtgaaccc
aagaaaaagcagccgccaccaccagaatcaggtccagagcaaagcaaacagaaaaaagtg
gctccccgcccaagtatccctgtaaaacaaaaaccaaaagaaaaggaaaaaccacctccc
gtcaataagcaggagaatgcaggcactttgaacatccttagcactctctccaacggcaat
agttctaagcaaaaaatcccagcagatggagtccataggatcagagtggactttaaggag
gattgtgaagcagaaaacgtgtgggacatgggaggcttaggaatcctgacctctgttcct
ataacccccagggtggtttgctttctctgtgccagtagtggacatgtagagtttgtgtat
tgccaagtctgctgtgagcccttccacaagttttgtttagaggagaatgagcgccctctg
gaggaccagctggaaaattggtgttgtcgtcgctgcaagttctgtcacgtttgtggaagg
caacatcaggccacaaagcagctgctggagtgtaataagtgccgaaacagctatcaccct
gagtgcctgggaccaaactaccctaccaaacccacaaagaaaaagaaagtttggatctgt
accaagtgtgttcgctgtaagagctgtgggtccacaaccccaggcaaagggtgggatgca
cagtggtctcacgatttctcactgtgccatgattgtgccaaactctttgctaaaggaaac
ttctgccctctctgtgacaaatgttatgatgacgatgactatgagagtaagatgatgcaa
tgtgggaagtgtgatcgctgggtccattccaaatgtgagaatctttcaggtacagaagat
gagatgtatgagattctatctaatctgccagaaagtgtggcctacacttgtgtgaactgt
actgagcgacaccctgcagagtggcgactggccctcgaaaaagagctccagacttctctg
aagcaagttctgacagccttgttgaattctcggactaccagccatttgctacgctaccgg
caggctgccaagccaccggacttaaatcctgagacagaggagagtataccttcccgcagt
tccccagaaggacctgatccacctgtccttactgaggtcagcaaacaggatgatcaacag
cctttagatctggaaggagtcaagaggaaaatggatcaagggaactacatatctgtgttg
gagttcagtgatgatattgtgaagatcattcaagcagccattaattcagatggagggcag
ccagaaattaaaaaagccaacagcatggtcaagtccttctttattcggcaaatggaacgt
gtttttccttggtttagtgtcaaaaagtccagattttgggagccaaataaagtatcaagc
aacagtgggatgttaccaaacgcagtgcttccaccttcacttgaccataattatgctcag
tggcaggagcgagaggaaaacagccacactgagcagcctcctttaatgaagaaaatcatt
ccagctcccaaacccaaagggcctggagaaccggactcaccaactcctctgcatcctcct
acaccaccaattctgagtactgataggagtcgagaagacagtccagaactgaacccaccc
ccaggcatagaagataacagacagtgcgcattgtgtttgatgtatggtgatgacagtgct
aatgatgctggccgtttgctatacattggccaaaatgaatggacacatgtaaattgtgct
ttgtggtcagcggaagtgtttgaagatgatgatggctcactaaagaacgtgcatatggct
gtgatcaggggcaagcagctgagatgtgaattctgcctgaagccaggagccacagtgggc
tgctgtctcacatcctgcaccagcaactatcacttcatgtgttcccgagccaagaactgt
gtctttctggatgataaaaaagtgtattgccaacgacatcgggatttgatcaaaggcgaa
gtggttcctgagaacggatttgaagtttttagaagagtgtttgtggactttgaaggaatc
agcttaagaaggaagtttctcaatggcttggaaccagaaaatatccacatgatgattggc
tccatgacaattgactgcttaggaattctgaatgatctctcggactgtgaagataagctc
tttcctattggatatcagtgttccagggtctattggagcaccacagatgctcgcaagcgc
tgcgtatatacatgcaagatagtggagtgccgtcctccagttatagagccagatatcaac
agcactgttgaacatgatgaaaacaggaccatcgcccatagtccaacatcttgtacagaa
agttcatctaaggaaagtcaaaatacagctgaaattgttagtcctccatcaccagaccga
cctcattcacaaacctctggctcctgttattatcatgtcatctcaaaggtccctaggatt
cgaacacccagttattctccaacacagagatcccctggctgtcggccgttaccttctgca
ggaagtcctaccccaaccactcatgaaatagtcacagtgggtgatcccttactttcctct
ggacttcgaagcattggctccaggcgtcacagcacttcttccttgtcaccccagcggtcc
aaactccggataatgtctccaatgagaactggaagtacttactccaggaatagtgtttcc
tcggtttccaccattgggactgctgcagatcttgagtcaagtgccaaaggagtcgaacat
gtcttagggccactgagttcaagtactaatttagggcagaacactcctacttcttcaaat
ttgcaaaggacagcagttactggaggcactaaaaccagtcacttggatggatcctcatct
tcagaaatgaagcagcccaacacttcagacttgacatctaagagctcttccttaaaggga
gagaagaccaaaatgctgagttccaagagttcagaaggacctgcacataatgtggcttac
cctggaattcctaaactggcctcacaggttcataacacaacatctggagaattgaatgtt
agtaaaattggcacttttgctgagccgtctgcagtctccttttcttctaaagaggccctc
tctttcccacaactccatctgagagggcaaaggaatgatcgagaccagcacacagattct
acccaatcagcaaacccttctccaaatgaagagactgaagtcaaaaccttgaagctatct
ggaatgagcaacagatcgtccattatcaatgaacatgtgggatctagttccagagacagg
agacagaaagggaaaaaatcctgtaaagaaactttcaaagaaaagcattccagtaagtct
tttttggaacctggtcaggtgacaactggtgaggaaggaaacctaaagccagagtttggt
gatgaggttttggctcctgagtttatggggcaacgaccatgtaacaacgtttcttctgat
aaaattggagataaagcgctttctattccaggagtccccaaagccccacccatgcaaata
gaaggatctgtcaaggaatcccaggcaccccggaaacgcacagtcaaagtaacgctgaca
cctctaaaaatggaaggtgagaaccaatccaaaagtgccctgaaagaaagtagtgctgct
tcccccttgcaaatggagtcggcatcaccaacagaaccaattccagcctctgaaagtcca
ggaaatggtccagtggcccaaccaagtcccaataatacctcatcccaggattctcaaagt
aacaactatcagaatcttccagtacaggacagaaacctaatgcttccagatggccccaaa
cctcaggaggatggctcttttaagaggagatatccccgtcgcagtgcccgtgcacgttct
aacatgttctttgggctcaccccactctatggagtaagatcctatggtgaagaagacatt
cccttctatagcagctcaactgggaagaagcgaggcaagagatcagctgaaggacaggtg
gatggggctgatgacttgagcacttcagatgaagatgacttatactattacaatttcaca
agaacagtgatttcttcaggtggagaggagcggctggcatcccataatttatttcgggag
gaggaacaatgtgatcttccaaaaatttcacaattagatggtgtggatgatgggacagag
agtgataccagtgtcacagccacgacaaggaaaagcagccagattccaaaaagaaacggt
aaagaaaatggaacagagaacttaaagattgatcgacctgacgattctggagaaaaagaa
catgtcattaagagtactgtgggtcacaaaaatgagccaaagatggataactgccatcct
gtaagcagagttaaaacacagggacaggattccttggaggctcagctgagctcgttggag
tcaagccgcagagtccacacaagcaccccctcagacaaaaatttacttgacacatacaat
actgagcttctgaagtcagattcagataataacaacagtgatgactgtgggaatatcctg
ccttcagacataatggactttgtgctaaagaatactccatccatgcaggctttgggtgag
agcccagagtcatcttcatcagaactcctgaatcttggggaaggtttggatcttgacagt
aaccgtgaaaaagacatgggtctttttggagtattttctcagcagctgccaacaacagaa
actgtggacagtagtgtctcttcctctatctcagcagaggagcaatttgagctgcctctg
gagctaccgtctgatctctctgtcctgaccacccgaagccccactgtccctagccagaat
cccagtaggctagctgtaatctcagactcaggggagaagagagtaaccatcacagaaaaa
tctgtagcctcctctgaaggtgacccagcactgctgagtcctggagtagatccaactcct
gaaggccacatgacccctgatcattttatccaaggacacatggatgcagaccacatctcc
agccctccttgtggtccagtggaacaaggtcatggcaacaatcaggatttaactagaaat
agtaacacccctggccttcaggtacctgtttcccctactgttcctatccagaaccagaag
tatgtgcccaattctactgacagtcctggcccatctcagatttctaatgcagctgtccag
accactccaccccacctgaaaccagccactgaaaaactcattgttgttaaccagaacatg
cagccactttatgttctccaaactcttccaaatggagtgacccaaaaaatccaattgacc
tcttctgttagttctacacccagtgtgatggagacaaatacttcagtattggggcccatg
ggaagtggtctcaccctaaccacaggactgaatccaagcttgccagcatctcaatctttg
ttccctcctgctagcaaaggattgctccccatgcctcatcaccagcacttacattccttc
cctgccgctactcaaagtagtttcccacccagcatcagcaatcctccttcgggcctcctt
attggggttcagcctcctccagatccccaacttttggtttcagaagcgagccagaggaca
gacctcagtaccacagtagccactccatcctctggactcaagaaaagacccatatctcgt
ctacaggcccgaaagaataaaaaacttgctccctctagtaccccttcaaacattgcccct
tctgacgtggtttctaatatgacgttgattaacttcacaccctcacagctttcaaatcat
cccaatctgttagatttggggtcacttaatacttcatctcaccgaactgtccccaacatc
ataaaaagatctaaatctggcatcatgtattttgaacaggcacccctgttaccacaaagt
gtgggaggaactgctgccacagcggcgggcacatcgacaataagccaagatactagccac
ctcgcatcagggcctgtgtctgccttggcatctggttcctctgtcttaaatgttgtatcc
atgccaactacaacagcccctacaagtagtacatcagttccaggacatgtgaccttaaca
aacccaaggttgcttggtaccccagatattggctcaataagcaatcttttaatcaaagct
agccagcagagcctgggaattcaagagcagcctgtggctttaccaccaagttcaggaatg
ttcccacaactggggacatcacagactccctctactgctgcaatgacagcagcgtcgagc
atctgtgtgctcccatctactcagactacaggcatcacagctgcttcaccctctggggag
gcagaagaacactatcagcttcagcatgtaaaccagctccttgccagcaaaactgggatt
ctctctacccagtgtgaccttgattctgcttcagggccccaggtgtccaactttacccag
acagtagatgctcctaatagcggggggctagagcagaacaaggcgttatcctcagctgtg
caagcccgctcatcctctcctgggagctccccatcctctgcacagcagtcagcaagccct
tcagtaccaggtcccaccaaacccaaaccaaaaatcaagcggattcagctgcccctggac
aaagggaatggcaagaagcacaaagtttctcatttgcggaccagttcttctgaagcacac
attccagaccaagaagccaacacaacatccctgacctcagccacagggactccaggaaca
gaagctgagcaacagaatacagctagtgtggaacagtcatcacaaaaggagtgtgggcaa
cctgcagggcaagtggctggtcttccagagattcaggtgacacaaaatccagcaaatgaa
ccagaaagtacagaacctaaaacggtggaagaagaagaaagtaatttcagctctccactg
atgctttggctccagcaagaacaaaagcggaaggaaagcattgctgagaaaaagcccaag
aaaggacttgtctttgaaatttcaagtgatgatggctttcagatctgtgcagaaagcatt
gaagatgcctggaagtcactgacagataaagtccaggaagctcgatcaaatgcccgccta
aagcagctctcatttgcaggtgttaatggtttgagaatgctgggaattctccatgatgca
gttgtattcctgattgagcagctatctggtgccaagcactgtcgaaattacaaatttcgt
tttcacaaaccagaagaggccaatgaaccccccttgaaccctcatggttcagccagggct
gaagtccacctcaggaagtcagcatttgacatgtttaacttcctggcttccaaacatcga
cagcctcctgaatacaacccaaatgatgaggaagaggaggaggtacagctgaagtcagct
cggagggcaaccagcatggatctgccaatgcccatgcgatttcggcacttaaaaaagact
tctaaggaggcagttggtgtctacaggtctcccatccatgggcggggtcttttctgtaag
agaaacattgatgctggtgagatggtgattgaatatgctggcaatgtcatccgttccatc
cagactgacaagagagagaagtattatgacagcaagggcattggttgctacatgttccga
attgatgactcagaggtagtggatgccaccatgcatggaaatgctgcacgcttcatcaat
cactcttgtgagcctaactgctactctcgagtcatcaatattgatgggcagaagcacatt
gtcatctttgccatgcgtaagatctaccgaggggaggaactcacttatgactataagttc
cccattgaggatgccagcaacaagctgccctgcaactgtggcgccaagaaatgccggaag
ttcctaaactaa
DBGET
integrated database retrieval system
